Download the press release in PDF format - Aptar
Download the press release in PDF format - Aptar
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PRESCRIPTION DIVISION<br />
PRESS RELEASE - PRESS RELEASE - PRESS RELEASE - PRESS RELEASE - PRESS RELEASE - PRESS RELEASE - PRESS RELEASE<br />
APTAR PHARMA’S ORO-MUCOSAL SPRAY DEVICE CHOSEN FOR SPASTICITY IN<br />
MULTIPLE SCLEROSIS MANAGEMENT<br />
Sativex ® Oromucosal Spray, which uses an <strong>Aptar</strong> Pharma spray pump, is <strong>the</strong> first<br />
approved cannabis-based prescription medic<strong>in</strong>e to be launched <strong>in</strong> Germany <strong>in</strong> <strong>the</strong><br />
field of spasticity <strong>in</strong> multiple sclerosis management.<br />
Louveciennes, France – December 15 th , 2011 – World leader <strong>in</strong><br />
nasal and pulmonary drug delivery devices, <strong>Aptar</strong> Pharma worked<br />
closely with GW Pharmaceuticals to develop <strong>the</strong> mouth spray<br />
device which allows Sativex ® (Delta-9-Tetrahydrocannab<strong>in</strong>ol (THC)<br />
and Cannabidiol (CBD), a cannab<strong>in</strong>oid medic<strong>in</strong>e, to be delivered to<br />
multiple sclerosis (MS) patients suffer<strong>in</strong>g from muscle spasticity.<br />
The adm<strong>in</strong>istration of Sativex ® by oromucosal spray (sprayed <strong>in</strong>to <strong>the</strong> mouth<br />
ei<strong>the</strong>r onto <strong>the</strong> <strong>in</strong>side of <strong>the</strong> cheek or under <strong>the</strong> tongue) provides patients with<br />
a flexible dos<strong>in</strong>g regime, particularly appropriate given <strong>the</strong> variable nature of<br />
both spasticity and multiple sclerosis from patient to patient.<br />
Sativex ® approved <strong>in</strong> Germany & Denmark and soon <strong>in</strong> more EU countries<br />
Sativex ® has recently been approved <strong>in</strong> Germany & Denmark for <strong>the</strong> relief of spasticity associated with<br />
MS. These new market launches follow successful completion <strong>in</strong> March 2011 of <strong>the</strong> European Mutual<br />
Recognition Procedure (MRP) with all six member states <strong>in</strong>volved recommend<strong>in</strong>g approval. Market<br />
launches <strong>in</strong> additional EU countries such as Sweden and Italy are expected <strong>in</strong> <strong>the</strong> months to come.<br />
Sativex ® has also been launched <strong>in</strong> <strong>the</strong> UK, Spa<strong>in</strong> and Canada.<br />
Sativex ® is marketed <strong>in</strong> Europe (exclud<strong>in</strong>g <strong>the</strong> UK) by Almirall S.A. The medic<strong>in</strong>e is marketed <strong>in</strong> <strong>the</strong> UK<br />
and Canada by Bayer Healthcare AG.<br />
A new step forward <strong>in</strong> systemic drug delivery via <strong>the</strong> oro-mucosal route<br />
Estimated at over 2 billion US dollars <strong>in</strong> 2009, <strong>the</strong> world market for nasally/buccally adm<strong>in</strong>istered<br />
systemic drugs has seen strong growth <strong>in</strong> <strong>the</strong> last few years. Systemic nasal sprays <strong>in</strong>clude such<br />
products as Miacalc<strong>in</strong> ® (Calciton<strong>in</strong>) for osteoporosis; Stimate ® and M<strong>in</strong>ir<strong>in</strong> ® (Desmo<strong>press</strong><strong>in</strong>e) for<br />
enuresis; Imitrex ® (Sumatriptan Succ<strong>in</strong>ate) and Zomig ® (Zolmitriptan) for migra<strong>in</strong>e attacks; non-opioid<br />
Sprix ® for post operative pa<strong>in</strong>, and opioid-like Instanyl ® and PecFent ® /Lanzada ® (Fentanyl) for cancer<br />
breakthrough pa<strong>in</strong>. With Sativex ® GW Pharmaceuticals has developed a first-<strong>in</strong>-class treatment for <strong>the</strong><br />
relief of spasticity <strong>in</strong> multiple sclerosis.<br />
Systemic drug delivery via <strong>the</strong> oro-mucusal route has a number of advantages due to fast onset of<br />
