WANG Jian-Ying ( USA)

NAME: 

CURRICULUM VITAE 

Jian-Ying Wang, MD, Ph.D 

PRESENT POSITION: Professor (with tenure) 

Departments of Surgery and Pathology 

Associate Chair for Basic Research 

Department of Surgery 

University of Maryland School of Medicine 

Senior Research Career Scientist 

Medical Research Service 

US Department of Veterans Affairs 

Office Address: Baltimore VA Medical Center (112), Room #5C-122 

10 North Greene Street 

Baltimore, Maryland 21201 

Tel: (410)-605-7000 ×5678 

Fax: (410)-605-7919 

E-mail: jwang@smail.umaryland.edu 

BIOGRAPHICAL: 

Birth Day: August 17, 1957 

Birth Place: Sannxi, PR. China 

Citizenship: USA (Naturalized on July 22, 1997) 

Home Address: 12216 Running Fence Lane 

Clarksville, Maryland 21029 

Marital Status: Married, Pauline Hsu, MD, Ph.D 

Children: Shelley R. Wang (11/86) 

Ashley R. Wang (3/00) 

EDUCATION: 

1978 MD. Sun Yat-Sen College of Medicine, Sun Yat-Sen University, 

Guangzhou, PR. China (Medicine) 

1983 MS. Department of Pathophysiology (Dr. C. Hou), Sun Yat-Sen 

College of Medicine, Sun Yat-Sen University, Guangzhou, PR China 

(Gastrointestinal Pathophysiology) 

1986 Ph.D. Department of Physiology (Dr. C-C. Wang), Peking (Beijing) 

University School of Medicine, Beijing, PR China (GI Physiology) 

Internship (Medicine): 

1977-1978 Sun Yat-Sen Memorial Hospital, Guangzhou, PR China 

Residency (Pathology): 

1979-1980 Department of Pathology, College of Medicine, Sun Yat-Sen 

University, Guangzhou, PR China 

Postdoctoral Fellowship:

1987-1988 Department of Applied Pharmacology (Dr. Susumu Okabe), Kyoto 

Pharmaceutical University, Kyoto, Japan 

1988-1992 Department of Physiology and Cell Biology (Dr. Leonard R. Johnson), 

University of Texas School of Medicine, Houston, TX 

ACADEMIC APPOINTMENTS: 

1992-1993 Instructor, Department of Physiology and Biophysics, College of 

Medicine, University of Tennessee, Memphis, TN 

1993-1994 Assistant Professor, Department of Physiology and Biophysics, 

College of Medicine, University of Tennessee, Memphis, TN 

1994-1998 Assistant Professor (on the tenure track), Department of Surgery, 

University of Maryland Medical School, Baltimore, Maryland 

1995-2001 Biological Scientist, Medical Research Service, Baltimore VA 

Medical Center, Baltimore, Maryland 

1998-2001 Associate Professor (on the tenure track), Division of General Surgery, 

Department of Surgery, University of Maryland School of Medicine, 

Baltimore, Maryland 

2001-2002 Associate Professor (with tenure), Department of Surgery, University 

of Maryland School of Medicine, Baltimore, Maryland 

2000-2002 Associate Professor (second appointment), Department of Pathology, 

University of Maryland School of Medicine, Baltimore, Maryland 

1998-2006 Director, Surgical GI Research Laboratories, Department of Surgery, 


2005-2008 Adjunct Member, Graduate School, University of Maryland College 

Park 

2001-2010 Research Career Scientist, Medical Research Service, US 

Department of Veterans Affairs 

2000- Member, University of Maryland Graduate School, Baltimore, 

Maryland 

2002- Professor, Departments of Surgery and Pathology, University of 

Maryland School of Medicine, Baltimore, Maryland 

2004- Member, Mucosal Biology Research Center, University of Maryland 

School of Medicine 

2005- Member, Molecular Medicine Graduate Program, University of 

Maryland School of Medicine 

2005- Associate Chair for Basic Research, Department of Surgery, 


2006- Director, Cell Biology Group, Department of Surgery, University of 

Maryland School of Medicine, Baltimore, Maryland 

2011- Senior Research Career Scientist, Medical Research Service, US 

Department of Veterans Affairs 

RESEARCH INTERESTS: 

Gut mucosal growth, injury and repair, and barrier function 

Biological functions of cellular polyamines

mRNA stability and translation 

RNA-binding proteins and microRNAs 

Gene transcriptional regulation and transcription factors 

Cell division, growth arrest, apoptosis, and cell-to-cell interactions 

K + channels, TRP channels, and intracellular Ca 2+ in epithelial cells 

Cytoskeleton and intercellular junctions 

HONORS/AWARDS: 

1978 Medical School, Honor Student at Graduation 

1983 Graduate School, Excellent Scientific Paper, Sun Yat-Sen University 

of Medical Science 

1989 Travel Award for International GI Peptide Research Conference, 

American Gastroenterological Association (AGA) 

1990 Travel Award for Junior Investigator Participation, FASEB Summer 

Conferences 

1992 Travel Award for Junior Investigator Participation, FASEB Summer 

Research Conferences 

1994 NIH FIRST Award, NIH 

2001 Medical Research Career Scientist Award, Medical Research Service, 

US Department of Veterans Affairs 

UNIVERSITY AND HOSPITAL SERVICE: 

1995-1997 Member, Committee on Biohazard and Radiation Safety, Baltimore 

VA Medical Center 

1998 Ad Hoc Reviewer for Intramural Grant, University of Maryland 

School of Medicine, Baltimore, Maryland 

2003-2005 Member, Search Committee for Associate Chief of Staff for Research 

and Development, VA Maryland Health Care System 

2002-2005 Member, Promotion and Tenure Committee, Department of Surgery, 


1995-2005 Member, Seminar Committee, Baltimore VA Medical Center 

1999-2007 Member, R&D Committee, Baltimore VA Medical Center 

2000- Member, Research Space Committee, Baltimore VA Medical Center 

2004- Member, Research Service Proposal Review Committee, Baltimore 

VA Medical Center 

2006- Member, Executive Committee of Surgery Department, UMB 

NATIONAL AND INTERNATIONAL ACTIVITIES: 

1999 Member, Abstract Review Committee, Section of Mechanisms of GI 

Mucosal Injury, American Gastroenterological Association (AGA) 

1999 Member, Study Section of Special Emphasis Panel ZDK1 GRB-7 

(M1), National Institute of Diabetes and Digestive and Kidney 

Diseases (NIDDK), NIH 

2000 Chair, Abstract Review Committee, Section of Mechanisms of 

Mucosal Injury, AGA 

2000 Member, Study Section of NIDDK Special Emphasis Panel ZDK1 

GRB-4, NIH

2000 Member, Study Section of Program Project Grants, National Heart, 

Lung, and Blood Institute (NHLBI), NIH 

2000, 2002 Honorarium for the External Examiner for M. Med. Sc. 

Examination, University of Hong Kong School of Medicine, Hong 

Kong 

2000-2002 Member, Abstract Review Committee, Section of Esophageal, 

Gastric and Duodenal mucosal injury and repair, AGA 

2000-2003 Ad Hoc Member, Study Section of Surgery and Bioengineering (SB), 

NIH 

2002 Ad Hoc Reviewer, Study Section of Biochemistry of Gene/Expression, 

National Science foundation (NSF) 

2003 Ad Hoc Reviewer, Gastroenterology Study Section, MERIT Review 

Board, VA 

2005 Member, Study Section of NIDDK Special Emphasis Panel ZDK1 

GRB-2 (M2), NIH 

2004-2005 Member, Study Section of Bioengineering, Technology and Surgical 

Science (BTSS), NIH 

2005 Member, Study Section of NIDCR Specific Review of R21s (ZDE1 

YL 05), NIH 

2001-2005 Member, Scientific Review Board, the Philip Morris External 

Research Program, USA 

2006 Ad Hoc Member, Study Section of Gastrointestinal Mucosal 

Pathobiology (GMPB), NIH 

2005-2006 Member, Abstract Review Committee, the Esophageal, Gastric and 

Duodenal Disorder Section, AGA 

2006, 2007 Member, Study Section of Special Emphasis Panel-ZRG1 SBIB-E (2) 

for SAT-study section member conflict, NIH 

2003-2007 International Member, Study Section of Physiology and Pathology, 

Chinese National Science Foundation 

2006-2007 Ad Hoc Member, Study Section of Surgery, Anesthesiology and 

Trauma, NIH 

2007-2009 Member, Eligibility Evaluation Committee for VA non-Clinician 

Investigators, VA Medical Research Service, VA 

2007- Member, Subcommittee for Surgery, VA Joint Biomedical Laboratory 

Research and Development and Clinical Research and Development 

Scientific Merit Review Board, VA 

2008- Member, Study Section of Surgery, Anesthesiology and Trauma 

(SAT), NIH 

2009- Chair, Abstract Review Committee, the Esophageal, Gastric and 

Duodenal Disorder Section, AGA 

PROFESSIONAL MEMBERSHIPS: 

