BRUCE CHRISTOPHER WHEELER University of Florida J. Crayton ...

BRUCE CHRISTOPHER WHEELER
University of Florida
J. Crayton Pruitt Family Department of Biomedical Engineering
JG-56 BioMedical Sciences Building, 1275 Center Drive, P.O. Box 116131, Gainesville FL 32611-6131
Phone: 352-273-9313 Dept: 352-273-9222 Fax: 352-273-9221 bwheeler@ufl.edu
RESEARCH
AREAS
Technologies for the Study of Small Neuronal Networks: Micropatterning the Growth of
Individual Neurons; Microelectrode Array Fabrication; Neural Signal Processing
Biomedical Engineering & Signal Processing
EDUCATION Ph.D., M.S., Cornell University, Electrical Engineering, 1981, 1977.
S.B., S.B., MIT, Physical Science / History, 1971 (courses XIIB and XXI)
POSITIONS 2009- Interim Chair, Department of Biomedical Engineering, University of Florida
2008 - Professor of Biomedical Engineering, University of Florida
2008- Professor Emeritus, University of Illinois
2004-2008 Professor of Bioengineering, University of Illinois
2004-2008 Interim and Founding Head, Department of Bioengineering, U. Illinois
2002-2003 Director, Bioengineering Program, University of Illinois
2000-2008 Professor of Electrical and Computer Engineering
1995-2001 ECE Dept. Assoc. Head for Undergraduate Affairs / Chief Advisor
1988-2000 Associate Professor of Electrical and Computer Engineering, U. Illinois
1990-1993 Chair, Neuroscience Graduate Program, University of Illinois
1989-1990 Chair, Bioengineering Faculty, University of Illinois
1982-1988 Assistant Professor of Electrical and Computer Engineering, U. Illinois
1980-1982 Visiting Assistant Professor of Electrical Engineering, University of Illinois
1974-1980 Research and Teaching Assistant, Cornell University, Ithaca NY
1972-1974 Programmer, Virginia Polytechnic Institute, Blacksburg VA.
1971-1972 Teacher, Niskayuna Public Schools, Schenectady NY.
PROFESSIONAL
ACTIVITIES
HONORS
ADMINISTRATIVE
HIGHLIGHTS
TEACHING
ACTIVITY
SUMMARY
2007-2013 Editor in Chief, IEEE Transactions on Biomedical Engineering (TBME)
Advisory Board, U. Fla Biomed. Eng. Dept. 2003-08. Advisory Board, Cornell U. Dept.
Biol.&Environ Eng., 2004-8, Adv. Board, Dept Brain and Bio Engineering, KAIST, Daejon
Korea, since ‘07. IEEE Trans Biomed Eng Assoc. Ed. ‘01-6. Ed. Board, J. Neurosci. Meth.
Since 1996; J Neuroeng, since ‘03, Nanomed, since ‘05. Front. Neurosci. Rev. Ed. 2009-.
Memberships: IEEE (Senior), BMES, ASEE, AAAS, Soc. Neurosci. Offices: IEEE local
offices, IEEE EMBS Student AdCom. MIT Ed Council (interview HS seniors) since 1978.
Extensive reviewing (NIH, NSF, TBME, et al.).
Fellow, IEEE, 2008. Fellow, American Institute for Medical and Biological Engineering,
2004. Sr Member IEEE. UIUC Outstanding MD/PhD Advisor 2003; UIUC Campus Wide
Award Excellence in Undergrad. Advising, 2000; Illinois Dad’s Assoc. Outstanding
Professor, 1999; Honorary Knight of St. Pat (student leader chosen award), 1999; Pierce
Award (student/faculty relations, Engineering College), 1987; Outstanding Advisor,
‘89,93,97,01. “Incomplete List” of Outstanding Instructors, UIUC, 84,87,96. Phi Beta
Kappa, Eta Kappa Nu. Cornell: McMullen Fellowship, 1979-80. MIT: NCAA Postgrad
Fellow, Outstanding Freshman. MVP Greater Boston Baseball League. Player of week,
Greater Boston Basketball. Senior Athlete of Year 1971.
