Acute ischemic stroke treatment in a nutshell
Acute ischemic stroke treatment in a nutshell
Acute ischemic stroke treatment in a nutshell
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Which antiplatelet better-Comb<strong>in</strong>ations<br />
• Aspir<strong>in</strong> and dipyrimadole better than aspir<strong>in</strong> post-<strong>stroke</strong> (ESPS II,<br />
ESPRIT)<br />
- NNT 104 per year for vascular death, MI, <strong>ischemic</strong> <strong>stroke</strong>, major<br />
bleed<br />
• Aspir<strong>in</strong> and Clopidogrel higher risk than clopidogrel post-<strong>stroke</strong><br />
(MATCH)<br />
– Similar rates for <strong>ischemic</strong> <strong>stroke</strong>/ MI<br />
– Higher rates for ICH/ ,major bleed<strong>in</strong>g<br />
– Not advised for <strong>ischemic</strong> <strong>stroke</strong> <strong>in</strong>dication<br />
– Special situations eg. post coronary <strong>in</strong>tervention<br />
- Aspir<strong>in</strong> + dipyridamole vs clopidogrel post-<strong>stroke</strong> (PROFESS)<br />
- Not superior<br />
- Cannot say if <strong>in</strong>ferior or not