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ACOG Practice Bulletin No. 101

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Indications for First-Trimester Ultrasonography<br />

• To confirm the presence of an intrauterine<br />

pregnancy<br />

• To evaluate a suspected ectopic pregnancy<br />

• To evaluate vaginal bleeding<br />

• To evaluate pelvic pain<br />

• To estimate gestational age<br />

• To diagnosis or evaluate multiple gestations<br />

• To confirm cardiac activity<br />

• As adjunct to chorionic villus sampling,<br />

embryo transfer, or localization and removal<br />

of an intrauterine device<br />

• To assess for certain fetal anomalies, such as<br />

anencephaly, in patients at high risk<br />

• To evaluate maternal pelvic or adnexal masses or<br />

uterine abnormalities<br />

• To screen for fetal aneuploidy<br />

• To evaluate suspected hydatidiform mole<br />

American College of Radiology. ACR practice guideline for the performance<br />

of obstetrical ultrasound. In: ACR practice guidelines and<br />

technical standards, 2007. Reston (VA): ACR; 2007. p. 1025–1033.<br />

formed whenever possible. The following factors should<br />

be considered during the examination.<br />

The uterus, including the cervix, and adnexa should<br />

be evaluated for the presence of a gestational sac. If a<br />

gestational sac is seen, its location should be documented.<br />

The gestational sac should be evaluated for the<br />

presence or absence of a yolk sac or embryo, and the<br />

crown–rump length should be recorded, when possible.<br />

The crown–rump length is a more accurate indicator of<br />

gestational (menstrual) age than is mean gestational sac<br />

diameter. However, the mean gestational sac diameter<br />

may be recorded when an embryo is not identified.<br />

Caution should be used in presumptively diagnosing a<br />

gestational sac in the absence of a definite embryo or<br />

yolk sac. Without these findings, intrauterine fluid collection<br />

could represent a pseudogestational sac associated<br />

with an ectopic pregnancy.<br />

Presence or absence of cardiac activity should be<br />

reported. With transvaginal scans, cardiac motion should<br />

be observed when the embryo is 5 mm or greater in<br />

length. An embryo should be visible by transvaginal<br />

ultrasonography with a mean gestational sac diameter of<br />

20 mm or greater. If an embryo less than 5 mm in length<br />

is seen without cardiac activity, a subsequent scan at a<br />

later time may be needed to assess the presence or<br />

absence of cardiac activity. Fetal number should be<br />

reported. Amnionicity and chorionicity should be documented<br />

for all multiple gestations when possible.<br />

Embryonic or fetal anatomy should be assessed according<br />

to gestational age.<br />

The uterus, including adnexal structures, should be<br />

evaluated. The presence, location, and size of adnexal<br />

masses should be recorded. The presence of leiomyomas<br />

should be recorded, and measurements of the largest or<br />

any potentially clinically significant leiomyomas may<br />

be recorded. The cul-de-sac should be evaluated for the<br />

presence or absence of fluid.<br />

For patients who desire an assessment of their individual<br />

risk of fetal aneuploidy, a standardized measurement<br />

of the nuchal translucency during a specific age<br />

interval is necessary. Nuchal translucency measurements<br />

should be used (in conjunction with serum biochemistry)<br />

to determine the risk of Down syndrome, trisomy 13, trisomy<br />

18, or other anatomic abnormalities, such as heart<br />

defects. In this setting, it is important that the practitioner<br />

measure the nuchal translucency according to established<br />

guidelines for measurement. In addition, a quality<br />

assessment program is recommended to ensure accurate<br />

results. Organizations currently providing guidelines and<br />

ongoing quality assessment include the Nuchal<br />

Translucency Quality Review program of the Maternal–<br />

Fetal Medicine Foundation and the program sponsored<br />

by the Fetal Medicine Foundation.<br />

Second- and Third-Trimester<br />

Ultrasound Examination<br />

Indications. Ultrasonography can be of benefit in many<br />

situations in the second and third trimesters. Indications<br />

for second- and third-trimester ultrasonography are listed<br />

in the box.<br />

Imaging Parameters for a Standard Fetal Examination.<br />

Fetal cardiac activity, fetal number, and fetal presentation<br />

should be reported. Any abnormal heart rates or<br />

rhythms should be reported. Multiple gestations require<br />

the documentation of additional information: chorionicity,<br />

amnionicity, comparison of fetal sizes, estimation of<br />

amniotic fluid volume (increased, decreased, or normal)<br />

on each side of the membrane, and fetal genitalia (when<br />

visualized).<br />

Ultrasonography can detect abnormalities in amniotic<br />

fluid volume. An estimate of amniotic fluid volume<br />

should be reported. Although it is acceptable for experienced<br />

examiners to qualitatively estimate amniotic fluid<br />

volume, semiquantitative methods also have been described<br />

for this purpose (eg, amniotic fluid index, single<br />

deepest pocket, two-diameter pocket).<br />

VOL. 113, NO. 2, PART 1, FEBRUARY 2009 <strong>ACOG</strong> <strong>Practice</strong> <strong>Bulletin</strong> Ultrasonography in Pregnancy 453

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