Anti-ranibizumab Neutralizing Antibody Assays
Anti-ranibizumab Neutralizing Antibody Assays
Anti-ranibizumab Neutralizing Antibody Assays
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Ranibizumab Dose-Response<br />
5800<br />
Inhibition of rhVEGF Induced-HUVEC (P3) Proliferation by Lucentis<br />
4800<br />
3800<br />
2800<br />
1800<br />
0.01 0.1 1 10<br />
Ranibizumab (ng/mL)<br />
Final Concentration of rhuFab V2 (nM)<br />
Ranibizumab<br />
y = ( (A - D)/(1 + (x/C)^B ) ) + D: A B C D R^2<br />
1 (VEGF165: Concentration vs Mean Value) 5004.349 4.709 0.418 2486.57 0.997<br />
PSWC2010-AAPS Annual Meeting – Nov 16, 2010<br />
Mauricio Maia Genentech 2010 14
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