research alert - University of Toronto Department of Obstetrics and ...

§§§§ RESEARCH ALERT §§§§
For May – August 2010
This is a publication of the Research Committee.
Deadlines of Interest
CIHR: See Funding overview at http://www.cihr-irsc.gc.ca/e/193.html
Fall 2010: Look for the next in the series, Linking bench to bedside: OBGYN
Research Discussions, on a topic in maternal health, to take place in the fall of 2010.
Research Day 2011 will take place on Friday, May 6, 2011, at Hart House in the
University of Toronto, 7 Hart House Circle, Toronto, M5S 3H3. Abstracts are due
Friday, March 7, 2011.
Of Note
27 th Annual Research Day 2010
The Department of Obstetrics & Gynaecology 27 th Annual Research Day took place Friday, May
7, 2010 with approximately 225 participants. There were 15 oral and 61 poster presentations by
trainees from the Department, covering a range of excellent research, both basic and clinical. We
also heard an excellent Henderson Lecture, delivered by Dr. Jane Norman, University of
Edinburgh, UK, on the topic of “Being born too soon – do obstetricians have anything to offer”
A big thank you to everyone who participated and special thanks to all those faculty members
who acted as Chairs and Judges.
Award winners are listed on page 16, in the Honours and Awards section.
New Research Grants and Awards
Brown, Theodore J; Rosen, Barry P (Principal Investigators); Colgan, Terence J;
Greenblatt, Ellen M; Murphy, K Joan; Tone, Alicia A; Virtanen, Carl; Winegarden,
Neil; Allen, Lisa; Farrugia, Michèle; Levinsky, Elyse, Shapiro, Jodi (Co-Investigators).
Sustained ovulation-associated inflammatory signaling in fallopian tube epithelium as a
predisposing factor of serous carcinoma. CIHR, Operating Grant, $435,884, 2010 – 2013.
Copy from one, it's plagiarism; copy from two, it's research.
Wilson Mizner
1

RESEARCH ALERT
May-August 2010
New Research Grants and Awards cont’d
Casper, Robert F (Principal Investigator), Rahman, Shadab A; Shapiro, Colin M (Co-
Investigators). Ameliorating affective disorder induced by circadian rhythm disruption.
CIHR, Operating Grant, $427,126, 2010 – 2013.
Feig, Denice S (Principal Investigator); Armson, Brian A; Asztalos, Elizabeth V; Fantus,
Ivan G; Lee, Shoo K; Lipscombe, Lorraine; Murphy, Kellie E; Ohlsson, Arne; Ryan,
Edmond A; Tomlinson, George A; Zinman, Bernard (Co-Investigators). The MiTY Trial
(Metformin in Women with Type 2 Diabetes in Pregnancy). CIHR, Operating Grant,
$1,735,119, 2010 – 2015.
Feig, Denice S, Lipscombe, Lorraine L, Booth, Gillian L., Shah, Baiju R, Ray, Joel G,
Lowe, Julia. Hypertensive disorders of pregnancy and future risk of diabetes in affected
women and their offspring. Canadian Diabetes Association Operating Grant, 2010-2012.
Jones, Jennifer M; Howell, Doris M (Principal Investigators); Buchman, Stephen (Sandy)
H; Catton, Pamela; Earle, Craig C; Ferguson, Sarah; Fitzgerald, Barbara J; Gagliardi,
Anna R; Gospodarowicz, Mary; Harrison, Margaret B; Jadad, Alejandro(Alex) R; Jusko
Friedman, Audrey; Sharpe, Michael B; Urowitz, Sara; Warde, Padraig R; Wiljer, David E
(Co-Investigators). Transition to Survivorship: Translating knowledge into action for
testicular and endometrial cancer populations. CIHR, Operating Grant, $256,582, 2010 –
2013.
Kim, Young-In J; O'Connor, Deborah L (Principal Investigators); Berger, Howard;
Lausman, Andrea Y (Co-Investigators). Effects of prenatal folate exposure on DNA
methylation in the newborn infants. CIHR, Operating Grant, $448,683, 2010 – 2013.
Kingdom, John C (Principal Investigator);Weksberg, Rosanna (Co-Investigator).
Villous trophoblast turnover. CIHR, Operating Grant, $593,799, 2010 – 2014.
Lye, Stephen J (Principal Investigator); Shynlova, Oksana (Co-Investigator).
Control of myometrial contractile activity during pregnancy. CIHR, Operating Grant,
$912,320, 2010 – 2015.
Rossant, Janet (Principal Investigator). Transcriptional networks in trophoblast stem cell
development. CIHR, Operating Grant, $1,049,389, 2010 – 2015.
Rossant, Janet. 2010 Premier's Summit Award in Medical Research, Government of
Ontario, $5,000,000, 2010 – 2015. This award is made to internationally recognized
leaders in medical research, to attract and retain them in Ontario and help them expand
their research programs.
2

