Stavros Apostolakis MD, PhD

Curriculum Vitae
Of
Stavros Apostolakis MD, PhD
Lecturer in Cardiology
Democritus University of Thrace
Alexandroupolis 2010
1

PERSONAL DETAILS
Surname:
Stavros
Forename:
Apostolakis
Date of birth: 11-10-1974
Place of birth:
Athens
Nationality:
Greek Citizen
Sex:
Male
Marital Status:
Married
Address:
Cardiology Department
Alexandroupolis General Hospital
Dragana Area
68100 Alexandroupolis
Greece
Phone: 00302551030387
Email:
sapostol@med.duth.gr
GMC registration number:7043518
MEDICAL EDUCATION
1993-1999 Graduate student in the faculty of Medicine University of Crete, Heraklion,
Crete, Greece.
Graduated in December 1999.
2003-2007 Postgraduate (PhD) student in the faculty of Medicine, University of Crete
Heraklion, Crete, Greece, under the supervision of Professor Demetrios A
Spandidos.
Graduated in July 2007.
PhD Thesis:
The role of fractalkine (FKN) and CX3CR1 receptor in atherogenesis in
patients with coronary artery disease, correlation of the disease with
genetic polymorphisms.
2

PROFESSIONAL ACTIVITIES
May 2010-present
Lecturer in Cardiology, in the Department of Cardiology, Democritus
University of Thrace
February 2010-May 2010
Research Fellow, in Haemostasis, Thrombosis and Vascular Biology Unit,
University Department of Medicine, City Hospital, Birmingham, UK
(honorary post).
November 2005-November 2010
Registrar in the Cardiology Department of 417 Army Veterans Hospital.
June 2009– July 2009
Research Fellow, in Haemostasis, Thrombosis and Vascular Biology Unit,
University Department of Medicine, City Hospital, Birmingham, UK
(honorary post).
July 2004-July 2005
SHO in the Diabetic outpatient clinic of Venizeleio General Hospital
Heraklion Crete Greece.
October 2002-July 2004
SHO in Internal Medicine at Venizeleio General Hospital, Heraklion Crete
Greece.
January 2000–March 2002
Three-month clinical practice in the departments of Internal Medicine,
Surgery and Cardiology of General Hospital of Rethymno, Crete,
Greece.
Five-month service in the regional health center of Roustica, Crete
Greece.
Seven-month service in the Intensive Care Unit of General Hospital of
Rethymno, Crete Greece.
May 2002-September 2003
Military service.
3

RESEARCH EXPERIENCE
July 2003-July 2007
July 2007-present
PhD student in the Laboratory of Clinical Virology faculty of Medicine
University of Crete under the supervision of Professor Demetrios A
Spandidos.
Research associate in the Laboratory of Clinical Virology faculty of
Medicine University of Crete and in the Department of Applied
Biochemistry and Immunology, Institute of Molecular Biology and
Biotechnology, FORTH, Heraklion, Crete, Greece, under the
supervision of Professor Demetrios A Spandidos and Professor Elias
Krambovitis.
GRANTS-AWARDS
8000 € research grant from the Hellenic Cardiological Society for the
research protocol entitled “The role of chemokine CXCL8 (IL-8) and the
chemokine receptors CXCR1 and CXCR2 in the pathogenesis of
coronary artery disease”.(Research grants 2008-2009).
Fellowship of the Αmerican Austrian Foundation (AAF) to attend the
International Seminar “SALZBURG WEILL CORNELL SEMINAR IN
CARDIOLOGY” 19-25 April 2009.
12000 € Scholarship from the Hellenic Cardiological Society for further
training in Cardiology in the United Kingdome (2009-2010 HCS
Scholarships).
50000 € Scholarship from the European Society of Cardiology (2010-
2011 Atherothrombosis Research Grant).
4

MEMBER OF SCIENTIFIC SOCIETIES
Member of the Hellenic Cardiological Society.
Member of the Hellenic Diabetes Association.
Member of the National workgroup “Diabetes and Heart disease” of
the Hellenic Diabetes Association.
5

