Sergey V. RAZIN CURRICULUM VITAE Personnel données Nom ...

Sergey V. RAZIN
CURRICULUM VITAE
Personnel données
Nom RAZIN
Prénom Sergey V.
Date et lieu de naissance 02.16.54 , Moscou, Russie
Nationalité Russe
Qualité de citoyen citoyen de Russie
Situation familiale marié, a une fille (1982)
Posts actuels
Directeur de laboratoire à l'Institut de Biologie de Gène à l'Académie
des Sciences de Russie
Affiliations Professeur, Membre Academia Europaea - Membre Corr.
Académie Russe des Sciences.
Honneurs 1997 Koltsov prime de l'Académie des Sciences de Russie pour le
meilleur cycle des publications sur génétique moléculaire y compris le livre
"The nuclear matrix and spatial organization of chromosomal DNA domains"
(R.G. Landes Company/Springer Verlag, 1997). 2000 Chaire Internationale de
Recherche Blaise Pascal de l'Etat et de la Region d'Ile-de-France.
Éducation et diplômes
1971-1976 étudiant de l' université à Moscou, Diplôme d'excellence des
études en biologie moléculaire et biochimie.
1979 - Degré du Candidat des Sciences Biologiques (équivalent au
PhD), attribue par l'Institut de Biologie Moléculaire (Académie des Sciences
de Russie). Thèse "Caractéristiques de l'ADN attaché a la matrice nucléaire".
Directeur de thèse: Académicien Georgii P. Georgiev.
1987 - Degré du docteur des Sciences Biologiques (Habilitation à
diriger des équipes et Thèse) attribué par l'Institut de Biologie Moléculaire
(Académie des Sciences de Russie).
Postes Académiques
77-78 Stagiaire à l'Institut de Biologie Moléculaire (Académie des
Sciences de Russie)
78-86 Chercheur à l'Institut de Biologie Moléculaire (Académie des
Sciences de Russie)
86-90 Senior Chercheur à l'Institut de Biologie Moléculaire (Académie
des Sciences de Russie)
Depuis 1990 Directeur de laboratoire à l'Institut de Biologie du Gène
(Académie des Sciences de Russie)

Stages et Recherche à l'Étranger
Institut J. Monod (Paris, France) 1983 6 mois
Chercheur invité 1989 6 mois
1992 3 mois
1997 10 mois
1998 8 mois
1999 10 mois
2000 9 mois
2001 10 mois
Centre des Recherches sur 1990 3 mois
le cancer de l'Université Laval, 1992 6 mois
(Québec, Canada)
Professeur Invité
Université d' Åarhus (Åarhus, 1993- 6 mois
Danemark) Professeur Invité 1994
Centre Internationale de Génie 1995- 16 mois
Génétiques et Biotechnologie 1996
(Trieste, Italie) Directeur de
laboratoire
Nombre des articles publié 145
Expérience en enseignement
1982-1997 Directeur de thèse de V.V. Chernokhvostov (reçu PhD en
1985), O.V. Iarovaia (reçu PhD en 1985), M.G. Kekelidze (reçu PhD en 1986),
Y.S.Vassetzky (reçu PhD en 1989), A.G. Kalandadze (reçu PhD en 1990),
E.G.Kintsurashvili (reçu PhD en 1991), M.A.Lagarkova (reçu PhD en 1995),
E.Yu. Svetlova (reçu PhD en 1996), L.V. Verbovaia (reçu PhD en 1996)

1
S.V. RAZIN
List of publications
1. Razin S.V., Mantieva V.L. and Georgiev G.P.1978. DNA adjacent to the
attachment points of DNP fibril to chromosomal axial structure is
enriched in reiterated base sequences. Nucl. Acids Res. 5:4737-4751.
2. Mantieva V.L., Razin S.V., Georgiev G.P.1979 .Isolation of DNA fraction
adjacent to the metaphase chromosome scaffold and study of its
renatureation parameters. Molecularnaya Biologiya SSSR 13:1360-
1363 (in Russian)
3. Razin S.V., Mantieva V.L., and Georgiev G.P. 1979. The similarity of DNA
sequences remaining bound to scaffold upon nuclease treatment of
interphase nuclei and metaphase chromosomes. Nucl. Acids Res.
7:1713-1735.
4. Razin S.V., Mantieva V.L., Georgiev G.P. 1980. Isolation and
characterization of DNA fraction adjacent to the interphase nuclei and
metaphase chromosome scaffold. Molecularnaya Biologiya SSSR
14:223-233 (in Russian).
5. Kulguskin V.V., Razin S.V. 1980. A family of double-stranded RNA in
cultured D.melanogaster cell nuclei. Dokl Akad Nauk SSSR 252:1505-
1506 (in Russian).
6. Georgiev G.P., Bakayev V.V., Nedospasov S.A., Razin S.V., and Mantieva
V.L. 1981. Studies on structure and function of chromatin. Mol. Cell.
Biochem. 40:29-48.
7. Razin S.V., Chernokhvostov V.V., Roodin A.V., Zbarsky I.B., and
Georgiev G.P. 1981. Proteins tightly bound to DNA in the regions of
DNA attachment to the skeletal structures of interphase nuclei and
metaphase chromosomes. Cell. 27:65-73.
