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Rationale for Thrombolysis

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Modified Rankin scores at 3 months<br />

0 1 2 3 4 5 Dead<br />

Pooled placebo<br />

0–3 h (n=465)<br />

14% 15% 11% 15% 20% 8% 17%<br />

Pooled alteplase<br />

0–3 h ( n=463)<br />

19% 23% 7% 14% 12% 7% 18%<br />

SITS-MOST<br />

(n=6,136)<br />

19% 20% 16% 15% 14% 5% 11%<br />

Modified Rankin scores at 3 months in SITS-MOST and randomised<br />

controlled trials <strong>for</strong> placebo and alteplase patients<br />

Wahlgren N et al Lancet 2007; 369: 275−282.

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