1993-1999 Member, Sigma Xi 

1993- Member, American Physiological Society (APS)

1997- Member, American Gastroenterological Association (AGA) 

EDITORIAL BOARDS: 

2003- Member, Editorial Board, American Journal Physiology - Gastrointestinal 

and Liver Physiology 

2003- Member, Editorial Board, American Journal Physiology - Cell 

Physiology 

2003- Member, Editorial Board, World Journal of Gastroenterology 

2007- Funding Member, Editorial Board of International Journal Clinical 

and Experimental Medicine 

2011- Member, Editorial Board of Acta Physioloica Sinica 

1991- Ad hoc Reviewer: 

Aging and development 

American Journal of Pathology 

American Journal of Physiology: Cell Physiology 

American Journal of Physiology: Gastrointestinal and Liver 

Physiology 

American Journal of Physiology: Regul Integr Comp Physiology 

Annual of Surgery 

Biochemical and Biophysical Research Communications 

Cancer Investigation 

Cell Motility and Cytoskeleton 

Digestion 

Endocrinology 

European Journal of Clinical Investigation 

Experimental Cell Research 

FASEB J 

FEBS Letters 

Gastroenterology 

Hepatology 

In Vitro 

International Journal of Biochemistry and Biology 

Journal of Cardiovascular Research 

Journal of Cell Biology 

Journal of Cellular Biochemistry 

Journal of Clinical Investigation 

Journal of Cellular Physiology 

Journal of Endocrinology 

Journal of Pediatric Gastroenterology and Nutrition 

Journal of Pharmacology and Experimental Therapeutics 

Journal of Surgical Research 

Laboratory Investigation 

Life Science 

Molecular and Cellular Biochemistry 

Nature Communication

Oncogene 

Pediatric Research 

Proceeding of Society for Experimental Biology and Medicine 

Regulatory Peptides 

Surgery 

World Journal of Gastroenterology 

Wound Repair and Regeneration 

TEACHING RESPONSIBILITIES: 

A. Lectures and Facilitator 

2001-2007 Problem-Based Learning (PBL) Program (S0M05) 

8 Sections/year (2 hours of each section), total 16 hours/year 

2000-2007 Subcellular and Molecular Pathobiology-A Organelle based Approach 

(Course: #713) 

Co-Director of the Course (2000-2002) 

Cell Membrane (2 lectures) 

Extracellular Matrix and Cell Interaction (2 lectures) 

Cellular Signaling (2 lectures) 

Cytoskeleton and Cell Motility (2 lectures) 

2009- Advanced Experimental Techniques in Biomedical Research 

Advanced Methodology in Posttranscriptional RNA Regulation (1 lecture) 

B. Graduate Students: 

1992-1994 Member, Thesis Committee, Ali Banan (Ph.D degree), Department of 

Physiology and Biophysics, University of Tennessee at Memphis, TN 

2004-2006 Member, Thesis Committee, John W. Parry (Ph.D degree), 

Department of Nutrition and Food Sciences, University of Maryland 

School of Agricultures, College Park, MD 

2003-2007 Mentor/Chair, Thesis Committee, Bernard Marasa (Ph.D degree), 

Department of Pathology, University of Maryland School of Medicine, 

Baltimore, MD 

2010- Member, Thesis Committee, Beth E. Zucconi (Ph.D degree), 

Biochemistry and Molecular Biologr Program, University of Maryland, 

Baltimore, MD 

C. Postdoctoral Fellows and Visiting Scientists: 

1. Anami R. Patel, Ph.D. -Postdoctoral fellow from June 1995 to May 

1997; currently an assistant professor, UT at Memphis, TN 

2 Ji Li, MD. -Research fellow and then associate from June 1995 to 

May 1999; currently a physician in San Francisco, CA 

3. Lih-Min Tsai, Ph.D. -Visiting scientist from January 1996 to June 

1996; currently a professor, National Defense Medical Institute, 

Taiwan 

4. Chi-Hin Cho, Ph.D. -Visiting professor from March 1996 to June 

1996; currently a chair professor, University of Hong Kong, China 

5. Li Li, MD. -Postdoctoral fellow from July 1997 to November 2001; 

currently a research scientist, VENTIS Pharmaceutical Company, NJ

6. Jaladanki N. Rao, Ph.D. -Postdoctoral fellow from October 1997 to 

July 2002; currently an assistant professor, UMB, Baltimore, MD 

7. Xin Guo, Ph.D. -Postdoctoral fellow from August 2000 to March 

2004; currently an instructor, Eastern Virginia Medical School, 

Norfolk, VA 

8. Mary Huifang Zhang, Ph.D. -Postdoctoral fellow from December 

2002 to October 2004; currently an assistant scientist, University of 

British Columbia School of Medicine, Vancouver, Canada 

9. Tongtong Zou, Ph.D. -Postdoctoral fellow from February 2002 to 

January 2005; currently an instructor, UMB, Baltimore, MD 

10. Dessy Boneva, MD. -Research fellow from June 2003 to July 2004; 

currently a surgical residency in UMB, Baltimore, MD 

11. Kaspar M. Keledjian, MD. - Research fellow from June 2004 – July 

2006; currently a research associate, UMB, Baltimore, MD 

12. Aihong Zhang, Ph.D. -Postdoctoral fellow from November 2004 – 

April 2007; currently a research associate, UMB, Baltimore, MD 

13. Jose Greenspon, MD. - Surgical resident from July 2005 – July 2007; 

currently pediatric surgical fellow, UMB, Baltimore, MD 

14. Jie Chen, Ph.D. - Postdoctoral fellow from March 2005 – December 

2007; currently a professor, Chongqing Medical University, PR. China 

15. Emily Bellavance, MD. - Surgical resident from July 2007 – July 

2008, current a surgical oncology fellow at University of Chicago 

16. Xiaoyu Zhu, MS. -Pre-doctoral international visiting student from 

February 2008 to October 2008, an instructor at Sun Yat-Sen 

University, China 

17. Xian Zhang, MS. - Pre-doctoral international visiting student from 

January 2008 – March, 2009; currently an instructor, Guangzhou 

University of Traditional Chinese Medicine, China 

18. Ying Xie, Ph.D - Postdoctoral fellow from November 2007- June, 

2008; currently a research fellow at UMB 

19. Peng-Yuan Wang, MD. - Postdoctoral fellow from January 2008 – 

December 2009; currently an attending surgeon and assistant professor, 

Beijing University School of Medicine, Beijing, China 

20. Lan Liu, MD. - Postdoctoral fellow from August 2000 – current 

21. Lan Xiao, MD. -Postdoctoral fellow from November 2004 – current 

22. Tingxi Yu, MD, Ph.D. - Postdoctoral fellow from November 2007- 

current 

23. Jennifer A. Timmons, MD. –Surgical resident from July 2008 - 

current 

24. Yu-Hong Cui, Ph.D. –Postdoctoral fellow from December 2008 – 

current 

25. Navneeta Rathor, MD. –Research fellow from June 2009 –current 

26. Ping Jiang, MD, Ph.D. –Postdoctoral fellow from December 30, 

2009 –current

27. Yu Chen, MD, Ph.D. –Postdoctoral fellow from August 

2010-currrent 

28. Alexis Smith, MD. –Surgical resident from July 2010 - current 

D. Research Mentor for Junior Faculty: 

2002-2004 Mark Cowan MD, Assistant Professor (Medicine) 

2000-2005 Eric D. Strauch MD, Associate Professor (Surgery) 

2005-2006 Debra L. Malone, MD, Assistant Professor (Surgery-Trauma Care) 

2001-007 Douglas J. Turner, MD, Associate Professor (Surgery) 

2009- James M. Donahue, MD, Assistant Professor (Surgery) 

2003- Jaladanki N. Rao, Ph.D, Assistant Professor (Surgery) 

2005- Tongtong Zou, Ph.D, Instructor (Surgery) 