Interim Chair, U Fla. Writing Undergrad Proposal. Interim Head, Illinois Dept. Bioen.. Start
dept. from zero to 8 faculty, 110 undergrads, 30 grad students. Director, Bioen. Pgm. Wrote
proposal for Dept., BS, MS, PhD degrees. Assoc. Head ECE (6 years). Proactive advising
policies reduced ECE undergraduate drop and probation rates. Earned campus wide award
for this effort. (Enrollment: 1600) Chaired both the Neuroscience (3 years) and
Bioengineering (1 year) Programs.
Ph.D. / M.S. Students Supervised: 9 / 31 graduated, 2 / 4 in progress. Postdocs 6.
Courses Taught: Electronic Ckts, Analog Filter Design, Digital Signals & Systems, Medical
Image Processing, Intro. Medical Imaging, Biomed. Instrumentation & Lab, Modeling of
BioSystems, Theory & Fab. Solid State Devices Lab, Integrated Ckt. Fab. Lab, Basic EE
Lab., Intro. Ckt Analysis, Intro to Bioeng., Coordinate ECE Undergrad Honors Seminar &
Neuroscience Seminar. ECE Explorations (undergrad seminar)
December 2009 Bruce C. Wheeler p. 1/23

PUBLICATIONS
Peer Reviewed
1. Wheeler, B.C. and Brewer, G.J. Designing Neural Networks in Culture, Proceedings of the IEEE, accepted.
2. Ide, AN, Andruska, A, Boehler, MD, Wheeler, BC, and Brewer, GJ. Chronic Network Stimulation Enhances
Evoked Action Potentials. accepted J. Neural Eng.
3. Brewer, GJ, Boehler, MD, Ide, AN, and Wheeler, BC. (2009) Chronic electrical stimulation of hippocampal
networks during development increases spontaneous spike rates, accepted, J. Nsci. Meth., 184, 104-109.
NIHMSID#137731. Publ.ID NSM5380. PubMed#19666055.
4. Musick, K., Khatami, D., and Wheeler, B.C. (2009) Three-dimensional microelectrode array for recording
dissociated neuronal cultures, Lab on Chip, 9, 2036-2042. DOI: 10.1039/b820596e.
5. Nam, Y., Brown, E.A., Ross, J.D., Blum, R.A., Wheeler, B.C., DeWeerth, S.P., (2009) A retrofitted neural
recording system with a novel stimulation IC to monitor early neural responses from a stimulating electrode.
J. Neurosci. Meth. 178, 99–102.
6. Dworak, B.J., and Wheeler, B.C., (2009) Novel MEA platform with PDMS microtunnels enables detection of
action potential propagation from isolated axons in culture, Lab on Chip, 9, 404-410.
7. Brewer, G.J., Boehler, M.D., Pearson, R.A., DeMaris, A.A., Ide, A.N., Wheeler, B.C. (2009), Neuron
network activity scales exponentially with synapse density, J. Neural Eng. 6., 014001, doi:10.1088/1741-
2560/6/1/014001.
8. Brown, E.A., Ross, J.D., Blum, R.A., Nam, Y., Wheeler, B.C., DeWeerth, S.P. (2008) Stimulus-artifact
elimination in a multi-electrode system. IEEE Trans. Biomed. Circuits and Systems, 2 (1), March., 10-21.
9. Brewer, G. J.; Boehler, M. D.; Jones, T. T.; Wheeler, B. C., (2008) NbActiv4 medium improvement to
Neurobasal/B27 increases neuron synapse densities and network spike rates on multielectrode arrays. Journal
of Neuroscience Methods, 170, (2), 181-187.
10. Boehler, MD, Wheeler, BC, and Brewer, GJ. (2008) Added astroglia promote greater synapse density and
higher activity in neuronal networks, Neuron Glia Biology, 3(2):127-140.
11. Vieira, M.; Christensen, B. L.; Wheeler, B. C.; Feng, A. S.; Kollmar, R., (2007) Survival and stimulation of
neurite outgrowth in a serum-free culture of spiral ganglion neurons from adult mice. Hearing Research, 230,
(1-2), 17-23.
12. Nam, Y, Brewer, GJ, Wheeler, BC. (2007) Development of astroglial cells in patterned neuronal cultures, J.
Biomaterials Science, Polymer Edition, 18(8), 1091-1100.
13. Rowe, L., Almasri, M., Lee, K., Fogleman, N., Brewer, G.J Nam, Y., Wheeler, B.C., Vukasinovic, J., Glezer,
A., Frazier, A.B. (2007) Active 3-D Microscaffold System with Fluid Perfusion for Culturing in Vitro
Neuronal Networks, Lab on a Chip (4),475-482.