8. Razin S.V, Chernokhvostov V.V., Roodin A.V., Zbarsky I.B., Georgiev
G.P. 1982. Proteins tigtly bound to DNA in the sites of its attachment to
the nuclear matrix of interphase nuclei. Dokl Akad Nauk SSSR
263:1019-1021 (in Russian).
9. Yarovaya O.V., Razin S.V. 1983. Two types of DNA attachment to the
nuclear matrix in Erlich ascite carcinoma cells. Molecularnaya
Biologiya SSSR 17:303-312 (in Russian).
10. Yarovaya O.V., Gorelova T.V., Shuppe N.G., Razin S.V. 1985. A pattern
of heat shock gene DNA attachment to to the nuclear matrix does not
depend on their functional state. Genetika (SSSR) 21:896-901 (in
Russian).
11. Razin S.V., Rzheshovska-Wolni I., Moreau J., and Scherrer K. 1985.
Localization of DNA attacment site to the nuclear matrix within the
domain of chicken a-globin genes in functionally actve and inactive
nuclei. Moleklarnaya Biologia USSR. 19:456-466 (in Russian).
12. Razin S.V., Yarovaya O.V., Georgiev G.P.1985. Endoogenous DNAassociated
RNA polymerase II is concentrated in nuclear skeleton-bound
DNA fraction and retains the ability to elongate chain in the nuclear
matrix preparations. Dokl Akad Nauk SSSR 281:220-223 (in Russian).

13. Razin S.V., Chernokhvostov V.V., Yarovaya O.V., and Georgiev G.P.
1985. Organization of the sites for DNA attachment to the nonhistone
proteinaceous nuclear skeleton. in "Progress in nonhistone protein
research" v.2:91-114 (I.Bekhor ed., CRC Press).
14. Razin S.V., Yarovaya O.V. 1985. Initiated complexes of RNA polymerase
II are concentrated in the nuclear skeleton associated DNA. Exp. Cell
Res. 158:273-275.
15. Razin S.V., Yarovaya O.V., and Georgiev G.P. 1985. Low ionic strength
extraction of nuclease-treated nuclei destroys the attachment of
transcriptionally active DNA to the nuclear skeleton. Nucl. Acids Res.
13:7427-7444.
16. Razin S.V., Kekelidze M.G., Lukanidin E.M., Scherrer K., and Georgiev
G.P. 1986. Replication origins are attached to the nuclear skeleton. Nucl.
Acids Res. 14:8189-8207.
17. Broders F., Razin S., Farache G., Moreau J., and Scherrer K. 1986.
Correlations of repetitive and AT-rich fragments within the chicken
globin gene domain. Mol.Biol.Rep. 11:177-187.
18. Razin S.V., Kekelidze M.G., Lukanidin E.M. 1986. Spatial organization of
replicons in eukaryotic nuclei. Attachment of replication origins to the
nuclear skeleton. Molecularnaya Biologiya SSSR 20:382-391. (in
Russian).
19. Kekelidze M.G., Lukanidin E.M., Razin S.V. 1986. The preparation of
short DNA chains synthesized in vivo after trioxalen treatment of cells is
not enriched in replication origins. Molecularnaya Biologiya SSSR
20:371-381. (in Russian).
20. Razin S.V., Yarovaya O.V. 1986. Association of transcriptionally active
DNA fraction with the nuclear matrix is destroyed after inccubation of
nuclei in low salt buffers. Molecularnaya Biologiya SSSR 20:646-655
(in Russian).
21. Chernokhvostov V.V., Stelmaschuk V.Ya., Razin S.V. 1986. Content,
composition and properties of some DNA-protein complexes in the sites
of attachment of DNA loops to the nuclear skeleton. Molecularnaya
Biologiya SSSR 20:1579-1588. (in Russian) .
22. Chernokhvostov V.V., Cherni N.E., Moskvin-Tarkhanov M.I., Razin S.V.
1986. Isolation and fractionation of the nuclear matrix from cultured
cells. Tsitologiya 28:843-847. (in Russian).
23. Razin S.V., Bandt D., Razina M.V., Chernokhvostov V.V. 1987. The
tightly bound to DNA proteins mediate association of the
transcriptionally active DNA with nuclear skeleton Molecularnaya
Biologiya SSSR 21:1276-1285. (in Russian).
24. Razin S.V. 1987. DNA interaction with the nuclear matrix and spatial
organisation of replication and transcription. BioEssays 6:19-23.
25. Razin S.V., V.V.Chernokhvostov, E.S.Vassetzky Jr., M.V.Razina, and
G.P.Georgiev. 1988. The distribution of tightly bound proteins along the
DNA chain reflects the pattern of cell differentiation. Nucl.Acids Res.
16:3617-3634.
2

26. Rzeszowska-Wolny J., Razin S.V., Puvion E., Moreau J., Scherrer K.
1988. Isolation and Characterization of stable nuclear matrix
preparations and associated DNA from avian erythroblasts. Biol. Cell.
64:13-22.
27. Vassetzky Jr. Y.S., Razin S.V., Georgiev G.P. 1988 DNA fragments,
which specifically bind to isolated nuclar matrix in vitro, interact with
the matrix-associated DNA topoisomerase II. Dokl Akad Nauk SSSR
300:999-1001. (in Russian).