PUBLICATIONS and CONGRESS PRESENTATIONS
32 congress presentations in National Medical Congresses
2 publications in national peer reviewed journals
Presentations in international congresses
1. Lydakis C, Basta M, Prokopiadou D, Apostolakis S, Karvunaris S, Karalis I, Seliniotaki E.
Association of obstructive sleep apnea syndrome severity with hypertension. 13 th European Meeting
on Hypertension, Milan, 2003, J Hypertension 2003, 21: S56-S56.
2. Apostolakis S, Komis G, Lydataki N, Tzortzakakis E, Zidianakis M. Changes in ischemic stroke
hospital admissions within the last decade. 7 th Mediterranean Medical Congress, Vilamura Portugal,
2003.
3. Lydakis C, Apostolakis S, Karalis J, Komis G, Lydataki N, Tzotzakakis E. CPK, CPK MB, and
Troponin I levels in patients with ischemic cerebrovascular accidents. 7 th Mediterranean Medical
Congress, Vilamura Portugal 2003.
4. Lydakis C, Apostolakis S, Komis G, Karalis J, Karvounaris S, Lydataki N, Tzotzakakis E.
Association of haemostatic inflammatory factors and lipoproteins with the 6-months outcome in
patients with ischemic stroke. 7 th Mediterranean Medical Congress, Vilamura Portugal 2003.
5. Lydakis C, Tzinas J, Apostolakis S, Thalassinos E, Athousakis E, Haritaki E, Seliniotaki E,
Apostolakis T. Evaluation of factors contributing to loss of follow up in hypertension. 14 th European
Meeting on Hypertension, Paris 2004, J Hypertension, 2004; 22: S398-S398.
6. Apostolakis S, Baritaki S, Krabovitis E, Spandidos DA. Frequencies of HIV/AIDS protective
mutations in SDF-1 Chemokine and CC Chemokine-Receptors gene within the Cretan population. 9 th
World Congress on Advances in Oncology and 7 th International Symposium on Molecular Medicine,
Crete 2004, Ιnt J Μol Μed, 2004; 14: S50-S50 Suppl 1.
7. Apostolakis S, Kochiadakis G, Baritaki S, Igoumenidis NE, Skalidis E, Hamilos M,
Panoutsopoulos D, Spandidos DA. 280M variant of CX3C receptor 1 gene is associated with reduced
risk for coronary artery disease. ESC congress Stockholm 2005.
8. Amanatidou V, Sourvinos G, Apostolakis S, Tsilimigaki A, and Spandidos DA. T280M variation
of the CX3C receptor gene is associated with increased risk for sever respiratory syncytial virus
bronchiolitis. 10 th World Congress on Advances in Oncology and 8 th International Symposium on
Molecular Medicine, Crete 2005, Int J Mol Med, 2005; 16: S55.
9. Apostolakis S, Baritaki S, Kochiadakis GE, Igoumenidis E, Panutsopulos D and Spandidos DA.
280M variation of CX3C receptor 1 gene is associated with lower prevalence and decreased
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angiographic severity of coronary artery disease. 10 th World Congress on Advances in Oncology and
8 th International Symposium on Molecular Medicine, Crete 2005, Int J Mol Med, 2005; 16: S59.
10. Thalassinos E, Lydakis C, Xaritaki E, Apostolakis S, Passam A, Krasanaki A, Athousakis E,
Mihou E. Change in lipid levels after acute ischemic stroke. 9 th Congress of the European Federation of
Neurological Societies (EFNS) Athens 2005.
11. Baritaki S, Kanellou P, Apostolakis S, Spandidos DA, Bonavida B. Role of plasma membrane
fluidity alterations in tumor cell sensitization to apoptosis-inducing stimuli: Therapeutic implications.
7 th AACR Annual Meeting, Washington DC 2006.
12. Zidianakis M, Apostolakis S, Tzinas I, Thalassinos E, Athousakis E, Lydakis C, Lydataki N,
Apostolakis T. Community acquired pneumonia in the elderly. 11 th Conference of the European
Society of Clinical Practice/Family Medicine, Kos 2005.
13. Amanatidou V, Sourvinos G, Apostolakis S, Neonaki P, Tsilimigaki A, and Spandidos DA.
RANTES promoter gene polymorphisms and susceptibility to RSV induced bronchiolitis. 11 th World
