The New Genetics: Paradigm Shifts in Prenatal Diagnosis
The New Genetics: Paradigm Shifts in Prenatal Diagnosis
The New Genetics: Paradigm Shifts in Prenatal Diagnosis
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
DANSR + FORTE<br />
• DANSR- Digital Analysis of Selected Regions<br />
• Chromosome selective approach: selectively evaluates specific<br />
genomic fragments from cfDNA<br />
• Determ<strong>in</strong>es fraction of fetal cfDNA <strong>in</strong> maternal plasma as well as the<br />
chromosome proportion by assay<strong>in</strong>g polymorphic and<br />
nonpolymorphic loci<br />
• FORTE- Fetal-fraction Optimized Risk of Trisomy Evaluation<br />
• Algorithm that takes <strong>in</strong>to account additional data: prior risk (based<br />
on maternal age and gestational age) as well as fetal fraction<br />
• Enables determ<strong>in</strong>ation of chromosome proportion and fetal fraction<br />
at same time<br />
• Requires less DNA sequenc<strong>in</strong>g and can analyze ~750 patient<br />
samples per run<br />
• Technique currently used by Ariosa
Change language