Obstructive Sleep Apnea Syndrome in Children

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The future: DYMOSA Dynamic Computational Modeling of Obstructive Sleep Apnea in Down Syndrome • Cincinnati Children’s Hospital: Otolaryngology, Pulmonary, Radiology • University of Cincinnati: Aerospace Engineering
Division of Pulmonary Medicine, Cincinnati Children’s Hospital Raouf Amin, MD Department of Radiology, Cincinnati Children’s Hospital Robert Fleck, MD Lane Donnelly, MD Department of Otolaryngology- Head and Neck Surgery, University of Cincinnati Cincinnati Children’s Hospital Sally Shott, MD Gas Dynamics and Propulsion Laboratory, Department of Aerospace Engineering and Engineering Mechanics, University of Cincinnati Ephraim Gutmark, PhD Goutham Mylavarapu, BTech Department of Otolaryngology- Head and Neck Surgery, University of Cincinnati Sid Khosla, MD Department of Anesthesia Mohamed Mahmoud, MD Department of Bioengineer Keith McConell, MS Serai Suraj, PhD Department of Bistatistics Sheila Slaisbury, PhD Mathew Fenchel, MS Kathleen VanDeGrift, RC Jenny Jeffries, RRN NIH 5 RO1HL105206-0
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Obstructive Sleep Apnea (OSA) in Ch
Page 3 and 4:
Obstructive Sleep Apnea Syndrome (O
Page 5 and 6:
OSA • More difficult to diagnosis
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• Not diagnostic of OSA Diagnosis
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Diagnosis of OSA Sleep patterns •
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Higher incidence of OSAS in: • Ob
Page 14 and 15:
Down Syndrome • 50% also have an
Page 16 and 17:
Before 1980’s • Despite 50% of
Page 18 and 19:
Child Abuse Amendments 1984 • All
Page 20 and 21:
Parents Of Children With DS Underes
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Behavior Changes with OSAS • Dayt
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Children who snore vs those who do
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OSAS and Growth • T&A hypertrophy
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• What is the incidence of OSA in
Page 30 and 31: Dyken et al (2003) • Prospective
Page 32 and 33: Shott et al 2006 • Prospective st
Page 34 and 35: Objective diagnosis of OSAS • Sle
Page 36 and 37: Sleep studies in children with deve
Page 38 and 39: Definitions of Sleep Abnormalities
Page 40 and 41: Obstructive Index Apnea-Hypopnea in
Page 42 and 43: Hypoventilation Syndrome • You br
Page 44 and 45: Repetitive Arousals and Sleep Fragm
Page 46 and 47: Treatment of OSA • Removal of ton
Page 49 and 50: Persistent OSA after T&A Current tr
Page 51 and 52: Treatment of OSA • Removal of ton
Page 53 and 54: Treatment is dependent upon appropr
Page 55 and 56: Lateral neck xray White arrow = lin
Page 57 and 58: Cine MRI • High resolution, dynam
Page 59 and 60: Results of cine MRI used to: • Pl
Page 61 and 62: Case 1 • 12 yr old F with DS •
Page 63 and 64: Case 1 - Treatment and results •
Page 65 and 66: Case 2 - Cine MRI • Adenoid regro
Page 67 and 68: Case 3 • 8 year old male with DS
Page 69 and 70: Case 3 • Lingual tonsillectomy do
Page 71: Medical options for persistent OSA
Page 75 and 76: Oral splints and dental appliances
Page 77 and 78: Medical and Surgical Treatment afte
Page 79: DYMOSA Dynamic Computational Modeli
Page 83 and 84: Computational Fluid Dynamics (CFD)
Page 85 and 86: Flow Structure Interaction modeling
Page 87 and 88: FSI and LES • LES can predict are
Page 89 and 90: Structure and Compliance Baseline M
Page 91 and 92: ROADMAP :: FSI MODELING :: 3D Case
Page 93 and 94: DYMOSA Aims • Aim 1: Collect data
Page 95 and 96: Long Term Goal Improve surgical out
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Obstructive Sleep Apnea Syndrome in Children

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