Congress on Advances in Oncology and 9 th International Symposium on Molecular Medicine, Crete
2006, Int J Mol Med 2006; 18: S77.
14. Apostolakis S, Vlata Z, Kochiadakis GE, Baritaki S, Krambovitis E, Spandidos DA. Effects of
angiotensin converting enzyme inhibitors on the chemokine receptors of THP-1 cells. 11 th World
Congress on Advances in Oncology and 9 th International Symposium on Molecular Medicine, Crete
2006, Int J Mol Med 2006; 18: S78.
15. Amanatidou V, Sourvinos G, Apostolakis S, Neonaki P, Tsilimigaki A, Spandidos DA.
Implication of RANTES in the pathogenesis of RSV bronchiolitis. A view through population genetics.
25 th International Congress of Pediatrics, Athens 2007.
16. Krambovitis E, Apostolakis S, Vlata Z, Spandidos DA. Angiotensins and chemokine receptor
profile of human monocytes. 12 th World Congress on Advances in Oncology and 10 th International
Symposium on Molecular Medicine, Crete 2007, Int J Mol Med 2007; 20: S78.
17. Vogiatzi K, Apostolakis S, Kochiadakis GE, Spandidos DA. Interleukin 8 gene polymorphisms
and susceptibility to coronary artery disease. A view through population genetics. 12 th World
Congress on Advances in Oncology and 10 th International Symposium on Molecular Medicine, Crete
2007, Int J Mol Med 2007; 20: S77.
18. Vogiatzi K, Voudris V, Apostolakis S, Zaravinos A, Thomopoulou S, Kochiadakis GE, Spandidos
DA. Genetic diversity of RANTES gene promoter and susceptibility to coronary artery disease and
restenosis. 13 th World Congress on Advances in Oncology and 11 th International Symposium on
Molecular Medicine, Crete 2008, Int J Mol Med 2008; 22: S89.
19. Vogiatzi K, Voudris V, Apostolakis S, Kochiadakis GE, Thomopoulou S, Zaravinos A, Arfanakis
DA, Spandidos DA, Vardas PE. RANTES gene promoter polymorphisms and susceptibility to coronary
artery disease and restenosis after percutaneous coronary intervention. ESC congress Barcelona 2009
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20. Vogiatzi K, Apostolakis S, Voudris V, Thomopoulou S, Kochiadakis GE, Arfanakis DA,
Spandidos DA, Vardas PE. Polymorphisms of the interleukin 8 gene and restenosis after percutaneous
coronary intervention. ESC congress Barcelona 2009
21. Apostolakis S, Vogiatzi K, Vlata Z, E. Krabovitis, D.A. Spandidos. CXCL8 and vascular
inflammation: Interactions with renin-angiotensin-system mediators and blockers. 15th World
Congress on Advances in Oncology and 13th International Symposium on Molecular Medicine,
Loutraki 2010.
22. Apostolakis S, Vogiatzi K, Voudris K, Zaravinos A, Thomopoulou S, Kochiadakis GE, Spandidos
DA. CCL5 and CXCL8 gene polymorphisms and susceptibility to coronary artery disease and restenosis
after percutaneous coronary intervention. 15th World Congress on Advances in Oncology and 13th
International Symposium on Molecular Medicine, Loutraki 2010.
23. Tsapaki A, Zaravinos A, Apostolakis S, Vogiatzi K, Voudris K, Kochiadakis GE, Spandidos DA.
Genetic variability of the distal promoter of the ST2 gene in coronary artery disease. 15th World
Congress on Advances in Oncology and 13th International Symposium on Molecular Medicine,
Loutraki 2010.
24. Zaravinos A, Tzoras S, Apostolakis S, Lazaridis K, Spandidos DA. Measurement of the plasma
cell-free DNA levels in heart failure using the ß-globin gene as a marker. 15th World Congress on
Advances in Oncology and 13th International Symposium on Molecular Medicine, Loutraki 2010.
25. Papadimitriou K, Soulitzis N, Apostolakis S, Spandidos DA. Association of CX3CR1 V249I and
T280M polymorphisms with benign prostatic hyperplasia and prostate cancer. 15th World Congress
on Advances in Oncology and 13th International Symposium on Molecular Medicine, Loutraki 2010.
8

