1st EuCornea Congress

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1st EuCornea Congress venice, 17-19 june 2010 FREE PAPER Abstracts average by 43% after 6 months. Six months after DAEK surgery, BSCVA improved from 1/10 to 6/10 on average. Post operatively , there was one graft failure at 1 month due to intraoperative complication. Conclusion: The opportunity to reduce significantly the donor corneal thickness, using a medium specific for EB pre-cut tissues, represents a further advantage to prepare very thin lenticule for DSAEK in EB. Financial Disclosure: 0 may become dry until it resumes generating its own natural moisture. Conclusion: In patients with ocular surface symptoms it is valuable to stop creams, moisturisers and make up removers. Lid hygiene is with only with a flannel and hot water. Once symptoms have settled, stopped agents can be reintroduced one at a time, at least two weeks apart to identify the culprit. FINANCIAL DISCLOSURE: 0 44 Corbett, Melanie New suture technique to prevent suture loosening in high-risk corneal grafts M Corbett 1,3 , N Lim 1,3 , S Wood 2,3 The Western Eye Hospital Plastic Surgery Department Imperial College NHS Trust, London, UK Purpose: to develop a suture technique to reduce the risk of suture loosening in high-risk corneal grafts. Setting: specialist Corneal and Anterior Segment Service receiving patients from at least four eye hospitals in West London (population 3 million). Methods: 12 patients with loosening of interrupted corneal graft sutures in the first six months after penetrating keratoplasty returned to theatres for suture replacement. The environment of the loose sutures was compared with those that had not become loose. The biomechanical effect of the loosening on the graft-host junction was assessed. From these results a box suture was designed and used, and its stability compared with interrupted sutures. Results: suture loosening occurred in regions of superficial corneal vascularisation and conjunctival swelling. In many cases the entry point of the interrupted suture through the donor had become more peripheral, especially superficially. Therefore the box suture was designed to minimise the length of suture lying superficially, and maintain tension across the graft-host junction. In practice the box sutures performed better in this respect than interrupted sutures, and remained in situ until routine suture removal. Conclusions: the box suture technique is suitable for reducing suture loosening in inflamed or vascularised areas of high-risk corneal grafts. It can be used both at the primary procedure and for suture replacement. FINANCIAL DISCLOSURE: 0 Corbett, Melanie The cryptic culprit in ocular surface disease M. Corbett 1,2 , P. Abeysiri 1,2 The Western Eye Hospital Imperial College NHS Trust, London, UK Purpose: Patients with ocular surface disorders, including blepharitis, can remain symptomatic despite what would normally be considered full management. The aim of this study was to test the hypothesis that facial applicants can cause ocular surface irritation and exacerbate ocular surface disease. Setting: a single-handed specialist corneal and ocular surface practice. Methods: 18 patients with blepharitis had persistent moderate or severe ocular surface symptoms including soreness, burning, stinging, grittiness, photophobia, smeary vision and contact lens intolerance. All had performed lid hygiene treatment for more than 3 months. Some had received topical artificial tears, antibiotic or steroid, or systemic doxycycline, which were then all stopped. They were advised to stop using all facial applicants for at least 2 months. These included face and lid creams, moisturisers and makeup removers; but patients could continue with eye liner and mascara if required. Ocular surface symptoms and signs were assessed before and after the study period. Results: Out of 18 patients, 5 (28%) had total resolution of their symptoms and 12 (67%) had a significant improvement. One patient (6%) had no change. All 6 patients who had been unable to wear their contact lenses had a dramatic improvement in symptoms and returned to a normal or near-normal lens wearing regime. Most patients showed an improvement in signs, including lid swelling, lid margin crusting and hyperaemia, subtarsal papillae, conjunctival injection, oiliness of the tear film and superficial punctate keratitis. It is worthwhile warning patients that their skin Cursiefen, Claus Combined DMEK and DALK: a new strategy to combat corneal donor shortage C Cursiefen University of Erlangen, Erlangen, Germany Background: Whereas penetrating keratoplasty so far is the gold standard for the surgical treatment of corneal endothelial pathologies, tremendous progress has been made in recent years in improving the technology of (posterior) lamellar keratoplasty techniques such as DMEK. Methods: Literature review using PUBMED and own clinical and experimental data. Results: Isolated