10 February: EXAM 1 24 March: EXAM 2 28 April: EXAM 3
10 February: EXAM 1 24 March: EXAM 2 28 April: EXAM 3
10 February: EXAM 1 24 March: EXAM 2 28 April: EXAM 3
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2006 Advanced Human Genetics MBG 7600 (4 credits) Draft 11/14/05<br />
Wednesdays and Fridays at 3:00-4:50 pm, in Rm. 2268 Scott Hall<br />
Course coordinators: Helena Kuivaniemi, MD, PhD Gerard Tromp, PhD<br />
Professor<br />
Associate Professor<br />
3125 Eugene Applebaum Building 3144 Eugene Applebaum Building<br />
Tel. (313) 577-8733 Tel. (313) 577-8773<br />
Fax: (313) 577-7736 Fax: (313) 577-7736<br />
e-mail: kuivan@sanger.med.wayne.edu tromp@sanger.med.wayne.edu<br />
Textbook: T. Strachan & A. P. Read: Human Molecular Genetics 3, 3rd edition, 2004. Published by Garland Science;<br />
ISBN# 0-8153-4182-2<br />
Recommended additional reading: F. Vogel & A.G. Motulsky: Human Genetics, 3rd edition, 1996, Springer-Verlag New<br />
York, Inc., ISBN#3-540-60290-9<br />
Date Topic Format Faculty<br />
11 January — Course intro and history of human genetics L Kuivaniemi & Tromp<br />
13 January — Human chromosomes I L Feldman<br />
18 January — Human chromosomes II L Heng<br />
20 January — Mutations I: mutagens L Kuivaniemi<br />
25 January — Mutations II: types and detection methods L Kuivaniemi<br />
27 January — Mutations III JC Kuivaniemi<br />
1 <strong>February</strong> — Human viruses L Lancaster<br />
3 <strong>February</strong> — Neurogenetics L Garbern<br />
8 <strong>February</strong> — Cardiovascular genetics L Li<br />
<strong>10</strong> <strong>February</strong>: <strong>EXAM</strong> 1<br />
15 <strong>February</strong> — Mitochondrial genetics L Grossman<br />
17 <strong>February</strong> — Mitochondrial genetics JC Grossman<br />
22 <strong>February</strong> — Genetic counseling and risk assessment L Greb<br />
<strong>24</strong> <strong>February</strong> — Animal models for human disease JC Li<br />
1 <strong>March</strong> — Imprinting L Carlock<br />
3 <strong>March</strong> — X-inactivation L Carlock<br />
8 <strong>March</strong> — Imprinting & X-inactivation JC Carlock<br />
<strong>10</strong> <strong>March</strong> — Cancer genetics I L Tainsky<br />
15 <strong>March</strong> — SPRING BREAK<br />
17 <strong>March</strong> — SPRING BREAK<br />
22 <strong>March</strong> — Cancer genetics II JC Tainsky<br />
<strong>24</strong> <strong>March</strong>: <strong>EXAM</strong> 2<br />
29 <strong>March</strong> — DNA linkage analysis I L Tromp<br />
31 <strong>March</strong> — DNA linkage analysis II L Tromp<br />
5 <strong>April</strong> — Genome analysis L Finley<br />
7 <strong>April</strong> — Genetic association studies I L Korczak<br />
12 <strong>April</strong> — Genetic association studies II JC Korczak<br />
14 <strong>April</strong> — Evolutionary genetics I L Wildman<br />
19 <strong>April</strong> — Evolutionary genetics II JC Wildman<br />
21 <strong>April</strong> — DNA linkage analysis III JC Tromp<br />
26 <strong>April</strong> — Gene therapy L Kuivaniemi<br />
<strong>28</strong> <strong>April</strong>: <strong>EXAM</strong> 3
Description of the course:<br />
The Advanced Human Genetics Course MBG7600 contains lectures covering the fundamental topics of human genetics<br />
