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Annual Report | Fiscal Year 2010–2011 

HARVARD 

SCHOOL OF 

DENTAL MEDICINE 

annual report 2010–2011 | harvard school of dental medicine 1

The mission of the 

Harvard School of 

Dental Medicine is 

to develop and foster 

a community of global 

leaders advancing oral 

and systemic health. 

2 

harvard school of dental medicine | annual report 2010–2011

p 

From the Dean 

hsdm is more than just teeth. So much 

more. Research on a variety of human diseases is part of the 

DNA here at HSDM, where our faculty are exploring causes of 

and treatments for conditions such as cancer, vascular disease, 

and osteoarthritis. Our world-class scientists work on the 

cellular and molecular levels to create a future of improved 

human health. The Harvard School of Dental Medicine is more deeply involved in cuttingedge 

bioengineering and therapeutic research than at any time in its 145 years. This report 

contains some highlights of HSDM research from this past year. 

Excellence in education is another hallmark of this School, the first dental school in 

the country to be connected with a university and coordinated to its medical school. In 

late 2010, HSDM welcomed visitors from the Commission on Dental Accreditation, who 

were impressed with the quality and scope of our DMD and advanced graduate education 

programs and pronounced them successfully accredited, with very favorable reviews. 

HSDM students, faculty, and alumni have had a long and very strong tradition of 

providing care to underserved individuals and populations, both locally and across the 

globe. The work itself is its own reward, and members of the HSDM community have thus 

reaped great personal rewards for their service during the past year. You will read about some 

of these projects in this report. 

I am proud to present this portrait of the Harvard School of Dental Medicine for the 

academic year 2010–2011. This is a special and dynamic place, one that produces meaningful 

scientific research, offers a rich educational experience, and develops leaders in all aspects of 

the profession. We are deeply grateful for the generosity of our donors, listed in this report, 

for their support, which makes possible the quality and breadth of our work. 

R. Bruce Donoff, DMD ’67, MD ’73 

Dean and Walter C. Guralnick Distinguished Professor 

of Oral and Maxillofacial Surgery 


explore 

science for improving human health 

Toward a “Fat-Busting” Pill 

In early 2011, headlines in newspapers from 

Brazil to India to Zimbabwe trumpeted the potential 

of research by HSDM’s Mohammed Shawkat 

Razzaque, MD, PhD, to lead to an anti-obesity pill. 

Razzaque, an assistant professor of oral medicine, 

infection, and immunity, disavows such claims, but 

notes that results of his research offer a small step 

toward finding a target for development of a “magic 

pill to reduce the suffering of obese and diabetic 

individuals and bring back the joy of healthy life.” 

In spite of improvement in technologies and 

therapies, diabetes and obesity are still major causes 

of death and disability worldwide. The research 

conducted by Razzaque and his team centers on the 

molecule klotho—a gene that controls the body’s 

metabolism of calcium, phosphate, and glucose— 

which has been identified in a number of tissues 

and can also be detected in the bloodstream. The 

researchers demonstrated that reducing klotho 

function from obese mice with high blood-sugar 

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Gates Foundation Grant 

levels can produce lean mice with reduced bloodsugar 

levels. “These novel findings,” says Razzaque, 

“form the basis of further studies to develop a new 

drug to selectively modify klotho activity to reduce 

obesity .” That is, the researchers hope to develop 

a drug that would reduce the potential harmful 

functions of klotho without impairing its necessary 

functions. 

“In the dark horizon of obesity and diabetes,” 

says Razzaque, “our promising results bring a ray 

of hope, as we believe that the levels of klotho will 

provide a clue toward a cure for obesity and its 

subsequent complications, such as type 2 diabetes. 

With our ongoing studies,” he continues, “we are still 

trying to discover how absence of klotho prevents 

weight gain, but for now there is hope that we might 

have identified a valid target for a new class of drug 

development for treatment of obesity.” p 

In May 2011, Pierre Striehl, PhD, an HSDM 

instructor in developmental biology, together with 

collaborator Ionita Ghiran, MD, an investigator in the 

Division of Allergy and Inflammation at Beth Israel 

Deaconess Medical Center and assistant professor 

of medicine at Harvard Medical School, received a 

$100,000 Grand Challenges Exploration Grant from 

the Bill & Melinda Gates Foundation. The project, 

“Malaria Screening with a Cell Phone and Magnetic 

Levitation,” was designed in response to the Gates 

Foundation challenge topic Creating Low-Cost Cell- 

Phone-Based Applications for Priority Global Health 

Conditions. The researchers developed an antibodyfree 

diagnostic screening device that separates 

malaria-infected red blood cells from uninfected 

red blood cells through magnetic levitation. If the 

technology proves successful, mass production of the 

device should be possible, given its construction from 

basic components. 

Opposite: Mohammed Shawkat Razzaque, MD, PhD (center), 

with colleagues Mutsuko Ohnishi, MD, PhD (left), and Junko 

Akiyoshi, MD. The team’s research could eventually lead to 

a drug for the treatment of obesity. Not pictured: Azeddine 

Atfi, PhD; Shigeko Kato, PhD. 

Prototype device consisting of lens assembly module and 

disposable magnetic levitation chip (actual size) attached to a 

generic camera phone. 




Focus on Osteoarthritis 

Several researchers at HSDM are directing their 

efforts toward developing preventive and therapeutic 

measures to address osteoarthritis, the most common 

form of arthritis and one of the leading causes of 

chronic disability. An estimated 30 million people 

suffer from this condition in the United States alone, 

and this figure is expected to grow significantly as our 

population ages. 

Osteoarthritis is a complex disease. The 

interconnected systems of cartilage, bone, ligaments, 

meniscus, tendons, and muscle are all affected. The 

disease involves multiple changes in joint composition 

and structure and can take decades to develop, with 

significant biomechanical and biochemical aspects 

working together and in parallel to attack normally 

functioning tissue. These many simultaneous factors 

lead to the eventual destruction of the cartilage and, 

ultimately, the joint. Targeting osteoarthritis thus 

requires a multidisciplinary approach. 

In 2009, HSDM researchers, led by Vicki 

Rosen, PhD, 

professor and chair 

of the Department 

of Developmental 

Biology, and Bjorn 

R. Olsen, MD, PhD, 

dean for research 

and Hersey professor 

of cell biology, 

began to formalize a 

collaborative initiative 

Vicki Rosen, PhD (left), 

chair and professor of 

developmental biology, 

and Yefu Li, PhD, assistant 

professor of developmental 

biology, are conducting 

research targeted toward 

prevention of and 

therapeutic treatments for 

osteoarthritis. 

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Dean’s Scholars 

with colleagues from Harvard’s academic medical 

centers and other institutions to create an impressive 

response to the challenge of osteoarthritis. These 

experts in developmental biology, orthopedic surgery, 

radiology, genetics, and biological chemistry, among 

other disciplines, are working toward prevention of 

this condition, as well as therapeutic treatments to 

slow the disease’s progression. 

Current treatment options for osteoarthritis 

patients focus on symptomatic relief and 

improvement of joint mobility. Unfortunately, 

these types of treatments have essentially no effect 

on the structural degradation of joint tissue, so the 

development of therapeutics that treat the disease 

itself rather than simply the symptoms is greatly 

needed. New collaborative research will shed light on 

this complicated disease and provide new avenues for 

novel product development. 

The OA initiative—with Rosen and Olsen as 

scientific directors and Yefu Li, an assistant professor 

of developmental biology at HSDM, as a principal 

faculty researcher—is the avenue through which 

this research will take place. By facilitating crosspollination 

among basic, translational, and clinical 

scientists, this project will provide the expertise 

and infrastructure necessary to make a cure for 

osteoarthritis a reality. p 

The Dean’s Scholars program, established in 2002, 

provides financial support to bridge an individual’s 

move from postdoctoral study to faculty, allowing 

promising scholars time to develop and refine the 

skills necessary for academic success. The following 

were inducted as Dean’s Scholars for the 2010–2011 

academic year: 

martin duplan, dds, phd 

“Regulation of podosome dynamics by microtubules in 

osteoclasts: Analysis of an EB1/Src/cortactin dependent 

mechanism.” Mentor: Roland Baron, DDS, PhD 

yanqiu liu, md, phd 

“Deciphering the role of osteoblast-derived VEGF in postnatal 

bone homeostasis.” Mentor: Bjorn R. Olsen, MD, PhD 

dorothy pazin, phd 

“Investigating the developmental origins of the meniscus.” 

Mentor: Vicki Rosen, PhD 

quan yuan, dds, phd 

“Role of PTH in FGF23/klotho-mediated mineral ion 

homeostasis.” Mentor: Beate Lanske, PhD 

davide zocco, phd 

“Exploiting the amino acid response to treat pathologic 

inflammation.” Mentor: Malcolm Whitman, PhD 

The following received continuation awards from last year: 

luciane capelo, phd 

“Localization of BMP2 in the postnatal skeleton.” Mentor: 

Vicki Rosen, PhD 

claudia nicolae, phd 

“Biochemical and genetic studies of an engineered 

endostatin-containing trimeric fragment of collagen XVIII.” 

