Douglas Korver, Implications of Changing Immune Function ...

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Diet n-3 PUFA and Rodent Survival Challenge Survival Challenge Survival Bacterial Viral Pseudomonas aeruginosa ↔ ↓ Cytomegalovirus ↔ Klebsiella pneumonia ↑ Murine leukemia virus ↔↑ Staphylococcus aureus ↑ Influenza ↔ Salmonella typhimurium ↔ ↓ ↓ Protozoa Bacteroides fragilis ↓ Plasmodium yoelii ↑ Streptococcus Group B ↑ Plasmodium berghei ↑ Listeria monocytogenes GI flora (undefined) ↔↓↓↓ ↑ ↑ Anderson & Fritsche, 2002
Implications • n-3 PUFA can “unlink” local and systemic responses • The “benefit” of n-3 PUFA depends on the type of disease challenge
Page 1 and 2: Implications of Changing Immune Fun
Page 3 and 4: The Immune System • Two arms of t
Page 5 and 6: The Immune System • Immune system
Page 7 and 8: Immunology for Nutritionists • In
Page 9 and 10: Environment and Growth 100 90 80 70
Page 11 and 12: % OF NON-INJECTED CONTROL Inflammat
Page 13 and 14: Modern Poultry Production • Comme
Page 15 and 16: The Immune System • What do we kn
Page 17 and 18: • Example -- Zinc - Zinc deficien
Page 19 and 20: Selection for Growth • Growth rat
Page 21 and 22: Selection for Growth • Selection
Page 23 and 24: Commercial “C” Random bred 1957
Page 25 and 26: Commercial “C” Random bred 1977
Page 27 and 28: T-cell Response to IL-1 Stimulation
Page 29 and 30: Implications • Genetic selection
Page 31 and 32: The Chick • First week of life be
Page 33 and 34: Innate Immune Development • Can w
Page 35 and 36: Implications • Early nutrition ca
Page 37 and 38: n-3 vs n-6 Fatty Acids Arachidonic
Page 39 and 40: 20-C PUFA Cyclooxygenase Lipoxygena
Page 41 and 42: Stimulation Index 3 Serum IL-1 Acti
Page 43 and 44: Nutritional Modulation of Immune Fu
Page 45: Lesion Score 2.5 2.0 ab Histopathol
Page 49: Conclusions • Understand the poss

Douglas Korver, Implications of Changing Immune Function ...

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