Drug Formulation/Drug Delivery â Raj Suryanarayanan
Drug Formulation/Drug Delivery â Raj Suryanarayanan
Drug Formulation/Drug Delivery â Raj Suryanarayanan
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<strong>Drug</strong> <strong>Formulation</strong> / <strong>Drug</strong> <strong>Delivery</strong><br />
<strong>Raj</strong> <strong>Suryanarayanan</strong> (Sury)<br />
Department of Pharmaceutics<br />
College of Pharmacy<br />
surya001@umn.edu<br />
1
Faculty Research hAreas<br />
• Biological Pharmaceutics (Pharmacokinetics,<br />
Pharmacodynamics, Metabolism)<br />
Elmquist, Fairbanks, Sawchuk, Zimmerman<br />
• Physical Pharmaceutics (Materials Science)<br />
<strong>Suryanarayanan</strong>, Sun<br />
• <strong>Drug</strong> <strong>Delivery</strong><br />
Kandimalla, Prabha, Panyam, Siegel, Wiedmann<br />
2
Center for Translational <strong>Drug</strong> <strong>Delivery</strong><br />
Developing collaborative relationships with<br />
pharmaceutical companies in the area of drug<br />
delivery<br />
<strong>Raj</strong> <strong>Suryanarayanan</strong>(Sury), Pharmaceutics<br />
Surya001@umn.edu<br />
4
Goals and missions of the Center<br />
• Bi Bring together faculty with ih interest in drug<br />
delivery<br />
• Leverage our comprehensive expertise in drug<br />
delivery – develop collaborations with<br />
pharmaceutical companies<br />
• Work with the different administrative units to<br />
expedite legal and contractual issues<br />
• Serve as a platform for training i grants and program<br />
project grants that are focused on drug delivery<br />
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AeroCore<br />
Supporting research and product<br />
development through inhalation<br />
drug delivery
Core Activities<br />
• Aerosol generation<br />
• Characterization of aerosol particles (output/particle<br />
size distributions)<br />
• Exposure of rodents to aerosol particles or vapors<br />
• Measurement of chemicals deposited in the<br />
respiratory tract and accumulation in blood of rodents<br />
• Gross and microscopic examinations of rodents<br />
• Disease induction in animal models (e.g. cancer)
1. <strong>Drug</strong> solubilization through engineering solid form<br />
(nanocaging, solid dispersion, cocrystallization, salt<br />
formation, etc.)<br />
2. Tablet formulation and manufacturing process<br />
understanding and control<br />
3. Structure-mechanical property relationship in<br />
organic crystals and powders<br />
CC C.C. Sun<br />
The aqueous solubility of poorly soluble drugs is significantly improved by<br />
nanocaging.
Kandimalla lab drug delivery<br />
projects<br />
Design of nanotheranostics for the diagnosis<br />
and treatment of cerebrovascular diseases.<br />
Elucidation of biophysical properties p of<br />
endogenous macromolecules and their transport<br />
across the cellular barriers, particularly the blood<br />
brain barrier.<br />
Development of novel drug delivery approaches<br />
to disrupt bacterial biofilms.<br />
Strategies to evaluate and enhance oxidative<br />
stability of natural carrier oils.
Prabha Research Interests<br />
Oral formulations to improve bioavailability of<br />
poorly soluble drugs<br />
Anti-angiogenic therapy for ovarian cancer<br />
Sustained protein/gene delivery for chronic wounds<br />
Photodynamic therapy for treating microbial<br />
infections in chronic wounds
Panyam Research Interests<br />
Targeted Antibiotic <strong>Delivery</strong> for Chlamydial Infections<br />
NIAID/NIH<br />
Magnetic Hyperthermia for Lung Cancer<br />
Department of Defense<br />
Polymeric Systems for Cancer Prevention/Treatment<br />
NCI/NIH<br />
Targeting Cancer Stem Cells<br />
Randy Shaver Foundation
SIEGEL LAB<br />
• Polymeric <strong>Drug</strong> <strong>Delivery</strong> Systems, Hydrogels<br />
• Microfabricated Sensors (e.g. temperature, pH,<br />
glucose)<br />
• Intranasal <strong>Delivery</strong> of Low Solubility, Fast Acting <strong>Drug</strong>s<br />
DZP in<br />
Bloodstream<br />
Diazepam (DZP)<br />
prodrug administered<br />
with converting<br />
enzyme<br />
Unabsorbed DZP<br />
Cleared in<br />
Nasopharynx<br />
“Crystallization” Horse<br />
“Absorption”<br />
Horse<br />
Application:<br />
Canine Epilepsy<br />
Starting Line<br />
Finish Line