RESEARCH ALERT
May-August 2010
New Research Grants and Awards cont’d
Wolever, Thomas MS, O'Connor, Deborah, Josse, Robert G, Feig, Denice S, Ray,
Joel G, El-Sohemy, Ahmed. The effect of a low glycemic index (GI) diet on maternal
and neonatal markers of glycemic control and post-partum diabetes risk. Canadian
Diabetes Association, 2010 – 2013.
Zinman, Bernard, Retnakaran, Ravi R, Hanley, Anthony J.G., Sermer, Mathew,
Connelly, Philip W. Role of the arginine/nitric oxide metabolome in the early natural
history of cardiovascular disease in young women with varying degrees of glucose
intolerance in pregnancy. Canadian Diabetes Association, 2010 – 2013.
New Publications (& Abstract Links)
Please click on titles to link to abstracts. If you are unable to make the link work, you may wish to copy
in the following link to your browser and download a free version of Adobe Acrobat 9 at
http://get.adobe.com/reader/promoid=BUIGO
May 2010
Ahmed K, Dehghani H, Rugg-Gunn P, Fussner E, Rossant J, Bazett-Jones DP.
Global chromatin architecture reflects pluripotency and lineage commitment in the early
mouse embryo. PLoS One 2010 May 7;5(5):e10531.
Bernardini MQ, Baba T, Lee PS, Barnett JC, Sfakianos GP, Secord AA, Murphy SK,
Iversen E, Marks JR, Berchuck A. Expression signatures of TP53 mutations in serous
ovarian cancers. BMC Cancer 2010 May 26;10:237.
Bortolini MA, Drutz HP, Lovatsis D, Alarab M. Vaginal delivery and pelvic floor
dysfunction: current evidence and implications for future research. Int Urogynecol J
Pelvic Floor Dysfunct 2010 May 6. [Epub ahead of print]
Freathy RM, Mook-Kanamori DO, Sovio U, …, Pennell CE, et al.Variants in ADCY5
and near CCNL1 are associated with fetal growth and birth weight.
Nat Genet 2010 May;42(5):430-5. Epub 2010 Apr 6.
Gien LT, Covens A. Fertility-sparing options for early stage cervical cancer.
Gynecol Oncol 2010 May;117(2):350-7. Epub 2010 Feb 16. Review.
Gunby J, Bissonnette F, Librach C, Cowan L; IVF Directors Group of the Canadian
Fertility and Andrology Society. Assisted reproductive technologies (ART) in Canada:
2006 results from the Canadian ART Register. Fertil Steril 2010 May 1;93(7):2189-201.
Epub 2009 May 12.
3

RESEARCH ALERT
May-August 2010
New Publications (& Abstract Links) May cont’d
Huang T, Hoffman B, Meschino W, Kingdom J, Okun N.
Prediction of adverse pregnancy outcomes by combinations of first and second trimester
biochemistry markers used in the routine prenatal screening of Down syndrome.
Prenat Diagn 2010 May;30(5):471-7.
Hutson JR, Koren G, Matthews SG. Placental P-glycoprotein and breast cancer
resistance protein: influence of polymorphisms on fetal drug exposure and physiology.
Placenta 2010 May;31(5):351-7. Epub 2010 Mar 27.
Kehoe SM, Zivanovic O, Ferguson SE, Barakat RR, Soslow RA. Clinicopathologic
features of bone metastases and outcomes in patients with primary endometrial cancer.
Gynecol Oncol 2010 May;117(2):229-33. Epub 2010 Mar 2
Koifman A, Feigenbaum A, Bi W, Shaffer LG, Rosenfeld J, Blaser S, Chitayat D.
A homozygous deletion of 8q24.3 including the NIBP gene associated with severe
developmental delay, dysgenesis of the corpus callosum, and dysmorphic facial features.
Am J Med Genet A 2010 May;152A(5):1268-72.
Kotsopoulos J, Chen Z, Vallis KA, Poll A, Ghadirian P, Kennedy G, Ainsworth P, Narod
SA. Toenail selenium status and DNA repair capacity among female BRCA1 mutation
carriers. Cancer Causes Control 2010 May;21(5):679-87. Epub 2010 Jan 9.
Kroft J, Klostermann NR, Moody JR, Taerk E, Wolfman W. A novel regimen of
combination transdermal estrogen and intermittent vaginally administered progesterone
for relief of menopausal symptoms. Gynecol Endocrinol 2010 May 21. [Epub ahead of
print]
Lawrentschuk N, Haider MA, Daljeet N, Evans A, Toi A, Finelli A, Trachtenberg J,
Zlotta A, Fleshner N. 'Prostatic evasive anterior tumours': the role of magnetic resonance
imaging. BJU Int 2010 May;105(9):1231-6. Epub 2009 Oct 8.
Lawrentschuk N, Lockwood G, Davies P, Evans A, Sweet J, Toi A, Fleshner NE.
Predicting prostate biopsy outcome: artificial neural networks and polychotomous
regression are equivalent models. Int Urol Nephrol 2010 May 13. [Epub ahead of print]
Mackay HJ, Gallinger S, Tsao MS, McLachlin CM, Tu D, Keiser K, Eisenhauer EA, Oza
AM. Prognostic value of microsatellite instability (MSI) and PTEN expression in women
with endometrial cancer: results from studies of the NCIC Clinical Trials Group (NCIC
CTG). Eur J Cancer 2010 May;46(8):1365-73. Epub 2010 Mar 19.
There is nothing like looking, if you want to find something. You certainly usually find something, if
you look, but it is not always quite the something you were after.
JRR Tolkien
4