Mentor: Bjorn R. Olsen, MD, PhD 

joel n. h. stern, phd 

“Mechanisms of pemphigus vulgaris and design of 

treatments.” Mentors: Bjorn R. Olsen, MD, PhD, and Winston 

P. Kuo, DDS 




Becoming Stem Cells 

The great English physician William Harvey, 

credited with the discovery—published in 1628—that 

our heart and blood vessels function like a plumbing 

system for the circulation of blood, once wrote, 

“Nature is nowhere accustomed more openly to 

display her secret mysteries than in cases where she 

shows traces of her workings apart from the beaten 

path.” Had he been alive today, he might have said 

that studying rare disorders can open the door to 

learning about the complexities of normal body and 

tissue functions and common disease processes. 

Recent work by Bjorn R. Olsen, MD, PhD, 

HSDM’s dean for research and professor of 

developmental biology and Hersey professor of cell 

biology at Harvard Medical School, and Damian 

Medici, PhD, currently an HSDM instructor of 

developmental biology, provides a remarkable 

example of the truth of this statement. In studies of 

the rare genetic bone disease fibrodysplasia ossificans 

progressiva (FOP), Olsen and Medici discovered a 

process by which blood-vessel-lining cells turn into 

stem cells. In FOP patients, these stem cells become 

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Student Research Day 

bone-forming cells in the patients’ muscles and soft 

tissues. The result is that, over time, these individuals 

are unable to move, much like marble statues. 

“This discovery opens the door to therapies that 

may prevent abnormal bone formation in FOP,” says 

Olsen. “It also leads to questions of whether bloodvessel-lining 

cells are utilized as a source of stem 

cells during normal development and maintenance 

of bones and cartilage and other organs. Finally, the 

findings raise the exciting possibility that bloodvessel-lining 

cells, with the proper stimulation, 

may be used by clinicians as a source of stem 

cells for local tissue repair in other diseases.” For 

example, Olsen notes, recruitment of stem cells 

from local tissue blood vessels may one day be used 

in restorative dentistry to build bone in the jaws of 

patients or in orthopedic surgery to repair difficultto-heal 

fractures elsewhere. p 

In April, the lobby of the Research and Education 

Building buzzed with activity, as the Harvard School 

of Dental Medicine held its annual Student Research 

Day. DMD, MMSc, and DMSc students, as well as 

visiting scholars, presented their research posters in 

partial fulfillment of their research requirement, with 

faculty evaluating the student poster presentations. 

Members of the HSDM community visited the 

poster sessions throughout the day and discussed the 

research projects with the presenters. 

This annual event, which showcases the work of 

HSDM’s predoctoral and advanced graduate students, 

always draws a large crowd and is a manifestation of 

the School’s focus not only on clinical dentistry but 

also on research and academics. p 

Below: Hessam Rahimi, DDS, DMSc ’11 (orthodontics), 

explains his research poster to a Research Day visitor. 

Opposite: Bjorn R. Olsen, MD, PhD 

(right), and Damian Medici, PhD, have 

discovered a process through which cells 

that line blood vessels turn into stem 

cells. This finding holds great promise 

for tissue repair and building bones. 



service for global and community health 

Care for Individuals with Special Needs 

Romesh Nalliah, BDS, an instructor in restorative 

dentistry and biomaterials sciences and Castle Society 

senior tutor, often works outside the walls of HSDM. 

Among his many activities, he is a participant in the 

Massachusetts Dental Society (MDS) Leadership 

Institute. 

Following a year of leadership classes, Institute 

members serve on a one-year Ad Hoc Project 

Committee, which identifies a need within the 

profession and works to create a program designed 

to address that need. Elected chair of the Ad Hoc 

Project Committee by his 2010 Leadership Institute 

colleagues, Nalliah led the group in identifying 

individuals with special needs as a population with 

unmet oral health requirements. With a grant from 

MDS, the team’s major focus is on developing an 

educational program for caregivers of individuals 

with special needs, including creating a video to 

inform caregivers about caring for the teeth of their 

loved ones or clients. 

One of the most important actions the 

committee undertook was to develop a referral list of 

dentists willing to treat individuals with special needs. 

Once the volunteers perform an oral health screening, 

they need to be able to refer the patient to a provider. 

The committee surveyed all 5,000 Massachusetts 

Dental Society dentists, and of those, 280 agreed to 

take one or two new patients with special needs into 

their practices. 

Engaging in action himself, 

Nalliah leads oral health screenings 

for individuals with special needs. 

One such event, in April 2011, took 

place at Triangle, an organization 

in Malden, Mass., dedicated to 

empowering people with special 

needs and their families. The group, 

which, in addition to Nalliah, 

Left: Archana Nadig (DMD 2012) performs 

an exam on an individual with special 

needs at the Charles River Center. 

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included two fourth-year HSDM students and other 

dentists, screened 45 individuals. Twenty of them 

had untreated caries, 38 had signs and/or symptoms 

of gingivitis or periodontitis, and six suffered from 

pain in their mouth, including one of the four people 

who had no teeth. Only one of the individuals was 

under the active care of a dentist. One person had no 

recollection of ever brushing and was taught to brush 

for the first time. Two had fractured teeth. The group 

referred 44 individuals to dentists for further care. 

A second screening event took place in late May, 

at the Charles River Center, a social service agency 

in Needham, Mass., that provides advocacy and 

services to people with developmental disabilities 

and their families. The HSDM group, including 

eight DMD students, Nalliah, and two Massachusetts 

Dental Society dentists, screened 35 people. The 

work opened horizons for the DMD 

students, as they have very little exposure 

to special-needs populations in the 

Teaching Practice at HSDM. Nalliah and 

the students continue to provide oral 

health screenings for individuals with 

Homeless Individuals 

Receive Oral Health Care 

Since 2009, HSDM students Rebecca Kibler and 

Shamik Desai (both DMD 2012), together with faculty 

mentor Romesh Nalliah, have organized oral health 

and cancer screenings, oral hygiene instruction, and 

dental-supply donations for Boston’s adult homeless 

population. To date, students from all four years of 

the predoctoral curriculum, as well as postdoctoral 

residents, have worked together to screen nearly 200 

homeless individuals. Screenings have taken place 

indoors at homeless shelters in downtown Boston, as 

well as at several outdoor community-outreach events 

in Cambridge. Although not surprising, the HSDM 

work has confirmed the need for oral health initiatives 

in this population: some 75 percent of the homeless 

individuals with natural teeth had untreated decay, 

among other serious conditions. p 

special needs. p 

Right: Nithya Chickmagalur (DMD 2012) 

examines a client at the Charles River Center. 




Operation Mouthguard 

Operation Mouthguard (OM) is a communityhealth 

project established by HSDM students in 2000. 

From its beginning, OM has worked to increase oral 

health awareness in young athletes from low-income 

areas in Greater Boston and provide them with 

custom-fitted mouthguards. Edward K. Brown, Jr., 

DDS (DMSc 2013, prosthodontics) has been acting 

director of the program since August 2010. 

According to the American Dental Association 

(ADA), the risk of damage to the mouth during sports 

activity is reduced 60 times by the use of mouthguards, 

and more than 200,000 sports-related oral injuries 

are prevented annually in the United States by use 

of sports mouthguards. Currently, the ADA requires 

the use of mouthguards in football, ice hockey, field 

hockey, boxing, and lacrosse and recommends their 

use in 24 other sports activities. The custom-fitted 

mouthguards that OM provides are superior to the 

traditional boil-and-bite, or stock, mouthguards that 

are usually available at sporting-goods stores. 

OM reaches out to underserved children in 

the Boston area who do not have access to customfitted 

mouthguards by partnering with nonprofit 

organizations such as the Boys & Girls 

Clubs of Boston, the YMCA, and the 

MGH Healthcare Center. At each event, 

HSDM students take impressions of the 

children’s mouths, then back at HSDM, 

student volunteers help pour models 

and finish preparing the mouthguards in 

the Preclinical Learning Center. Finally, 

HSDM students return to ensure a 

correct fit for the mouthguards. 

In early 2011, several HSDM students participated 

in taking impressions, then, back at HSDM, more 

students created some 70 mouthguards. One cold and 

snowy Friday evening in March, the distribution of 

finished mouthguards took place at the Charlestown 

(Mass.) Boys & Girls Club. Youth from Boys & Girls 

Clubs across Greater Boston gathered for a dinner of 

Chinese food and mouthguard fitting before heading 

off to a Boston Celtics basketball game. Brown and Go 

Eun Kim (DMD 2012) fitted the mouthguards, while 

first-year Harvard Medical School student Michael 

Simoni staffed the survey station, where the youth 

filled out short questionnaires about their sports 

activities, their oral health, and their mouthguards. 

Results of the survey showed the importance of 

wearing mouthguards: 64 percent of the respondents 

said they had received a blow to the face while playing 

sports; 26 percent had sustained a tooth injury during 

sports activities; and 50 percent knew 

of a friend’s sports-related tooth injury. 

Of the survey respondents, 95 percent 

reported that they were happy or very 

happy with their new custom-fitted 

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Presidential Scholars 

mouthguards (5 percent were neutral). The following 

day, the young people participated in their own 

basketball tournament, the Unity Games—sponsored 

in part by the Celtics—sporting their newly acquired 

mouthguards to keep their mouths safe. The HSDM 

students had produced color-coded mouthguards, 

with a different color for each Boys & Girls Club. The 

youth were mixed together in the tournament teams, 

so each team featured multicolored mouths. p 

Below: Go Eun Kim (DMD 2012), left, and Edward K. Brown, Jr., 

DDS (DMSc 2013), ensure that the custom-fitted mouthguards 

prepared by HSDM students fit each person perfectly. 