14. Chang, J.C., Brewer, G.J, Wheeler, B.C. (2006) Neuronal network structuring induces greater neuronal
activity through enhanced astroglial development, J. Neuroeng. 3, 217-226.
15. Nam, Y., Musick, K., and Wheeler, B.C. (2006) Application of a PDMS microstencil as a replaceable
insulator toward a single-use planar microelectrode array, Biomedical Microdevices, 8(4), 375-381.
16. Phatak, SA, Ratnam, R, Wheeler, BC, O'Brien, WD, Jr., Feng, AS (2006). Effect of reflectors on sound
source localization with two microphones, J. Audio Eng. Soc., 54 (6), 512-524. ]
17. Nam, Y., Branch, D.W., and Wheeler, B.C. (2006) Epoxy-silane linking of biomolecules is simple and
effective for patterning neuronal cultures, Biosensors and Bioelectronics, 22(5), 589-597.
18. Nam, Y, Wheeler, B.C., and Heuskel, M.O. (2006) Neural recording and stimulation of dissociated
hippocampal cultures in vitro using microfabricated three dimensional tip electrode array, J. Nsci. Meth., 155
(2), 296-299.
19. Nam, Y., Chang, J.C., Khatami, D., Brewer, G.J., and Wheeler, B.C., (2004) “Patterning to enhance activity
of cultured neuronal networks”, IEE Proc. Nanobiotechnology, 151(3), 109-115.
20. Larsen, J., Lansing, C., Bilger, R., Wheeler, B., Phatak, S., Lockwood, M., O’Brien, W., Jr., and Feng, A.S,
(2004) “Speech perception in noise with a two-sensor FMV beamforming algorithm”, Acoustics Research
Letters Online, 5(3), 100-105.
21. Lockwood, M.E., Jones, A.L., Bilger, R.C., Lansing, C.R., O'Brien, W.D., Wheeler, B.C. and Feng, A.S.,
(2004) “Performance of time-and frequency-domain binaural beamformers based on recorded signals from
real rooms,” J. Acoust. Soc. Am., 115, 379-391.
December 2009 Bruce C. Wheeler p. 2/23

22. Nam, Y., Chang, J.C., Wheeler, B.C., Brewer, G.J., (2004) “Gold coated microelectrode array with thiol
linked self-assembled monolayers to engineer neuronal cultures”, IEEE Trans Biomed. Eng., 51(1), 158-165,
January.
23. Ratnam, R., Jones, D.L., Wheeler, B.C., O’Brien, W.D., Jr., Lansing, C., Bilger, R.C., and Feng, A.S., (2003)
“The blind estimation of reverberation time,” J. Acoust. Soc. Am., 114, 2877-2892.
24. Chang, J.C., Brewer, G.J., Wheeler, B.C. (2003) “A Modified Microstamping Technique Enhances Polylysine
Transfer and Neuronal Cell Patterning”, J. Biomaterials, 24(17) (August): 2863-2870.
25. Cornish T, Branch DW, Wheeler BC, Campanelli JT (2002) “Microcontact printing: a versatile technique for
the study of synaptogenic molecules,” Mol. Cell. Neurosci. 20(1):140-53.
26. Liu, C., Wheeler, B.C., O'Brien, W.D. Jr., Bilger, R.C., Lansing, C.R., Feng, A.S. (2001) “A two microphone
dual delay-line approach for extraction of a speech sound in the presence of multiple interferers,” J. Acoust.
Soc. Amer., 110(6), 3218-3231.
27. Chang, J.C., Brewer, G.J., and Wheeler, B.C., (2001) "Modulation of neural network activity by patterning",
Biosensors and Bioelectronics, 16 (7-8) (Sept): 527-533.
28. Branch, DW, Wheeler, BC Brewer, GJ & D.E. Leckband, DE (2001) “Long-term stability of microstamped
sub-strates of polylysine and grafted polyethylene glycol in cell culture conditions,” J. Biomaterials, 22, 1035-
1047.
29. Chang, J.C., Wheeler, B. C., and Brewer, G. J. (2000) "Microelectrode array recordings of patterned
hippocampal neural networks for four weeks," Biomedical Microdevices, 2:4, 245-253.
