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David Watkins - The Royal Marsden

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<strong>The</strong> <strong>Royal</strong> <strong>Marsden</strong><br />

Risk of second malignancies<br />

Relative risk<br />

Time at risk<br />

Sites at risk<br />

Chemotherapy<br />

alone<br />

2.0<br />

(95%CI 1.7-2.4)<br />

Peaks 5-9 years<br />

Nil > 15 years<br />

Lung<br />

NHL<br />

Leukeamia<br />

Combined<br />

modality<br />

3.9<br />

(95%CI 3.5-4.4)<br />

0-4 years to<br />

> 20 years<br />

In addition<br />

Colon<br />

NM Skin<br />

Breast<br />

Leukaemia risk and all-malignancies risk increased strongly with<br />

number of cycles of alkylating chemotherapy

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