The Presidential Scholars in Dental Medicine 

awards, funded by the Office of the Harvard University 

President and by HSDM, provide significant financial 

support for individuals who are committed to public 

service through career pathways such as academic 

dentistry, research, leadership roles in public health 

or public policy, and a commitment to underserved 

populations or international health issues. The 

following were the 2010–2011 Presidential Scholars: 

satheesh elangovan, DSc, DMSc ’11 

(periodontology) 

martin fu, MS (DMSc 2012, periodontology) 

gayatri gunda, DMD ’09 (DMSc 2013, 

orthodontics) 

daniel ho, DMD, MSc (DMSc 2012, 

periodontology) 

zainab khan, DMSc ’11 

soo-woo kim, DMD ’08 (DMSc 2012, 

periodontology) 

samuel koo (DMSc 2013, periodontology) 

min kyeong lee, DMD ’10 (DMSc 2014, 

orthodontics) 

jason outlaw (DMSc 2015) 

vinícius rodrigues, DDS, DMSc ’11 

(periodontology) 

shokoufeh shahrabi farahani, MS, 

DDS (DMSc 2013, oral pathology) 




Giving Kids—and Students—a Smile 

As they do every year, HSDM students 

volunteered their time for several hours on a 

Saturday in March in the Harvard Dental Center 

Teaching Practice to improve oral health in the local 

community. During Give Kids a Smile, a national 

program of the American Dental Association, 

students and dentists across the country provide 

free oral health care services for children from lowincome 

neighborhoods. 

Sixty-four DMD students participated in the 

HSDM event in early March, with the third- and 

fourth-years providing screenings and cleanings and 

the first- and second-years assisting and offering fun 

activities on oral health education for the kids. HSDM 

pediatric dentistry faculty and alumni supervised. 

Parents had made appointments for some 120 

children in advance of the event, and the HSDM 

students accommodated another 30 walk-ins. The 

Teaching Practice was abuzz—in several languages— 

and, as usual, the HSDM students were as full of 

smiles as were the children who received the care. 

The young people received goodie bags filled with 

toothbrushes, toothpaste, and floss and participated 

in activities to help them learn about the importance 

of oral health care. Several parents made followup 

appointments for their children to return for 

further care, 

representing the 

beginning of 

lifelong attention 

to their oral 

health. p 

Left: Diane Lee 

(DMD 2014), left, 

assists while Matt 

Lawler (DMD 2012) 

examines the 

mouth of Marquis 

Simmons, 15. 

12 


Distinguished Service 

At the annual meeting 

of the Harvard Dental 

Alumni Association, Dean 

Bruce Donoff presented 

Above: Jeffrey McCullogh (DMD 2012) performed an exam and cleaning 

on Willa Schifilliti, 3½, as she sat on the lap of her mother, Lisa 

Schifilliti. 

Below: Lauren Feldman (DMD 2014), right, helps Sophia Zhao, 3, and 

her brother Maxwell, 2, learn how to brush teeth and use dental floss. 

The children’s mother, Donhong Wu, looks on. 

the HSDM Distinguished 

Alumnus Award to Thomas 

Albert, DMD ’71, MD ’77, 

an oral and maxillofacial 

surgeon and longtime 

professor at Oregon Health 

Sciences University in 

Portland, Oregon. The 

School honored Albert for 

Thomas Albert 

his support of HSDM, his many years of teaching, and 

his innovative humanitarian work through the FACES 

Foundation, of which he is president and cofounder. 

The FACES mission is to model comprehensive, locally 

sustainable, high-quality care—including surgery 

and speech therapy—for indigent, medically isolated 

patients with cleft lip/palate deformities. In addition 

to his work in Peru with FACES, Albert was involved 

in an extensive medical education effort concerning 

cleft care with Project Hope in China from 1983 to 

1993 and has continued to be involved independently. 

Throughout his career, Albert has focused on providing 

care to some of the world’s most vulnerable individuals, 

exemplifying the global leadership that is the hallmark 

of alumni of the Harvard School of Dental Medicine. p 




Oral Health Care in Ecuador 

In June 2010, the Harvard School of Dental 

Medicine signed an agreement with the Pan American 

Health Organization (PAHO), a regional office of 

the World Health Organization, to make PAHO 

internships in international oral health available to 

HSDM students. In June 2011, Ashley Orynich, DMD 

’11 (MPA 2012), left Boston to spend the summer in 

Quito, Ecuador, on a teaching and research fellowship. 

The visit was arranged by Dr. Saskia Estupiñán-Day, 

PAHO’s regional adviser on oral health, together 

with the HSDM Office of Global and Community 

Health—the umbrella for the School’s public health 

work both in the United States and abroad—and the 

Harvard Medical School Scholars in Medicine Office. 

Among Orynich’s responsibilities was teaching 

three days a week as a clinical instructor at La 

Universidad Cristiana Latinoamericana’s (UCL) Escuela 

de Odontologia. “I had to pinch myself,” she says. “I 

had been in these dental students’ shoes not more than 

a month before, and here I was thinking back to all of 

those lessons I learned from HSDM and teaching those 

same lessons to my students—but in Spanish!” 

Helping others learn skills struck a chord. “I 

believe I understand why the professors at HSDM 

became teachers,” says Orynich. During a trip to the 

Amazon, she was the lone supervisor for 20 dental 

students for several hours as they treated indigenous 

patients in the middle of the rainforest. “I questioned 

whether I could do it,” she remembers. 

“But at the end of that day, after 

all of the patients, and after all the 

extractions, restorations, and suturing 

were completed, I had gained a new 

sense of confidence as a clinician. 

I received hug after hug from the 

students, thanking me for how much 

they had learned from me that day.” 

In addition, Orynich worked as a 

teaching fellow, conducting research on 

integrating pediatric oral health services 

into primary care using PAHO’s Oral 

Health Module. After delivering an 

14 


New Public Health Courses 

educational oral 

health seminar to 

mothers of infants 

at the Ministry of 

Health public health center, she gathered data on the 

oral health attitudes and opinions of the participants. 

Another component of her research involved a policy 

analysis of Ecuador’s Ministry of Health and various 

United Nations agencies. Orynich also served as a 

dentist, gaining hands-on pediatric clinical experience 

in a variety of settings through the Ecuadorian 

Ministry of Health, the Ecuadorian Red Cross’s mobile 

clinic, and UCL’s teaching practice. 

“My experience in Ecuador was such an amazing 

gift and so inspiring,” says Orynich. “The dean of 

UCL, Dr. Mario Abad, and his entire faculty not 

only demonstrated a true passion for teaching, 

but also a dedication to working with underserved 

populations. This opportunity has helped shape my 

global health career goals to include teaching and 

research in developing settings,” she continues, “and it 

has inspired me to take on the incredible challenge of 

Brittany Seymour, DDS, 

MPH ’11, joined the HSDM 

Department of Oral Health 

Policy and Epidemiology in 

2011. Specializing in global and 

community health, Seymour 

has created two new courses for 

Brittany Seymour 

HSDM students. Career Development in Global and 

Community Health examines career opportunities in 

these areas through invited speakers currently working 

in the field. Global Oral Health: Interdisciplinary 

Approaches investigates the extensive relationship between 

oral health and global health, including the ways in which 

globalization affects oral health and the association of 

oral diseases with poverty, HIV/AIDS, diabetes, maternal 

and child health, poor mental health, cardiovascular 

disease, poor nutrition, tobacco, and alcohol. p 

leading a life of service.” p 

Opposite: Ashley Orynich, DMD ’11 (MPA 2012), left, treats 

a patient at the Ecuadorian Red Cross Mobile Clinic in 

Atacucho, Ecuador. Right: Orynich treats a patient in Tena, 

a city in the Amazon. Above: A team of third-year dental 

students from Universidad Cristiana Latinoamericana (UCL), 

supervised by Orynich (right), treated patients in Tena 

through UCL’s outreach program in tents provided by the 

local Ecuadorian military. 



excellence in education 

Advances in Learning 

In fall 2010, the Committee on Dental 

Accreditation conducted an extensive review— 

including a site visit—of HSDM’s DMD program, as 

well as the advanced graduate education programs 

in endodontics, oral pathology, orthodontics, 

periodontics, and prosthodontics. The School had 

previously undergone an external review of the 

advanced graduate education programs, and several 

changes resulting from that review had been completed 

by the time of the accreditation process. HSDM passed 

the accreditation with a very favorable review. 

The past year saw continued expansion of the use 

of digital technology, including digital radiographs, 

throughout the HSDM curricula. The School installed 

flat panel screens in all tutorial rooms, allowing 

students to bring information directly into the 

tutorials. The implementation of electronic health 

records in the Harvard Dental Center has facilitated 

student access to patient information during tutorials, 

allowing for richer and more realistic discussions. And 

HSDM has conducted a pilot project to determine 

whether training using haptic technology—which 

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Nanocourses Go In-Depth 

is capable of providing physical sensations such as 

vibrations and forces—could improve students’ manual 

dexterity in the preclinical module. This technology, in 

combination with 3D imaging, allows the user to safely 

practice a new surgical technique or procedure before 

performing it on a live patient. This virtual-reality 

environment lends itself to training in several dental 

procedures, from simple cavity preparations to implant 

surgery. p 

Above: Hiroe Ohyama, DDS, PhD, DMD, an instructor in 

restorative dentistry and biomaterials sciences and director of 

the Predoctoral Program in Operative Dentistry, demonstrates 

proper technique to Richard Senatore (DMD 2013). 