RESEARCH ALERT
May-August 2010
New Publications (& Abstract Links) May cont’d
MacRae AR, Chodirker BN, Davies GA, Palomaki GE, Knight GJ, Minett J, Kavsak PA,
Toi A, Chitayat D, Van Caeseele PG. Second and first trimester estimation of risk for
Down syndrome: implementation and performance in the SAFER study. Prenat Diagn
2010 May;30(5):459-66.
Osborne LR. Animal models of Williams syndrome. Am J Med Genet C Semin Med
Genet 2010 May 15;154C(2):209-19.
Osborne LR. Caveat mTOR: aberrant signaling disrupts corticogenesis.
J Clin Invest 2010 May 3;120(5):1392-5. doi: 10.1172/JCI43030. Epub 2010 Apr 26.
Parr G, Leyland N. The hockey stick sign in appendiceal endometriosis.
J Obstet Gynaecol Can 2010 May;32(5):421, 422. English, French. No abstract available.
Pober BR, Wang E, Caprio S, Petersen KF, Brandt C, Stanley T, Osborne LR, Dzuria J,
Gulanski B.High prevalence of diabetes and pre-diabetes in adults with Williams
syndrome. Am J Med Genet C Semin Med Genet 2010 May 15;154C(2):291-8.
Ray JE, Garcia J, Jurisicova A, Caniggia I. Mtd/Bok takes a swing: proapoptotic
Mtd/Bok regulates trophoblast cell proliferation during human placental development and
in preeclampsia. Cell Death Differ 2010 May;17(5):846-59. Epub 2009 Nov 27.
Unlugedik E, Alfaidy N, Holloway A, Lye S, Bocking A, Challis J, Gibb W.
Expression and regulation of prostaglandin receptors in the human placenta and fetal
membranes at term and preterm. Reprod Fertil Dev 2010;22(5):796-807.
Vause TD, Cheung AP, Sierra S, Claman P, Graham J, Guillemin JA, Lapensée L,
Steward S, Wong BC; Society of Obstetricians and Gynecologists of Canada.
Ovulation induction in polycystic ovary syndrome. J Obstet Gynaecol Can 2010
May;32(5):495-502.
You B, Brade A, Magalhaes JM, Siu LL, Oza A, Lovell S, Wang L, Hedley DW, Nicacio
LV, Chen EX. A dose-escalation phase I trial of nimotuzumab, an antibody against the
epidermal growth factor receptor, in patients with advanced solid malignancies.
Invest New Drugs 2010 May 8. [Epub ahead of print]
Yudin MH, Shapiro HM, Loutfy MR. Access to infertility services in Canada for HIVpositive
individuals and couples: a cross-sectional study. Reprod Health 2010 May
12;7:7.
Research is formalized curiosity. It is poking and prying with a purpose.
Zora Neale Hurston
5

RESEARCH ALERT
May-August 2010
New Publications (& Abstract Links) cont’d
June 2010
Alarab M, Bortolini MA, Drutz H, Lye S, Shynlova O. LOX family enzymes
expression in vaginal tissue of premenopausal women with severe pelvic organ prolapse.
Int Urogynecol J Pelvic Floor Dysfunct 2010 Jun 18. [Epub ahead of print]
Bentov Y, Esfandiari N, Gokturk A, Burstein E, Fainaru O, Casper RF. An ongoing
pregnancy from two waves of follicles developing during a long follicular phase of the
same cycle. Fertil Steril 2010 Jun;94(1):350.e8-11.
Brenner DR, Hung RJ, Tsao MS, Shepherd FA, Johnston MR, Narod S, Rubenstein W,
McLaughlin JR. Lung cancer risk in never-smokers: a population-based case-control
study of epidemiologic risk factors. BMC Cancer 2010 Jun 14;10(1):285. [Epub ahead of
print]
Chamberlain S, Bocking A, McGrath M, Faught W, Liston R, Wilson RD, Morris M,
Sagle P, Armson A, O'Grady T, Richardson B. Teaching pelvic examinations under
anaesthesia: what do women think J Obstet Gynaecol Can 2010 Jun;32(6):539-40. No
abstract available.
Chitayat D, Glanc P. Diagnostic approach in prenatally detected genital abnormalities.
Ultrasound Obstet Gynecol. 2010 Jun;35(6):637-46. No abstract available.
Chua SJ, Bielecki R, Yamanaka N, Fehlings MG, Rogers IM, Casper RF. The Effect of
Umbilical Cord Blood Cells on Outcomes After Experimental Traumatic Spinal Cord
Injury. Spine (Phila Pa 1976) 2010 Jun 24. [Epub ahead of print]
Chung HY, Uster-Friedberg T, Pentaz S, Blaser S, Murphy K, Chitayat D.
Fetal parietal foramina: ultrasound and MRI findings. Ultrasound Obstet Gynecol 2010
Jun 28. [Epub ahead of print] No abstract available.
Corbett SL, Walsh CM, Spitzer RF, Ngan BY, Kives S, Zachos M. Vulvar inflammation
as the only clinical manifestation of Crohn disease in an 8-year-old girl. Pediatrics 2010
Jun;125(6):e1518-22. Epub 2010 May 10.
Dennis J, Ghadirian P, Little J, Lubinski J, Gronwald J, Kim-Sing C, Foulkes W, Moller
P, Lynch HT, Neuhausen SL, Domchek S, Armel S, Isaacs C, Tung N, Sweet K,
Ainsworth P, Sun P, Krewski D, Narod S; the Hereditary Breast Cancer Clinical Study
Group. Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2
mutation carriers. Breast 2010 Jun 11. [Epub ahead of print]
6