30. Venkateswar, R.A., Wheeler, B.C., and Branch, D.W. (2000) "An electrophoretic method for producing
patterned biomolecule gradients," Biomedical Microdevices, 2:4, 255-264.
31. Branch, D.W., Wheeler, B.C., Brewer, G.J., and Leckband, D. (2000) “Long-term maintenance of patterns of
hippocampal pyramidal cells on substrates of polyethylene glycol and microstamped polylysine,” IEEE Trans.
Biomed. Eng., 47, 290-300.
32. Liu, C., Wheeler, B.C., O’Brien, W.D., Jr., Bilger, R.C., Lansing, C.R., and Feng, A.S. (2000) “Localization
of multiple sound sources with two microphones in complex acoustic environments,” J. Acoust. Soc. Amer.,
108(4), 1888-1905.
33. Wheeler, B.C., Corey, J.M., Brewer, G.J., & Branch, D.W (1999), “Microcontact printing for precise control
of nerve cell growth in culture,” J. Biomech. Eng., 121, 73-78.
34. Gordon, S.H, Wheeler, B.C., Schudy, R.B., Wicklow, D.T., and Greene, R.V. (1998). “Neural network
pattern recognition of photoacoustic FTIR spectra and knowledge-based techniques for detection of
mycotoxigenic fungi in food grains,” J. of Food Protection, 61(2), 221-230.
35. Branch, D.W., Corey, J.M., Weyhenmeyer, J. A., Brewer, G. J., & Wheeler, B.C. (1998) “Micro-stamp
patterns of biomolecules for high-resolution neuronal networks,” Med. & Biol. Comp. & Eng., 36, 135-141.
36. Corey, J.M., Brunette, A.L., Chen, M.S., Weyhenmeyer, J.A., Brewer, G.J., and Wheeler, B.C.(1997),
“Differentiated B104 neuroblastoma cells are a high-resolution assay for micropatterned substrates,” J.
Neurosci. Methods, 75, 91-97.
37. Gordon, S.H., Schudy, R.B., Wheeler, B.C., Wicklow, D.T., & Greene, R.V. (1997) “Identification of Fourier
transform infrared photoacoustic spectral features for detection of aspergillis flavus infection in corn,” Int. J.
Food Microbiol., 35, 179-185.
38. Corey, J.M., Wheeler, B.C., & Brewer, G.J. (1996) "Micrometer resolution silane-based micropatterning of
hippocampal neurons: a comparison of photoresist and laser ablation methods for fabricating substrates,"
IEEE Trans. Biomed. Eng., 43, 944-955.
39. Gordon, S.H., Greene, R.V., Wheeler, B.C., and James, C. (1993) “Multivariate FTIR analysis of substrates
for protein, polysaccharide, lipid and microbe content: Potential for solid-state fermentations,” Advances in
Biotechnology, 11, 665-675.
40. Boppart, S., Wheeler, B.C., and Wallace, C. (1992) "A flexible, perforated microelectrode array for extended
neural recordings," IEEE Trans. Biomed. Eng., BME-39, 37-42.
41. Corey, J.L, Wheeler, B.C., and Brewer, G.J. (1991) "Compliance of hippocampal neurons to patterned
substrate networks," J. Neurosci. Res., 30, 300-307.
42. Willming, D.A. and Wheeler, B.C. (1990) "Real-time multichannel neural spike recognition with DSPs,"
IEEE EMBS Magazine, 9, 37-40.
43. Novak, J.L. and Wheeler, B.C. (1989) "Two-dimensional current source density analysis of propagation
delays for components of epileptiform bursts in rat hippocampal slices," Brain Res., 497, 223-230.
44. Novak, J.L. and Wheeler, B.C. (1989) "A high-speed multichannel neural data acquisition system for IBM PC
compatibles," J. Neurosci. Meth., 26, 239-247.
December 2009 Bruce C. Wheeler p. 3/23

45. Wheeler, B.C. and Smith, S.R. (1988) "High-resolution alignment of action potential waveforms using cubic
spline interpolation," J. Biomed. Eng., 10, 47-53, 1988.
46. Novak, J.L. and Wheeler, B.C. (1988) "Multisite hippocampal slice recording and stimulation using a 32
element microelectrode array," J. Neurosci. Meth., 23, 149-159.
47. Smith, S.R. and Wheeler, B.C. (1988) "A real-time multiprocessor system for acquisition of multichannel
neural data," IEEE Trans. Biomed. Eng., BME-25, 875-877.