E. Other Teaching Activities 

a) Teach Basic Surgical Research for Second/Third-Year Medical Students 

and General Surgical Residents 

b) Host Investigator for College Student Summer Research, Baltimore VA 

Medical Center, MD 

F. Previous Other Teaching Experience: 

1979-1980 Lecturer, Pathophysiology of Gastrointestinal Tract: Injury and 

Healing (for Medical students), Sun Yat-Sen Medical University, 

Guangzhou, China 

1985-1986 Lecturer, Physiology of Gastrointestinal Tract: Liver Physiology (for 

medical students), Beijing Medical University, Beijing, China 

1992-1994 Lecturer, Gastrointestinal Physiology: Secretory Functions of the 

Alimentary Tract (for medical and dental students), University of 

Tennessee, Memphis, TN 

1992-1994 Lecturer, Cell Growth: Polyamines and Protooncogene Expression 

(for graduate students), University of Tennessee, Memphis, TN 

1998-2000 Gastrointestinal Physiology: “Digestion and Absorption” (1 

Lecture/year), Dental School, University of Maryland at Baltimore, 

MD 

MAJOR INVITED LECTURESHIP AND SEMINARS: 

Speaker, Continuing Series of Seminars for Pharmacology, Kyoto 

Pharmaceutical University, Kyoto, Japan, March 21, 1988 

Speaker, Continuing Series of Seminars, Department of Physiology & 

Biophysics, University of TN at Memphis, October 9, 1991 

Speaker, Continuing Series of Seminars, Department of Physiology & 

Biophysics, University of TN at Memphis, May 18, 1993 

Invited Lecture, Department of Physiology, Beijing Medical University, 

Beijing, China, November 26, 1994 

Invited Speaker, 8th International Conference on Ulcer Research, Kyoto, 

Japan, November 22, 1994 

Speaker, Continuing Series of Seminars, Department of Surgery, UMAB, 

April 11, 1996

Invited Speaker, G. I. Forum 1996 in San Francisco, San Francisco, 

California, May 23, 1996 

Invited Speaker, 9th International Conference on Ulcer Research, Hong 

Kong, December 14, 1997 

Invited Speaker, FASEB Summer Research Conference: Cellular and 

Molecular Basis of Gastroduodenal Defense, Wilsonville, Oregon, August 19, 

1998 

Invited Speaker, International Conference on Polyamines, the Gut and 

Cancer, Bad Nauheim, Germany, April 30, 1999 

Speaker, Mini-symposium of Enterocyte function and proliferation, 

Experimental Biology 2000, San Diego, CA, April 15, 2000 

Invited Speaker, GI Research Seminars, Department of Medicine, Johns 

Hopkins University School of Medicine, January 24, 2001 

Speaker, Continuing Series of Seminars, Department of Surgery, UMAB, 

March 23, 2001 

Invited Speaker, Gordon Research Conferences: Polyamines, Connecticut 

College-New London, Connecticut, June 26, 2001 

Speaker, Continuing Series of Seminars, Program of Cancer Research and 

Experimental Therapeutics, UMAB, July 12, 2001 

Invited Speaker, CMIER Seminars in “Biology and Chemistry,” Children’s 

Memorial Institute for Education and Research, Northwestern University 

Medical School, Chicago, November 8, 2001 

Speaker, Series of Research Seminars, Baltimore VA Medical center, 

November 20, 2001 

Invited Speaker, Second International Symposium on Ulcer Healing: Focus 

on Angiogenesis and Gene Therapy, Long Beach, CA, May 22, 2002 

C-C Wang Distinguished Lectureship, Chinese Association of Physiological 

Sciences, Wuyi-Shan, RP China, October 14, 2002 

Invited Speaker, Institute of Basic Medical Sciences, Peking Union Medical 

College, Beijing, PR China, October 23, 2002 

Speaker, Continuing Series of Seminars, Inflammation Research Group, 

UMAB, March 21, 2003 

Invited Speaker and Visiting Professor, University of Texas Medical 

Branch at Galveston, Texas, January 15-16, 2004 

Speaker, Continuing Series of Seminars on GI Research, UMAB, January 20, 

2004 

Visiting Professor, Kyoto Pharmaceutical University, Kyoto, Japan, February 

1-2, 2004 

Invited Speaker, Distinguished Speaker Seminar, Department of Nutrition 

and Food science, University of Maryland at College Park, April 28, 2004 

Invited Speaker, 32nd Japanese Ulcer Research Meeting, Kyoto, Japan, 

November 19, 2004

Invited Speaker, IUPHAR-GI Symposium: Advances in GI Pharmacology: 

From Acid Secretion to Mucosal Protection, Otsu, Shiga, Japan, November 21, 

2004 

Invited Speaker, International Mini-Symposium on Translational Research, 

Trondhein, Norway, December 9, 2005 

Invited Speaker, 4 th International Symposium of Tissue and Cell 

Injury/Protection, Long Beach, CA, May 18-19, 2006 

Invited Speaker, International Conference on the Role of Polyamines and 

their Analogs in Cancer and Other Diseases, Rome (Tivoli), Italy, September 

10-14, 2006 

Visiting Professor, Sun Yat-Sen University School of Medicine, Guangzhou, 

PR China, November 20-26, 2006 

Visiting Professor, Guangdong Provincial Hospital of TCM, Guangzhou, PR 

China, November 21-22, 2006 

Invited Speaker, 2006 World Congress on Chinese Medicine: Charting the 

Course of Development, Hong Kong, November 23-25, 2006 

Invited Speaker, Distinguished Speaker Seminar, Departments of Physiology 

and Medicine, Peking University School of Medicine, Beijing, PR China, 

March 14, 2007 

Invited Speaker, Continuing Series of Research Seminar, Department of 

Surgery, Peking University First Hospital, Beijing, PR China, March 16, 2007 

Invited Speaker, International Congress on Biogenic Amines: Biological and 

Clinical Perspectives, Sicily, Italy, October 10 -15, 2007 

Invited Speaker, 5 th International Symposium of GI Mucosal 

Injury/Protection, San Diego, CA, May 21-22, 2008 

Invited Speaker, Polyamines: Forty years of Mammalian Ornithine 

Decarboxylase, Kuopio, Finland, June 26-30, 2008 

Invited Speaker, Continuing Series of Research Seminar, Department of 

Surgery, University of California Davis, Sacramento, CA, September 30, 2008 

Visiting Professor, Sun Yat-Sen University School of Medicine, Guangzhou, 

PR China, November 17-23, 2008 

Visiting Professor, Capital Medical University, Beijing, PR China, November 

24-29, 2008 

Invited Speaker, Gordon Research Conferences: Polyamines, Waterville 

Valley Resort, NH, June 22, 2009 

Invited Speaker, Chengdu International GI Symposium, Chengdu, China, 

November 29-30, 2009 

Visiting Professor, Southwest University of China, School of Medicine, 

Chengdu, December 1-2, 2009 

Speaker, Surgical Grand Rounds, University of Maryland School of Medicine, 

December 10, 2009 

Invited Speaker (State-of-the-art lecture), Digestive Disease Week, AGA, 

New Orleans, May 4, 2010 

MODERATOR/CHAIR AT SCIENTIFIC CONFERENCES:

Chair, Section of Mechanisms of Rapid Epithelial Restitution, 8th 

International Conference on Ulcer Research, Kyoto, Japan, November 16, 

1995 

Chair, Section of Gastric Mucosal Injury, 9th International Conference on 

Ulcer Research, Hong Kong, November 20, 1997 

Chair, Section of the Future of Polyamine Research, International Conference 

on Polyamines, the Gut and Cancer, Bad Nauheim, Germany, April 24, 1999 

Moderator, Signaling during Mucosal Healing, Digestive Disease Week 

(DDW), American Gastroenterological Association (AGA), Orlando, FL, May, 

18, 1999 

Moderator, Gene Expression of Growth Factors in Mucosal Injury and 

Healing, DDW, AGA, San Diego, CA, May 22, 2000 

Moderator, Cell Biology of Mucosal Repair, DDW, AGA, Atlanta, Georgia, 

May 23, 2001 

Chair, Section of Molecular Mechanisms of Ulcer Healing in the GI Tract, 

Second International Symposium on Ulcer Healing, Long Beach, CA, May 24, 

2002 

Chair, Section of Intracellular Cell Signaling during Intestinal Epithelial 

Restitution, Advances in GI Pharmacology: From Acid Secretion to Mucosal 

Protection, Otsu, Shiga, Japan, November 21, 2004 

Chair, Section of Polyamine Signaling, Gordon Research Conference: 

-Polyamines, New London, CT, June 15, 2005 

Chair, Section of Cellular Signaling, International Mini-Symposium on 

Translational Research, Trondheim, Norway, December 10, 2005 

Chair, Section of Molecular Mechanism of GI Mucosal Repair, 4 th 

International Symposium of Tissue and Cell Injury/Protection, Long Beach, 

CA, May 19, 2006 

Chair, Session V, 3 rd Annual Research Symposium: -Mucosal Response to 

Microorganisms in the GI Tract, Baltimore, Maryland, June 12, 2007 

GRANT SUPPORT: 

Active 

Principal Investigator: 

Funding Period: 05/01/00-10/31/2016 

Source and Type: NIH, RO1 DK57819 

Dollar amount: $180,000/per year 

Title: Intestinal Mucosal Growth in Health & Surgical Disease 

This project is to investigate the fundamental mechanism by which intestinal 

epithelial cell renewal is impaired in critical surgical conditions. The roles 

of polyamines and polyamine-regulated genes in this process are elucidated. 


