NHLBI Asthma Phenotypes-Lockey - World Allergy Organization

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Asthma Phenotypes • Define 9 phenotypes in 3 general categories: - Trigger-induced asthma 1) Allergic 2) Non-allergic 3) Aspirin-exacerbated respiratory disease (AERD) 4) Infection 5) Exercise-induced
Background Exercise-Induced Asthma • Most patients with asthma will develop EIB if they perform sufficient exercise to reach 80-85% of maximum predicted heart rate. • EIB has been described in 7-20% of the general population. • EIB is sometimes (incorrectly) thought of as a unique form of asthma, when it is seen in subjects whose disease is so mild (“mild intermittent”), that they experience bronchoconstriction only when they exercise. – However, it can be seen in subjects of all ages and severities, correlating best with degree of bronchial hyperresponsiveness.
Page 1 and 2: Defining Phenotypes: Expanding Our
Page 3 and 4: Asthma Phenotype Task Force NHLBI,
Page 5 and 6: Asthma Phenotype Task Force Goal Co
Page 7 and 8: Asthma Phenotypes • Define 9 phen
Page 11 and 12: Allergic Proposed Definition • Se
Page 13 and 14: Allergic Asthma: Clinical Informati
Page 15 and 16: Non-Allergic Asthma Background •
Page 17 and 18: Non-Allergic Asthma: Demographic an
Page 19 and 20: Aspirin-Exacerbated Respiratory Dis
Page 21 and 22: AERD Task Force Proposed Definition
Page 23 and 24: AERD Genetics 1. Familial cases rep
Page 25 and 26: AERD Clinical Features (cont’d) 4
Page 27 and 28: Infection-Induced Asthma: Definitio
Page 29: Infection-Induced Asthma: Histopath
Page 33 and 34: Exercise-Induced Bronchospasm: Defi
Page 35 and 36: Clinical Characteristics • EIB oc
Page 37 and 38: Background on Pre-Asthma Wheezing i
Page 39 and 40: Pre-Asthma Wheezing in Infants and
Page 41 and 42: Pre-Asthma Wheezing in Infants and
Page 43 and 44: Asthma Phenotypes - Clinical presen
Page 45 and 46: Background Exacerbation Prone Asthm
Page 47 and 48: Definition Exacerbation Prone Asthm
Page 49 and 50: Background Irreversible Airflow Lim
Page 51 and 52: Irreversible Airflow Limitation in
Page 53 and 54: Background Eosinophilic Asthma: Ass
Page 55 and 56: Asthma Phenotypes - Clinical presen
Page 57 and 58: Definition Neutrophilic Asthma Intr
Page 59 and 60: Asthma Phenotypes Task Force Nation
Page 61 and 62: Summary: Asthma Phenotype Definitio
Page 63 and 64: Haldar P et al. Am J Respir Crit Ca
Page 66: Asthma: Challenges in Treating a He
Page 69 and 70: Asthma Is Prevalent: Significant Mo
Page 71 and 72: Asthma Phenotype Task Force NHLBI,
Page 73 and 74: Asthma Phenotype Task Force Goal Co
Page 77 and 78: Co-Morbid Conditions which Complica
Page 79 and 80: 6. Osteopenia and Osteoporosis 7. P
Page 82 and 83:
Asthma • Historical Definition: -
Page 84 and 85:
Airway Inflammation • Also caused
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Early Phase Reaction (EPR) Occurs W
Page 88 and 89:
Short and long-acting beta-2 agonis
Page 90 and 91:
Short and long-acting beta-2 agonis
Page 92 and 93:
Inhaled Corticosteroids (ICS)
Page 94 and 95:
Inhaled Corticosteroids (ICS) • S
Page 96 and 97:
GC Resistance in Asthma: • Defini
Page 98 and 99:
Leukotriene Modifiers • Strengths
Page 100 and 101:
Theophylline • Limitations: - Inf
Page 102 and 103:
Omalizumab • FDA-approved for pat
Page 104 and 105:
Omalizumab (Cochrane Database) •
Page 106 and 107:
Allergen Immunotherapy - Allergen i
Page 108 and 109:
Asthma Assessment and Monitoring: K
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Assessing Asthma Severity: Risk Dom
Page 114:
Categories of Evidence Used to Supp
Page 117:
Estimated Comparative Daily Dosages
Page 121:
Page 125:
Page 128 and 129:
Conclusions • Severity, control,
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NHLBI Asthma Phenotypes-Lockey - World Allergy Organization

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