28. Kalandaze A.G., Razin S.V., Georgiev G.P. 1988. Cloning and analysis of
DNA fragments, permanently attached to the nuclear matrix. Dokl Akad
Nauk SSSR 300:1001-1005. (in Russian).
29. V.V.Chernokvostov, I.B.Bronstein, A.V.Timofeev, S.V.Razin. 1988
Immunochemical analysis of protease-resistant DNA-protein complexes:
comparison of antigenic structure of the nuclear matrix proteins and
DNA topoisomerase I. Dokl Akad Nauk SSSR 304:1013-1014. (in
Russian).
30. Vassetzky Jr. Y.S., Razin S.V., and Georgiev G.P .1989. DNA fragments
which specifically bind to isolated nuclear matrix in vitro interact with
matrix-assocoated DNA topoisomerase II. Biochem. Biophys. Res.
Commun. 159:1263-1268.
31. Chernokhvostov V.V., Stelmashchuk V.Ya., Razin S.V. Georgiev G.P.
1989. DNA-protein complexes of the nuclear matrix:visualization and
partial characterization of the protein component. Biochem. Biophys.
Res. Commun. 162:175-183.
32. Gromova I.I., Bronstein I.B., Timopheev A.V., Razin S.V., Kalandadze
A.G., Kaphiani K.A. 1989. Specific cleavage of alpha A - globin gene by
molecular forms of calf thymus topoisomerase I. Biochimia 54:640-650.
(in Russian).
33. Vassetzky Y.S., Kalandadze A.G., Razin S.V. and Georgiev G.P. 1989.
Topoisomerase I cleavage site is located in regulatory domain of SV-40
genome in vicinity to the DNaseI hypersensi tive site and topoisomerase
II cleavage site. Doclady AN SSSR v. 306 (in Russian)
34. Kalandadze A.G., Bushara S.A., Vassetzky Y.S. and Razin S.V. 1989.
Characterization of DNA sequences in the regions of permanent
attachment of DNA to the nuclear matrices which colocalize with
replication origins. Moleculiarnaya Biologia 23:1309-1320. (in
Russian).
35. Farache G., Razin S.V., Recillas Targa F. and Scherrer K.1990.
Organization of the 3'-bondary of the chicken a-globin gene domain and
characterization of a CR1 - specific protein binding site. Nucl. Acids
Res. v.18 p. 401-409.
36. Razin S.V., Vassetskii Y.S., Georgiev G.P. 1990. Replication origins of
higher eukaryotes - a minireview. J. Biomedical Sci. 1: 18 - 22.
37. Kalandadze A.G., Bushara S.A., Vassetzky Jr. Y.S., and Razin S.V..1990.
Characterization of DNA pattern in the site of permanent attachment to
the nuclear matrix located in the vicinity of replication origin. Biochem.
Biophys. Res. Commun. 168: 9-15.
3

38. Vassetzky Y.S., Bakayev V.V., Kalandadze A.G., Razin S.V. 1990.
Topoisomerase I is associated with the regulatory region of
transcriptionally active SV 40 minichromosomes. Mol. Cell. Biochem.
95(2):95 - 106.
39. Farache G., Razin S.V., Rzeszowska-Wolny J., Moreau J., Recillas Targa
F., and Scherrer K. 1990. Mapping of structural and transcription-related
matrix attachment sites in the a-globin gene domain of avian
erythroblasts and erythrocytes. Mol.Cell Biol. 10(10): 5349 - 5358.
40. Razin S.V., Kalandadze A.G., Kintsurashvili E.G. and Vassetzky Y.S.
1990. Characterization of DNA pattern in the vicinity of a replication
origin located upstream from the domain of chicken a-globin genes.
"Nuclear structure and function", Edited by J.R.Harris and
I.B.Zbarsky, Plenum Press, New York. p.377-382 .
41. Vassetzky Y.S., Kalandadze A.G., Kintsurashvili E.G., Turpaev K.T.,
Grinenko N.F., Alstein A.D., and Razin S.V. 1990. A fragment of
chicken nuclear matrix-associated DNA can maintain autonomous
replication of plasmids in mammalian cells. "Nuclear structure and
function", Edited by J.R.Harris and I.B.Zbarsky, Plenum Press, New
York. p.345-350.
42. Vassetzky Jr. Y.S., Kvartskhava A.I., Grinenko N.F. and Razin S.V.1990.
A replication origin located within the upstream area of the domain of
chicken alpha-globin gene colocalize with a transcriptional enhancer.
Doclady Academii Nauk SSSR. 313:485-487 (in Russian).
43. Kintsurashvili E.G., Adler V.V., Klenova E.M., Lobanenkov V.V. and
Razin S.V. 1990. Multiple recognition sites for the sequence-specific
DNA-binding proteins in vicinity of DNA replication origin located in
the upstream area of chicken domain of alpha-globin genes. Doclady
Academii Nauk SSSR 310:227-228 (in Russian).
44. Razin S.V., Vassetzky Jr. Y.S., Kvartskhava A.I., Grinenko N.F., Georgiev
G.P. 1991 Transcriptional enhancer in the vicinity of a replication origin
within the 5'-region of the chicken a-globin gene domain. J. Mol. Biol.