Opposite: Thomas Burk (DMD 2013), center, works on 

a patient simulator as Supattria Chutinan, DDS, MSD, 

an instructor in restorative dentistry and biomaterials 

sciences, explains a procedure in the HSDM Preclinical 

Learning Laboratory. At left is Daniel Ravens (DMD 2013). 

HSDM has developed several short courses, 

taught by Dean’s Scholars, that focus on specific 

topics and highlight cutting-edge areas of science: 

autoimmune diseases and their mechanisms 

Joel N. H. Stern, PhD 

This nanocourse focuses on the mechanisms of 

autoimmune diseases and their treatments. Lectures 

begin with an in-depth introduction to immune cells, 

such as T and B cells, as well as antigen presenting 

cells, followed by a discussion of T cell and B cell 

mediated autoimmune diseases to demonstrate how 

these cells are involved in maintaining immunity. 

The course covers additional topics on cancer 

immunology and immunotherapies, concluding with 

a discussion of the direct and indirect involvement 

of stem cells and their microenvironments in the 

prevention and maintenance of autoimmunity. 

bone development and diseases 

Yanqiu Liu, PhD 

This nanocourse focuses on the molecular and cellular 

mechanisms of bone development and homeostasis. 

The lectures cover VEGF and BMP signaling during 

bone development and postnatal homeostasis, 

stem cell research in bone biology, and pathological 

processes and treatment of bone diseases. The goal 

of the course is to provide students with the basic 

knowledge of bone biology and recent progress in the 

research field of bone development and homeostasis, 

as well as the most recent mechanistic studies and 

potential therapeutic insights into bone diseases. 

Students acquire a fundamental understanding of the 

molecular and cellular basis of cancer and are exposed 

to the most cutting-edge therapeutic strategies for 

current and future treatment. 

continued on page 27 



leadership 

Dean’s Advisory Board 

The Dean’s Advisory Board assists the School 

in achieving its mission and furthering the School’s 

strategic plan by raising funds and advising and 

consulting with the dean on initiatives important to 

expanding the HSDM revenue base and leadership 

position. Great energy and excitement followed a 

presentation this spring by Jane Barrow, director 

of the HSDM Office of Global and Community 

Health, and Lois Cohen, consultant and Paul G. 

Rogers Ambassador for Global Health Research at 

the National Institute of Dental and Craniofacial 

Research, who outlined plans for HSDM to develop, 

promote, and sustain initiatives in oral public health 

both in the United States and around the world. p 

Members of the Dean’s Advisory Board: from left, Ellen Libert, DMD ’87, MMSc ’90, a clinical instructor in oral medicine, 

infection, and immunity at HSDM and president of the Harvard Dental Alumni Association; Seung-Han Lee, PhD, president and 

CEO of Samsung Tesco, South Korea; Steven Kess, vice president for global professional relations at Henry Schein, representing 

James Breslawski, Henry Schein’s president and COO; Dean Bruce Donoff, DMD ’67, MD ’73; Chester Douglass, DMD, PhD, 

professor emeritus of oral health policy and epidemiology at HSDM; Gregory Serrao, chair, president, and CEO of American 

Dental Partners, Inc.; Kimberly Ritrievi, PhD (Board chair); Dan Perkins, president and CEO of AEGIS Communications. Not 

pictured: James Breslawski; Allen Finkelstein, DDS, CEO of Bedford HealthCare Solutions; Tuan Ha-Ngoc, president and CEO 

of AVEO Pharmaceuticals, Inc.; Anne Eiting Klamar, MD, president and CEO of Midmark Corporation; Gerard Moufflet (former 

Board cochair), CEO and founder, Acceleration International; and Jeffrey Slovin, president of Sirona Dental Systems. 

18 


q 

Scholar and Leader 

Colleen Greene (DMD/MPH 

2013) is making her mark at two 

schools, in multiple fields, and 

on the local and national levels. 

Greene was selected by HSDM 

as the inaugural recipient of the 

Nathan and Phyllis Goodman 

Colleen Greene 

Scholarship, which benefits a 

deserving student throughout the four years of his or 

her DMD studies. She is simultaneously pursuing a 

master of public health degree in health management at 

the Harvard School of Public Health, where she holds a 

Catherine B. Reynolds Foundation Fellowship in Social 

Entrepreneurship. These fellowships are designed to 

equip individuals for national leadership positions that 

bring real-world insights to bear on social problems. 

In true leadership style, however, Greene is 

involved in much more than her graduate studies. 

In late 2010, she assumed the position of editor-inchief 

of ASDA News, the newsletter of the American 

Student Dental Association. Before that, she had been a 

contributing editor of that publication. And in March 

2011, she became a member of the editorial board of 

the Journal of the American Dental Association. 

Greene was also the founding president of OPEN 

(Oral Health Pursuit of Equity Network), a student 

chapter of the American Association of Public Health 

Dentistry. OPEN fosters a community consciousness 

HDSM in the HAA 

Sonia Molina, DMD ’89, 

MPH ’89, was elected in May 

2011 to the Board of Directors of 

the Harvard Alumni Association 

(HAA). Since receiving her 

DMD, Molina has been actively 

involved with Harvard’s alumni 

Sonia Molina 

community in Southern California, 

where she lives. “Staying connected and engaging 

the future generations of Harvard alumni make our 

community stronger,” she says. 

As a member of the HAA Board, she plans to 

strengthen ties between the School and the University 

and champion the interests of Harvard’s dental 

community. She is particularly interested in the HAA’s 

efforts to enhance and unify the various Harvard Clubs 

and to encourage active participation from Harvard 

alumni. “I will do my best to represent the School that 

means so much to all of us,” says Molina, who was 

also recently elected the first Latina president of the 

1,200-member Los Angeles Dental Society. p 

based on public health principles among future 

dental and medical professionals, offering educational 

programming and direct volunteer action. Members 

pursue oral health equity at all community levels, 

including locally and internationally. Colleen Greene is 

truly the embodiment of HSDM’s mission. p 



generosity and commitment 

HSDM Donors 

The Harvard School of Dental Medicine is deeply grateful to the following individuals and organizations for gifts received during 

fiscal year 2010–2011, from July 1, 2010, through June 30, 2011. 

HENRY C. WARREN SOCIETY 

Henry Warren made the first 

planned gift to HSDM in 1899 

through a bequest of $23,000. 

Today’s planned gifts may include 

annuities, life insurance, trusts, 

and bequests and may perpetuate 

a family name, assist deserving 

students, or simply strengthen the 

School. We are exceedingly grateful 

to those who have expressed their 

intention to provide for HSDM 

in their estates, and to recognize 

this thoughtfulness, the School 

established the Henry C. Warren 

Society. Below are the Society’s 

members. 

Aina M. Auskaps, DMD ’55 

Michael L. Barnett, SDM ’73 

Jorge Bianchi, MMSc ’01 

James D. Billie, DMD ’73, and 

Corinne Billie 

Arnold E. Binder, DMD ’54 

Frank F. Bliss, DMD ’38 

Charles R. Bowen, DMD ’66, and 

Gerlinde Bowen 

John J. Bowen 

Allena Burge-Smiley, DMD ’82 

Robert Chuong, DMD ’77, MD ’77, 

PD ’82, and Elaine G. Wong 

Michelle Copeland, DMD ’77, and 

Jonathan L. Halperin 

Michael R. Coppe, DMD ’70, 

DMSc ’78, PD ’74 

Albert S. Cowie, PD ’78 

Reed H. Day, DMD ’85 

Douglas S. Dick, DMD ’67, PD ’72, 

and Eltress M. Dick 

Robert M. Donahue, DMD ’62, PD ’64, 

and Sherrie Stephens Cutler 

Chester W. Douglass and 

Joy A. Douglass 

Ilona E. Ferraro and Richard H. Ferraro 

Brian B. Fong, DMD ’96 

Wallace J. Gardner, DMD ’39* 

Gladys C. Goddard 

Lorne M. Golub, PD ’68 

Alexander H. Halperin, DMD ’56, 

and Carol Halperin 

Robert N. Hennessy, DMD ’44, and 

Jeanette Hennessy 

Lee Edward Hershon, PD ’74, and 

Nina Haskins Hershon 

T. Howard Howell Jr., PD ’76, and 

Jeffrey Stevens 

Jae-Woong Hwang, DMSc ’03 

Alvin A. Krakow and 

Barbara Krakow 

Mark E. Levine, DMD ’75, PD ’77 

Gayle J. Lowe and John E. Lowe 

Gordon J. Macdonald and 

Ruth M. Macdonald 

Ginat Wintermeyer Mirowski, MD ’85, 

DMD ’86, MMSc ’88, PD ’88, and 

Stephen F. Wintermeyer 

Edward R. Mopsik, DMD ’67, and 

Kaye Appleman Mopsik 

Edward M. Morin, DMD ’60 

Thomas R. Mullen, DMD ’76, and 

Carolyn A. Mullen 

W. Patrick Naylor, MPH ’81, PD ’81 

Robert N. Nishimura, SDM ’72 

Shirley A. Nylund, DMD ’81 

Arthur G. Ship, DMD ’52, and 

Enid S. Ship 

Paul J. Styrt, DMD ’85, MPH ’85, and 

Stacey Lynn Styrt 

Hans-Peter Weber, DMD ’90, and 

Cheryl O’Neil-Weber 

DEAN’S SOCIETY 

($100,000–$999,999) 

Alumni and Friends 

Douglas Dick, DMD ’67, PD ’72, and 

Eltress Dick 

Organizations 

Straumann U.S.A. 

