Pheochromocytoma Presentation.pptx - University of Georgia ...
Pheochromocytoma Presentation.pptx - University of Georgia ...
Pheochromocytoma Presentation.pptx - University of Georgia ...
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Case 07-451Colleen Monahan3 rd Year Veterinary Student<strong>University</strong> <strong>of</strong> Tennessee College <strong>of</strong> Veterinary MedicinePermission granted only for viewing on SEVPAC website
History! 1-day history <strong>of</strong> colic signs! At presentation, the patient was trembling! Ultrasound: Distended small intestine with decreasedmotility! Rectal Exam: Possible displaced colonPermission granted only for viewing on SEVPAC website
Postmortemhttp://www.cartoonstock.com/directory/e/equine.aspPermission granted only for viewing on SEVPAC website
4xPermission granted only for viewing on SEVPAC website
Churukian-Schenk StainingPermission granted only for viewing on SEVPAC website
MorphologicDiagnosisRight adrenal gland:<strong>Pheochromocytoma</strong>Permission granted only for viewing on SEVPAC website
Equine <strong>Pheochromocytoma</strong>s! Infrequent findingPermission granted only for viewing on SEVPAC website
Equine <strong>Pheochromocytoma</strong>s! Infrequent finding! Functional or Non-functionalPermission granted only for viewing on SEVPAC website
Equine <strong>Pheochromocytoma</strong>s! Infrequent finding! Functional or Non-functional! Low incidence <strong>of</strong> malignancyPermission granted only for viewing on SEVPAC website
Equine <strong>Pheochromocytoma</strong>s! Infrequent finding! Functional or Non-functional! Low incidence <strong>of</strong> malignancy! UnilateralPermission granted only for viewing on SEVPAC website
Functional <strong>Pheochromocytoma</strong>s! No known breed or gender predilectionPermission granted only for viewing on SEVPAC website
Functional <strong>Pheochromocytoma</strong>s! No known breed or gender predilection! Only reported in horses >12 yearsPermission granted only for viewing on SEVPAC website
Functional <strong>Pheochromocytoma</strong>s! No known breed or gender predilection! Only reported in horses >12 years! Tumor cells produce catecholaminesPermission granted only for viewing on SEVPAC website
Functional <strong>Pheochromocytoma</strong>s! No known breed or gender predilection! Only reported in horses >12 years! Tumor cells produce catecholamines! Similar clinical signs to colic,rhabdomyolysis, or acute laminitisPermission granted only for viewing on SEVPAC website
Clinical Signs! Abdominal painhttp://www.leanintree.com/get-well-card-fallen-and-cant-giddyup-18574.htmlPermission granted only for viewing on SEVPAC website
Clinical Signs! Abdominal pain! Muscle tremorshttp://www.leanintree.com/get-well-card-fallen-and-cant-giddyup-18574.htmlPermission granted only for viewing on SEVPAC website
Clinical Signs! Abdominal pain! Muscle tremors! Pr<strong>of</strong>use sweatinghttp://www.leanintree.com/get-well-card-fallen-and-cant-giddyup-18574.htmlPermission granted only for viewing on SEVPAC website
Clinical Signs! Abdominal pain! Muscle tremors! Pr<strong>of</strong>use sweating! Tachycardiahttp://www.leanintree.com/get-well-card-fallen-and-cant-giddyup-18574.htmlPermission granted only for viewing on SEVPAC website
Clinical Signs! Abdominal pain! Muscle tremors! Pr<strong>of</strong>use sweating! Tachycardia! Tachypneahttp://www.leanintree.com/get-well-card-fallen-and-cant-giddyup-18574.htmlPermission granted only for viewing on SEVPAC website
Diagnosis! Difficult todiagnosehttp://www.cartoonstock.com/directory/h/horse_whisperer.aspPermission granted only for viewing on SEVPAC website
Diagnosis! High serumconcentration <strong>of</strong>catecholamines ortheir metabolitesin urinehttp://www.thehorse.com/articles/30832/breeders-cup-all-equine-drug-testsnegativePermission granted only for viewing on SEVPAC website
Diagnosis! High serumconcentration <strong>of</strong>catecholamines ortheir metabolitesin urine! Catecholamineslabilehttp://www.thehorse.com/articles/30832/breeders-cup-all-equine-drug-testsnegativePermission granted only for viewing on SEVPAC website
Diagnosis! AdditionalDiagnostics:! Ultrasonography! Blood PressurePermission granted only for viewing on SEVPAC website
Prognosis! Poor prognosisdue to surgicalcomplicationsPermission granted only for viewing on SEVPAC website
Prognosis! Poor prognosisdue to surgicalcomplications! Induction <strong>of</strong>fatalarrhythmiasPermission granted only for viewing on SEVPAC website
Prognosis! Poor prognosisdue to surgicalcomplications! Induction <strong>of</strong>fatalarrhythmias! Anatomiclocation <strong>of</strong>adrenalsPermission granted only for viewing on SEVPAC website
Prognosis! Poor prognosisdue to surgicalcomplications! Induction <strong>of</strong>fatalarrhythmias! Anatomiclocation <strong>of</strong>adrenalsPermission granted only for viewing on SEVPAC website
Prognosis! Poor prognosisdue to surgicalcomplications! Induction <strong>of</strong>fatalarrhythmias! Anatomiclocation <strong>of</strong>adrenalsPermission granted only for viewing on SEVPAC website
Prognosis! Poor prognosisdue to surgicalcomplications! Induction <strong>of</strong>fatalarrhythmias! Anatomiclocation <strong>of</strong>adrenalsPermission granted only for viewing on SEVPAC website
Comparative <strong>Pheochromocytoma</strong>s! More common in cattle, laboratoryrats, and dogsPermission granted only for viewing on SEVPAC website
Comparative <strong>Pheochromocytoma</strong>s! More common in cattle, laboratoryrats, and dogs! Bulls: may be part <strong>of</strong> multipleendocrine neoplasiaPermission granted only for viewing on SEVPAC website
Comparative <strong>Pheochromocytoma</strong>s! More common in cattle, laboratoryrats, and dogs! Bulls: may be part <strong>of</strong> multipleendocrine neoplasia! Dogs: tachycardia, edema, cardiachypertrophy, polyuria and polydipsiaPermission granted only for viewing on SEVPAC website
Comparative <strong>Pheochromocytoma</strong>s! More common in cattle, laboratoryrats, and dogs! Bulls: may be part <strong>of</strong> multipleendocrine neoplasia! Dogs: tachycardia, edema, cardiachypertrophy, polyuria and polydipsia! 50% metastasize to the liver, regional lymphnodes, spleen, and lungsPermission granted only for viewing on SEVPAC website
Case Summary! Presented as a colicPermission granted only for viewing on SEVPAC website
Case Summary! Presented as a colic! <strong>Pheochromocytoma</strong> found onnecropsyPermission granted only for viewing on SEVPAC website
Case Summary! Presented as a colic! <strong>Pheochromocytoma</strong> found onnecropsy! Catecholamines produce clinicalsignsPermission granted only for viewing on SEVPAC website
Case Summary! Presented as a colic! <strong>Pheochromocytoma</strong> found onnecropsy! Catecholamines produce clinicalsigns! Poor prognosisPermission granted only for viewing on SEVPAC website
Acknowledgements! Dr. Danielle Reel! Dr. Linden Craig! UTCVM Pathology Department! UTCVM Histology LabPermission granted only for viewing on SEVPAC website
Questions?Permission granted only for viewing on SEVPAC website
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