Publications published in international peer reviewed journals
(36 publications in peer reviewed journal cited in PubMed database (either published or Epub ahead
of print, 1 manuscript currently accepted)
1. Lydakis C, Apostolakis S, Lydataki N, Tzortzakakis E, Komis G. Stroke complicated
endocarditis with positive lupus anticoagulant. Angiology 2005; 56: 503-506.
2. Apostolakis S, Baritaki S, Krambovitis E, Spandidos DA. Distribution of HIV/AIDS protective
SDF-1, CCR5 and CCR2 gene variants within Cretan population. J Clin Virol 2005; 34: 310-314.
3. Lydakis C, Apostolakis S, Thalassinos E, Stamataki A, Saridaki A, Basta M. “PIP syndrome”. A
potentially threatening manifestation of a psychiatric disorder. Int J Clin Pract 2005; 59: 612-613.
4. Apostolakis S, Chalkiadakis I, Ventouri M, Maraki S, Tsoussis S. Lymphocutaneous
Nocardiosis in a breast cancer patient under treatment with docexatel. The Breast Journal 2005; 11:
469.
5. Lydakis C, Thalassinos E, Apostolakis S, Athousakis E, Michou E, Kontopoulou E. Hoarseness as
imminent symptom of aortic aneurysm rupture (Ortner’s syndrome) Int Angiol 2006; 25: 231-233.
6. Tsoussis S, Vourliotaki I, Ekonomidou F, Apostolakis S. Capecitabine as an alternative in a
case of fluorouracil- induced photodermatitis. Clin Oncol (R Coll Radiol). 2006; 18:158-159.
7. Amanatidou V, Sourvinos G, Apostolakis S, Tsilimigaki A, Spandidos DA. T280M variation of
CX3C receptor gene is associated with increased risk for severe respiratory syncytial virus
bronchiolitis. Ped Inf Dis J 2006; 25: 410-414.
8. Apostolakis S, Baritaki S, Kochiadakis GE, Igoumenidis N, Panutsopulos D, Spandidos DA.
Effects of polymorphisms in chemokine ligands and receptors on susceptibility to coronary artery
disease. Thromb Res 2006; 119: 63-71.
9. Apostolakis S, Papadakis EG, Krambovitis E, Spandidos DA. Chemokines in vascular pathology
(Review) Int J Mol Med 2006; 17: 691-701.
10. Baritaki S, Apostolakis S, Kanellou P, Dimanche-Boitrel MT, Spandidos DA and Bonavida B.
Reversal of tumor resistance to apoptotic stimuli by alteration of membrane fluidity: therapeutic
implications. Adv Cancer Res 2007; 98: 149-190.
11. Apostolakis S, Krambovitis E, Vlata Z, Kochiadakis GE, Baritaki S, Spandidos DA. CX3CR1
receptor is up-regulated in monocytes of coronary artery diseased patients: Impact of preinflammatory
stimuli and renin-angiotensin system modulators. Thromb Res 2007;121: 387-95.
12. Amanatidou V, Sourvinos G, Apostolakis S, Neonaki P, Tsilimigaki A, Krambovitis E, Spandidos
DA. RANTES promoter gene polymorphisms and susceptibility to severe RSV induced bronchiolitis.
Ped Inf Dis J 2008; 27: 38-42.
13. Tsoussis S, Ikonomidou F, Vourliotaki I, Papadaki A, Apostolakis S. Clinical burden of terminal
phase in cancer patients. J BUON. 2007; 12: 383-8.
9