Source and Type: NIH, R01 DK061972 

Dollar Amount: $200,000/per year 

Title: Mucosal Repair in Gut Surgical Disorders

The goal of this grant is to identify the molecular mechanism by which 

polyamines and Wnt signaling are involved in regulating gut mucosal injury 

and repair in patients with critical illness. 


Source and Type: NIH, R01 DK068491 


Title: Surgical Studies of Gut Permeability 

The goal of this study is to define cellular and molecular mechanism 

underlying gut epithelial barrier dysfunction in critical surgical conditions. 


Source and Type: VA, MERIT Review Award 


Title: Regulation of Intestinal Epithelial Restitution 

The goal of this project is to determine the roles of TRPC channels and 

[Ca 2+ ] cyt in intestinal epithelial restitution in health and surgical conditions. 

Co-Investigator: 



Dollar Amount: $600,000 (total) 

PI: 

Susan Keay, MD 

Title: APF Inhibition of Carcinoma Cell Proliferation 

The goal of this project is to define the mechanism through which APF 

represses carcinoma cell proliferation in vivo as well as in vitro. 

Funding Period: 07/01/2005-06/30/2010 (non-cost extension 

until 6/30/2011) 

Source and Type: NIH, RO1 R01 CA-107345 

PI: 

Jean-Pierre Raufman, MD 

Title: Bile Acid-Induced Colon Cancer Cell Proliferation 

Goal of this project is to define cellular and molecular mechanisms by 

which bile salts modulate colon cancer cell proliferation. 


Source and Type: VA Career Development Award 

Title: Posttranscriptional Regulation in Esophageal Cancer 

Trainee/PI: James M. Donahue, MD (Role: Mentor/Sponsor) 


Source and Type: VA Career Development Award 

Title: Testing Antibody Dependent Cellular Cytotoxicity of Colon 

Cancer in Vivo 

Trainee/PI: Ajay Jain, MD (Role: Co-mentor/Co-I) 

Completed 

Principal Investigator: J-Y. Wang 

Dates of Entire Project: 8/1/1994-7/31/1999 

Source and Type: NIH, R29 

Project: Mechanism of Polyamine-Stimulated GI Mucosal Healing



Source and Type: University of Maryland at Baltimore, SRIS 

Project: Proto-oncogene in Gastrin-Induced Mucosal Cell 

Proliferation 

Co-Investigator: J-Y. Wang 


Principal Investigator: BL. Bass, M.D 


Project: Enhancing Gut Regeneration: Enterocytes and the Basement 

Membrane 




Project: Cytoskeleton in Polyamine-Dependent GI Mucosal Restitution 




Project: Regulation of Polyamine-Dependent Intestinal Epithelial 

Restitution 

Co-Investigator: J-Y. Wang 


Principal Investigator: BL. Bass, M.D 


Project: Enhancing Gut Regeneration: Enterocytes and the Basement 

Membrane 

Funding Period: 07/0103-06/30/06 

Source and Type: CDA, Research grant 


PI: Douglas Turner, MD (Mentor/Co-Investigator: J-Y. Wang) 

Title: Regulation of Intestinal Epithelial Repair by Substance P 


Source and Type: VA, Career Development Award 

PI: Douglas Turner, MD (Mentor/Co-Investigator: J-Y Wang) 

Title: Neuronal Modulation of Intestinal Epithelial Motility 

Funding period: 10/01/2005-9/30/2009 



PI: 

Jean-Pierre Raufman, MD 

Title: Interaction of Bile Acids with Gastrointestinal Cholinergic 

Receptors 

BIBLIOGRAPHY: 

I. Books:

1. Editors: Chi-Hin Cho and Jian-Ying Wang 

Title: Gastrointestinal Mucosal Repair and Experimental Therapeutics 

Publisher: S. KARGER AG (Switzerland) 

May 2002. ISBN 3-8055-7382-0 

2. Editors: Jian-Ying Wang and Robert A. Casero Jr 

Title: Polyamine Cell Signaling -Physiology, Pharmacology, and 

Cancer Research 

Publisher: Humana Press Inc (New Jersey, USA) 

August 2006. ISBN: 1-58829-625-3; E-ISBN: 1-59475-145-2 

3. Editors: Jaladanki N. Rao and Jian-Ying Wang 

Title: Regulation of Gastrointestinal Mucosal Growth (eBook) 

Integrative Systems Physiology eBook 

Publisher: Morganclay pool Inc (USA) 

(Pending, but coming soon) 

II. Original Articles in Peer-Reviewed Journals (1988-present): 

1. Wang J-Y, Takeuchi K, and Okabe S. Dissolution of antisecretory and 

cytoprotective action of PGE 2 in rats. Jpn J Pharmacol 47:103-105, 1988. 

2. Wang J-Y, Yamasaki S, Takeuchi K, and Okabe S. Delayed healing of 

acetic acid-induced gastric ulcers in rats by indomethacin. Gastroenterology 

96:393-402, 1989. 

3. Wang J-Y and Johnson LR. Induction of gastric and duodenal mucosal 

ornithine decarboxylase during stress. Am J Physiol Gastrointest Liver 

Physiol 257:G259- 

G265, 1989. 

4. Iwami K, Wang J-Y, Jain R, McCormack S, and Johnson LR. Intestinal 

ornithine decarboxylase: half-life and regulation by putrescine. Am J Physiol 

Gastrointest Liver Physiol 258:G308-G315, 1990. 

5. Wang J-Y and Johnson LR. Role of ornithine decarboxylase in repair of 

gastric mucosal stress ulcers. Am J Physiol Gastrointest Liver Physiol 

258:G78-G85, 1990. 

6. Wang J-Y and Johnson LR. Gastric and duodenal mucosal ornithine 

decarboxylase and damage after corticosterone. Am J Physiol Gastrointest 

Liver Physiol 258:G942-G950, 1990. 

7. Wang J-Y, Nagai H, and Okabe S. Effect of omeprazole on delayed 

healing of acetic acid-induced gastric ulcers in rats. Jpn J Pharmacol 

54:82-85, 1990. 

8. Wang J-Y and Johnson LR. Luminal polyamines stimulate repair of 

gastric mucosal stress ulcers. Am J Physiol Gastrointest Liver Physiol 

259:G584-G592, 1990. 

9. Wang J-Y, Johnson LR, Tsai Y-H, and Castro GA. Mucosal ornithine 

decarboxylase, polyamines, and hyperplasia in infected intestine. Am J Physiol 

Gastrointest Liver Physiol 260:G45-G51, 1991.

10. Wang J-Y and Johnson LR. Polyamines and ornithine decarboxylase 

during repair of duodenal mucosa after stress in rats. Gastroenterology 

100:333-343, 1991. 

11. Wang J-Y, McCormack SA, Viar MJ, and Johnson LR. Stimulation of 

proximal small intestinal mucosal growth by luminal polyamines. Am J 

Physiol Gastrointest Liver Physiol 261:G504-G551,1991. 

12. Wang H, Wang J-Y, Johnson LR, and Scott RE. Selective induction of 

c-jun and jun-B but not c-fos or c-myc during mitogenesis in SV 

40-transformed cells at the predifferentiation growth arrest state. Cell 

Growth & Differentiation 2:645-652, 1991. 

13. Wang J-Y and Johnson LR. Luminal polyamines substitute for tissue 

polyamines in duodenal mucosal repair after stress in rats. Gastroenterology 

102:1109-1117, 1992. 

14. Wang J-Y and Johnson LR. Role of transglutaminase and protein 

cross-linking in the repair of mucosal stress erosions. Am J Physiol 


15. Wang J-Y, Viar MJ, McCormack SA, and Johnson LR. Effect of 

putrescine on S-adenosylmethionine decarboxylase in a small intestinal crypt 

cell line. Am J Physiol Gastrointest Liver Physiol 263:G494-G501, 1992. 