*deceased 

CARLOTTA A. HAWLEY 

SOCIETY ($50,000–$99,999) 

Carlotta Augusta Hawley, DDS, 

PD ’38 (orthodontics), was the first 

woman graduate of the Harvard 

School of Dental Medicine. 


Gregory A. Serrao/American Dental 

Partners Foundation 

ROBERT T. FREEMAN 

SOCIETY ($10,000–$49,999) 

Robert Tanner Freeman, DMD 

1869, was the first African- 

American graduate of the Harvard 



James P. Breslawski 

Ethel Goldhaber 

Tuan Ha-Ngoc 

Seung-Han Lee 

Gerard M. Moufflet 

Hugh Y. Rienhoff 

Kimberly Ritrievi 

Jeffrey T. Slovin 

Charles M. Trauring, DMD ’68 

G. Gorham Peters Trust 

Organizations 

Teijin Pharma Limited 

188 LONGWOOD SOCIETY 

($5,000–$9,999) 

This society is named for the 

permanent home of the Harvard 



Paul D. Cashion, DMD ’68, and 

Maggie Cashion 

Ray English, PD ’86 

Allen Finkelstein 

Dan Perkins 

Harry V. Temple Jr., DMD ’76 

Matthew L. Warman 

We have made every effort to ensure the accuracy of these lists. Please let us know of any errors or omissions so that we 

may correct our records. Degrees listed reflect HSDM and affiliated degrees only. 

Faculty and Staff 

R. Bruce Donoff, DMD ’67, MD ’73, 

and Madelyn B. Donoff 

Jacob B. Silversin, DMD ’72, MPH ’73, 

DPH ’75 

Organizations 

Children’s Orthopaedic Surgery 

Foundation 

Eastern Dentists Insurance Company 

Nobel Biocare USA, Inc. 

Pew Charitable Trusts 

Tufts University 

NATHAN COOLEY KEEP 

SOCIETY ($1,867–$4,999) 

Nathan Cooley Keep, MD 1827, 

DMD 1870 (honorary), was the 

founding dean of the Harvard 

School of Dental Medicine. 1867 

is the founding year of the School. 


Thomas W. Albert, DMD ’71, MD ’77, 

and Kathy Albert 

Michael C. Alfano, PD ’74 

Grandchildren of Douglas Atwood 

Steven R. Bader, DMD ’81, and 

Angela M. Bader 

Richard F. Black, DMD ’84, MPH ’84, 

and Mary Katherine Blower Black 

Carlos Ferrer Leonardo Bordador, 

DMD ’01, and Josie L. Lorenzo 

Allena Burge-Smiley, DMD ’82 

Jarrel G. Burrow, DMD ’47 

Robert Chuong, DMD ’77, MD ’77, 

PD ’82, and Elaine G. Wong 

Leo & Eve Condakes Charitable 

Foundation 

Michael R. Coppe, DMD ’70, DMSc ’78, 

PD ’74 

Victor T. Curtin, DMD ’51, MD ’51 

Michael D. Debiak 

Kenneth R. Diehl, DMD ’70 

Marc B. Ehrlich, DMD ’84, MMSc ’88, 

PD ’88 

Richard L. Elias, DMD ’95, MD ’97, PD ’00 

David M. Feinerman, DMD ’89 

20 


David D. Feuer, PD ’73 

Stuart L. Fischman, DMD ’60 

John R. Frank 

F. Edward Gallagher, DMD ’71 

Lawrence M. Gettleman, DMD ’66, 

and Erica Gettleman 

Lorne M. Golub, PD ’68 

Jeffrey M. Gordon, DMD ’77, MMSc ’80 

David J. Greene, DMD ’82 

Christine L. Hamilton-Hall, DMD ’88 

Cedric F. Harring Jr., DMD ’62 

Herbert H. Hau, DMD ’77, and 

Frances Hau 

Douglas D. Hauer 

Michael S. Hauser, PD ’81 

Carol A. Hawkes 

Eugenio G. Herbosa, MMSc ’85, PD ’85 

James R. Hupp, DMD ’77, and 

Carmen E. Hupp 

Leila Jahangiri, MMSc ’95, DMD ’97, 

PD ’95 

Marjorie J. Jeffcoat, DMD ’76 

Maud C. Johnson 

Samuel Kaplan, DMD ’59 

John P. Kelly, DMD ’71, MD ’71 

Lester Kochanowsky, DMD ’57 

Ira B. Lamster, MMSc ’80, PD ’80 

William H. Liggett Jr., DMD ’86, 

DMSc ’91, MD ’91 

Gary S. Lindner, DMSc ’83, and 

Rochelle H. Lindner, DMD ’82 

Max A. Listgarten, PD ’63 

David M. Livingston 

Mortimer Lorber, DMD ’50, MD ’52 

William Ralph Maas, MPH ’82 

Gordon J. Macdonald and 

Ruth M. Macdonald 

Eugene A. Mickey, MPH ’82, PD ’82 

Ginat Wintermeyer Mirowski, MD ’85, 

DMD ’86, MMSc ’88, PD ’88, and 

Stephen F. Wintermeyer 

Edward M. Morin, DMD ’60 

Thomas R. Mullen, DMD ’76 

John B. Mulliken 

Lonnie Harold Norris, DMD ’76, 

MPH ’77, and Donna M. Norris 

Deji Ogundiya 

Eun-Jin Park, MMSc ’07 

Sheldon Peck and Leena Peck 

Wayne H. Pulver, PD ’76, and 

Marlene J. Pulver 

John D. Puskas, MD ’86, and 

Jane C. Puskas, DMD ’87, MPH ’87 

David I. Rosenstein, DMD ’70 

Michael E. Rowan, DMD ’67 

Todd K. Rowe, DMD ’86, MPH ’86 

Clifford Ruddle, PD ’76, and 

Phyllis S. Ruddle 

Joseph Henry Schulz, PD ’74 

Michael Scianamblo, PD ’77 

Rose D. Sheats, DMD ’79, PD ’80 

Charles F. Shuler, DMD ’79 

Daniel J. Simon, MMSc ’05 

Richard S. Sobel, PD ’70 

Martin Stern, DMD ’56 

Jeffrey D. Stone, DMD ’73, MD ’73 

Hans-Peter Weber, DMD ’90, and 

Cheryl O’Neil-Weber 

Peter Wohrle, DMD ’88, MMSc ’91, PD ’91 

Jeremy M. Young, MMSc ’04 

S. J. Zackin, DMD ’57 


Mary Cassesso and Peter L. Miller 

Richard J. Catrambone 

John D. Da Silva, DMD ’87, MPH ’87, 

PD ’89, PD ’91 

Donald B. Giddon, DMD ’59, PD ’62 

Jack Z. Gilad, MMSc ’98 

Joseph W. Griffin, MPH ’03 

Walter C. Guralnick, DMD ’41 

Leonard B. Kaban, DMD ’69, MD ’69 

Elsbeth Kalenderian, MPH ’89 

Alvin A. Krakow 

Ellen M. Libert, DMD ’87, MMSc ’90, 

PD ’90 

Dieu T. Ly, MMSc ’98 

Wanda Mock 

Ali A. Nasseh, MMSc ’97, PD ’97 

Bjorn R. Olsen 

Pamela Pappas 

Edwin J. Riley III, DMD ’73 

Edward Bert Seldin, DMD ’68, MD ’68 

J. H. Stempien, DMD ’58, and 

Elaine L. Stempien 

Robert F. Wright 

Organizations 

American Association of Anatomists 

Bristol-Myers Squibb Company 

Charlestown Cardiological Research 

Foundation 

Children’s Hospital Boston 

DENTSPLY Tulsa Dental 

Dickerman Dental Prosthetics 

Ira S. and Anna Galkin Charitable 

Trust 

Ivoclar Vivadent, Inc. 

Millennium Dental Lab 

Oral Design Boston, Inc. 

Quintessence Publishing Company, Inc. 

