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A Case Report and Literature Review Anucha Thatrimontrichai ...

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เชื้อเมลิออยด์ในทารกแรกเกิด อนุชา ธาตรีมนตรีชัย<br />

pediatric melioidosis who were bacteremia was<br />

reported to be between 25-80%. 4,14,15 There was no<br />

mortality reported in localized infection 4,14 There<br />

was no report of relapsed infection in survived<br />

newborns <strong>and</strong> some patients were not elucidated.<br />

Burkholderia pseudomallei has unusual<br />

antimicrobial susceptibility patterns. It is resistant<br />

to aminoglycosides except kanamycin, <strong>and</strong> sensitive<br />

to the cefazidine, amoxycillin/clavulanate, <strong>and</strong><br />

carbapenems. There have been no guidelines of<br />

types of antibiotic <strong>and</strong> duration of therapy available<br />

for neonatal melioidosis.<br />

Conclusion<br />

Melioidosis is a rare bacterial infection in<br />

neonates <strong>and</strong> should be considered in the cases<br />

of sepsis. We hope this report alerts general<br />

pediatricians <strong>and</strong> neonatologists, especially in<br />

endemic areas, to consider melioidosis as a<br />

possible cause of sepsis in neonates.<br />

References<br />

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pathophysiology, <strong>and</strong> management. Clin<br />

Microbiol Rev 2005; 18: 383 - 416.<br />

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et al. Burkholderia pseudomallei antibodies in<br />

individuals living in endemic regions in Northeastern<br />

Brazil. Am J Trop Med Hyg 2011; 84:<br />

302 - 5.<br />

3. How SH, Ng TH, Jamalludin AR, et al. Pahang<br />

melioidosis registry. Med J Malaysia 2009; 64: 27-<br />

30.<br />

4. How HS, Ng KH, Yeo HB, et al. Pediatric melioidosis<br />

in Pahang, Malaysia. J Microbiol Immunol<br />

Infect 2005; 38: 314 - 9.<br />

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The epidemiology of melioidosis in Ubon Ratchatani,<br />

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Immun 1995; 63: 3959 - 65.<br />

7. Chaowagul W, White NJ, Dance DA, et al. Melioidosis:<br />

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Acute suppurative parotitis caused by Pseudomonas<br />

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654 - 60.<br />

9. K<strong>and</strong>asamy Y, Norton R. Paediatric melioidosis in<br />

North Queensl<strong>and</strong>, Australia. J Paediatr Child<br />

Health 2008; 44: 706 - 8.<br />

10. Lumbiganon P, Pengsaa K, Puapermpoonsiri S,<br />

et al. Neonatal melioidosis: a report of 5 cases.<br />

Pediatr Infect Dis J 1988; 7: 634 - 6.<br />

11. Noyal MJC, Harish BN, Bhat V, et al. Neonatal<br />

melioidosis: a case report from India. Indian J<br />

2009; 27: 260 - 3.<br />

12. Silpapojakul K. Melioidosis in southern Thai<br />

children. Songkla Med J 2004; 22: 363 - 9.<br />

13. Currie BJ, Ward L, Cheng AC. The epidemiology<br />

<strong>and</strong> clinical spectrum of melioidosis: 540 cases<br />

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Negl Trop Dis 2010; 4: e900.<br />

14. Lumbiganon P, Chotechuangnirun N, Kosalaraksa P.<br />

Clinical experience with treatment of melioidosis<br />

in children. Pediatr Infect Dis J 2004; 23: 1165 - 6.<br />

15. Pagnarith Y, Kumar V, Thaipadungpanit J, et al.<br />

Emergence of pediatric melioidosis in Siem Reap,<br />

Cambodia. Am J Trop Med Hyg 2010; 82: 1106 - 12.<br />

16. Osteraas GR, Hardman JM, Bass JW, et al.<br />

Neonatal melioidosis. Am J Dis Child 1971; 122:<br />

446 - 8.<br />

17. Halder D, Abdullah WA, Johari MR, et al. Neonatal<br />

melioidosis. Singapore Med J 1993; 34: 85 - 6.<br />

242<br />

ส§¢ÅÒ¹¤ÃÔ¹·ร์àǪสÒà »‚·Õè 29 ©ºÑº·Õè 5 ก.ย.-ต.ค. 2554

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