The New Genetics: Paradigm Shifts in Prenatal Diagnosis
The New Genetics: Paradigm Shifts in Prenatal Diagnosis
The New Genetics: Paradigm Shifts in Prenatal Diagnosis
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• 25 tw<strong>in</strong> pregnancies<br />
• 17 normal pairs<br />
• 5 with Down syndrome <strong>in</strong> one fetus of tw<strong>in</strong> pair<br />
• 2 with Down syndrome <strong>in</strong> both fetuses of tw<strong>in</strong> pair<br />
• 1 with trisomy 13 <strong>in</strong> one fetus of tw<strong>in</strong> pair<br />
• All pregnancies were correctly classified<br />
• 25/25 confidence <strong>in</strong>terval [59-100]<br />
• Two triplet pregnancies studied<br />
• Unaffected; correctly classified<br />
• Authors note tw<strong>in</strong> pregnancies have higher placental mass<br />
and therefore might have higher fetal fraction and thus better<br />
separation of affected and unaffected fetuses despite the<br />
presence of multiples.
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