16. Wang J-Y, Viar MJ, and Johnson LR. Transglutaminase in response to 

hypertonic NaCl-induced gastric mucosal injury. Gastroenterology 

104:65-74, 1993. 

17. Wang J-Y, McCormack SA, Viar MJ, Wang H, Tzen C-Y, Scott, RE, and 

Johnson LR. Decreased expression of proto-oncogenes c-fos, c-myc and 

c-jun following polyamine depletion in IEC-6 cells. Am J Physiol 


18. Wang J-Y, Viar MJ, and Johnson LR. Regulation of transglutaminase 

activity by polyamines in the gastrointestinal mucosa of rats. Pro Sco Exp 

Biol Med 205:20-28, 1994. 

19. Wang J-Y and Johnson LR. Expression of proto-oncogenes c-fos and 

c-myc in healing of gastric mucosal stress ulcers. Am J Physiol Gastrointest 


20. McCormack SA, Wang J-Y, Viar MJ, Tague L, Davies PJA, and Johnson 

LR. Polyamines influence transglutaminase activity and cell migration in 

two cell lines. Am J Physiol Cell Physiol 267:C706-C714, 1994. 

21. McCormack SA, Wang J-Y, and Johnson LR. Polyamine deficiency causes 

reorganization of F-actin and tropomyosin in IEC-6 cells. Am J Physiol Cell 

Physiol 267:C715-C722, 1994. 

22. Wang J-Y, McCormack SA, Viar MJ, and Johnson LR. Secretin inhibits 

induction of ornithine decarboxylase activity by gastrin in duodenal mucosa 

and IEC-6 cells. Am J Physiol Gastrointest Liver Physiol 267:G276-G284, 

1994.

23. Wang J-Y, McCormack SA, Viar MJ, and Johnson LR. Inhibition of 

ornithine decarboxylase activity but not expression of the gene by cimetidine 

in intestinal mucosal cells. J Pharmacol Exp Ther 274:521-529, 1995. 

24. Wang J-Y, Wang H, and Johnson LR. Gastrin stimulates expression of 

proto-oncogene c-myc through a process involving polyamines in IEC-6 cells. 

Am J Physiol Cell Physiol 269:C1474-C1481, 1995. 

25. Wang J-Y, McCormack SA, and Johnson LR. Role of non-muscle myosin 

II in polyamine-dependent intestinal epithelial cell migration. Am J Physiol 


26. Wang J-Y, Viar MJ, Blanner PM, and Johnson LR. Expression of the 

ornithine decarboxylase gene in response to asparagine in intestinal crypt cells. 

Am J Physiol Gastrointest Liver Physiol 271:G164-G171, 1996. 

27. Wolpert SI, Wong M-L, Wang J-Y, and Bass BL. Epithelial-matrix 

interactions: laminin downregulates enterocyte EGF receptor and IGF-I 

receptor expression. J Surgical Res 63:345-348, 1996. 

28. Banan A, Wang J-Y, McCormack SA, and Johnson LR. Relationship 

between polyamines, actin distribution, and gastric mucosal healing in rats. 


29. Wang J-Y, Viar MJ, Li, J, Shi HJ, McCormack SA and Johnson LR. 

Polyamines are necessary for normal expression of the transforming growth 

factor- gene during epithelial cell migration. Am J Physiol Gastrointest 


30. Patel AR and Wang J-Y. Polyamines modulate transcription but not 

posttranscription of c-myc and c-jun in IEC-6 cells. Am J Physiol Cell 

Physiol 273:C1020-C1029, 1997. 

31. Wang J-Y, Viar MJ, Li J, Shi H-J, Patel AR, and Johnson LR. Differences 

in transglutaminase mRNA after polyamine depletion in two cell lines. Am J 

Physiol Cell Physiol 274:C522-C530, 1998. 

32. Wang J-Y, Li J, Patel A, Summers S, and Bass LB. Synergistic induction of 

ornithine decarboxylase by asparagine and gut peptides in intestinal crypt cells. 


33. Patel AR, Li J, Bass BL, and Wang J-Y. Expression of the transforming 

growth factor- gene during growth inhibition following polyamine depletion. 


34. Sayles JM, D’Addio V, Wang J-Y, and Bass LB. Epidermal growth 

factor-stimulated rabbit esophageal mucosal growth: Role of polyamines. J 

Gastroenterology and Hepatology 13:S149-S155, 1998. 

35. Wang J-Y. Polyamines and cytoskeletal proteins in intestinal epithelial cell 

migration. J Gastroenterology and Hepatology 13:S257-S261, 1998. 

36. Buzdon MM, Napolitano LM, Wang J-Y, Summers S, and Bass BL. 

Differentiation decreases enterocyte adhesion and integrin expression: a 

mechanism of villus tip release. Surgical Forum, Vol. XLIX:130-131, 1998.

37. Patel AR and Wang J-Y. Polyamine depletion is associated with an 

increase in JunD/AP-1 activity in small intestinal crypt cells. Am J Physiol 


38. Li L, Li J, Rao JN, Li M-L, Bass BL, and Wang J-Y. Inhibition of 

polyamine synthesis induces p53 gene expression but not apoptosis. Am J 


39. Wolpert SI, Lally KM, Li J, Wang J-Y, and Bass BL. Extracellular matrix 

modulatesenterocyte growth via downregulation of c-jun but is independent of 

p21 and p27 expression. J Gastrointest Surg 3:319-324, 1999. 

40. Rao JN, Li J, Li L, Bass BL, and Wang J-Y. Differentiated intestinal 

epithelial cells exhibit increased migration through polyamines and myosin II. 


41. Ma L, Liu ESL, Chow JYC, Wang J-Y, and Cho CH. Interaction of EGF 

and ornithine decarboxylase activity in the regulation of gastric mucus 

synthesis in cigarette smoke exposed rats. Chinese Journal of Physiology 

(Taiwan) 42(3):137-143, 1999. 

42. Wang J-Y, Wang J, Golovina VA, Li L, Platoshyn O, and Yuan J X-J. 

Role of K + channel expression in polyamine-dependent intestinal epithelial 

cell migration. Am J Physiol Cell Physiol 278:C303-C314, 2000. 

43. Rao JN, Li L, Bass BL, and Wang J-Y. Expression of the TGF- receptor 

gene and sensitivity to growth inhibition following polyamine depletion. Am 

J Physiol Cell Physiol 279:C1034-C1044, 2000. 

44. Rao JN, Li L, Golovina VA, Platoshyn O, Strauch ED, Yuan J X-J, and 

Wang J-Y. Ca 2+ -RhoA signaling pathway required for 

polyamine-dependent intestinal epithelial cell migration. Am J Physiol Cell 

Physiol 280:C993-C1007, 2001. 

45. Platoshyn O, Yu Y, Golovina VA, McDaniel SS, Krick S, Li L, Wang J-Y, 

Rubin LJ, and Jason Yuan JX-J. Chronic hypoxia decreases Kv channel 

expression and function in pulmonary artery myocytes. Am J Physiol Lung 

Physiol 280:L801-L812, 2001. 

46. Li L, Rao JN, Bass BL, and Wang J-Y. NF-B activation and 

susceptibility to apoptosis after polyamine depletion in intestinal epithelial 

cells. Am J Physiol Gastrointest Liver Physiol 280:G992-G1004, 2001. 

47. Strauch ED, Wang J-Y, Lally KM, and Bass BL. Bile acid modulates 

intestinal epithelial cell migration through TGF- signaling pathway. J 

Surgical Res 97:49-53, 2001. 

48. Li L, Rao JN, Guo X, Liu L, Santora R, Bass BL, and Wang J-Y. 

Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal 

epithelial cell proliferation. Am J Physiol Cell Physiol 281:C941-C953, 

2001. 

49. McDaniel SS, Platoshyn O, Yu Y, Sweeney M, Sweeney M, Miriel VA, 

Golovina VA, Krick S, Lapp BR, Wang J-Y, and Yuan J X-J. Anorexic 

effect of K + channel blockade in mesenteric artery smooth muscle and 

intestinal epithelial cells. J App Physiol 91:2322-2333, 2001.

50. Shi VY, Liu ESL, Koo MWL, Wang J-Y, Matsui H, and Cho CH. 

Cigarette smoke extracts delay wound healing in the stomach: involvement of 

polyamine synthesis. Exp Biol Med 227:114-124, 2002. 

51. Rao JN, Platoshyn O, Li L, Guo X, Golovina VA, Yuan J X-J, and Wang 

J-Y. Activation of K + channels and increased migration of differentiated 

intestinal epithelial cells after wounding. Am J Physiol Cell Physiol 

282:C885-C898, 2002. 

