Endocan / ESM-1 - BioNovus Life Sciences
Endocan / ESM-1 - BioNovus Life Sciences
Endocan / ESM-1 - BioNovus Life Sciences
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<strong>Endocan</strong> / <strong>ESM</strong>-1<br />
Your solution for the analysis of<br />
vascular remodeling<br />
Monoclonal Antibody MEP08
The monoclonal antibody against human endocan / <strong>ESM</strong>-1 called<br />
MEP08 1 (LIA-0901) developed by Lunginnov can analyze the activation of<br />
the endothelium by immunohistochemistry<br />
Background<br />
<strong>Endocan</strong> also called endothelial cell specific molecule 1 or <strong>ESM</strong>-1 is a biomarker of endothelial<br />
dysfunction (Sarrazin et al. 2010). This proteoglycan of 50 kDa is overexpressed by vessels in lung,<br />
liver, brain and kidney cancers (Grigoriu et al. 2006 ; Maurage et al. 2009 ; Leroy et al. 2010 ; Sarrazin<br />
et al. 2010).<br />
Recently endocan / <strong>ESM</strong>-1 was identified as a biomarker of tip cells , endothelial cells involved in<br />
tumor angiogenesis (Sarrazin et al. 2010). The expression of endocan / <strong>ESM</strong>-1 is correlated with the<br />
expression of VEGF (Grigoriu et al. 2009). Anti-angiogenic treatment of endothelial cells decrease<br />
the expression of endocan / <strong>ESM</strong>-1 induces by the Vascular Endothelial Growth Factor (Grigoriu et<br />
al. 2006 ; Leroy et al. 2010).<br />
By discriminating tumor vessels from normal vessels, the antibody MEP08 (LIA-0901) allows an<br />
analysis of vascular remodeling and represents a pertinent tool to evaluate the neoangiogenesis.<br />
Main features<br />
Monoclonal antibody (mouse)<br />
Recommanded for immunohistochemistry<br />
(paraffin and frozen sections)<br />
Specific of the N-terminus of human<br />
endocan / <strong>ESM</strong>-1<br />
Easy to use / do not required any enzymatic<br />
pre-treatment<br />
Can be use with automatized procedures<br />
Stored at 4°C / -20°C<br />
References<br />
Bechard et al. (2000) J. Vasc. Res. 37:417-425<br />
Carrillo et al. (2011) Eur. J. Histochem. In Press<br />
Grigoriu et al. (2006) Clin. Cancer Res. 12:4575-4582<br />
Leroy et al. (2010) Histopathology 56:180-187<br />
Maurage et al. (2009) Exp. Neurol. 68:836-844<br />
Sarrazin et al. (2010) J. Cancer. Sci. Ther. 2:47-52<br />
1<br />
This product is for research use only and is not intended for diagnostic or therapeutic use<br />
Lunginnov s.a.s<br />
Campus de l’Institut Pasteur de Lille<br />
1 rue du Pr Calmette, 59000 LILLE, France<br />
Tel : (33) 320 877 211 / Fax : (33) 320 877 884<br />
E mail : contact@lunginnov.com<br />
www.lunginnov.com
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