Cancer Pharmacogenomics Development, Science, Translation
Cancer Pharmacogenomics Development, Science, Translation
Cancer Pharmacogenomics Development, Science, Translation
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Functional Characterization of FKBP5<br />
Gemcitabine<br />
Survival cell by control<br />
1.2<br />
1.0<br />
0.8<br />
0.6<br />
0.4<br />
0.2<br />
SU86<br />
neg-siRNA<br />
FKBP5-siRNA<br />
0.0<br />
-5 -4 -3 -2 -1 0 1 2 3 4 5<br />
Gemcitabine concentration Log(uM)<br />
Survival cells by control<br />
1.2<br />
1.0<br />
0.8<br />
0.6<br />
0.4<br />
0.2<br />
MDA-MB-231<br />
neg-siRNA<br />
FKBP5-siRNA<br />
0.0<br />
-5 -4 -3 -2 -1 0 1 2 3 4 5<br />
Gemcitabine concentration Log(uM)<br />
Reprinted with permission from Li et al. <strong>Cancer</strong> Res. 2008; 68:7050-7058.
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