52. Gobert AP, Cheng Y, Wang J-Y, Boucher JL, Lyer RK, Cederbaum SD, 

Casero RA Jr, Newton JC, and Wilson KT. Helicobacter pylori induces 

macrophage apoptosis by activation of arginase II. J Immunol 

168:4692-4700, 2002. 

53. Guo X, Rao JN, Liu L, Rizvi M, Turner DJ, and Wang J-Y. Polyamines 

regulate -catenin tyrosine phosphorylation via Ca 2+ during intestinal 

epithelial cell migration. Am J Physiol Cell Physiol 283:C722-C734, 2002. 

54. Li L, Liu L, Rao JN, Esmaili A, Strauch ED, Bass BL, and Wang J-Y. 

JunD stabilization results in inhibition of normal intestinal epithelial cell 

growth through p21 after polyamine depletion. Gastroenterology 

123:764-779, 2002. 

55. Rao JN, Guo X, Liu L, Zou T, Murthy KS, Yuan J X-Y, and Wang J-Y. 

Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal 

epithelial restitution. Am J Physiol Cell Physiol 284:C848-C859, 2003. 

56. Strauch ED, Bass BL, Rao JN, Vann JA, and Wang J-Y. NF-B regulates 

intestinal epithelial cell and bile salt-induced migration after injury. Ann 

Surg 237:494-501, 2003. 

57. Guo X, Rao JN, Liu L, Zou TT, Turner DJ, Bass BL, and Wang J-Y. 

Regulation of adherens junctions and epithelial paracellular permeability: a 

novel function for polyamines. Am J Physiol Cell Physiol 285:C1174-C1187, 

2003. 

58. Liu L, Santora R, Rao JN, Guo X, Zou TT, Zhang HM, Turner DJ, and Wang 

J-Y. Activation of TGF--Smad signaling pathway following polyamine 

depletion in intestinal epithelial cells. Am J Physiol Gastrointest Liver 

Physiol 285:G1056-G1067, 2003. 

59. Strauch ED, Yamaguchi J, Bass BL, and Wang J-Y. Bile salts regulate 

intestinal epithelial cell migration by nuclear factor-happa B-induced 

expression of transforming growth factor-beta. J Am Coll Surg 197:974-84, 

2003. 

60. Yamaguchi J, Toledo A, Bass BL, Celeste FA, Rao JN, Wang J-Y, and 

Strauch ED. Taurodeoxycholate increases intestinal epithelial cell 

proliferation through c-myc expression. Surgery 135:215-221, 2004. 

61. Zou T, Rao JN, Guo X, Liu L, Zhang HM, Strauch ED, Bass BL, and Wang 

J-Y. NF-B-mediated IAP expression induces resistance of intestinal 

epithelial cells to apoptosis after polyamine depletion. Am J Physiol Cell 

Physiol 286:C1009-C1018, 2004.

62. Zhang HF, Rao JN, Guo X, Liu L, Zou T, Turner DJ, and Wang J-Y. Akt 

kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting 

caspase-3 after polyamine depletion. J Biol Chem 279:22539-22547, 2004. 

63. Toledo A, Yamaguchi J, Wang J-Y, Bass BL, Turner DJ, and Strauch ED. 

Taurodeoxycholate stimulates intestinal cell proliferation and protects against 

apoptotic cell death through activation of NF-κB. Dig Dis Sci 49:1664-1671, 

2004. 

64. Liu L, Li L, Rao NJ, Zou TT, Zhang HM, Boneva D, Bernard MS, and Wang 

J-Y. Polyamine-modulated expression of c-myc plays a critical role in 

stimulation of normal intestinal epithelial cell proliferation. Am J Physiol 

Cell Physiol 288:C89-C99, 2005. 

65. Guo X, Rao JN, Liu L, Zou TT, Keledjian KM, Boneva D, Marasa BS, and 

Wang J-Y. Polyamines are necessary for synthesis and stability of occludin 

in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 288: 

G1159-G1169, 2005. 

66. Zou T, Rao JN, Liu L, Marasa BS, Keledjian KM, Zhang AH, Xiao L, Bass 

BL, and Wang J-Y. Polyamine depletion induces nucleophosmin 

modulating stability and transcriptional activity of p53 in intestinal epithelial 

cells. Am J Physiol Cell Physiol 289:C686-C696, 2005. 

67. Zhang C-O, Wang J-Y, Koch K, and Keay S. Regulation of tight junction 

proteins and bladder epithelial paracellular permeability by an antiproliferative 

factor from interstitial cystitis patients. J Urology 174:2382-2387, 2005. 

68. Rao JN, Platoshyn O, Golovina VA, Liu L, Zou T, Marasa BS, Turner DJ, 

Yuan J X-J, and Wang J-Y. TRPC1 functions as a store-operated Ca 2+ 

channel in intestinal epithelial cells and regulates early mucosal restitution 

after wounding. Am J Physiol GI and Liver Physiol 290:G782-G792, 2006. 

69. Zhang HF, Keledjian KM, Rao JN, Zou T, Liu L, Marasa BS, Wang SR, Ru 

L, Strauch ED, and Wang J-Y. Induced focal adhesion kinase expression 

suppresses apoptosis by activating NF-κB signaling in intestinal epithelial 

cells. Am J Physiol Cell Physiol 290:C1310-C1320, 2006. 

70. Marasa BS, Rao JN, Zou T, Liu L, Keledjian KM, Zhang AH, Xiao L, Chen J, 

Turner DJ, and Wang J-Y. Induced TRPC1 expression sensitizes intestinal 

epithelial cells to apoptosis by inhibiting NF-κB activation through Ca 2+ influx. 

Biochem J 397:77-87, 2006. 

71. Parry J, Su L, Moore J, Cheng Z, Luther M, Rao JN, Wang J-Y, and Yu LL. 

Chemical compositions, antioxidant capacities, and antiproliferative activities 

of selected fruit seed flours. J Agric Food Chem 54:3773-3778, 2006. 

72. Zou T, Mazan-Mamczarz K, Rao JN, Liu L, Marasa BS, Zhang AH, Xiao L, 

Pullmann R, Gorospe M, and Wang J-Y. Polyamine depletion increases 

cytoplasmic levels of RNA-binding protein HuR leading to stabilization of 

nucleophosmin and p53 mRNAs. J Biol Chem 281:19387-19394, 2006. 

73. Liu L, Guo X, Rao JN, Zou T, Marasa BS, Chen J, Greenspon J, Casero Jr 

RA, and Wang J-Y. Polyamine-modulated c-Myc expression in normal

intestinal epithelial cells regulates p21Cip1 transcription through a proximal 

promoter region. Biochem J 398:257-267, 2006. 

74. Turner DJ, Alaish SM, Zou T, Rao JN, Wang J-Y, and Strauch ED. Bile 

salts induce resistance to apoptosis through NF-κB-mediated XIAP expression. 

Ann Surg 245:415-425, 2007. 

75. Turner DJ, Martin PC, Rao JN, Greenspon J, Zou T, Bass BL, Wang J-Y, 

and Strauch ED. Substance P regulates migration in rat intestinal epithelial 

cells. Ann Surg 245:408-414, 2007. 

76. Rao JN, Liu L, Zou T, Marasa BS, Greenspon J, Malone DL, Turner DJ, and 

Wang J-Y. Polyamines are required for phospholipase-Cγ1 expression 

promoting intestinal epithelial restitution after wounding. Am J Physiol GI 

and Liver Physiol 292:G335-G343, 2007. 

77. Xiao L, Rao JN, Zou T, Liu L, Marasa BS, Chen J, Turner DJ, Panoniti T, 

and Wang J-Y. Induced JunD in intestinal epithelial cells represses CDK4 

transcription through its proximal promoter region following polyamine 

depletion. Biochem J 403:573-581, 2007. 

78. Zhang AH, Rao JN, Zou T, Liu L, Marasa BS, Xiao L, Chen J, Turner DJ, 

and Wang J-Y. p53-Dependent NDRG1 expression induces inhibition of 

intestinal epithelial cell proliferation but not apoptosis following polyamine 

depletion. Am J Physiol Cell Physiol 293:C379-C389, 2007. 

79. Chen J, Rao JN, Zou T, Liu L, Marasa BS, Xiao L, Zeng X, Turner DJ, and 

Wang J-Y. Polyamines are required for expression of Toll-like receptor 2 

modulating intestinal epithelial barrier integrity. Am J Physiol Gastrointest 


80. Zhou H, Jarujaron S, Gurley EC, Ding H, Chen L, Studer E, Hu W, Pandak 

WM, Zou T, Wang J-Y, and Hylemon PB. HIV protease inhibitors increase 

TNF-α and IL-6 expression in macrophages: involvement of the RNA-binding 

protein HuR. Atherosclerosis 195:e134-e143, 2007. 

