CurcuVET ® - Thorne Research

A Revolutionary Supplement
to Maintain a Healthy
Inflammatory Response
CurcuVET ®
curcumin phytosome for
enhanced bioavailability
A Thorne Research Exclusive:
• Supports gastrointestinal health
• Promotes healthy joints and muscles
• Provides hepatic support
• Promotes ocular health
• Provides support for oncology patients
• Supported by clinical studies

CurcuVET ®
The Science Behind
CurcuVET
Numerous studies in dogs, horses, sheep, rodents, and
humans demonstrate CurcuVET’s (Meriva® in the case
of humans) potential for maintaining normal inflammatory
processes.
Joint and Muscle Support
Studies demonstrate CurcuVET supports a healthy
inflammatory response in small animals and horses.
A recent European study analyzed the bioactivity of
CurcuVET compared to non-steroidal anti-inflammatory
drugs and found their bioactivity was similar. The
study’s sponsors, who were studying canine arthritis,
found CurcuVET was effective in down-regulating the
pro-inflammatory substances, tumor necrosis factoralpha
(TNF-α) and nuclear factor-kappaB (NF-κB). 1
A similar equine study on the effect of CurcuVET on
cytokine gene expression found significant down-regulation
of interleukin (IL)-1β and IL-1RN in mares and
inhibition of cyclooxygenase-2, TNF-α, and IL-1RN and
increase in IL-6 in foals. 2
Similar results were achieved in an eight-month human
trial of Meriva. Enhanced joint health was reflected in
improvements in both clinical and biochemical end
points. 3
Hepatic Support
Several studies have illustrated curcumin's hepatoprotective
effects, leading researchers to suggest its use can
protect the liver from exogenous insults from environmental
toxins, such as acetaminophen and carbon tetrachloride.
Curcumin also has the capacity to increase
both the flow and solubility of bile. Curcumin's hepatoprotective
effects are due in part to direct free radical
scavenging; but curcumin also enhances the body's
natural antioxidant system, which increases glutathione
levels, thereby aiding in hepatic detoxification and
inhibiting nitrosamine formation. In a 2007 absorption
study, liver levels of curcumin were significantly higher
after dosing with the curcumin-phosphatidylcholine
complex found in CurcuVET compared to conventional
curcumin extracts. 4
Gastrointestinal Support
Curcumin has demonstrated its potential to help maintain
the body’s normal inflammatory response. For
example, in numerous animal studies, curcumin has
shown the ability to help maintain healthy intestinal
mucosa under various adverse conditions. Among the
effects noted in the various trials have been decreased
NF-κB, nitric oxide, and free radicals in the colonic mucosa.
In two human studies, patients who had poor
gastrointestinal health demonstrated that the administration
of curcumin improved overall well-being,
maintained the levels of biomarkers generally associated
with the body’s normal inflammatory response,
and served as a non-drug adjunct that did not disrupt
the use of conventional medications. 5,6 In addition, in a
study of curcumin-phosphatidylcholine complex in humans
for joint health, patients experienced a decrease
in gastrointestinal complaints. The authors speculated
it was because of a decrease in NSAID use. 3
Supports Ocular Health
In a clinical study of 106 patients with a long-term condition
adversely affecting ocular health, Meriva (Curcu-
VET) resulted in alleviation of signs and symptoms of
eye discomfort in 80 percent of participants. It was well
tolerated, improved overall quality of life, and helped
maintain the eye’s normal inflammatory response. 7
Provides Support for
Oncology Patients
A recent in vitro study on mice found that the curcumin
phytosome in CurcuVET increased the receptivity of
various mice cells to subsequent oxaliplatin chemotherapy.
In addition, curcumin phytosome also positively
increased markers associated with the desired
effects of oxaliplatin chemotherapy. These results demonstrate
that CurcuVET should be considered for the
nutritional support of oncology patients. 8
Maintains a Healthy Inflammatory
Response in Ruminants
CurcuVET was shown to limit early neutrophil infiltration
in vitro in sheep neutrophils, indicating it might
have a place in helping to maintain a normal inflammatory
response in ruminants. 9