RESEARCH ALERT
May-August 2010
New Publications (& Abstract Links) June cont’d
Dodd JM, McLeod A, Windrim RC, Kingdom J.
Antithrombotic therapy for improving maternal or infant health outcomes in women
considered at risk of placental dysfunction. Cochrane Database Syst Rev 2010 Jun
16;6:CD006780.
Dodd JM, Windrim RC, van Kamp IL. Techniques of intrauterine fetal transfusion for
women with red-cell isoimmunisation for improving health outcomes. Cochrane
Database Syst Rev 2010 Jun 16;6:CD007096. Review.
Foulkes WD, Reis-Filho JS, Narod SA.Tumor size and survival in breast cancer--a
reappraisal. Nat Rev Clin Oncol 2010 Jun;7(6):348-53. Epub 2010 Mar 23.
Freedman OC, Dodge J, Shaw P, Oza AM, Bernardini M, Klachook S, Murphy KJ,
Lo E, Rosen B, Mackay H. Diagnosis of epithelial ovarian carcinoma prior to
neoadjuvant chemotherapy. Gynecol Oncol 2010 Jun 28. [Epub ahead of print]
Gertsenstein M, Nutter LM, Reid T, Pereira M, Stanford WL, Rossant J, Nagy A.
Efficient generation of germ line transmitting chimeras from C57BL/6N ES cells by
aggregation with outbred host embryos. PLoS One 2010 Jun 22;5(6):e11260.
Hamoudi A, Shier M. Late complications of childhood female genital mutilation.
J Obstet Gynaecol Can 2010 Jun;32(6):587-9.
Hartley JL, Zachos NC, Dawood B, Donowitz M, Forman J, Pollitt RJ, Morgan NV, Tee
L, Gissen P, Kahr WH, Knisely AS, Watson S, Chitayat D, Booth IW, Protheroe S,
Murphy S, de Vries E, Kelly DA, Maher ER. Mutations in TTC37 cause
trichohepatoenteric syndrome (phenotypic diarrhea of infancy). Gastroenterology 2010
Jun;138(7):2388-98, 2398.e1-2. Epub 2010 Feb 20.
Hauspy J, Jiménez W, Rosen B, Gotlieb WH, Fung-Kee-Fung M, Plante M.
Laparoscopic surgery for endometrial cancer: a review. J Obstet Gynaecol Can 2010
Jun;32(6):570-9.
Hazan AD, Smith SD, Jones RL, Whittle W, Lye SJ, Dunk CE. Vascular-Leukocyte
Interactions. Mechanisms of Human Decidual Spiral Artery Remodeling in Vitro.
Am J Pathol 2010 Jun 17. [Epub ahead of print]
Jaeggi E, Laskin C, Hamilton R, Kingdom J, Silverman E.
The importance of the level of maternal anti-Ro/SSA antibodies as a prognostic marker
of the development of cardiac neonatal lupus erythematosus a prospective study of 186
antibody-exposed fetuses and infants. J Am Coll Cardiol 2010 Jun 15;55(24):2778-84.
7

RESEARCH ALERT
May-August 2010
New Publications (& Abstract Links) June cont’d
Jhaveri KS, Mazrani W, Chawla TP, Filobbos R, Toi A, Jarvi K. The role of crosssectional
imaging in male infertility: a pictorial review. Can Assoc Radiol J 2010
Jun;61(3):144-55. Epub 2010 Feb 26. Review.
Lehman AM, Eydoux P, Doherty D, Glass IA, Chitayat D, Chung BY, Langlois S, Yong
SL, Lowry RB, Hildebrandt F, Trnka P. Co-occurrence of Joubert syndrome and Jeune
asphyxiating thoracic dystrophy. Am J Med Genet A 2010 Jun;152A(6):1411-9.
Liu X, Fernandes R, Jurisicova A, Casper RF, Sun Y. In situ mechanical
characterization of mouse oocytes using a cell holding device. Lab Chip 2010 Jun 14.
[Epub ahead of print]
Mackay HJ, Hirte H, Colgan T, Covens A, MacAlpine K, Grenci P, Wang L, Mason J,
Pham PA, Tsao MS, Pan J, Zwiebel J, Oza AM. Phase II trial of the histone deacetylase
inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and
micropapillary (LMP) ovarian tumours. Eur J Cancer 2010 Jun;46(9):1573-9. Epub 2010
Mar 19.
Mai S, Wei K, Flenniken A, Adamson SL, Rossant J, Aubin JE, Gong SG.
The missense mutation W290R in Fgfr2 causes developmental defects from aberrant IIIb
and IIIc signaling. Dev Dyn 2010 Jun;239(6):1888-900.
Narod SA. Genes, the environment, and breast cancer. Lancet 2010 Jun
19;375(9732):2123-4. No abstract available.
Proulx E, Young EJ, Osborne LR, Lambe EK. Enhanced prefrontal serotonin 5-HT(1A)
currents in a mouse model of Williams-Beuren syndrome with low innate anxiety.
J Neurodev Disord 2010 Jun;2(2):99-108. Epub 2010 Mar 19.
Retnakaran R, Qi Y, Connelly PW, Sermer M, Hanley AJ, Zinman B. Risk of Early
Progression to Pre-diabetes or Diabetes in Women with Recent Gestational Dysglycemia
but Normal Glucose Tolerance at 3-months Postpartum. Clin Endocrinol (Oxf) 2010 Jun
9. [Epub ahead of print]
Robertson D, Lefebvre G, Leyland N, Wolfman W, Allaire C, Awadalla A, Best C,
Contestabile E, Dunn S, Heywood M, Leroux N, Potestio F, Rittenberg D, Senikas V,
Soucy R, Singh S. Adhesion prevention in gynaecological surgery. J Obstet Gynaecol
Can 2010 Jun;32(6):598-602.
Rugg-Gunn PJ, Cox BJ, Ralston A, Rossant J. Distinct histone modifications in stem cell
lines and tissue lineages from the early mouse embryo. Proc Natl Acad Sci U S A. 2010
Jun 15;107(24):10783-90. Epub 2010 May 17.
Research is the act of going up alleys to see if they are blind.
Plutarch
8

