Iridociliary Adenocarcinoma
Iridociliary Adenocarcinoma
Iridociliary Adenocarcinoma
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<strong>Iridociliary</strong><br />
adenocarcinoma<br />
Athens<br />
Veterinary<br />
Diagnostic<br />
Lab (AVDL)<br />
Elijah Edmondson, DVM<br />
Angela Ellis, DVM PhD
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Signalment<br />
• 7 year old female<br />
Yorkshire terrier
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Clinical Work-up<br />
Opthalmology Referral<br />
‣ Buphthalmia and glaucoma OD (OD 47, OS 16 mmHg)<br />
‣ The right cornea was noted to be heavily vascularized<br />
‣ No corneal uptake of fluorescein stain in either eye<br />
‣ CBC / Chem were normal<br />
Surgery<br />
‣ Right eye enucleated and fixed in formalin
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Gross Findings<br />
• A single globe was submitted to the<br />
Athens veterinary diagnostic lab (AVDL)<br />
in formalin.<br />
• Irregular thickening in the iris<br />
• Hyphema
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Permission granted only for viewing on SEVPAC website<br />
Hyphema<br />
Drainage angle<br />
Pigmented<br />
epithelial cells
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Permission granted only for viewing on SEVPAC website<br />
Pigmented<br />
epithelial cell<br />
Mitotic<br />
figure<br />
Basement<br />
membrane
Necrosis<br />
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Corneal<br />
invasion<br />
Neovascularization
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Mineralization<br />
Neoplastic<br />
cells
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Sclera
Retina<br />
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Subepithelial hemorrhage<br />
along the limbus<br />
Hyphema<br />
Drainage angle<br />
Pigmented<br />
epithelial cells
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Corneal epithelial<br />
hyperplasia<br />
Neovascularization
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Morphologic Diagnosis<br />
1. <strong>Iridociliary</strong> adenocarcinoma with intraocular<br />
hemorrhage, retinal detachment, and scleral<br />
and extraocular invasion<br />
2. Moderate to coalescing lenticular degeneration<br />
with multifocal mineralization
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<strong>Iridociliary</strong><br />
epithelial tumors<br />
• Second most common primary intraocular tumor in dogs<br />
• Primary differential for this type of tumor would be an<br />
amelanotic melanoma.<br />
• Features for diagnosis:<br />
1. Pigmented epithelial cells<br />
2. Thick, smooth basement membrane structures<br />
3. Positive for Vimentin, S-100, NSE
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Immunohistochemistry<br />
Vimentin<br />
Cytokeratin<br />
1. Dubielzig, et al
Periodic acid-Schiff (PAS) stain<br />
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Permission granted only for viewing on SEVPAC website<br />
<strong>Iridociliary</strong><br />
Adenoma vs. adenocarcinoma<br />
<strong>Iridociliary</strong> adenocarcinomas are tumors which invade<br />
the sclera and are named due to their invasiveness.
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Follow-up<br />
• Although iridociliary neoplasms may be locally<br />
invasive within the globe, distant metastases<br />
are extremely rare.<br />
• Macy missed her most recent recheck
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Thanks!<br />
• Angela E. Ellis, DVM PhD<br />
• AVDL Histology Lab<br />
• Dr. Susan Winston
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Questions<br />
References<br />
1. Dubielzig RR, Steinberg H, Garvin H, Deehr AJ, Fischer B. <strong>Iridociliary</strong> epithelial tumors in 100 dogs and 17 cats: a<br />
morphological study. Veterinary Ophthalmology 1, 223-231 1998.<br />
2. Dubielzig RR, Ketring K, McLellan GJ, Alber DM. Veterinary Ocular Pathology, a comparative review. pages 160-163.<br />
2010 Elseveir Saunders.
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