and includes the background information related to the structure, functions and defects of chromosomes, developmental<br />
genetics, neurogenetics, cardiovascular genetics, cancer genetics, statistical genetics, mutations, evolutionary genetics,<br />
genome analysis, gene therapy and genetic counseling. The course also contains student presentations in Journal Club<br />
format based on preassigned scientific articles on current topics of human genetics.<br />
Three written examinations will be given:<br />
1. <strong>10</strong> <strong>February</strong>, 2006: lectures and J Clubs 1/11 - 2/8/06<br />
2. <strong>24</strong> <strong>March</strong>, 2006: lectures and J Clubs 2/<strong>10</strong> - 3/22/06<br />
3. <strong>28</strong> <strong>April</strong>, 2006: lectures and J Clubs 3/29 - 4/26/06<br />
All examinations will consist of series of questions to which concise, but comprehensive answers are requested<br />
integrating material given during the course. Each exam will account 20% towards the final grade. Each student will give<br />
two J Club-type presentations on preassigned scientific articles. These presentations will account for 40% of the final<br />
grade.<br />
Instructors:<br />
Leon Carlock, PhD<br />
Associate Professor<br />
452.1 Lande Building<br />
tel. (313) 577-<strong>10</strong>13<br />
e-mail: lcarlock@genetics.wayne.edu<br />
Gerald L. Feldman, MD, PhD<br />
Professor<br />
2375 Scott Hall<br />
tel. (313) 577-9139<br />
email: gfeldman@med.wayne.edu<br />
Russell Finley, Jr., PhD<br />
Associate Professor<br />
41<strong>24</strong> Eugene Applebaum Building<br />
tel. (313) 577-7845<br />
Fax. (313) 577-5218<br />
email: rfinley@wayne.edu<br />
James Y. Garbern, MD, PhD<br />
Associate Professor<br />
3<strong>10</strong>9 Elliman Building<br />
tel. (313) 577-2648<br />
Fax. (313) 577-7552<br />
jgarbern@genetics.wayne.edu<br />
Anne E. Greb, MS<br />
Assistant Professor<br />
2375 Scott Hall<br />
tel. (313) 577-9138<br />
Fax. (313) 577-5218<br />
email: agreb@med.wayne.edu<br />
Lawrence Grossman, PhD<br />
Professor<br />
4122 Eugene Applebaum Building<br />
tel. (313) 577-5326<br />
Fax. (313) 577-5218<br />
e-mail: l.grossman@wayne.edu<br />
Henry Heng, PhD<br />
Associate Professor<br />
5115 BSB<br />
tel. (313) 577-9544<br />
Fax. (313) 577-6200<br />
email: hheng@genetics.wayne.edu<br />
Jeannette Korczak, PhD<br />
Assistant Professor<br />
1<strong>10</strong> E. Warren Avenue<br />
tel. (313) 833-0715 ext. 22<strong>10</strong><br />
Fax. (313) 831-7806<br />
email: korczakj@karmanos.org<br />
Wayne Lancaster, PhD<br />
Professor<br />
015 Lande Building<br />
tel. (313) 577-00<strong>28</strong><br />
Fax. (313) 577-5218<br />
e-mail: lancaster@wayne.edu<br />
Li Li, PhD<br />
Associate Professor<br />
1<strong>10</strong>7 Elliman Building<br />
tel. (313) 577-8749<br />
Fax. (313) 577-8615<br />
lili@med.wayne.edu<br />
Michael Tainsky, PhD<br />
Professor<br />
311 Prentis Building<br />
tel. (313) 833-0715 x2641<br />
Fax. (313) 832-7294<br />
email: tainskym@karmanos.org<br />
Derek E. Wildman, PhD<br />
Assistant Professor<br />
4118 Eugene Applebaum Building<br />
tel. (313) 577-1253<br />
Fax. (313) 577-5218<br />
email: dwildman@genetics.wayne.edu
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