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Koh KK, et al. Circulation. 2004

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Fenofibrate<br />

• Peroxisome Proliferator-Activated Receptors<br />

Transcription factors belonging to nuclear<br />

receptor superfamily<br />

PPARa, PPARb/d, PPARγ<br />

• Fibrates<br />

Synth<strong>et</strong>ic ligands for PPARa<br />

• PPARa<br />

1. Anti-inflammatory function<br />

2. Reduce oxidative stress<br />

3. Expression of inhibitory protein IkBa<br />

Inhibit NF-kB activation

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