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8 Brodsky FM, Lem L, Solache A, Bennett EM. 1999. Human pathogen subversion of antigen presentation. Immunol. Rev. 168: 199-215. Koopmann JO, Hämmerling GJ, Momburg F. 1997. Generation, intracellular transport and loading of peptides associated with MHC class I molecules. Curr. Opin. Immunol. 9: 80-8. Mellman I, Steinman RM. 2001. Dendritic cells: specialized and regulated antigen processing machines. Cell. 106: 255-8. Brocke P, Garbi N, Momburg F, Hämmerling GJ. 2002. HLA-DM, HLA-DO and tapasin: functional similarities and differences. Curr. Opin. Immunol. 14: 22-9. Note: Immunol. Rev. Vol 207 (2005) is dedicated to “Antigen processing and presentation” and contains more review articles for those who would like to read further. DISCUSSION PAPERS Narayan, K. et al. HLA-DM targets the hydrogen bond between the histidine at position 81 and peptide to dissociate HLA-DR-peptide complexes. Nature Immunol. 8: 92-100 (2007) Blander, JM & Medzhitov, R. Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 440: 808-812 (2006) Schmid, D, Pypaert, M., Munz, C. Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity 26: 79-92 (2007) Peaper, DR & Cresswell, P. The redox activity of Erp57 is not essential for its function in MHC class I peptide loading. Proc. Natl. Acad. Sci. USA 105: 10477-10482 (2008) Van der Wel, N. et al. Mycobacterium tuberculosis and Mycobacterium leprae translocate from the phagolysosome to the cytosol in myeloid cells. Cell 129: 1287-1298 (2007). 5. Inflammation & inflammatory disease – Geoffrey Krissansen REVIEWS Galli SJ, Tsai M, Piliponsky AM. The development of allergic inflammation. Nature 454: 445-54, 2008. Hansson GK, Libby P. The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol. 6: 508-519, 2006. Tang Q, Bluestone JA. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol. 9: 239-44, 2008. DISCUSSION PAPERS Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464:104-7, 2010. NEWS & VIEWS Calfee CS, Matthay MA. Clinical immunology: Culprits with evolutionary ties. Nature 464:41-2, 2010. Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T, Sakaguchi S. CTLA-4 control over Foxp3+ regulatory T cell function. Science 322: 271-5, 2008.
9 Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D. Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature 449: 361-365, 2007. Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317: 256-60, 2007. Sun H, Gong S, Carmody RJ, Hilliard A, Li L, Sun J, Kong L, Xu L, Hilliard B, Hu S, Shen H, Yang X, Chen YH. TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell 133: 415-26, 2008. 6. Tumour immunology – Kevin Sun REVIEWS Zitvogel L, Tesniere A, Kroemer G.(2006) Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol 6(10): 715-27. Bhardwaj N. Harnessing the immune system to treat cancer. (2007) J Clin Invest 117: 1130-1136. Tacken PJ. de Vries IJ. Torensma R. Figdor CG. (2007) Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting. Nat Rev Immunol 7(10):790-802. Zou W. (2005) Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer. 5:263-74. DISCUSSION PAPERS Eisenring M, vom Berg J, Kristiansen G, Saller E, Becher B. (2010) IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46. Nat Immunol. 11(11):1030-8. Pellegrini M, Calzascia T, Elford AR, Shahinian A, Lin AE, Dissanayake D, Dhanji S, Nguyen LT, Gronski MA, Morre M, Assouline B, Lahl K, Sparwasser T, Ohashi PS, Mak TW. (2009) Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nat Med. 15(5):528-36 Pastor F, Kolonias D, Giangrande PH, Gilboa E. (2010) Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay. Nature. 465(7295):227-30. Stephan MT, Ponomarev V, Brentjens RJ, Chang AH, Dobrenkov KV, Heller G, Sadelain M. (2007) T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection. Nat Med. 13(12):1440-9. Tanaka H, Kono E, Tran CP, Miyazaki H, Yamashiro J, Shimomura T, Fazli L, Wada R, Huang J, Vessella RL, An J, Horvath S, Gleave M, Rettig MB, Wainberg ZA, Reiter RE. (2010) Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance. Nat Med. 16(12):1414-20.
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