Molecular epidemiology of HCV - Viral Hepatitis Prevention Board
Molecular epidemiology of HCV - Viral Hepatitis Prevention Board
Molecular epidemiology of HCV - Viral Hepatitis Prevention Board
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RNA<br />
dependent<br />
RNA<br />
polymerase<br />
RNA RNA<br />
LACK OF PROOFREADING MECHANISMS<br />
Mutation rates (mutations / nucleotide / cicle <strong>of</strong> replication)<br />
F.Penin et al Hepatol 2004;39:5-19<br />
10 -3 -10 -5<br />
Exemple: 10 4 nts and mut.rate <strong>of</strong> 10 -4<br />
= 1 mutation/new genoma
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