University of Medicine and 

Dentistry of New Jersey 

PARTNERS ($500–$1,866) 


Matthew J. Atwood 

Stephen Atwood and Claire Atwood 

Aina M. Auskaps, DMD ’55 

Jonathan S. Bailey, DMD ’94, MD ’96, 

PD ’99 

Ladan Basiri, DMD ’93 

John J. Bowen 

Roger A. Bronstein, PD ’77, SDM ’76 

Annie N. Cheng, DMD ’94, PD ’96 

Sharon M. Chiu 

Peter M. Dinnerman, DMD ’68 

Edward J. Finsilver, DMD ’72 

Raul I. Garcia, DMD ’80, MMSc ’85 

Jonas R. Gavelis, PD ’78 

Natalie Glovsky 

George D. Gordon, DMD ’66, and 

Roberta Gordon 

David K. Hiranaka, DMD ’88, MD ’90 

Joseph T. Hung, DMD ’98, MMSc ’00 

Renato V. Iozzo 

Eunduck Kay 

Peter G. Kimball, DMD ’60 

Marc Levitan, PD ’75 

Richard Liu, MMSc ’98 

Jay Morgenstern 

Ichiro Nishimura, DMSc ’86,DMD ’93, 

PD ’93, and Claudia Nishimura 

Robert N. Nishimura, SDM ’72 

Joseph Carter Oakley, DMD ’58 

Mark S. Obernesser, MMSc ’88, PD ’88 

Peter J. Polverini, DMSc ’77, PD ’77 

Elizabeth Reilinger 

Ilena Sack 

Robert M. Sainato 

Michelle A. Schaeffer, MPH ’01, PD ’01 

Eli C. Schneider, DMD ’73 

Kenneth S. Serota, MMSc ’81 

Ann Freedman Spoont, DMD ’79 

Marilyn Steinert Lyons, MMSc ’81, 

PD ’81 

August L. Stemmer, DMD ’53, MD ’55 

Michael Stern, DMD ’86 

Paul J. Styrt, DMD’85, MPH ’85 

Tina Wang 

Marjorie K. Weston 

Xudong Yang, MMSc ’10 

Helen S. Youm, DMD ’06, MMSc ’09 

Wilfried J. Zehm, SDM ’87 

continued on next page 


ugenerosity and commitment, continued 

22 


Nicholas M. Dello Russo 

Robert A. Frank, DMD ’68 

Zachary U. Kano 

Edward S. Katz 

Toshihisa Kawai 

David M. Kim, DMSc ’05 

Lawrence L. Phan, PD ’86 

Fiza Singh, MMSc ’10 

Mark Wang, DMSc ’99 

Organizations 

Astra Tech Inc. 

Cusp Dental Research, Inc. 

Hu-Friedy Manufacturing Company, 

Inc. 

LEXI-COMP, Inc. 

Luitpold Pharmaceuticals, Inc. 

Massachusetts Dental Society 

North Shore Dental Porcelains 

Laboratories, Inc. 

Pfizer, Matching Gifts 

Whip Mix Corporation 

FRIENDS ($1–$499) 


Gordon Abbott Jr. 

William C. Ackerly 

James L. Ackerman, PD ’62 

Katayoun Adab, MMSc ’03 

Milton H. Alper 

Marvin C. Amayun, DMD ’02 

Natalie Amerkanian, DMD ’98 

Elizabeth Chanenson Applebaum, 

DMD ’06 

David W. Archibald, DMD ’79 

Hrair H. Atikian, DMD ’66 

Thomas C. Atwood and Eileen S. Atwood 

Margrit Babikyan 

Lawrence S. Bacow and Adele Bacow 

Howard L. Bailit 

Patricia A. Baker 

Susan E. Bannon 

Marjorie Bornstein Baraban 

Michael L. Barnett, SDM ’73 

Laurence I. Barsh, DMD ’61 

Dasha E. Barss, MMSc ’02 

Peter W. Bauer, DMD ’59 

Robert L. Beal 

Andrea N. Beltzner, DMD ’05 

A. Scott Bennion, PD ’80 

Anne B. Berman 

Dino Bertini, DMD ’97, MMSc ’99 

Daniel A. Bills, DMD ’01 

Robert E. Binder, DMD ’66, and 

Ruth S. Binder 

Terri A. Binder, DMD ’84 

Larry P. Bleier, PD ’78 

Michael S. Block, DMD ’79 

Eleanor B. Bloom 

John F. Bowley, PD ’87, SDM ’87 

Brian P. Boyle and Martha A. Boyle 

Janet Brandwein 

Jennifer B. Brandwein 

Margaret Wacker Brawley 

Mims E. Brinker 

Michael J. Bundy, DMD ’08 

Melanie W. Burns, DMD ’93, MPH ’93, 

PD ’93 

Marilyn R. Carlson, DMD ’82 

Rene O. Casavantes, DMD ’75, MPH ’76 

Nina B. Casaverde, DMD ’03, SDM ’03 

Christopher L. Case, DMD ’78 

Francisco J. Castano, DMD ’01 

Luis Chamorro, MPH ’99, PD ’97, 

SDM ’00 

Perry Chowdhury 

Benjamin Chung, DMD ’96 

H. Daniel Clark, MD ’00, PD ’03 

Carl G. Cohen, DMD ’58 

Neil Cohen 

Jose E. Colon, DMSc ’02 

Michael G. Contompasis 

Arline W. Davis 

Regina F. De Leon-Reynoso, MMSc ’05 

Betsy K. Disharoon, DMD ’88, MPH ’88 

David H. Doherty 

World-renowned stem-cell researcher Dr. George Q. Daley, of Harvard Medical School and Children’s 

Hospital Boston, spoke to guests at the HSDM 2011 Appreciation Dinner on “Stem Cells: Battles and 

Breakthroughs.” Donors at the Nathan Cooley Keep level and above receive an invitation to the annual 

Appreciation Dinner, which features a reception, a presentation by a thought-provoking speaker, and 

an elegant sit-down dinner in the lobby of the School’s Research and Education Building. 

harvard school of dental medicine | annual report 2010–2011 

Cara Donley, DMD ’99, PD ’01 

Charles B. Dow 

Gerard Dubois 

Julia H. Dubois 

Sharon Eagan 

Marilyn S. Ebbitt 

Richard A. Edelstein, DMD ’56 

Fernando J. Ehrhardt, DMD ’99 

Mildred Ehrlich 

Ellen Eisenberg, PD ’76 

Kevin P. Eldredge 

Mary V. Eldredge 

Leon Elitov and Mrs. Leon Elitov 

Aram E. Elovic, DMD ’89, DMSc ’92, 

PD ’89, and Rebecca P. Elovic, 

DMD ’89, DMSc ’94 

Robert E. Evans, DMD ’63 

William S. Falla, DMD ’64 

David J. Farrell, DMD ’51 

Lynne L. Farrell 

Merrill I. Feldman, DMD ’50, MD ’52 

Howard A. Fine, DMD ’85, MMSc ’87, 

PD ’87 

Martha W. Finger 

Norton Fishman, DMD ’54 

Marybeth Flynn 

Gregory Frazer, PD ’84 

Mari C. Fukami, DMD ’98 

Margaret C. Gannon 

Diane Levine Gardener 

Eduardo J. Gerlein, MMSc ’02 

Thomas F. Gessel, DMD ’08 

Kelly M. Giannetti, DMD ’95, MPH ’95 

Barrett L. Gilchrist 

Laurel Glaser 

Andres Glovsky 

Mark B. Glovsky 

Samuel Z. Goldhaber 

Joel Goldin, DMD ’63 

Ronald T. Goldstein, DMD ’78 

Maria Christina Gonzalez 

Phoebe M. Good, DMD ’04 

Nancy Goodale 

Philip Gordon and Sandra Gordon 

David W. Grau, DMD ’80 

Dana T. Graves, DMSc ’84 

Colleen Collins Greene (DMD/MPH ’13) 

Roderic R. Greene, DMD ’74 

David Gross 

Elizabeth S. Gross 

Harvey L. Gross 

Mark Gross 

James E. Grumbach 

Deepak Kumar Gupta, DMD ’08 

Mark L. Hall, DMD ’98, PD ’98, and 

Jeannette P. Hall, DMD ’98, PD ’98 

Douglas O. Haltom 

Chester S. Handelman, DMD ’61 

Robert S. Hardy

John T. Hazel Jr. 