transplantation of Descemet’s membrane with endothelial cells after stripping off hosts Descemet’s membrane is a new surgical technique for Fuchs endothelial dystrophy and pseudophakic bullous keratopathy. Visual rehabilitation seems to be faster and better with DMEK compared to penetrating keratoplasty. Conclusion: Posterior lamellar keratoplasty techniques such as DMEK will replace penetrating keratoplasty as the gold standard for treatment of a large segment of corneal endothelial pathologies. Cusati, Giorgio Results of corneal calcareous caustification G. Cusati 1 , A. Colaci 2 , G. Colaci 1 , W. Cusati 3 1. Clinica GE.PO.S. Telese Terme (BN) 2. Servizio Patologia Corneale C.S.M Mesagne (BN) 3. S.G Medical Centre, San Giorgio a Cr. (NA) PURPOSE To demonstrate how the combination between surgical removal of a cicatrizial proliferation of the bulbar conjunctiva, completely covering cornea in both eyes, with a severe visual compromission, and an excimer laser ptk could better complications and outcomes from calcaureous corneal caustication. SETTING Before the surgical treatment was effected, for precaution, a sample of limbal cells in both eyes was taken and so cells were examinated and counted. METHODS Microsurgery let us remove conjuntival cicatrizial proliferation and PTK laser treatment (100Âµ with abundant mask fluid) acting on corneal opacities. Before treatment the patient had 1/12 A.V. in OD and he just perceived motu mano in OS. RESULTS After six months from the treatment AV was 3/10 in OD and 1/10 in OS. The same results were present after one year from the treatment. CONCLUSIONS We founded useful to illustrate this case because with an adequate combination of surgery and laser therapy we were able to better the visual capacity of the patient. The subject, that is still young, with the help of low vision aids, is now capable to lead a nearly normal life. Dobrowolski, Dariusz Application of the new corneal epithelial culture bed – chitosan hydrogel. D. Dobrowolski 1 , E. Wylegala 1 , A. Nowiñska 1 , M. Grolik 2 , K. Szczubialka 2 , M. Nowakowska 2 1. Dept. of Ophthalmology, District Railway Hospital, Katowice, Poland 2. Dept. of Physical Chemistry and Electrochemistry, Jagielonian University, Krakow, Poland Purpose: Comparison of novel corneal epithelial culture carrier with amniotic membrane. Setting: Dept. of Ophthalmology, District Railway Hospital, Katowice,
1st EuCornea Congress venice, 17-19 june 2010 FREE PAPER Abstracts Poland. Dept. of Phisical Chemistry and Electrochemistry, , Jagielonian University, Cracow, Poland Methods: 4 patients were donors of limbal epithelium for corneal epithelial culture in each method. Each patient suffer from limbal stem cell deficiency in one eye, contralateral was healthy. Cells from limbal biopsy were seeded on amniotic membrane and on genipin crosslinked chitosan hydrogel scaffolds. Cultures were carried in standard conditions (atmosphere: 5% CO2, 95% air) in supplememted DMEM in presence of 3T3 fibroblasts. After 2 weeks cultures were qualified for grafting. After superficial keratectomy carriers with cells were transplanted on denuded corneas. Stabilisation of corneal surface was evaluated. Results: 1 month after surgery eyes with amniotic membrane showed stabile epithelium with corneal haze caused by the amnion. In eyes covered by chitosan hydrogel epithelium was stabile, however we observed prolonged hydrogel presence under epithelium. Results were evaluated with histological examination of corneal biopsies. Conclusions: Chitosan hydrogels ware valuable epithelial grafts carriers. Financial disclosure: 0 Dobrowolski, Dariusz Surgical approach in corneal perforations and deep ulcers. D. Dobrowolski 1,2 , E. Wylegala 1 , D. Tarnawska 1 , D. Janiszewska 1 1. Dept. of Ophthalmology, District Railway Hospital, Katowice, Poland 2. Dept. of Ophthalmology, St. Barbara Hospital, Sosnowiec, Poland Purpose: Outcomes of patch grafts in corneal perforations and deep ulcers. Setting Departments of Ophthalmology in: District Railway Hospital in Katowiceand in St. Barbara Hospital in Sosnowiec, Poland Methods: For the study 128 patients (follow-up at least 6 months) were qualified: 73 men and 55 women, mean age 50,2,±16,6 years. 135 procedures (82 in corneal perforations and 53 in deep ulcers) were performed. We applied grafts with diameter from 2,5 to 5 mm with oversize of 0,5 1 mm. Visual outcomes and corneal surface stability were analysed. Results In 104 eyes we achieved stabile corneal surface, 6 grafts were failed due to graft melting. Among 133 eyes improvement of VA was achieved in 59 eyes, 74 required further procedures of penetrating keratoplasty or cataract surgery. The best visual outcomes were achieved in peripheral ulcers or perforations, central changes usually required further management or were connected with poor prognosis for good vision. 