14. Apostolakis S, Vogiatzi K, Krambovitis E, Spandidos DA IL-1 Cytokines in Cardiovascular
Disease: Diagnostic, Prognostic and Therapeutic Implications. Cardiovasc Hematol Agents Med Chem.
2008; 6: 150-8.
15. Vogiatzi K, Apostolakis S, Voudris V, Thomopoulou S, Kochiadakis GE, Spandidos DA.
Interleukin 8 and susceptibility to coronary artery disease: A population genetics perspective. J Clin
Immunol. 2008; 28: 329-35.
16. Xenaki E, Hassoulas J, Apostolakis S, Sourvinos G, Spandidos DA. Detection of
Cytomegalovirus in atherosclerotic plaques and non-atherosclerotic arteries. Angiology 2009; 60: 504-
8.
17. Amanatidou V, Apostolakis S, Spandidos DA. Genetic diversity of the host and severe RSV
induced lower respiratory tract infection. Ped Inf Dis J 2009; 28: 135-40.
18. Tzortzis S, Apostolakis S, Xenakis K, Spiropoulos G, Lazaridis K. Catheter-related septic
thrombophlebitis of the superior vena cava involving the atrial septum: a case report. Cases J 2008,
1:272.
19. Vogiatzi K, Voudris V, Apostolakis S, Kochiadakis GE, Thomopoulou S, Zaravinos A and
Spandidos DA. Genetic diversity of RANTES gene promoter and susceptibility to coronary artery
disease and restenosis after percutaneous coronary intervention. Thromb Res 2009; 124: 84-9.
20. Apostolakis S, Shantsila E, Lip GY. Evidence guided antiplatelet treatment: Time to move
from bench to bedside. Thromb Res 2009; 124: 649-50.
21. Apostolakis S, Amanatidou V, Papadakis EG, Spandidos DA. Genetic diversity of CX3CR1 gene
and coronary artery disease: New insights through a meta-analysis. Atherosclerosis 2009; 207: 8-15.
22. Vogiatzi K, Apostolakis S, Voudris V, Thomopoulou S, Kochiadakis GE, Spandidos DA.
Interleukin 8 gene polymorphisms and susceptibility to restenosis after percutaneous coronary
intervention. J Thromb Thrombolysis 2010; 29: 134-40.
23. Apostolakis S, Shantsila E, Lip GY. Angiopoietins and Preeclampsia: New perspectives in the
quest for markers Am J Hypertens 2009; 22: 820.
24. Apostolakis S, Shantsila E, Lip GY. New anticoagulants for the prevention of Deep Venous
Thrombosis. Time to consider cost effectiveness Pharmacoeconomics (accepted).
25. Apostolakis S, Vogiatzi K, Amanatidou V, Spandidos DA. Interleukin 8 and cardiovascular
disease. Cardiovasc Res 2009; 84: 353-60.
26. Antoniades D, Apostolakis S, Tzoras S, Lazaridis K. Iatrogenic right coronary artery dissection
distal to a total occlusion. Cases J 2009; 2: 6797.
27. Apostolakis S, Shantsila E, Lip GY, Lane DA. Contra: "Anti-platelet therapy is an alternative to
oral anticoagulation for atrial fibrillation". Thromb Haemost 2009; 102:914-5.
28. Apostolakis S, Shantsila E, Lip GY. Vascular imaging as a cardiovascular risk stratification tool
in systemic lupus erythematosus. J Rheumatol 2009;36:2141-3.
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29. Apostolakis S, Lip GY, Shantsila E. Monocytes in heart failure: relationship to a deteriorating
immune overreaction or a desperate attempt for tissue repair Cardiovasc Res 2010; 85: 649-60.
30. Apostolakis S, Vlata Z, Vogiatzi K, Krambovitis E, Spandidos DA. Angiotensin II up-regulates
CX3CR1 expression in THP-1 monocytes: impact on vascular inflammation and atherogenesis. J
Thromb Thrombolysis 2010; 29: 443-8.
31. Dresios C, Apostolakis S, Tzortzis S, Lasaridis K, Gardikiotis A. Apical hypertrophic
cardiomyopathy associated with multiple coronary artery-left ventricular fistulae. A report of a case
and review of the literature. Eur J Echocrdiography 2010; 11: E9.
32. Apostolakis S, Lip GYH, Lane DA, Shantsila E. The quest for new anticoagulants: From clinical
development to clinical practice. Cardiovasc Ther 2010 [Epub ahead of print].
33. Apostolakis S, Amanatidou V, Spandidos DA. Therapeutic implications of chemokinemediated
pathways in atherosclerosis: realistic perspectives and utopias. Acta Pharmacol Sin 2010;
31: 1103-10.
34. Tsarouhas K, Soufla G, Apostolakis S, Zaravinos A, Panagiotou M, Khoury M, Hassoulas JA,
Tsatsakis AM, Spandidos DA. Transcriptional regulation of TIMPs in ascending aorta aneurysms.
Thromb Res. 2010 [Epub ahead of print]
35. Tsapaki A, Zaravinos A, Apostolakis S, Voudris K, Vogiatzi K, Kochiadakis GE, Spandidos DA.
Genetic variability of the distal promoter of the ST2 gene is associated with angiographic severity of
coronary artery disease. J Thromb Thrombolysis. 2010; 30: 365-71.
36. Zaravinos A, Tzoras S, Apostolakis S, Lazaridis K, Spandidos DA. Levosimendan reduces plasma cell
free DNA levels in patients with ischemic cardiomyopathy. J Thromb Thrombolysis 2010 accepted.
11

Curricu
lum
Vitae
OTHER SCIENTIFIC ACTIVITIES
Member of the organizing committee of the annual World Congress
on Advances in Oncology and the anual International Symposium on
Molecular Medicine since 2004.
Invited reviewer of the International Journal of Cardiology, the
International Journal of Molecular Medicine, the American Journal of
Hypertension and the Thrombosis Research Journal.
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