RESEARCH ALERT
May-August 2010
New Publications (& Abstract Links) June cont’d
Shynlova O, Dorogin A, Lye SJ. Stretch-induced uterine myocyte differentiation during
rat pregnancy: involvement of caspase activation. Biol Reprod 2010 Jun;82(6):1248-55.
Epub 2010 Feb 24.
Suchy J, Cybulski C, Wokołorczyk D, Oszurek O, Górski B, Debniak T, Jakubowska A,
Gronwald J, Huzarski T, Byrski T, Dziuba I, Gogacz M, Wiśniowski R, Wandzel P,
Banaszkiewicz Z, Kurzawski G, Kładny J, Narod SA, Lubiński J. CHEK2 mutations and
HNPCC-related colorectal cancer. Int J Cancer 2010 Jun 15;126(12):3005-9.
Uxa R, Baczyk D, Kingdom JC, Viero S, Casper R, Keating S. Genetic
polymorphisms in the fibrinolytic system of placentas with massive perivillous fibrin
deposition. Placenta 2010 Jun;31(6):499-505. Epub 2010 May 5.
Vicus D, Finch A, Cass I, Rosen B, Murphy J, Fan I, Royer R, McLaughlin J, Karlan B,
Narod SA. Prevalence of BRCA1 and BRCA2 germ line mutations among women with
carcinoma of the fallopian tube. Gynecol Oncol 2010 Jun 4. [Epub ahead of print]
Wolf N, Yang W, Dunk CE, Gashaw I, Lye SJ, Ring T, Schmidt M, Winterhager E,
Gellhaus A. Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3)
by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the
human trophoblast. Endocrinology 2010 Jun;151(6):2835-45. Epub 2010 Mar 17.
New Publications (& Abstract Links)
July 2010
Bailey CD, De Biasi M, Fletcher PJ, Lambe EK. The nicotinic acetylcholine receptor
alpha5 subunit plays a key role in attention circuitry and accuracy. J Neurosci 2010 Jul
7;30(27):9241-52.
Bambao C, Nofech-Mozes S, Shier M. Giant condyloma versus verrucous carcinoma: a
case report. J Low Genit Tract Dis 2010 Jul;14(3):230-3.
Billingsley G, Bin J, Fieggen KJ, Duncan JL, Gerth C, Ogata K, Wodak SS, Traboulsi EI,
Fishman GA, Paterson A, Chitayat D, Knueppel T, Millán JM, Mitchell GA, Deveault
C, Héon E. Mutations in chaperonin-like BBS genes are a major contributor to disease
development in a multiethnic Bardet-Biedl syndrome patient population.
J Med Genet 2010 Jul;47(7):453-63. Epub 2010 May 14.
Chua SJ, Bielecki R, Yamanaka N, Fehlings MG, Rogers IM, Casper RF.
The effect of umbilical cord blood cells on outcomes after experimental traumatic spinal
cord injury. Spine (Phila Pa 1976) 2010 Jul 15;35(16):1520-6.
9

RESEARCH ALERT
May-August 2010
New Publications (& Abstract Links) July cont’d
Chung HY, Chu L, Forrest C, Silver R, Toi A, Blaser S, Viero S, Taylor G, Chitayat D.
Fetal forehead hemangiopericytoma: prenatal diagnosis and postnatal outcome.
Ultrasound Obstet Gynecol 2010 Jul;36(1):121-4. No abstract available.
Colgan TJ. The 2006 consensus guidelines for the management of women with
abnormal cervical screening tests: challenges remain. Cancer Cytopathol 2010 Jul 13.
[Epub ahead of print]
Coultas L, Nieuwenhuis E, Anderson GA, Cabezas J, Nagy A, Henkelman RM, Hui CC,
Rossant J. Hedgehog regulates distinct vascular patterning events through VEGFdependent
and -independent mechanisms. Blood 2010 Jul 29;116(4):653-60. Epub 2010
Mar 25.
Crook J, Borg J, Evans A, Toi A, Saibishkumar EP, Fung S, Ma C. 10-Year Experience
with I-125 Prostate Brachytherapy at the Princess Margaret Hospital: Results for 1,100
Patients. Int J Radiat Oncol Biol Phys 2010 Jul 31. [Epub ahead of print]
Desouza LV, Krakovska O, Darfler MM, Krizman DB, Romaschin AD, Colgan TJ, Siu
KW. mTRAQ-based quantification of potential endometrial carcinoma biomarkers from
archived formalin-fixed paraffin-embedded tissues. Proteomics 2010 Jul 19. [Epub ahead
of print]
Ezzat H, Ross S, von Dadelszen P, Morris T, Liston R, Magee LA; CPN Collaborative
Group (Jon Barrett). Ethics review as a component of institutional approval for a
multicentre continuous quality improvement project: the investigator's perspective.
BMC Health Serv Res 2010 Jul 30;10:223.
Goldszmidt E, Macarthur A, Silversides C, Colman J, Sermer M, Siu S. Anesthetic
management of a consecutive cohort of women with heart disease for labor and delivery.
Int J Obstet Anesth 2010 Jul;19(3):266-72. Epub 2010 Mar 2.
Gunby J, Bissonnette F, Librach C, Cowan L; on behalf of the IVF Directors Group of
the Canadian Fertility and Andrology Society. Assisted reproductive technologies (ART)
in Canada: 2007 results from the Canadian ART Register. Fertil Steril 2010 Jul 23. [Epub
ahead of print]
Hafezi-Bakhtiari S, Morava-Protzner I, Burnell MJ, Reardon E, Colgan TJ.
Choriocarcinoma arising in a serous carcinoma of ovary: an example of histopathology
driving treatment. J Obstet Gynaecol Can 2010 Jul;32(7):698-702.
10

