Graduate Study in - Chemistry - Johns Hopkins University

More documents

Recommendations

Info

Thomas Lectka Organic Chemistry lectka@jhu.edu The thrust of our research is towards the development of new catalytic asymmetric reactions. In particular we are interested in chiral, all-organic molecules, and Lewis acids as catalysts, as illustrated in three projects: Project I. Catalytic, Asymmetric -Lactam and -Amino Acid Synthesis. We have developed practical methodology for the catalytic, asymmetric synthesis of lactams in high diastereo- and enantioselectivity employing chiral nucleophiles as catalysts. Our reactions should provide access to a large number of serine protease inhibitors of prostate specific antigen, cytomegalovirus protease, elastase, thrombin, and cell metathesis. We have also recently developed a new synthesis of amino acid derivatives through a catalytic, asymmetric process in which the chiral nucleophile benzoylquinine (BQ) plays no less than five discrete roles. The reaction is a multistage, multicomponent reaction in which the starting materials are inexpensive. Project II. Asymmetric Catalysis on Sequentially-Linked Columns. The all-organic nature of our catalyst systems renders them attractive to attach to a solid phase. Along those lines, we have developed a catalytic, asymmetric process in which reactions are conducted on a series of sequentially-linked columns packed with solid-phase based catalysts and reagents. Our goal is ultimately to produce a “synthesis machine” in which a complex series of transformations is conducted on the column assemblies. Project III. Catalytic, Asymmetric Halogenation. The third project we have underway concerns the development of catalytic, asymmetric halogenation reactions. Asymmetric halogenation represents a challenging new frontier in asymmetric synthesis. Representative Publications: “Catalytic, Enantioselective Alkylation of Imino Esters: The Synthesis of Nonnatural Amino Acid Derivatives” J. Am. Chem. Soc. 2002, 124, 67-77. “Asymmetric Catalysis on Sequentially-Linked Columns” J. Am. Chem Soc. 2001, 123, 10853-10859. “Reactive Ketenes through a Carbonate/Amine Shuttle Deprotonation Strategy: Catalytic, Enantioselective Halides” Org. Lett. 2001, 3, 2049-2051. “Catalytic, Asymmetric Halogenation” J. Am. Chem. Soc. 2001, 123, 1531-1532. “Catalytic, Asymmetric Synthesis of Lactams” J. Am. Chem. Soc. 2000, 122, 7831-7832. Bromination of Acid Ph.D. Cornell University Postdoctoral, Universität Heidelberg NIH Postdoctoral Fellow, Harvard University Alfred P. Sloan Research Fellowship Camille Dreyfus Teacher- Scholar Award DuPont ATE Award NSF CAREER Award Eli Lilly Young Investigator Grantee NIH First Award Graduate Study in Chemistry at The Johns Hopkins University 15
Gerald J. Meyer Inorganic Materials Chemistry Environmental Chemistry meyer@jhu.edu (a) Ph.D., University of Wisconsin at Madison Postdoctoral, University of North Carolina at Chapel Hill The Meyer group research focuses on inorganic chemistry with a particular emphasis on the interface between molecules and solid-state materials. A theme of our research has been to design materials at the molecular level that have desired optical, electrical, environmental, biological, magnetic, and/or catalytic functions. Summarized below are three key research areas: We prepare solar cells, based on Nanocrystalline Semiconductor Interfaces. nanocrystalline semiconductors sensitized to light with inorganic coordination compounds that efficiently convert sunlight into electrical power. These materials also allow interfacial electron transfer processes to be quantified in unprecedented molecular detail. Shown below, is a schematic representation of an interface designed for fundamental photo-induced electron transfer studies. Other ongoing research projects with these interfaces include the study of bimetallic compounds, charge transport, energy transfer, and catalysis. Magnetic Nanowire Interfaces. Nanowires with segments of different magnetic and non-magnetic materials are prepared in our labs. An example is shown below where a magnetic nickel segment has been functionalized with a fluorescent dye while a non-magnetic gold segment has not. In the visible image (a) the two wire segments appear similar while the fluorescent image (b) clearly reveals the nickel segment. The magnetic properties of the nanowire materials are under active study as part of the Hopkins’ NSF-funded MRSEC and can be used for applications in separations, sensing, magnetic recording and biotechnology. Environmental Interfaces. We prepare materials that convert sunlight into electrical power and materials that can decontaminate water of halocarbon pollutants. This latter project is the subject of a NSF-funded ‘CRAEMS’ program that involves interdisciplinary research with five Hopkins groups. Our approach has been to study mechanistic aspects of organohalide reaction with natural and synthetic iron porphyrins. These studies provide insights into how living organisms can both dehalogenate organic halocarbons and die from exposure to them. Recent Publications: Pseudo-halogens for Dye-Sensitized TiO 2 Photoelectrochemical Cells. Oskam, G.; Bergeron, B.V; Meyer, G.J.; Searson, P.C. J. Phys. Chem. B 2001, 105, 6867. Long Distance Electron Transfer Across Molecular-Nanocrystalline Semiconductor Interfaces. Galoppini, E.; Guo, W.; Qu, P.; Meyer, G.J. J. Am. Chem. Soc. 2001, 123, 4342. Magnetic Alignment of Fluorescent Nanowires. Tanase, M.; Bauer, L.A.; Hultgren, A.; Silevitch, D.M.; Sun, L.; Reich, D.H.; Searson, P.C.; Meyer, G.J. NanoLett. 2001, 1, 155. Proton Controlled Electron Injection from Molecular Excited States to the Empty States in Nanocrystalline TiO 2 . Qu, P.; Meyer, G.J. Langmuir 2001, 17, 6720. (b) Crowded Cu(I) Complexes Involving Benzohquinoline: π-Stacking Effects and Long Lived Excited States. Riesgo, E.C.; Hu, Y.-Z.; Bouvier, F.; Thummel, R.P.; Scaltrito, D.V.; Meyer, G.J. Inorg. Chem. 2001, 40, 3413-3422. 16 Graduate Study in Chemistry at The Johns Hopkins University
Page 1 and 2: Chemistry Graduate Study in www.jhu
Page 3 and 4: Welcome Rendition of new chemistry
Page 5 and 6: Johns Hopkins University Establishm
Page 7 and 8: The Department of Chemistry Faculty
Page 9 and 10: Paul J. Dagdigian Experimental Phys
Page 11 and 12: D. Howard Fairbrother Ph.D., Northw
Page 13 and 14: Marc M. Greenberg Organic and Bioor
Page 15: Kenneth D. Karlin Ph. D., Columbia
Page 19 and 20: Gary H. Posner Organic Chemistry; M
Page 21 and 22: Joel R. Tolman Biophysical Chemistr
Page 23 and 24: Craig A. Townsend Bioorganic Chemis
Page 25 and 26: Instrumentation The department is w
Page 27 and 28: Useful Information Student Activiti
Page 29: Baltimore Map & Directions to Campu

Graduate Study in - Chemistry - Johns Hopkins University

Create successful ePaper yourself

Delete template?

Save as template?