217: 595-598.
45. Bronstein I.B., Gromova I.I., and Razin S.V. 1991. Specific cleavage of
chicken aA-globin and human c-Ha-ras genes by two molecular forms of
calf thymus tipoisomerase I. Mol.Cell.Biochem. 101: 115-124.
46. Razin S.V., Vassetzky Y.S., and Hancock R. 1991. Nuclear matrix
attachment region and topoisomerase II binding and reaction sites in the
vicinity of a chicken DNA replication origin.
Biochem.Biophys.Res.Commun. 177: 265 - 270.
47. Razin S.V., Petrov P. and Hancock R. 1991. Precise localisation of the a-
globin gene claster within one of the 20 to 300 kb DNA fragments
released by cleavage of chicken chromosomal DNA at topoisomerase II
sites in vivo: evidence that the fragments are DNA loops or domains.
Proc. Natl. Acad.Sci. USA. v.88 p. 8515-8519.
48. De Moura-Gallo C.V., Vassetzky Y.S., Recillas Targa F., Georgiev G.P.,
Scherrer K. and Razin S.V. 1991. The presence of sequence-specific
protein binding sites correlate with replication activity and matrix
4

inding in a 1.7 Kb-long DNA fragment of the chicken a-globin gene
domain. Biochem. Biophys. Res. Commun. v.179, p.512-519.
49. Georgiev G.P., Vassetzky Y.S., Luchnik A.N., Chernokhvostov V.V., and
Razin S.V. 1991. Nuclear skeleton, DNA domains and control of
replication and transcription. Eur. J. Biochem. v.200, p.613-624.
50. Kintsurashvili E.G., Vassetzky Y.S., Razin S.V. Nuclear matrix binding
sites in vicinity of chicken a-globin gene domain replication origin. Dokl
Akad Nauk SSSR v.318, p.1000-1002. (in Russian).
51. Krajewski W.A. and Razin S.V. 1992. Organization of specific DNA
sequence elements in the region of replication origin and matrix
attachment site of the chicken alpha-globin gene domain.
Mol.Gen.Genet. v.235, p.381-388.
52. Razin S.V., Vassetzky Y.S. 1992. Domain organization of eukaryotic
genome. Cell Biol. Int. Rep. v. 16, p. 697-708.
53. Krajewski W.A. Kvartskhava A.I., Mikhailov V.S. Razin S.V. 1992. Bent
DNA in the vicinity of chicken alpha-globin gene domain replication
origin. Dokl Akad Nauk v.322, p.780-782 (in Russian).
54. Vassetzky Y.S., Kintsurashvili E.G., Bogdanova A.N., Grinenko N.F.,
Razin S.V. 1992. Analysis of a replication potential of the DNA
fragment permanently attached to the nuclear matrix Dokl AN v.327,
p.272-275 (in Russian).
55. Vassetzky Y.S., Bogdanova A.N., Razin S.V. 1992. DNA-binding domains
in the nuclear matrix are heterogeneous. Dokl AN v.327, p.165-168. (in
Russian).
56. Krajewski W.A., Mikhailov V.S., Razin S.V. 1992. Bent DNA and lowmelting
DNA sequences in the region of replication origin of the chicken
a-globin gene domain. Molekuliarnaya Biologia v.26, p.1011-1021. (in
Russian).
57. Krajewski W.A., Mikhailov V.S., Razin S.V. 1992. Spatial organization
and conformational mobility of DNA within the nucleoprotein
complexes. Moleculiarnaya Biologia. v.26, p.745-756. (in Russian).
58. Krajewski W.A., Krylov D.Yu., Razin S.V., Mikhailov V.S. 1992.
Conformational flexibility of DNA is restricted in transcriptionally
active nucleosomes. Dokl Akad Nauk v.326, p.380-383 (in Russian).
69. Vassetzky Y.S., De Moura Gallo C.V., Bogdanova A.N., Razin S.V. and
Scherrer K. 1993. The sequence-specific nuclear matrix-binding factor
F6 is a chicken GATA-like protein. Mol.Gen.Genet. v. 238, p.309-314.
60. Krajewski W.A., Panin V.M., Krylov D.Yu. and Razin S.V. 1993.
Flexibility of DNA within transcriptionally active nucleosomes: Analysis
by circular dichroism measurements. J. Biomol. Structure and
Dynamics. v.10, p. 1001-1011.
61. Krajewski W.A., Panin V.M. and Razin S.V. 1993. Dynamics of unfolded
nucleosomal fiber. J. Biomol. Structure and Dynamics. v.10, p.1013-
1022.
62. Lagarkova M.A., Razin S.V. 1993. Topoisomerase II-mediated in vivo
cleavage of genome into structural domains. Dokl Akad Nauk v.330,
p.383-385 (in Russian).
5

63. Vassetsky Y.S., Razin S.V. 1993. Cells of higher eukaryotes contain
protein binding to yeast ARS element. Dokl Akad Nauk v.330, p.111-
112 (in Russian).
64. Iarovaia O.V., Razin S.V., Hancock R. 1993. Domain organization of
mammalian ribosomal genes cluster Dokl Akad Nauk v.330, p.120-122
(in Russian).
65. Krajewski W.A., Panin V.M., and Razin S.V. 1993. A simple and
reproducible method for analysis of chromatin condensa tion. Biochem.
