Anti-ranibizumab Neutralizing Antibody Assays
Anti-ranibizumab Neutralizing Antibody Assays
Anti-ranibizumab Neutralizing Antibody Assays
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NAb <strong>Assays</strong> – Points to Consider<br />
Nab assay measures opposite effect of drug<br />
The larger the drug-induced signal, the higher the Nab concentration<br />
needed to counter-act that effect<br />
Thus, in general, best Nab sensitivity achieved at lowest drug concentrations<br />
Challenge for inhibitory mAb therapeutic drugs:<br />
at low drug concentrations, the degree of signal inhibition<br />
is reduced, as well…<br />
Goal – select drug-inhibited effect that gives<br />
highest signal-to-noise with the lowest drug concentrations …<br />
PSWC2010-AAPS Annual Meeting – Nov 16, 2010<br />
Mauricio Maia Genentech 2010 9
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