21 eyes due to dry eye, no light localization or retinal detachment (2 eyes) were disqualified to other procedures. Conclusions: Patch grafts are useful to restore vision and maintain corneal integrity. FINANCIAL DISCLOSURE: 0 Dua, Harminder Singh Profile of Ocular surface antimicrobial peptides. H.S. Dua, A. Hopkinson, I. Mohammed University of Nottingham, Nottingham, UK Antimicrobial peptides (AMPs) are the eukaryotic analogues of antibiotics. They are recognised as one of the earliest effectors of the innate immune response and as such are widely distributed throughout the plant and animal kingdoms with remarkably conserved structures. In addition to their antimicrobial activity, these peptides can signal to host cells and are therefore intermediaries between the innate and adaptive immune systems. AMPs signal to cells via Toll Like Receptors (TLRs), a range of of which have also been shown at the ocular surface. Over the years our laboratory has exensively profiled AMPs at the ocular surace in health and disease. The ocular surface is endowed with a generous range of AMPs including Beta defensins 1-4, Cathelicidin (LL37), Leap 1 and 2. Recently we have demonstrated another novel defensin, DEF-109 and another AMP, RNAse-7, at the ocular surface. The expression of AMPs in health and ocular surface disease has been studied with some being consistently increased, others variably so and DEF-109 being decreased, in inflammation. This talk will provide an overview of the spectrum of antimicrobial peptide expression at the ocular surfaces. AMPs have implications in the normal homeostasis of mucosal surfaces and a potential for novel antimicrobial and anti-inflammatory therapies. El Danasoury, Alaa Customized Ablation (CATZ) for highly irregular corneas after keratorefractive surgery A. El Danasoury Magrabi Eye and Ear Hospital, Jeddah, Saudi Arabia Purpose: To evaluate the efficacy & safety of topography guided customized ablation (CATZ) for correction of high corneal irregularities after keratorefractive surgery. Methods: 8 eyes of 7 patients were included in the study; all eyes had previous unsuccessful corneal refractive surgery (RK, LASIK, PRK or keratomileusis in situ), corneal irregularities more than 20 µm, spectaclecorrected visual acuity of 20/30 or better and severe night vision symptoms. All eyes received LASIK with CATZ ablation using Nidek CXIII excimer laser & Final fit 1.13 software. Results: At baseline, mean spherical equivalent was -1.23 D (-4.38 to 2.50 D); 64% eyes could see 20/20 or better, mean high order MTF was 0.34, corneal total high order aberrations RMS was 0.71 and the mean entire eye spherical aberrations was 1.0. One year after operation, 80% eyes could see 20/20 or better; average high order MTF improved to o.47; cornea total high order aberrations RMS decreased from to 0.26 µm and spherical aberrations decreased to 0.55 µm. Conclusion: Customized topography guided ablations using NIDEK CXIII, CATZ ablation profile & Final Fit software 1.13 is effective and safe in correction of high corneal irregularities after unsuccessful keratorefractive surgical procedures Elmekawey, Hany Multizonal LASIK for presbyopia using solid state customvis laser: an early preliminary results H. Elmekawey 1 , I. Othman 1 , S. Sadek 2 1. Faculty of Medicine Cairo University, Cairo, Egypt 2. Faculty of Medicine Alfayoum University, Alfayoum, Egypt Purpose: The primary aim of this study is to evaluate the safety and effectiveness of the Pulzar Z1 CustomVis Multizone Ablation Software for Presbyopia, for the improvement of near visual acuity with simultaneous good distance vision. Method:A prospective clinical trial in which patients were enrolled, treated with the Multizone Presbyopia Software, and followed for up to 3 months. A full medical history, complete ocular examinations, and informed consent were done for each patient. The patient underwent laser vision correction with the CustomVis Pulzar Z1 Solid State Refractive Laser System. The treatment involved the application of the Multizone Ablation Software, and standard treatment for distance vision (if required). Patients were examined at 1 day, 1 week, 1 month, and 3 months following surgery. Results: 17 eyes (non dominant) 0f 17 patients were treated by multizonal presby lasik. Average patient age was 53.3 years. Preoperative cycloplegic refraction ranged from -4.75 to +4.25 diopters (D). Near add ranged from +1.0 to +2.5 diopters (average 1.75 D). At 3 months follow-up, 92.4% of all patients, 88% of hyperopes, and 91% of myopes reported complete spectacle independence. Distance unaided visual acuity was at least 6/6 in 84.3% and 6/12 or better in 94.2%. No side effects or complications were reported in the treated eyes. Conclusion: Monocular multizonal presbyLASIK using solid state CustomVis system is an effective and safe option for presbyopic lasik considering refractive surgery. Financial Disclosure: 0 45
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1st EuCornea Congress

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