RESEARCH ALERT
May-August 2010
New Publications (& Abstract Links) July cont’d
Kollara A, Brown TJ. Variable expression of nuclear receptor coactivator 4 (NcoA4)
during mouse embryonic development. J Histochem Cytochem 2010 Jul;58(7):595-609.
Epub 2010 Mar 30.
Malvasi A, Tinelli A, Guido M, Zizza A, Farine D, Stark M. Should the visceral
peritoneum at the bladder flap closed at cesarean sections A post-partum sonographic
and clinical assessment. J Matern Fetal Neonatal Med 2010 Jul;23(7):662-9.
McDonald SD, Han Z, Mulla S, Beyene J; Knowledge Synthesis Group (Murphy
KE).Overweight and obesity in mothers and risk of preterm birth and low birth weight
infants: systematic review and meta-analyses. BMJ 2010 Jul 20;341:c3428. doi:
10.1136/bmj.c3428. Review
Metcalfe K, Poll A, Llacuachaqui M, Nanda S, Tulman A, Mian N, Sun P, Narod SA.
Patient satisfaction and cancer-related distress among unselected Jewish women
undergoing genetic testing for BRCA1 and BRCA2. Clin Genet 2010 Jul 1. [Epub ahead
of print]
Mittal P, Romero R, Tarca AL, Gonzalez J, Draghici S, Xu Y, Dong Z, Nhan-Chang CL,
Chaiworapongsa T, Lye S, Kusanovic JP, Lipovich L, Mazaki-Tovi S, Hassan SS,
Mesiano S, Kim CJ. Characterization of the myometrial transcriptome and biological
pathways of spontaneous human labor at term. J Perinat Med 2010 Jul 14. [Epub ahead of
print]
Narod SA. Screening of women at high familial risk of breast cancer. Womens Health
(Lond Engl). 2010 Jul;6(4):509-10.
Narod SA. Testing for CHEK2 in the cancer genetics clinic: ready for prime time
Clin Genet 2010 Jul;78(1):1-7.
Neal MS, Mulligan Tuttle AM, Casper RF, Lagunov A, Foster WG. Aryl hydrocarbon
receptor antagonists attenuate the deleterious effects of benzo[a]pyrene on isolated rat
follicle development. Reprod Biomed Online 2010 Jul;21(1):100-108. Epub 2010 Mar
30.
Nevo O, Bronshtein M. Fetal transient occipital bone protuberance during early
pregnancy. Prenat Diagn 2010 Jul 26. [Epub ahead of print]
Nevo O, Soustiel JF, Thaler I. Maternal cerebral blood flow during normal pregnancy: a
cross-sectional study. Am J Obstet Gynecol 2010 Jul 2. [Epub ahead of print]
11

RESEARCH ALERT
May-August 2010
New Publications (& Abstract Links) July cont’d
Peixoto A, Santos C, Pinheiro M, … Narod S, et al. International distribution and age
estimation of the Portuguese BRCA2 c.156_157insAlu founder mutation. Breast Cancer
Res Treat 2010 Jul 22. [Epub ahead of print]
Petropoulos S, Gibb W, Matthews SG. Effect of glucocorticoids on regulation of
placental multidrug resistance phosphoglycoprotein (P-gp) in the mouse.
Placenta. 2010 Jul 22. [Epub ahead of print]
Pinto D, Pagnamenta AT, Klei L, …Weksberg R, et al. Functional impact of global rare
copy number variation in autism spectrum disorders. Nature 2010 Jul 15;466(7304):368-
72. Epub 2010 Jun 9.
Retnakaran R, Qi Y, Connelly PW, Sermer M, Hanley AJ, Zinman B. The Graded
Relationship between Glucose Tolerance Status in Pregnancy and Postpartum Levels of
Low-Density-Lipoprotein Cholesterol and Apolipoprotein B in Young Women:
Implications for Future Cardiovascular Risk. J Clin Endocrinol Metab 2010 Jul 14. [Epub
ahead of print]
Retnakaran R, Qi Y, Sermer M, Connelly PW, Zinman B, Hanley AJ. Gestational
diabetes and postpartum physical activity: evidence of lifestyle change 1 year after
delivery. Obesity (Silver Spring) 2010 Jul;18(7):1323-9. Epub 2009 Oct 8.
Rischin D, Narayan K, Oza AM, Mileshkin L, Bernshaw D, Choi J, Hicks R, McClure B,
Fyles A. Phase 1 Study of Tirapazamine in Combination With Radiation and Weekly
Cisplatin in Patients With Locally Advanced Cervical Cancer. Int J Gynecol Cancer 2010
Jul;20(5):827-833.
Saad RS, Ismiil N, Ghorab Z, Nofech-Mozes S, Dubé V, Covens A, Khalifa MA.
Lymphatic vessel density as a prognostic marker in clinical stage I endocervical
adenocarcinoma. Int J Gynecol Pathol 2010 Jul;29(4):386-93.
Stratford AL, Reipas K, Maxwell C, Dunn SE. Targeting tumour-initiating cells to
improve the cure rates for triple-negative breast cancer. Expert Rev Mol Med 2010 Jul
26;12:e22.
Ternamian AM, Vilos GA, Vilos AG, Abu-Rafea B, Tyrwhitt J, Macleod NT.
Laparoscopic Peritoneal Entry with the Reusable Threaded Visual Cannula.
J Minim Invasive Gynecol 2010 Jul;17(4):461-467.
Truth often suffers more by the heat of its defenders than the arguments of its opposers.
William Penn
12