81. Xiao L, Rao JN, Zou T, Liu L, Marasa BS, Chen J, Turner DJ, Zhou H, 

Gorospe M, and Wang J-Y. Polyamines regulate the stability of activating 

transcriotion factor-2 mRNA through RNA-binding protein HuR in intestinal 

epithelial cells. Mol Biol Cell 18:4579-4590, 2007. 

82. Zou T, Liu L, Rao JN, Marasa BS, Chen J, Xiao L, Zhou H, Gorospe M, and 

Wang J-Y. Polyamines modulate the subcellular localization of 

RNA-binding protein HuR through AMP-activated protein kinase-regulated 

phosphorylation and acetylation of importin α1. Biochem J 409:389-398, 

2008. 

83. Wu WKK, Li GR, Wong TM, Wang J-Y, Yu L, and Cho C-H. 

Involvement of voltage-gated K + and Na + channels in gastric epithelial cell 

migration. Mol Cell Biochem 308:219-226, 2008. 

84. Marasa BS, Xiao L, Rao JN, Zou T, Liu L, Wang J, Bellavance E, Turner DJ, 

and Wang J-Y. Induced TRPC1 expression increases protein phosphatase 

2A sensitizing intestinal epithelial cells to apoptosis through inhibition of 

NF-κB activation. Am J Physiol Cell Physiol 294: C1277-C127, 2008.

85. Chen J, Rao JN, Zou T, Lan L, Xiao L, Bellavance E, Gorospe M, and Wang 

J-Y. JunD represses transcription and translation of the tight junction protein 

ZO-1 modulating intestinal epithelial barrier function. Mol Biol Cell 

19:3701-3712, 2008. 

86. Rao JN, Liu SV, Zou T, Zhang X, Liu L, Xaio L, Peng-Yuan Wang, and 

Wang J-Y. Rac1 promotes intestinal epithelial restitution by increasing Ca 2+ 

influx through interaction with phospholipase C-γ1 after wounding. Am J 


87. Greenspon J, Li R, Xiao L, Rao JN, Marasa BS, Strauch ED, Wang J-Y, and 

Turner DJ. Sphingosine-1-Phosphate protects intestinal epithelial cells from 

apoptosis through the Akt signaling pathway. Dig Dis Sci 54:499-510, 2009. 

88. Shant J, Cheng K, Marasa B, Wang J-Y, and Raufman JP. Akt-dependent 

NF-κB activation is required for bile acids to rescue colon cancer cells from 

stress-induced apoptosis. Exp Cell Res 315: 432-50, 2009. 

89. Liu L, Guo X, Rao JN, Zou T, Xiao L, Yu TX, Timmons JA, Turner DJ, and 

Wang J-Y. Polyamines regulate E-cadherin transcription through c-Myc 

modulating intestinal epithelial barrier function. Am J Physiol Cell Physiol 

296:C801-C810, 2009. 

90. Yu Y, Keller SH, Remilard CV, Safrina O, Nicholson A, Zhang SL, Jiang W, 

Vangala N, Landsberg JW, Wang J-Y, Thistlethwaite PA, Channick RN, 

Robbins IM, Loyd JE, Ghofrani HA, Grimminger F, Schermuly RT, Cahalan 

MD, Rubin LJ, and Yuan J X-J. A functional single-nucleotide 

polymorphism in the TRPC6 gene promoter associated with idiopathic 

pulmonary arterial hypertension. Circulation 119: 2313-2322, 2009. 

91. Liu L, Rao NJ, Zou T, Lan X, Wang P-Y, Turner DJ, Gorospe M, and Wang 

J-Y. Polyamines regulate c-Myc translation through Chk2-dependent HuR 

phosphorylation. Mol Biol Cell 20: 4885-4898, 2009. 

92. Li M, Sun Y, Simard JM, Wang J-Y, and Chai T. Augmented bladder 

urothelial polyamine signaling and block of BK channel in the 

pathophysiology of overactive bladder syndrome. Am J Physiol Cell Physiol 

297: C1445-C1451, 2009. 

93. Zhang X, Zou T, Rao JN, Liu L, Xiao L, Wang PY, Cui Y-H, Gorospe M, 

and Wang. J-Y. Stabilization of XIAP mRNA through the RNA-binding 

protein HuR regulated by cellular polyamines. Nucleic Acids Research 37: 

7623-7637, 2009. 

94. Wu X, Sun L, Zha W, Studer E, Gurley E, Chen L, Wang X, Hylemon PB, 

Pandak WM, Sanyal AJ, Zhang L, Wang GJ, Jie Chen, Wang J-Y, and Zhou 

H. HIV protease inhibitors induce endoplasmic reticulum stress and disrupt 

barrier integrity in intestinal epithelial cells. Gastroenterology 138:197-209, 

2010. 

95. Wang P-Y, Rao JN, Zou T. Liu L, Xiao L, Yu T-X, Turner DJ, Gorospe M, 

and Wang J-Y. Posttranscriptional regulation of MEK-1 by polyamines 

through RNA-binding protein HuR in intestinal epithelial cells. Biochem J 

426:293-306, 2010.

96. Xiao L, Rao JN, T Zou, Liu L, Yu T, and Wang J-Y. Induced ATF-2 

represses CDK4 transcription through dimerization with JunD inhibiting 

intestinal epithelial cell growth after polyamine depletion. Am J Physiol Cell 

Physiol 298:C1226-C1234, 2010. 

97. Huo X, Zhang HY, Zhang XI, Lynch JP, Strauch ED, Wang J-Y, Melton SD, 

Genta RM, Wang DH, Spechler SJ, and Souza RF. Acid and bile 

salt-induced CDX2 expression differs in squamous cells from patients with 

and without Barrett’s esophagus. Gastroenterology 139:194-203, 2010. 

98. Chang E, Donahue J, Smith A, Hornick J, Wang J-Y, and Battafarano RJ. 

Loss of p53, rather than β-catenin over-expression, induces 

surviving-mediated resistance to apoptosis in esophageal cancer cell line. J 

Thorac Cardiovasc Surg 140: 225-232, 2010. 

99. Rao JN, Rather N, Zou T, Liu L, Xiao L, and Wang J-Y. STIM1 

translocation to the plasma membrane enhances intestinal epithelial restitution 

by inducing TRPC1-mediated Ca 2+ signaling after wounding. Am J Physiol 

Cell Physiol 299: C579-C588, 2010. 

100. Zou T, Rao JN, Liu L, Xiao L, Yu T-X, Jiang P, Gorospe M, and Wang J-Y. 

Polyamines regulate the stability of JunD mRNA by modulating the 

competitive binding of its 3’-umtranslated region to HuR and AUF1. Mol 

Cell Biol 30: 5021-5032, 2010. 

101. Greenspon J, Li R, Xiao L, Rao JN, Sun R, Strauch ED, Shea-Donohue T, 

Wang J-Y, and Turner DJ. Sphingosine-1-phosphate regulates the 

expression of adherens junction protein E-cadherin and enhances intestinal 

epithelial cell barrier function. Dig Dis Sci Epub ahead of print on October 9, 

2010. 

102. Masuda K, Abdelmohsen K, Kim MM, Srikantan S, Lee EK, Tominaga K, 

Selimyan R, Martindale JL, Yang X, Lehrmann E, Zhang Y, Becker KG, 

Wang J-Y, Kim HH, Gorospe M. Global dissociation of HuR-mRNA 

complexes promotes cell survival after ionizing radiation. EMBO J Epub 

ahead of print on Feb 11, 2011. 

103. Yu TX, Wang PY, Rao JN, Zou T, Liu L, Xiao L, Gorospe M, and Wang J-Y. 

Chk2-dependent HuR phosphorylation regulates occludin mRNA translation 

and gut barrier function during septic stress. Nucleic Acids Research (In 

Review) 

104. Xiao L, Cui Y-H, Rao JN, Zou T, Yu T-X, Turner DJ, Gorospe M, and Wang 

J-Y. Regulation of RNA-binding protein CUGBP1 and miR-22 by 

polyamines modulates CDK4 translation and epithelial cell proliferation. 