Biophys. Res. Commun. v. 193, p. 113-118.
66. Krajewski W.A., Krylov D.Yu, Razin S.V., Mihailov V.S. 1993. Analysis
of conformational flexibility of DNA in transcriptionally-active
chromatin. Biofizika (in Russian) v.38, p.108-116.
67. Krajewski W.A., Panin V.M., and Razin S.V. 1993. Acetilation of core
histones causes the unfolding of 30 nm chromatin fiber: analysis by
agarose gel-electrophoresis. Biochem. Biophys. Res. Commun. v. 196,
p.455-460.
68. Krajewski W.A. and Razin S.V. 1993. DNA-protein interactions and
spatial organization of DNA. Mol.Biol.Reports v. 18, p. 167 - 175.
69. Krajewski W.A., Panin V.M., Razin S.V. 1994. Analysis of chromatin
decondensation by means of gelelectrophoresis in low-density agarose.
Moleculiarnaia Biologia (in Russian) v. 28, p. 76 - 81.
70. Razin S.V. 1994. Mapping of DNase I - hypersensitive sites in the
upstream region of the chicken a-globin genes domain. Genetica (Rus)
v. 30, p. 33-36.
71. Yarovaia O.V., Razin S.V. and Hancock R. 1994. Nuclear matrix
topoisomerase II digests genome DNA at junctions of topological
domains. Genetica (Rus) v. 30, p. 25 - 32.
72. Recillas Targa F., Razin S.V., De Moura-Gallo C.V. and Scherrer K.
1994. Excision close to matrix attachment regions of the whole domain
of the chicken a-globin genes by nuclease S1 and characterization of the
framing structures. Proc. Natl. Acad. Sci. USA v.91, p. 4422-4426.
73. Razin S.V., De Moura-Gallo C.V. and Scherrer K. 1994. Characterization
of the chromatin structure in the upstream area of the chicken a-globin
genes domain. Mol. Gen. Genet. v. 242, p. 649 - 652.
74. Razin S.V., Hancock R., Iarovaia O.V., Westergaard O., Gromova I.I., and
Georgiev G.P. 1993 Structural-functional organization of chromosomal
DNA domains. Proceedings of the Cold Spring Harbor Symposia on
Quantitative Biology N58, p.25-35.
75. Verbovaia L.V., Surjik, V.V., Svetlova E. Yu., Razin S.V. 1994. Map ping
of replication origin in the chicken a-globin gene domain by analysis of
the leading DNA strands polarity. Dokl Akad Nauk (in Russian) v. 336,
p. 403-405.
76. Gol'dman I.L., Razin S.V., Ernst L.K., Kadulin S.G., Grashchuk M.A.
1994. Molecular biology aspects of the position-independent expression
of foreign genes in transgenic animals cells. Biotekhnologia (in
Russian) N. 2, p. 3-8.
6

77. Kraevskii V.A., Panin V.M., Razin S.V. 1994. Increase in the degree of
histone acetylation in the nucleosome core leads to unfolding of 30 nm
nucleosome fibril. Dokl Akad Nauk v.334, p.109-111 (in Russian).
78. Iarovaia O.V., Razin S.V., Hancock, R. 1994. Analysis of the character of
large-scale fragmentation of Drosophila melanogaster DNA by
topoisomerase II in vivo. Dokl Akad Nauk v. 335, p. 653-655 (in
Russian).
79. Kraevskii V. A., Panin V.M., Razin S.V. 1994. Acetilation of histones in
vitro causes chromatin decompactization. Biofizica (in Russian) v. 39, p.
613-618.
80. Kraevskii V. A., Panin V.M., Razin S.V. 1994. Dependence of the
chromatin condensation process on the temperature and ionic strength of
the media: investigation using gel electrophoresis in low density agarose.
Biofizica (in Russian) v. 39, p. 619-627.
81. Iarovaia O.V., Lagarkova M.A., and Razin S.V. 1995. The specificity of
human lymphocyte nucleolar DNA long-range fragmentation by
endogenous topoisomerase II and exogenous Bal 31 nuclease depends on
cell proliferation status. Biochemistry v.43, p. 4133-4138.
82. Gromova I.I., Thomsen B., and Razin S.V. 1995. Different topoisomerase
II antitumor drugs direct similar specific long-range fragmentation of an
amplified c-myc gene locus in living cells and in high-salt extracted
nuclei. Proc. Natl. Acad. Sci. USA v. 92, p. 102-106.
83. Razin S.V., Gromova I.I., Iarovaia O.V. 1995. Specificity and functional
significance of DNA interaction with the nuclear matrix: New
approaches to clarify the old questions. International Review of
Cytology v.162B, chapter 10. p. 405-448.
84. Lagarkova M.A., Iarovaia O.V., Razin S.V. (1995) Excision of
chromosomal DNA loops by pretreatment of permeabilised cells with
Bal 31 nuclease . Mol. Gen. Genet. 249, 253-256.
85. Razin S.V., Iarovaia O.V., Lagarkova M.A., Gromova I.I. and Hancock R.
1995. Functional architecture of chromosomal DNA domains. J. Cell.
Biochem. Suppl. 21B, p. 120.