RESEARCH ALERT
May-August 2010
New Publications (& Abstract Links) July cont’d
van Dijk M, van Bezu J, van Abel D, Dunk C, Blankenstein MA, Oudejans CB, Lye SJ.
The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast
invasion by alpha-T-catenin upregulation. Hum Mol Genet 2010 Jul 1;19(13):2658-67.
Epub 2010 Apr 16.
Wieczorek PM, Guest S, Balki M, Shah V, Carvalho JC. Breastfeeding success rate
after vaginal delivery can be high despite the use of epidural fentanyl: an observational
cohort study. Int J Obstet Anesth 2010 Jul;19(3):273-7. Epub 2010 Jun 2.
Yinon Y, Grisaru-Granovsky S, Chaddha V, Windrim R, Seaward PG, Kelly EN,
Beresovska O, Ryan G. Perinatal outcome following fetal chest shunt insertion for
pleural effusion. Ultrasound Obstet Gynecol 2010 Jul;36(1):58-64.
Zhang K, Li L, Huang C, Shen C, Tan F, Xia C, Liu P, Rossant J, Jing N.
Distinct functions of BMP4 during different stages of mouse ES cell neural commitment.
Development. 2010 Jul;137(13):2095-105. Epub 2010 May 26.
New Publications (& Abstract Links)
August 2010
Akbari MR, Tonin P, Foulkes WD, Ghadirian P, Tischkowitz M, Narod SA.
RAD51C germline mutations in breast and ovarian cancer patients. Breast Cancer Res
2010 Aug 19;12(4):404. [Epub ahead of print] No abstract available.
Biagi JJ, Oza AM, Chalchal HI, Grimshaw R, Ellard SL, Lee U, Hirte H, Sederias J, Ivy
SP, Eisenhauer EA. A phase II study of sunitinib in patients with recurrent epithelial
ovarian and primary peritoneal carcinoma: an NCIC Clinical Trials Group Study. Ann
Oncol 2010 Aug 12. [Epub ahead of print]
Bortolini MA, Drutz HP, Lovatsis D, Alarab M. Vaginal delivery and pelvic floor
dysfunction: current evidence and implications for future research. Int Urogynecol J
Pelvic Floor Dysfunct 2010 Aug;21(8):1025-30. Epub 2010 May 6.
Cleary JD, Tomé S, Castel AL, Panigrahi GB, Foiry L, Hagerman KA, Sroka H,
Chitayat D, Gourdon G, Pearson CE. Tissue- and age-specific DNA replication patterns
at the CTG/CAG-expanded human myotonic dystrophy type 1 locus. Nat Struct Mol Biol
2010 Aug 15. [Epub ahead of print]
Cox BJ, Vollmer M, Tamplin O, Lu M, Biechele S, Gertsenstein M, van Campenhout C,
Floss T, Kühn R, Wurst W, Lickert H, Rossant J. Phenotypic annotation of the mouse X
chromosome. Genome Res 2010 Aug;20(8):1154-64. Epub 2010 Jun 14.
13

RESEARCH ALERT
May-August 2010
New Publications (& Abstract Links) August cont’d
Davies GA, Maxwell C, McLeod L, Gagnon R, Basso M, Bos H, Delisle MF, Farine D,
Hudon L, Menticoglou S, Mundle W, Murphy-Kaulbeck L, Ouellet A, Pressey T,
Roggensack A, Leduc D, Ballerman C, Biringer A, Duperron L, Jones D, Lee LS,
Shepherd D, Wilson K; Society of Obstetricians and Gynaecologists of Canada.
Obesity in pregnancy. No. 239, February 2010. Int J Gynaecol Obstet 2010
Aug;110(2):167-73.
Forrest JL, Ackerman I, Barbera L, Barnes EA, Davidson M, Kiss A, Thomas G.
Patient outcome study of concurrent chemoradiation, external beam radiotherapy, and
high-dose rate brachytherapy in locally advanced carcinoma of the cervix.
Int J Gynecol Cancer 2010 Aug;20(6):1074-8.
Grafodatskaya D, Chung B, Szatmari P, Weksberg R. Autism spectrum disorders and
epigenetics. J Am Acad Child Adolesc Psychiatry 2010 Aug;49(8):794-809. Epub 2010
Jul 3.
Hazan AD, Smith SD, Jones RL, Whittle W, Lye SJ, Dunk CE. Vascular-leukocyte
interactions: mechanisms of human decidual spiral artery remodeling in vitro.
Am J Pathol 2010 Aug;177(2):1017-30. Epub 2010 Jun 17.
Kassam Z, Mackay H, Buckley CA, Fung S, Pintile M, Oza A, Brierley J, Swallow C,
Cummings B, Knox JJ, Kim J, Wong R, Siu L, Feld R, Ringash J. Adjuvant
chemoradiation for gastric cancer with infusional 5-fluorouracil and cisplatin: a phase i
study. Curr Oncol 2010 Aug;17(4):34-41.
Liu X, Fernandes R, Jurisicova A, Casper RF, Sun Y. In situ mechanical
characterization of mouse oocytes using a cell holding device. Lab Chip 2010 Aug
21;10(16):2154-61. Epub 2010 Jun 14.
Mackay HJ, Brady MF, Oza AM, Reuss A, Pujade-Lauraine E, Swart AM, Siddiqui N,
Colombo N, Bookman MA, Pfisterer J, du Bois A; Gynecologic Cancer InterGroup.
Prognostic relevance of uncommon ovarian histology in women with stage III/IV epithelial
ovarian cancer. Int J Gynecol Cancer 2010 Aug;20(6):945-52.
Murji A, Sobel ML, Feig DS, Sermer M. Propylthiouracil-induced agranulocytosis in
the third trimester of pregnancy. Obstet Gynecol 2010 Aug;116 Suppl 2:485-7.
Petropoulos S, Gibb W, Matthews SG. Developmental expression of multidrug
resistance phosphoglycoprotein (P-gp) in the mouse fetal brain and glucocorticoid
regulation. Brain Res 2010 Aug 12. [Epub ahead of print]
Retnakaran R, Qi Y, Sermer M, Connelly PW, Hanley AJ, Zinman B. Beta-cell function
declines within the first year postpartum in women with recent glucose intolerance in
pregnancy. Diabetes Care 2010 Aug;33(8):1798-804. Epub 2010 May 18.
14