Mol Cell Biol (In Review) 

105. Timmons JA, Rao JN, Zou T, Liu L, Xiao L, Wang P-Y, Turner DJ, and 

Wang J-Y. Induced expression of STIM1 sensitizes intestinal epithelial 

cells to apoptosis by modulating store-operated Ca 2+ influx. J Sur Res (In 

Revised)

106. Liu L, Rao JN, Zou T, Keledjian K, Marasa BS, Xiao L, Turner DJ, and 

Wang J-Y. c-Myc increases susceptibility of intestinal epithelial cells to 

apoptosis by inhibiting Akt kinase activity. In preparation 

Original Articles in Peer-Reviewed Journals from 1982 to 1988: 

107. Wang J-Y and Hou C. Effect of treatment with large doses of 

adrenocortical hormone on activity of gastric mucosal Na + -K + dependent 

ATPase in rats. J New Medicine 13:597-598, 1982. 

108. Wang J-Y and Hou C. Vulnerability of gastric mucosa to injury and its 

relation to ATPase in rats treated by adrenocortical hormone. Chinese 

Journal of Medicine 64:112-115, 1984. 

109. Wang J-Y, Gou,YS, and Wang C-C. Gastric adaptive cytoprotection 

produced by pepsin and its possible mechanism. Acta Physioloica Sinica 

37:525-531, 1985. 

110. Wang J-Y, Wang C-C, and Li ZJ. Adaptive cytoprotection of gastric 

mucosa by pepsin and its relation to endogenous prostaglandins. Chinese 

Journal of Physiological Sciences 1(2):87-95, 1985. 

111. Wang J-Y and Li ZJ. Endogenous prostaglandins E 2 and F 2 mediate the 

adaptive cytoprotection on gastric mucosa by pepsin. Acta Physioloica 

Sinica 38:451-458, 1986. 

112. Wang J-Y, Wang C-C, and Li, ZJ. Role of prostacyclin and thromboxine 

A 2 in adaptive cytoprotection of gastric mucosa by pepsin. Acta Physioloica 

Sinica 38:459-467, 1986. 

113. Wang J-Y, Wang C-C, Li ZJ, and Yang SJ. Role of endogenous 

prostaglandins in adaptive cytoprotection: observation on gastric mucosal 

atrophy in the rat. Chinese Journal of Physiological Sciences 2(3):200-208, 

1986. 

114. Wang J-Y, Wang C-C, Yang SJ, and Li ZJ. Effect of gamma irradiation on 

gastric mucosal vulnerability and its relation to endogenous prostaglandins 

and thromboxane A 2 in rats. Journal of Applied Physiologica 2:110-114, 

1986. 

115. Wang J-Y and Wang C-C. Somatostatin mediates the gastric adaptive 

cytoprotection produced by mild irritants in rat stomachs. Chinese Journal of 

Physiological Sciences 2:335-341, 1986. 

116. Wang J-Y, Wang C-C, Li ZJ, and Yang SJ. Change of the adaptive 

cytoprotection and its relation to endogenous prostaglandins in rats with 

gastric mucosal atrophy. Acta Physiologica Sinica 39(1):10-18, 1987. 

117. Wang J-Y and Wang C-C. Effect of adaptive cytoprotection by mild 

irritants on the content of somatostatin in the gastric mucosa. Science 

Bulletin 32:548-551, 1987. 

118. Wang J-Y. Cysteamine as a depletor of endogenous somatostatin on the 

gastric adaptive cytoprotection in rats. Acta Beijing Medical University 

19(3):165-168, 1987.

119. Wang J-Y and Wang C-C. The relation between adaptive cytoprotection 

and gastric mucus-bicarbonate barrier. Acta Physioloica Sinica 39:161-167, 

1987. 

120. Wang J-Y and Wang C-C. Somatostatin: a mediator of the gastric adaptive 

cytoprotection afforded by mild irritants. Proc Natl Acad Sci Sinica (Kexue 

Tongbao) 33(6):506-511, 1988. 

121. Wang J-Y and Wang C-C. Role of gastric mucosal Na + -K + -Mg ++ 

dependent ATPase in the adaptive cytoprotection by mild irritants in rats. 

Chinese Journal of Physiological Sciences 4(1):54-60, 1988. 

122. Wang J-Y and Wang C-C. Gastric mucosal Na + -K + -Mg ++ dependent ATPase 

and adaptive cytoprotection. Acta Physioloica Sinica 40:215-222, 1988. 

III. Invited Articles, Reviews, and Book Chapters: 

1. Wang J-Y and Hou C. Role of energy metabolism in gastric mucosal injury. 

J Foreign Medicine: Section of Internal Medicine 10:550-553, 1883. 

2. Wang J-Y. Adaptive cytoprotection of the gastric mucosa. Progress in 

Physiological Sciences 17:266-269, 1986. 

3. Wang C-C and Wang J-Y. Cytoprotection in the gastrointestinal tract. In: 

Physiology of the Gastrointestinal Tract: -Basic Science and Clinical Practice, 

edited by L. Zhou. Science Press, Beijing, China, pp208-221, 1991. 

4. Johnson LR, McCormack SA, and Wang J-Y. Regulation of gastrointestinal 

mucosal growth. In: Gastrin, edited by J. H. Walsh. New York: Raven 

Press, pp285-300, 1993. 

5. Wang J-Y. Mucosal damage, defense, and repair in the gastrointestinal tract. 

In: Cytoprotection. edited by C-C Wang. Beijing Medical University Press, 

Beijing, China, pp78-92, 1995. 

6. Wang J-Y. Adaptive cytoprotection by natural mild irritants. In: 

Cytoprotection. edited by C-C Wang. Beijing Medical University Press, 

Beijing, China, pp353-366, 1995. 

7. Wang J-Y, and K Takeuchi. Polyamines in gastrointestinal mucosal cell 

proliferation. Journal of Gastrointestinal Research 4:86-92, 1996. (Invited 

Review) 

8. Wang J-Y. Role of polyamine biosynthesis in mucosal repair. In: 

Molecular Biological Approach to Peptic Ulcer Disease, edited by A. Terano 

et al., Tokyo, Yamanouch, Japan, pp43-46, 1996. 

9. Wang J-Y. Expression of primary response genes in cell renewal during 

healing. In: Gastrointestinal Mucosal Repair and Experimental Therapeutics, 

edited by CH Cho and J-Y Wang, S. KARGER AG, Switzerland, pp82-100, 

2002. 

10. Rao JN and Wang J-Y. Ca 2+ signaling in epithelial restitution. In: 

Gastrointestinal Mucosal Repair and Experimental Therapeutics, edited by 

CH Cho and J-Y Wang, S. KARGER AG, Switzerland, pp29-42, 2002. 

11. Wang J-Y. Cellular signaling in rapid intestinal epithelial restitution: 

Implication of polyamines and K + channels. Acta Physiloica Sinica 55 

(4):365-372, 2003. (Invited Review).

12. Lo CM, Wang J-Y, and Tso P. Apoproteins. In: Encyclopedia of 

Gastroenterology, edited by Leonard R. Johnson. Elsevier Inc, Volume 1, 

A-E, pp99-104, 2004. 

13. Wang J-Y. Polyamines regulate E-cadherin and play an important role in 

control of intestinal epithelial barrier function. Inflammopharmacology 13 

(No.1-3): 91-101, 2005. 

14. Wang J-Y. Cellular signals mediating growth arrest after polyamine 

depletion. In: Polyamine Cell Signaling -Physiology, Pharmacology, and 

Cancer Research, edited by J-Y Wang and RA Casero Jr. Humana Press Inc, 

New Jersey, pp51-73, 2006. 

15. Rao JN and Wang J-Y. Regulation of Kv channels activity and adherens 

junctions by polyamines in intestinal epithelial cells. In: Polyamine Cell 

Signaling -Physiology, Pharmacology, and Cancer Research, edited by J-Y 

Wang and RA Casero Jr, Humana Press Inc, New Jersey, pp365-381, 2006. 

16. Zhou H and Wang J-Y. Application of cellular and molecular biology in 

modern surgical practice. In: Modern Surgical Care -Physiological 

Foundations and Clinical Applications, edited by TA Miller, Informa 

Healthcare USA Inc, New York, pp253-270, 2006. 

17. Wang J-Y. Regulation of mRNA stability by polyamines in intestinal 

epithelial cells. Amino Acids 33: 241-252, 2007 (Invited Review) 

18. Xiao L and Wang J-Y. Posttranscriptional regulation of gene expression in 

epithelial cells by polyamines. In Methods in Molecular Biology, edited by 

AE Pegg and RA Casero Jr, 720:67-79, 2011. 

19. Timmons JA and Wang J-Y. Polyamines and gut epithelial homeostasis. 

International J Clinical and Experimental Medicine (Submitted, Invited 

Review)

WANG Jian-Ying ( USA)

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