A Breakthrough in Curcumin Absorption
CurcuVET ®
Phytosome Technology
Phytosome
• Marked enhancement of bioavailability
• Significantly greater clinical benefits
• Assured delivery to the tissues
• No compromise of nutrient safety
Thorne Research/Thorne Vet has teamed up with Indena S.p.A.,
the global expert in botanical extract technology, to bring veterinarians
an exciting new curcumin phytosome called CurcuVET.
CurcuVET provides your patients with significantly more bioavailability
than any curcumin extract or compound currently
available. CurcuVET is manufactured to the high quality standards
you’ve learned to expect from Thorne and Indena.
What are phytosomes Phytosomes are created by a patented
process that binds an herbal extract to a phospholipid – in this
case phosphatidylcholine, a principal element of cell membranes.
This unique phytosome complex easily crosses the gut barrier,
unlike common herbal extracts, and results in significantly higher
blood levels than standardized 95-percent curcumin extract.
Superior Absorption Supported by Research
Curcumin
Phosphatidylcholine
Curcumin-phosphatidylcholine
Complex
A 2007 study in rodents and published in the journal Cancer Chemotherapy and Pharmacology demonstrated CurcuVET’s
superior bioavailability, compared to ordinary curcumin. Liver levels of curcumin were also higher with CurcuVET
supplementation. 4 In a more recent (soon to be published) randomized, single-blind, crossover study in nine humans,
total curcuminoid bioavailability, as evaluated by the plasma area under the curve (AUC), was about 29-fold higher for
Meriva than for the conventional turmeric extract.
References
1. Gaspardo B, Colitti M, Scaini C, et al. Transcriptome modification of peripheral white blood cells after dietary administration of curcumin in
osteoarthritic affected dogs. Plant & Animal Genomes XVIII Conference, January 2010; San Diego, CA.
2. Farinacci M, Gaspardo B, Colitti M, Stefanon B. Dietary administration of curcumin modifies transcriptional profile of genes involved in inflammatory
cascade in horse leukocytes. Ital J Anim Sci 2009;8(Suppl 2):84-86.
3. Belcaro G, Cesarone MR, Dugall M, et al. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex during extended administration
in osteoarthritis patients. Altern Med Rev 2010;15:337-344.
4. Marczylo TH, Verschoyle RD, Cook DN, et al. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine.
Cancer Chemother Pharmacol 2007;60:171-177.
5. Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci 2005;50:2191-2193.
6. Hanai H, Iida T, Takeuchi K, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled
trial. Clin Gastroenterol Hepatol 2006;4:1502-1506.
7. Allegri P, Mastromarino A, Neri P. Management of chronic anterior uveitis relapses: efficacy of oral phospholipid curcumin treatment. Longterm
follow-up. Clin Ophthalmol 2010;4:1-6.
8. Howells LM, Sale S, Sriramareddy SN, et al. Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in
vitro and in vivo. Int J Cancer 2010 Sept. 13. [Epub ahead of print]
9. Farinacci M, Colitti M, Stefanon B. Modulation of ovine neutrophil function and apoptosis by standardized extracts of Echinacea angustifolia,
Butea frondosa and Curcuma longa. Vet Immunol Immunopathol 2009;128:366-373.

CurcuVET ® is available
in three sizes for dosing
convenience
For cats and small dogs
CurcuVET-SA50
Product Facts
Active Ingredients per Capsule:
Curcumin Phytosome* (Curcuma longa extract (root) /
Phosphatidylcholine complex) (CurcuVET®)
Inactive Ingredients:
Hypromellose (derived from cellulose) capsule,
Microcrystalline Cellulose, Silicon Dioxide.
50 mg
Directions For Use:
Cats: 1/2 capsule daily
Dogs: 1 capsule per 25 lbs body weight daily
90 Capsules
Code: V931
now available from
Thorne Vet
call customer service at
(800)228-1966 and ask
for details on all 3 of our
CurcuVET products
For larger dogs
CurcuVET-SA150
Product Facts
Active Ingredients per Capsule:
Curcumin Phytosome* (Curcuma longa extract (root) /
Phosphatidylcholine complex) (CurcuVET®)
Inactive Ingredients:
Hypromellose (derived from cellulose) capsule,
Microcrystalline Cellulose, Silicon Dioxide.
150 mg
Directions For Use:
Dogs: 1 capsule per 75 lbs body weight daily
90 Capsules
Code: V932
For horses
CurcuVET-EQ
Product Facts
Active Ingredients per 2.75 g Scoop:
Curcumin Phytosome* (Curcuma longa extract (root) /
Phosphatidylcholine complex) (CurcuVET®)
2.5 g
P.O. Box 25
Dover, Idaho 83825
(800)228-1966
(800)747-1950 fax
www.thorne.com
info@thorne.com
*These products use Indena S.p.A.’s curcumin phytosome (CurcuVET®).
CurcuVET is a registered trademark of Indena S.p.A.
Inactive Ingredients:
Microcrystalline Cellulose, Silicon Dioxide.
Directions For Use:
Horses: 1 scoop twice daily
5.8 OZ (165 G)
Code: V930