86. Razin S.V., Gromova I.I. 1995. The channels model of nuclear matrix
structure. BioEssays v. 17. p. 443-450.
87. Lagarkova M.A., Iarovaia O.V. and Razin S.V. 1995. The large-scale
fragmentation of mammalian DNA in the course of apoptosis proceeds
via excision of chromosomal DNA loops and their oligomers. J. Biol.
Chem. 270, 20239-20241.
88. Gromova I.I., Nielsen O.F. and Razin S.V. 1995. Long-range
fragmentation of the eukaryotic genome by exogenous and endogenous
nucleases proceeds in a specific fashion via preferential DNA cleavage
at matrix attachment sites. J. Biol. Chem. 270, 18685-18690.
89. Verbovaia, L. and Razin, S.V. 1995. Analysis of the replication direction
through the domain of a-globin-encoding genes. Gene 166, 255-259.
90. Recillas-Targa, F., Razin, S.V., DeMoura-Gallo, C.V., Marcaud, L. and
Scherrer, K. 1995. Silencer and enhancer elements in the framing
7

structures of the chicken a-globin gene domain. Hemoglobin Switching.
Intercept LTD. pp. 203-215.
91. Bogdanova A.N., Razin S.V. and Vassetzky Y.S. 1995. Nuclear matrixassociated
fragments enhance autonomous replication of plasmids in
chicken cells. Biochimie 77, 880-887.
92. Lagarkova MA, Iarovaia OV, Gnuchev NV, Razin SV. 1995. Treatment of
permeabilized cells with nuclease Bal 31 results in excision of DNA
loops from the genome. Dokl Akad Nauk v. 335, p. 690-693 (in
Russian).
93. Iarovaia O.V., Hancock, R., Lagarkova, M., Miassod, R. and Razin S.V.
1996. Mapping of genomic DNA loop organization in a 500-kilobase
region of the Drosophila X chromosome by the topoisomerase IImediated
DNA loop excision protocol. Mol. Cell. Biol.16, 302-308.
94. Razin S.V. 1996. Functional architecture of chromosomal DNA domains.
Crit. Rev. Eukar Gene Expr. 6, 247-269.
95. Iarovaia O.V., Razin S.V. 1996. Comparison of positions of matrix
attachment sites, MAR-elements and autonomously replicating
sequences in an extended region of Drosophila melanogaster X-
chromosome. Moleculiarnaia Biologia (in Russian) v. 30, p. 1184-
1192.
96. Verbovaia L.V., Razin S.V. 1996. The gene of Duchenne muscular
dystrophy is organized into several replicons. Moleculiarnaia Biologia
(in Russian) v. 30, p. 1334-1338.
97. Goldman I.L., Kadulin S.G. and Razin S.V. 1996. Transgenic agricultural
animals: expression of foreign genes. Biotechnologia (in Russian) N9,
P. 3-23.
98. Razin S.V. 1997. The nuclear matrix and spatial organization of
chromosomal DNA domains (monograph) R.G. Landes Company,
Austin, Texas, USA
99. Miassod R., Razin S.V., Hancock R. 1997. Distribution of topoisomerase
II-mediated cleavage sites and relation to structural and functional
landmarks in 830 kb of Drosophila DNA. Nucleic Acids Res. 25, 2041-
2046.
100. Gnuchev N.V., Sashchenko L.P., Iarovaia O.V., Dukhanina E.,
Lukianova T., and Razin S.V. 1997. Joint cultivation of human
erythroblastoid cells and mouse fibroblasts triggers release of a wide
spectrum of cytotoxic factors. Biochem. Biophys. Res. Commun. 234,
655-659.
101. Razin S.V. 1997. Chromosomal DNA loops and domain organization of
the eukaryotic genome. In "Genome Structure and Function, From
Chromosomes Characterization to Genes Technology" (Nicolini C.,
ed.) Kluwer Academic Publishers (Dordrecht, Boston, London) pp. 39-
56.
102. Svetlova E.Iu., Razin S.V., Filipski, J. 1997. Mapping segments of the S1
nuclease hypersensitive sites in chromosome III of Sacharomyces
cerevisiae. Dokl. Akad. Nauk (in Russian) 353, 831-833.
8

103. Svetlova E.Iu., Razin S.V., Filipski, J. 1997. Determination of segments
of yeast artificial chromosomes, hypersensitive to nuclease S1, including
a domain of human beta-globin genes. Dokl. Akad. Nauk (in Russian)
353, 562-564.
104. Verbovaia L.V, Razin S.V 1997. Mapping of replication origins and termination
sites in the duchenne muscular dystrophy gene. Genomics 45, 24-30.
105. Iudinkova ES, Lagarkova MA, Razin SV. 1997. Molecular cloning and
characterization of the 5'-terminal end of alpha-globin genes domain of chickens
including potential regulator element of domain level. Dokl. Akad. Nauk (in
Russian) 356, 407-408.
106. Lagarkova M.A., Svetlova E, Giacca M, Falaschi A. and Razin S.V. 1998.
A DNA loop anchorage region colocalizes with the replication origin
located downstream to the human gene encoding lamin B2. J. Cell.
Biochem. 69, 13-18.