Murray H. Helfant 

John R. Henkelman 

David J. Higginbotham, DMD ’74 

Adele Hoffman 

Leonard E. Holenport 

Cornelia Dunning Hollister 

Andrea B. Holstein, DMD ’01 

Yeu-Min Hong, DMD ’08 

Jeffrey Hoover, DMD ’73 

Christopher Horan 

Tun-Yi Hsu, DMD ’07 

Evelyn Taly Huaman, DMD ’07 

Guillermo Huber, PD ’76 

Michelle G. Hutchinson, DMD ’87, 

MPH ’87 

Richard S. Hymoff, DMD ’69 

Jennifer C. Jackson, DMD ’04 

Carol R. Johnson 

Douglas W. Johnson, PD ’72 

Yan Kalika, DMD ’98 

Rute I. Kalpins, DMD ’78, PD ’81, 

MMSc ’82 

Paul R. Kamen, PD ’79 

Shou-Yen Kao, DMSc ’96 

Phyllis J. Kaplan 

Wendy T. Kaplan and Alma Tarlow 

Richard S. Kates and Leslie V. Kates 

Dae Hyun Kim 

Irene H. Kim, DMD ’91, MPH ’91 

Jea S. Ko 

Daniel J. Kolzet, PD ’77 

Tellervo Korhonen 

Stephen M. Krane 

Fanna M. Kreidberg 

Mary H. Kreitzer, DMD ’76 

Melvyn R. Krohn, DMD ’70 

Kiel LaFrance and Neil LaFrance 

Craig Lankhorst 

Michael P. Lazarski, DMD ’98, MPH ’98 

Robert J. Leaf, DMD ’69 

Jean M. Lesik 

Mark E. Levine, DMD ’75, PD ’77 

Kenneth E. Liffmann, DMD ’55 

Seok-Bee Lim, DMD ’79 

Walter J. Loesche, DMD ’61 

A. Vincent Lombardi, PD ’76 

Kristian Lundgren-Koszeghy, MMSc ’04 

Donald S. Malament, DMD ’80 

Nelda S. Maltz 

John H. Manhold Jr., DMD ’44 

Thelma S. Marcus 

Jiro Masuda 

Michelle Mazur-Kary, MPH ’00, PD ’01 

Patricia J. McArdle 

Walter P. McGinn, DMD ’87 

Michael McGovern, PD ’79 

Maryann McKenna 

Gilda Mechem 

Nancy Medina, DMD ’01, PD ’04 

Thomas M. Menino and 

Angela Menino 

Diana V. Messadi, MMSc ’85, DMSc ’87, 

PD ’85 

Ellyn G. Michaelis, DMD ’82 

Jean S. Miller 

S. Murray Miller 

Charles B. Millstein, MPH ’80 

Robert Minkoff, DMD ’55 

Steven A. Mitchnick, DMD ’92 

Robert L. Mittendorf, SDM ’74, 

MPH ’87, DPH ’91, SPH ’92 

Kambiz Moin, MPH ’78, DMD ’86, 

PD ’77, and Sogole S. Moin, DMD ’09 

William M. Montgomery, DMD ’74 

Anzir M. Moopen, DMD ’03 

Edward R. Mopsik, DMD ’67 

Fusako Morita 

Donald Mossman 

James E. Mulvihill, DMD ’66, PD ’69 

Jeffrey L. Musman 

David G. Nathan 

Jean F. Nathan 

W. Patrick Naylor, MPH ’81, PD ’81 

Linda C. Niessen, DMD ’77, MPH ’77, 

PD ’82 

Shirley A. Nylund, DMD ’81 

Gregory S. Odierna, DMD ’98 

Jimin Oh, DMD ’03 

Frederic Paperth, PD ’73 

John Parchue, SDM ’85 

Margaret Chu Park, DMD ’97, MPH ’97 

Sheila Vinod Patwardhan, DMD ’08 

Mercedes A. Paz 

Elizabeth F. Peabody 

Oscar J. Peguero, DMD ’09 

Issac Perkins, MPH ’82, and 

Teresa M. Perkins, DMD ’81, MMSc ’85 

Martha Epstein Pierce 

Howard Poorvu and Joan Poorvu 

Rishi Popat, PD ’09 

Zigmunt W. Pozatek, DMD ’64 

Sally Preston, DMD ’80 

Robert J. Prifty, DMD ’60 

Lars Ramstrom 

Michael J. Ribera, DMD ’89 

Virginia E. Rice 

Barbara E. Rigney 

Robbins Charitable Foundation 

Phyllis Robbins 

Grace M. Rogers 

Yoonchul Roh, PD ’03 

Steven M. Roser, DMD ’68, MD ’72 

Henry Rosovsky 

Elliot Paul Rothman and 

Martha L. Rothman 

Daniel Royzman, MMSc ’02 

Rebecca Lash Rubin, DMD ’99 

Sheldon K. Salins, DMD ’04 

John Saunders 

Robert E. Schifferle, MMSc ’84 

Sheldon Schumer, DMD ’58 

Harry C. Schwartz, DMD ’71, MD ’71 

David Scott 

Elliott Scott 

Michele A. Scrime, MMSc ’00 

Philip T. Sehl, DMD ’44 

Daniela Sever, DMD ’80 

Emily Shamieh 

Rabie Shanti, DMD ’08 

Ida Shaw 

Norbert J. Shay, DMD ’69 

Peter C. Sheffer, DMD ’77, and 

Karen O’Donnell 

Michael S. Sherman 

Jason L. Shoe, DMD ’05 

Robert M. Sholler, DMD ’61 

Babak Shoushtari, DMD ’99 

Leonard B. Shulman, DMD ’60 

Frances B. Shuman 

Carl L. Siegel, DMD ’66, SDM ’76 

Shirley A. Simone 

Norma Skoler 

Eileen M. Smith 

James Snider and Susan G. Snider 

Robert Snider and Miriam R. Snider 

Robert J. Sperber, DMD ’53 

Richard F. Stafford, PD ’80 

Robert L. Stanley, DMD ’66 

Margo W. R. Steiner 

Patricia H. Stern 

Joseph M. Stolman, DMD ’55 

Ward R. Stoops, DMD ’55 

Peter E. Strock, PD ’69 

Brian O. Sullivan 

Heejoon Y. Sun, DMD ’88, MPH ’88 

Richard H. Swan 

Gabriel C. Tagher, PD ’85 

Norton Taichman, PD ’64 

Dania F. Tamimi, DMSc ’05 

Carol M. Tashjian 

James A. Thliveris 

Bruce H. Thompson, DMD ’76 

Krestine K. Tiziani, DMD ’97, MPH ’97 

Norman Trieger, DMD ’54 

Scott D. Urban, DMD ’97 

Nader M. Vafaie, DMD ’97, MMSc ’99 

Clifford G. Walters, DMD ’84, MPH ’84 

John D. Walters, MMSc ’84, and 

Ann Wesolowski Walters, PD ’83 

Hwa-Ying Wang, DMSc ’87, DMD ’88, 

PD ’88 

Robert H. Warner 

Meredith Weenick 

Diane G. Weisberg-Cutler, DMD ’78 

Jefferson J. Weishaar Jr., DMD ’42 

Robert W. Wilson, DMD ’04 

Jon Winokur 

Kenneth M. Yamada 

Seiichi Yamano, MMSc ’07 

James T. Yang, DMSc ’96, PD ’96 

Jean A. Yang, DMD ’02 

Kathy Y. Yeung, DMD ’00, PD ’00, and 

Chia-Hung Yuan 

Henry Yu, DMD ’77 

Bertina C. Yuen, DMD ’04, MMSc ’07 

Bradford A. Zamer, DMD ’80 

Athanasios I. Zavras, DMSc ’99 

Nicholas T. Zervas and 

Thalia Poleway Zervas 

Doris D. Zimmer 


Myron Allukian Jr., MPH ’67, PD ’69 

Jason A. Boch, DMD ’97, DMSc ’01 

Stephen A. Colchamiro, DMD ’70 

Constant C. Crohin, DMD ’98, MMSc ’01 

I. Leon Dogon, DMD ’63 

Joel L. Dunsky 

Nalton F. Ferraro, DMD ’74, MD ’74 

Jessica Fisher-Willson and 

Charles H. Willson 

Julianne Glowacki 

Norman L. Goldberg, DMD ’67 

Jack L. Hertzberg, PD ’76 

Nadeem Karimbux, DMD ’91, 

MMSc ’93, PD ’93 

Saeed Kashefi, PD ’04 

David A. Keith, DMD ’83 

Ralph L. Kent Jr. 

Taru H. Kinnunen 

Agnes Lau 

Carol A. Lorente, DMD ’80, PD ’83 

Susan A. McTaggart 

Maritza Morell 

Kathleen Myers 

Howard L. Needleman, DMD ’72, PD ’74 

Jan Reiss and Michael Reiss 

Diane Spinell 

Brian Jeffrey Swann, MPH ’08 

Anne C. Tanner 

Richard W. Valachovic, MPH ’81, 

PD ’82 

Stanley Wang, MMSc ’01 

Organizations 

Harvard School of Dental Medicine 

DMD Class of 2011 

James K. Oppenheim Family 

Foundation 

National Marfan Foundation 

Pierce, Davis & Perritano, LLP 

The Trinity Foundation 

United Natural Foods, Inc. 



funded research projects under way 

roland baron, dds, phd 

AP1-Dependent Regulation of Bone Mass and Energy 

Expenditure in the Hypothalmus | Funder: National 

Institutes of Health/National Institute of Arthritis and 

Musculoskeletal and Skin Diseases 

From Adhesion to Bone Resorption: The Role 

of Dynamin in Osteoclasts | Funder: National 



Regulation of Osteoclastic Bone Resorption: Role of 

Cb1b | Funder: National Institutes of Health/National 

Institute of Dental and Craniofacial Research 

Role of C-src Proto-Oncogene in Osteoclasts | Funder: 

National Institutes of Health/National Institute of 

Arthritis and Musculoskeletal and Skin Diseases 

Regulation of Osteoblast Differentiation by Delta FosB 

Funder: National Institutes of Health/National Institute 

of Arthritis and Musculoskeletal and Skin Diseases 

fabienne coury, md 

Role of Cbi Proteins in RANK Signaling and 

Osteoclasts Differentiation | Funder: International 

Bone and Mineral Society 

john d. da silva, dmd, mph 

Primary Care iMET to Reduce Teen Tobacco, Alcohol, 

and Drug Use | Funder: National Institutes of Health/ 

National Institute of Dental and Craniofacial Research 

Outcomes for Single Implant Unit Placement and 

Restoration in General Dental Practice | Funder: New 

York University via National Institutes of Health/National 


german o. gallucci, dmd, dr med dent 

Accuracy Outcomes of Closed-Tray and Open-Tray 

Impression Techniques for Bone-Level Implants: A 

Clinical Study | Funder: Straumann Company 

german o. gallucci, continued 

Clinical and Radiographic Evaluation of New 

Titanium-Zirconium Narrow Diameter Dental 

Implants: A Multicenter Randomized Controlled 

Clinical Trial | Funder: ITI Foundation for the 

Promotion of Oral Implantology 

A Comparison of Zirconia CAD/CAM and 

Conventionally Fabricated Single Implant Abutments 

and Restorations in the Esthetic Zone: A Randomized 

Controlled Clinical Trial | Funder: ITI Foundation for 

the Promotion of Oral Implantology 

Dimensions of Peri-Implant Bone and Mucosa: A 

Cone Beam CT and Clinical Pilot Evaluation | Funder: 