RESEARCH ALERT
May-August 2010
New Publications (& Abstract Links) August cont’d
Robinson M, Oddy WH, McLean NJ, Jacoby P, Pennell CE, de Klerk NH, Zubrick SR,
Stanley FJ, Newnham JP. Low-moderate prenatal alcohol exposure and risk to child
behavioural development: a prospective cohort study. BJOG 2010 Aug;117(9):1139-50.
Epub 2010 May 28.
Skupski DW, Luks FI, Walker M, Papanna R, Bebbington M, Ryan G, O'Shaughnessy
R, Moldenhauer J, Bahtiyar O; North American Fetal Therapy Network (NAFTNet).
Preoperative predictors of death in twin-to-twin transfusion syndrome treated with laser
ablation of placental anastomoses. Am J Obstet Gynecol 2010 Aug 5. [Epub ahead of
print]
Taylor SK, Chia S, Dent S, Clemons M, Agulnik M, Grenci P, Wang L, Oza AM, Ivy P,
Pritchard KI, Leighl NB. A Phase II Study of Pazopanib in Patients with Recurrent or Metastatic
Invasive Breast Carcinoma: A Trial of the Princess Margaret Hospital Phase II Consortium.
Oncologist 2010 Aug 3. [Epub ahead of print]
Tobler D, Fernandes SM, Wald RM, Landzberg M, Salehian O, Siu SC, Colman JM,
Sermer M, Silversides CK. Pregnancy outcomes in women with transposition of the
great arteries and arterial switch operation. Am J Cardiol 2010 Aug 1;106(3):417-20.
White CR, Doherty DA, Henderson JJ, Kohan R, Newnham JP, Pennell CE.Benefits of
introducing universal umbilical cord blood gas and lactate analysis into an obstetric unit.
Aust N Z J Obstet Gynaecol 2010 Aug;50(4):318-28.
Whitehouse AJ, Robinson M, Zubrick SR, Ang QW, Stanley FJ, Pennell CE.
Maternal life events during pregnancy and offspring language ability in middle
childhood: The Western Australian Pregnancy Cohort Study. Early Hum Dev 2010
Aug;86(8):487-492. Epub 2010 Jul 10.
Winsor EJ, Akoury H, Chitayat D, Steele L, Stockley TL. The role of molecular
microsatellite identity testing to detect sampling errors in prenatal diagnosis. Prenat
Diagn 2010 Aug;30(8):746-52.
Yinon Y, Chitayat D, Blaser S, Seed M, Amsalem H, Yoo SJ, Jaeggi ET. Fetal cardiac
tumors: a single-center experience of 40 cases. Prenat Diagn 2010 Aug 18. [Epub ahead
of print]
15

RESEARCH ALERT
May-August 2010
New Honours and Awards
Promoted to the rank of Professor, effective July 1, 2010:
Theodore J Brown
Isabella Caniggia
Jose Carvalho
Guylaine Lefebvre
Barry Rosen
Gareth Seaward
Promoted from Lecturer to Assistant Professor:
Oluleke Badmos
Elyse Lackie
Modupe Tunde-Byass
***********************************************************************
Dr. Oluleke Badmos has been appointed Chief of the Department of Obstetrics and
Gynecology at the Toronto East General Hospital, effective July 1, 2010.
***********************************************************************
Research Day JW Knox Ritchie Research Awards
The 2010 JW Knox Ritchie Research Awards for best abstract/presentation by trainee
category were awarded during the celebratory wine and cheese reception at the end of the
Department’s 27 th Annual Research Day, held on May 7, 2010 at Victoria College,
University of Toronto. The award winners were:
Clinical Fellow: Dini Hui (Supervisor: N. Okun) for Poster Presentation, B4,
Combinations of First and Second Trimester Maternal Serum Biochemical Markers
and Prediction of Adverse Pregnancy Outcomes: Systematic Review and Meta-
Analysis. Dini Hui, Prakeshkumar Shah, Kellie Murphy, Elizabeth Uleryk, John
Kingdom, Nan Okun.
Graduate Student: Jocelyn Ray (Supervisor: I. Caniggia) for Poster Presentation, C5,
A Story of Life and Death: The Dual Role of Mtd/Bok in Trophoblast Cell Fate.
Jocelyn Ray, Julia Garcia, Yuan Wu, Tullia Todros, Andrea Jurisicova, Isabella
Caniggia.
Post-Graduate Fellow: Alicia Tone (Supervisor: T.J. Brown) for Oral Presentation,
05, DAB2 Enhances Glucocorticoid Receptor-Mediated Anti-Inflammatory
Signalling in ES2 Ovarian Cancer Cells. Alicia Tone, Carl Virtanen, Patricia Shaw,
Theodore J. Brown.
16

RESEARCH ALERT
May-August 2010
New Honours and Awards cont’d
Resident: Mara Sobel (Supervisor: J. Kingdom) for Poster Presentation, C2,
Angiogenic response of the human placenta to heparin: Implications for the
prevention of pre-eclampsia Mara Sobel, Sascha Drewlo, John Kingdom.
Medical Student: Marie Wegener (Supervisor: Sarah Ferguson) for Oral
Presentation, O6, Validation of the Modified Sexual Adjustment and Body Image
Scale in Women with a Diagnosis of Gynaecologic Cancer (SABIS-G) Marie
Wegener, Sara Urowitz, Catherine Classen, David Wiljer, Christine Massey, Sarah E.
Ferguson.
In addition, the Papsin Award for postgraduate resident in final year of training, based
on teaching ability, mentorship activities and leadership, as chosen by peers, was
awarded to Rebecca Cash.
For other awards and honours, please go to page 4 of the Department’s August 2010
newsletter:
http://www.obgyn.utoronto.ca/Assets/OBGYN+Digital+Assets/about/NLAgu2010.pdf
If we knew what we were doing, it would not be called research, would it
Albert Einstein
17