107. Verbovaia L.V., Razin S.V. 1998. Replicon Map of the Human
Dystrophin Gene: Asymmetric Replicons and Putative Replication
Barriers. Gene Ther. Mol. Biol. 1, 591-598.
108. Iarovaia O.V., Razin S.V. 1998. New approaches to studying the structural and
functional organization of the eukaryotic genome. Moleculiarnaia Biologia (in
Russian) 32, 43-53.
109. Razin S.V., Ioudinkova E. Yu. 1998. Large-scale fragmentation of DNA during
apoptosis: Is the genome cleaved at borders of topological domains Izvestia
Academii Nauk, biological seria (in Russian) N2, P. 167-171.
110. Ioudinkova E., Bystritsky A., Razin S. 1998. Does the apoptotic fragmentation of
DNA starts by excision of chromosomal DNA loop domains Cellular &
Molecular Biology Letters 3, 103-109.
111. Schwartz Yu.B., Ioudinkova E.S., Demakov S.A., Razin S.V. and
Zhimulev I.F. 1999. Interbands of Drosophila melanogaster polytene
chromosomes contain matrix association regions. J. Cell. Biochem. 72,
368-372.
112. Razin S.V., Kang S., Ioudinkova, E., Scherrer, K. 1999. Functional
analysis of DNA sequences located within a cluster of DNase I
hypersensitive sites colocalizing with a MAR element at the upstream
border of the chicken a-globin gene domain. J. Cell. Biochem. 74, 38-
49.
113. Schwartz Y.B., Ioudinkova E.S., Demakov S.A., Razin S.V. and
Zhimulev I.F. 1999. DNA fragments from regions of inter-disk polytene
chromosomes of Drosophila melanogaster bind the nuclear matrix in
vitro. Moleculiarnaia Biologia (in Russian) 33, 268-272.
114. De Conto F., Razin S.V., Geraud G., Arcangeletti K., and Scherrer K.
1999. In the nucleus and cytoplasm of chicken erythroleukemic cells,
prosomes containing the p23K subunit are found in centres of globin
(pre-)mRNA processing and accumulation. Exp. Cell. Res. 250, 569-
575.
115. Iudinkova E.S., Iarovaia O.V., Sashchenko L.P., Lukianova T.I.,
Romanova E.A., Gnuchev N.V. and Razin S.V. 1999. Expression of
cytotoxic factors by cells of non-lymphoid nature is activated upon
9

physical contact of cells of various organisms. Dokl. Akad. Nauk (in
Russian) 367, 273-275.
116. Sashchenko L.P., Dukhanina E.A., Lukianova T.I., Romanova E.A.,
Iudinkova E.S., Iarovaia O.V., Iashin D.V., Razin S.V., Gnuchev N.V.
1999. Characterization of cytotoxic proteins, expression of which is
activated in some non-lymphoid cells upon contact of cells of different
organisms. Dokl. Akad. Nauk (in Russian) 367, 834-836.
117. Sashchenko L.P., Dukhanina E.A., Lukianova T.I., Romanova E.A.,
Iudinkova E.S., Iarovaia O.V., Iashin D.V., Razin S.V., Gnuchev N.V.
1999. Physical contact between human erythroid cells and murine
fibroblasts induces espression of both secreted and membrane-associated
cytotoxic proteins. Dokl. Akad. Nauk (in Russian) 368, 122-124.
118. Iarovaia O.V., S'jakste N.I., Razin S.V. 1999. Regulation of globin genes
expression during erythroid differentiation. Dokl. Akad. Nauk (in
Russian) 368, 12O-121.
119. Ioudinkova E.S., Razin S.V. 1999. Nuclear matrix binding site (MARelement)
is located within the cluster of DNase I hypersensitive sites in
the upstream area of the chicken domain of α-globin genes.
Moleculiarnaia Biologia (in Russian) 33, 603-604.
120. Pietrowska M., Rusin M., Widlak P., Razin S.V. and Rzeszowska-Wolny
J. 1999. Characterization of DNA sequence located 11 to 17.5 kb
upstream of chicken embryonic pi-globin gene. Acta Biochim. Pol. 46,
777-784.
121. Razin S.V. 1999. Chromosomal DNA loops may constitute basic units of
eukaryotic genome organization and evolution. Crit. Rev. Eukaryot.
Gene Expr. 9, 279-283.
122. Sjakste N., Iarovaia O.V., Razin S.V., Linares-Cruz G., Sjakste T., Le
Gac V., Zhao Z. and Scherrer K. 2000. A novel gene is transcribed in the
chicken α-globin gene domain in the direction opposite to the globin
genes. Mol. Gen. Genet. 262, 1012-1021.
123. Sashchenko L.P., Dukhanina E.A., Ioudinkova, E.S., Iarovaia1 O.V.
Lukianova T.I., Kabanova O.D., Gnuchev N.V. and Razin S.V. 2000.
Non-lymphoid cultured cells possess a system controlling cellular
compatibility. J. Cell. Biochem. 78, 186-196.
124. Vassetzky Y.S., Bogdanova A.N. and Razin S.V. 2000. Analysis of the
chicken DNA fragments that contain structural sites of attachment to the
nuclear matrix: DNA-matrix interactions and replication. J. Cell.
Biochem. 79, 1-14.
