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NHLBI Asthma Phenotypes-Lockey - World Allergy Organization

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AERD Clinical Features (cont’d)<br />

4. Anosmia is common.<br />

5. <strong>Asthma</strong> and aspirin sensitivity become<br />

apparent 1-5 years after initial onset<br />

of upper respiratory symptoms.<br />

6. Symptoms manifest within 1-3 hours<br />

of ingestion of aspirin and other COX-<br />

1 inhibitors.<br />

7. Refractory period to ASA and other<br />

COX-1 inhibitors is 2-5 days after ASA<br />

desensitization.

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