ITI Foundation for the Promotion of Oral Implantology 

Effect of Changing Horizontal Offset Dimension and 

Abutment Dis/Reconnection on Peri-Implant Crestal 

Bone and Soft Tissue in Implants with Nonmatching 

Implant and Abutment Diameters | Funder: Friadent 

GmbH 

Preliminary In Vivo Investigation of the Biodegradability 

of a Novel Elastomer Material for 

Bone Regeneration | Funder: ITI Foundation for the 

Promotion of Oral Implantology 

arthur garvey, phd 

Duration of Behavioral Counseling Treatment 

Needed to Optimize Smoking Abstinence | Funder: 

National Institutes of Health/National Institute on 

Drug Abuse 

donald b. giddon, dmd, phd 

Evaluation of Oral Physicians for Primary Care 

Funder: The William F. Milton Fund 

william c. horne, phd 

Calcitonin Regulation of Osteoclast Integrin Functions 

Funder: National Institutes of Health/National Institute 

of Arthritis and Musculoskeletal and Skin Diseases 

24 


giuseppe intini, phd, dds 

BMP2 Regulation of the Intramembranous Bone 

Stem Cell Niche | Funder: National Institutes of Health/ 


elsbeth kalenderian, dds, mph 

A Cognitive Approach to Refine and Enhance Use of 

a Dental Diagnostic Terminology | Funder: National 

Institutes of Health/National Institute of Dental and 

Craniofacial Research 

Development of an Inter-University Oral Health 

Research Database | Funder: National Institutes of 

Health/National Library of Medicine 

Early Performance in the Patient-Doctor Relationship 

as a Predictor of Success in Dental Education | Funder: 

American Dental Association 

beate lanske, phd 

Innovative Mouse Model to Study Parathyroids and 

an Application to Human Disease | Funder: National 

Institutes of Health/National Institute of Diabetes and 

Digestive and Kidney Diseases 

Pathophysiologic Regulation of Fgf-23 in Phosphate 

Homeostasis: Role of Vitamin D | Funder: National 

Institutes of Health/National Institute of Diabetes and 

Digestive and Kidney Diseases 

Role of Indian Hedgehog in Endochondral Bone 

Formation | Funder: National Institutes of Health/ 

National Institute of Arthritis and Musculoskeletal and 

Skin Diseases 

continued on next page 

nadeem karimbux, dmd, dmsc 

Potential of a Novel PDGF-BB/VEGF PLGA 

Microsphere for Hard Tissue Regeneration | Funder: 

Osteology Foundation 

T-Regulatory Cells in Periodontitis | Funder: National 

Institutes of Health/National Institute of Dental and 

Craniofacial Research 

david kim, dmd, dmsc 

Potential of a Novel Alginate-Hydrogel Scaffold as a 

Platelet Derived Growth Factor Delivery System for 

Hard Tissue Regeneration: An In Vitro and In Vivo 

Study | Funder: Osteology Foundation 

taru kinnunen, phd 

Oral Cancer Detection Methods in a Community 

Setting | Funder: National Institutes of Health/National 


winston p. kuo, dds, dmsc 

Label-Free Magnetophoretic Analysis of Blood | Funder: 

United States Naval Research Laboratory 


u 

funded research projects under way, continued 

yefu li, md, phd 

Defining Common Molecular Patterns for Onset 

and Progression of Osteoarthritis | Funder: Hospital 

for Special Surgery via National Institutes of Health/ 


Skin Diseases 

Harvard Catalyst Pilot Project | Funder: Harvard 

Medical School via National Institutes of Health/ 

National Center for Research Resources 

Role of DDR2 in OA-Like Pathogenesis in 

Osteochondrodyspasias | Funder: National Institutes 

of Health/National Institute of Arthritis and 


shigemi i. nagai, dmd, phd 

Assessment of Dental Anatomy of Interproximal Area 

by Use of NIR Optics | Funder: Olympus Corporation 

Assessment of Novel Osteoinductive Peptides Screened 

by a Newly Developed Bioplanning Method | Funder: 

ITI Foundation for the Promotion of Oral Implantology 

shigemi nagai, continued 

Development of an Efficient Dental Porcelain Shade 

System for Computer Color Matching | Funder: 

Noritake Dental Supply Co. Ltd. 

In Vivo Assessment of Feasibility of a Prototype 

Interproximal Caries Detection System Using Infra 

Red Fluorescence | Funder: Olympus Corporation 

martin t. nweeia, dmd 

Using Inuit Qaujimajatuqangit, Traditional 

Knowledge, to Guide the Development of Hypotheses 

on Narwhal Tusk Function | Funder: National Science 

Foundation 

bjorn r. olsen, md, phd 

Biogenesis of Extracellular Matrix | Funder: National 



Collagen Gene Structure and Expression | Funder: 



26 


q 

bjorn r. olsen, continued 

Molecular and Cellular Mechanisms of Vascular 

Anomalies | Funder: National Institutes of Health/ 


Skin Diseases 

mohammed shawkat razzaque, md, phd 

In Vivo Interactions of FGF-23 Klotho and Vitamin 

D | Funder: National Institutes of Health/National 

Institute of Diabetes and Digestive and Kidney Diseases 

vicki rosen, phd 

BMP-2 Regulation of Bone Homeostasis | Funder: 



BMP-3 Signaling in the Formation and Regulation of 

Bone | Funder: National Institutes of Health/National 

Institute of Arthritis and Musculoskeletal and Skin Diseases 

xiu-ping wang, md, dmd 

Wnt Signaling in the Induction of New Tooth 

Formation | Funder: National Institutes of Health/ 


malcolm whitman, phd 

Regulation of Xenopus Embryonic Development 

by TGFbeta Superfamily Ligands and SM | Funder: 


Child Health and Human Development 

Mechanism of Action of Halofuginone as a Novel 

Therapeutic | Funder: National Institutes of Health/ 

National Institute of General Medical Sciences 

Nanocourses, continued from page 17 

inflammation and fibrosis in health 

and disease 

Davide Zocco, PhD 

Inflammation and fibrosis are physiological 

mechanisms activated by the body in response to 

infections, injuries, and other stresses. Deregulation 

of these finely tuned mechanisms can lead to 

chronically inflamed and fibrotic tissues that are no 

longer capable of functioning properly and/or are 

irreversibly damaged. Chronic inflammation and 

fibrosis are key features of a plethora of diseases, 

including periodontal disease, Crohn’s disease, 

rheumatoid arthritis, and cancer. This nanocourse 

outlines the basic cellular and molecular mechanisms 

involved in inflammatory and fibrotic processes in 

health and disease. The course also acquaints the 

student with current tools and techniques in cellular 

and molecular biology, providing the basis for the 

analysis of scientific manuscripts in these fields. 

mechanisms of cancer progression 

Damian Medici, PhD 

This nanocourse covers the fundamental mechanisms 

of cancer biology. These mechanisms include stages 

of tumor formation, metastasis, angiogenesis, 

tumor microenvironment, and cancer immunology/ 

immunotherapy. This goal of this course is to 

provide students with a concise review of the latest 

mechanistic insights into cancer progression and 

therapeutic potential for treatment of the disease. 

Students acquire a fundamental understanding 

of the molecular and cellular basis of cancer and 

are exposed to the most cutting-edge therapeutic 

strategies for current and future treatment. p 

Opposite: HSDM researchers conduct basic, clinical, and 

translational studies to improve human health. 


Financial Summary 

comparative financial statement 

Year ended June 30, 2010 2011 

Income Summary 

Tuition and fees $8,910,600 $9,613,800 

Endowment 6,977,400 5,975,100 

Dean’s endowment 833,600 750,900 

Gifts for current use 262,100 232,900 

Faculty Group Practice indirect 700,000 700,000 

Other income 207,100 107,500 

Government 

Direct 5,218,100 7,620,400 

Indirect 2,938,000 3,610,900 

Nongovernment 

Direct 488,400 770,300 

Indirect 9,700 59,900 

TOTAL INCOME $26,545,000 $29,441,700 

Expenses Summary 

Academic departments $2,807,900 $3,151,000 

Harvard Dental Center 

net clinical operations 876,100 328,000 

Educational services 5,153,700 5,466,900 

Administration* 4,569,300 4,799,100 

University assessments 1,371,200 1,395,300 

Operations and debt service 5,327,700 5,595,500 

Research and training 5,877,200 8,566,900 

TOTAL EXPENSES $25,983,100 $29,302,700 

*Includes Offices of the Dean, Administration and Finance, Development and Alumni Relations, and Research 

28 


A blending of old and new: The Harvard 

School of Dental Medicine honors its 

proud history—reflected in the brick 

Main Building—while also looking 

toward the future with innovation 

and cutting-edge scientific research, 

which is conducted in the glass 

Research and Education Building. 

a publication of hsdm communications 

Bruce Donoff, DMD ’67, MD ’73, Dean 

Wanda Mock, MA, Assistant Dean for Development and Alumni Relations 

Jan Reiss, PhD, Editor and Designer 

photography credits 

All photographs by Jan Reiss, except: 

Page 3: Courtesy Pierre Striehl 

Pages 8–9: Courtesy Charles River Center 

Pages 14–15: Courtesy C. Ashley Orynich (Ecuador photos)

p 

www.hsdm.harvard.edu 

Harvard School of Dental Medicine 

188 Longwood Avenue 

Boston, Massachusetts 02115 

30

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