125. Razin S.V., Ioudinkova E.S. and Scherrer K. 2000. Extensive methylation
of a part of the CpG island located 3.0-4.5 Kbp upstream to the chicken
alpha-globin gene cluster may contribute to silencing the globin genes in
non-erythroid cells. J. Mol. Biol. 209, 845-852.
126. De Conto F., Pilotti E., Razin S.V., Ferraglia F., Geraud G., Arcangeletti
C. and Scherrer K. 2000. In mouse myoblasts nuclear prosomes are
associated with the nuclear matrix and accumulate preferentially in the
perinucleolar areas. J. Cell. Sci. 113, 2399-2407.
10

127. Razin S.V. 2000. Molecular biology at the turn of the third millennium.
Bioorganicheskaya Khimia (in Russian) 26 (10), 790-793.
128. Vassetzky Y., Hair A. and Razin S.V. 2000. Rearrangement of chromatin
domains in cancer and development. J. Cell. Biochem. S35, 54-60.
129. Iarovaia O.V., Sashchenko L.P., Gnuchev N.V. and Razin S.V. 2000
Mixed cultures of eukaryotic cells: Cytotoxic processes. Mol. Biol. (in
Russian) 34, 731-735.
130. Razin S.V., Verbovaia L.V., Gol'dman I.L. 2000. New approaches to
construction of transgenic animals with high level tissue-specific
expression of foreign genes: construction and reconstruction of genomic
domains. Genetika. (in Russian) 36(11), 1443-1453.
131. Iudinkova E.S., Razin S.V. 2000. Regulatory sequences of DNA, located
in segments hypersensitive to DNAase I in the 5-terminal region of
chicken alpha-globin genes. Mol. Biol. (In Russian) 34(5), 821-827
132. Svetlova E.Yu., Razin S.V. and Debatisse M. 2001. Mammalian
recombination hot spot in a DNA loop anchorage region: A model for
the study of common fragile sites. J. Cell. Biochem. 81(S36), 170-178.
133. Razin S.V. (2001) The nuclear matrix and chromosomal DNA loops: Is
their any correlation between partitioning of the genome into loops and
functional domains Cell. & Mol. Biol. Letters 6, 59-69.
134. Razin S.V., Ioudinkova E.S., Trifonov E.N. and Scherrer K. 2001. Nonclonability
versus genomic instability: a case study of a unique DNA
region. J. Mol. Biol. 307, 481-486.
135. Iarovaia O.V., Ioudinkova E.S. and Razin S.V. 2001. CpG-methylation
does not influence the mode of MARs interaction with the nuclear
matrix. Dokl. Akad. Nauk (in Russian) 377, N2, p.1-2.
136. Ioudinkova E.S., Trifonov E.N., Scherrer K. and Razin S.V. 2001.
Characterization of “non-clonable” DNA sequence located in the
intergenic spacer between π and α D chicken globin genes. Dokl. Akad.
Nauk (in Russian) 378,
137. Svetlova E.S. and Razin S.V. 2001. The mode of chromosomal DNA
organization into loops may differ significuntly in AT-rich and GC-rich
isochores. Dokl. Akad. Nauk (in Russian), 377 (6), 135-136.
138. Bistritskii A.A., Hancock R. Razin S.V. Iarovaia O.V. 2001. The sites of
hypersensitivity to the DNA toppoisomerase II in the 5’-region of hyman
dystrophin gene. Dokl. Akad. Nauk (in Russian), 378 (6),
139. Bistritskii A.A., Verbovaia L.V., Razin S.V. and Iarovaia O.V. 2001.
Analysis of the cleavage pattern of human dystrophin gene by
endogenous topoisomerase II reveals significunt special features of the
spatial organization of this gene in eukaryotic cell nuclei. Mol. Biol. (in
Russian) 35, 417-419.
140. Iarovaia O.V., Avetisyan A.V., Chernyak B.Y., Ioudinkova E.S. and
Razin S.V. 2001. Uncoupling of oxidative phosphorilation in L929 cells
under coculturing of transformed murine fibroblasts L929 and human
erythroleukemia cells K562 or in result of action of Tumor Necrosis
Factor. Dokl. Akad. Nauk (in Russian) In Press
11

141. Recillas_Targa F. and Razin S.V. 2001. Chromatin domains and
regulation of gene expression: familiar and enigmatic clusters of chicken
globin genes. Crit Rev Eukaryot Gene Expr. 11(1-3), 227-42.
142. Iarovaia O, Razin SV, Linares-Cruz G, Sjakste N, Scherrer K. 2001. In
chicken leukemia cells globin genes are fully transcribed but their RNas
are retained in the perinucleolar area. Exp Cell Res. 270(2), 159-65.
143. Ioudinkova, E.S., Iarovaia, O.V., Scherrer, K., Razin, S.V., 2001.
Regulation of globin genes expression: New findings made with the
chicken domain of alpha globin genes. Gene Ther. Mol. Biol. 6, 149-
157.
144. Goldman I.L., Kadulin S.G., Razin S.V. (2002) Transgenic goats in the
Word Pharmaceutical Industry of the 21 st Century. Genetica 38, 5-21. (In
Russian)
145. Razin S.V. 2003. MARs and SARs. In Encyclopedia of the Human
Genome. Nature Publishing Group, Macmillan Publishers Limited. In
Press.
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