action and reduced <strong>the</strong>rapeutic dose as a result of high bioavailability for well formulated selected<br />
compounds. After be<strong>in</strong>g sprayed <strong>in</strong>to <strong>the</strong> buccal cavity and absorbed by <strong>the</strong> mucosa, <strong>the</strong> medication<br />
enters <strong>the</strong> vascular system directly, allow<strong>in</strong>g <strong>the</strong> active <strong>in</strong>gredients to take effect rapidly while m<strong>in</strong>imiz<strong>in</strong>g<br />
<strong>in</strong>tolerable unwanted side effects.<br />
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PRESCRIPTION DIVISION<br />
PRESS RELEASE - PRESS RELEASE - PRESS RELEASE - PRESS RELEASE - PRESS RELEASE - PRESS RELEASE - PRESS RELEASE<br />
The VP7 spray pump – mak<strong>in</strong>g drug delivery easier and safer while improv<strong>in</strong>g patient comfort<br />
<strong>Aptar</strong> Pharma’s high-performance VP7 spray pump is widely used <strong>in</strong> drug delivery for both systemic<br />
and local treatment via <strong>the</strong> nasal and <strong>the</strong> buccal routes. For Sativex ® , GW Pharmaceuticals selected<br />
<strong>the</strong> VP7 spray pump fitted with a specific buccal actuator of ergonomic design that is comfortable to<br />
use by <strong>the</strong> patient. The VP7 platform is recognized globally for its comfort of use by patients as well as<br />
for its robustness coupled with outstand<strong>in</strong>g dose accuracy and spray performance.<br />
“GW Pharmaceuticals is a key client for <strong>Aptar</strong> Pharma, and we are proud that our collaboration<br />
has now led to <strong>the</strong> launch of <strong>the</strong>ir important new medic<strong>in</strong>e for patients suffer<strong>in</strong>g from multiple<br />
sclerosis.” said Pierre Carlotti, Vice President Market<strong>in</strong>g and Communication for <strong>Aptar</strong> Pharma<br />
Prescription Division.<br />
Sativex ® is a registered trademark of GW Pharmaceuticals.<br />
For more <strong>in</strong><strong>format</strong>ion about Sativex ® , visit http://www.gwpharm.com/Sativex.aspx<br />
Sativex ® is <strong>in</strong>dicated as treatment for symptom improvement <strong>in</strong> patients with moderate to severe<br />
spasticity due to multiple sclerosis (MS) who have not responded adequately to o<strong>the</strong>r anti-spasticity<br />
medication and who demonstrate cl<strong>in</strong>ically significant improvement <strong>in</strong> spasticity related symptoms<br />
dur<strong>in</strong>g an <strong>in</strong>itial trial of <strong>the</strong>rapy.<br />
About <strong>Aptar</strong> Pharma<br />
<strong>Aptar</strong> Pharma is part of <strong>the</strong> <strong>Aptar</strong>group family of companies, along with <strong>Aptar</strong> Beauty + Home and <strong>Aptar</strong> Food + Beverage. We create<br />
<strong>in</strong>novative drug delivery systems that meet <strong>the</strong> evolv<strong>in</strong>g needs of biotechnology, healthcare and pharmaceutical companies around <strong>the</strong><br />
world. We provide our customers with a wide range of delivery technologies and analytical services backed by years of proven expertise.<br />
<strong>Aptar</strong>group (NYSE: ATR) is headquartered <strong>in</strong> <strong>the</strong> US and has manufactur<strong>in</strong>g sites <strong>in</strong> North America, Europe, Asia and South America.<br />
For more <strong>in</strong><strong>format</strong>ion, visit http://www.aptar.com/pharma<br />
Press Contacts<br />
Elisa Eschylle, Events and Press relations manager<br />
Tel.: +33 (0)1 39 17 20 41 - Email : elisa.eschylle@aptar.com<br />
Marion Baschet Vernet , Press attaché<br />
Tel.: +44 (0)797 609 41 00 - Email : mbvernet@gmail.com<br />
Deliver<strong>in</strong>g solutions, shap<strong>in</strong>g <strong>the</strong> future.<br />
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