48. Wheeler, B.C. and Novak, J.L. (1986) "Current source density estimation using microelectrode array data
from the hippocampal slice preparation," IEEE Trans. Biomed. Eng., BME-33, 1204-1212, 1986.
49. Novak, J.L. and Wheeler, B.C. (1986) "Recording from the Aplysia abdominal ganglion with a planar
microelectrode array," IEEE Trans. Biomed. Eng., BME-33, 196-202.
50. Wheeler, B.C. (1985) "Exercises for an introductory image processing class," IEEE Trans.Educ., E-28,31-35.
51. Wheeler, B.C. and Valesano, W.R. (1985) "A real-time digital filter based data acquisition system for the
detection of neural signals," Med. & Biol. Eng. & Comput., 23, 243-248.
52. Wheeler, B.C. and Heetderks, W.J. (1982) "A comparison of techniques for classification of multiple neural
signals," IEEE Trans. Biomed. Eng., BME-29, 752-759.
53. Kim, M., Wheeler, B.C., Shin, K.B., and Perry, S. (1979) "Design of optimal chemotherapy schedules using
kinetic models for cancerous and normal tissues, " J. Cybernetics & Info.Science, 2, 92-108.
54. Kim, M., Wheeler, B.C., and Perry, S. (1978) "Quantitative description of cell cycle kinetics under
chemotherapy utilizing flow cytometry, " Cell Tissue Kinetics, 11, 497-512.
Submitted and in Preparation:
1. Chang, J.C., Nam, Y., Wheeler, B.C., Brewer, G.J. Silane modified platinum and titanium nitride electrodes
are biocompatible for patterning hippocampal cultures, in revision.
2. Khatami, D.B., Nam, Y., and Wheeler, B.C., A new approach for semi-automated stimulation and
connectivity analysis of neuronal networks grown on multielectrode arrays, in preparation.
3. Scharnweber, R.F., Brewer, G.J., and Wheeler, B.C. Polarized axon growth of hippocampal neurons cultured
on tapered lines of laminin – approximate title. In preparation.
4. Scharnweber, R.F., Nam, Y., and Wheeler, B.C. Improved microchamber design for selectively harvesting
CNS axons for molecular signaling studies – approximate title. In preparation.
Book Chapters
1. Chang, J.C., and Wheeler, B.C., (2006) “Pattern technologies for structured neuronal networks on MEAs,”
book chapter in Advances in Network Electrophysiology using Multi Electrode Arrays, M. Taketani and M.
Baudry (eds), Kluwer Academic/Plenum.
2. Wheeler, B. C. (1998) “Automatic discrimination of single units,” in M. Nicolelis, Ed., Methods for Neural
Ensemble Recordings, CRC Press, Ch. 4, 61-77.
3. Wheeler, B. C., & Brewer, G. J. (1994). “Multineuron patterning and recording”, in McKenna & Stenger
(Eds.), Enabling Technologies for Cultured Neural Networks, 167-185, Academic Press.
4. Novak, J. L. & Wheeler, B. C. (1987) “Epileptiform activity recorded simultaneously at multiple sites on the
surface of a hippocampal slice with a planar microelectrode array,” in Brain Slices: Fundamentals,
Applications and Implications, A.Schurr, TJ Teyler, & M.Tseng, Eds, S.Karger, Basel, Switzerland, 177-183.
Patents Granted
1. Feng, A.S., Lansing, C.R., Liu, C., O'Brien, W.D. and Wheeler, B.C. "Binaural Signal Processing System
and Method" Patent issued on April 24, 2001. (US Patent #6,222,927).
2. Feng, A.S., Liu, C., Jones, D.L., Bilger, R.C., Lansing, C.R., O’Brien, W.D, Wheeler, B.C., “Binaural Signal
Processing Using Multiple Acoustic Sensors and Digital Filtering,” US Patent 6,978,159 B2, Dec. 20, 2005.
3. Feng, A.S., Liu, C., Bilger, R.C., Jones, D.L., Lansing, C.R., O’Brien, W.D, Wheeler, B.C., “Binaural Signal
Processing Techniques,” US Patent 6,987,856 B1, Jan. 17, 2006.Canadian Patent #2,348,894 issued on
09/25/2007; European Patent #1133899 issued on August 6, 2008.
4. Feng, A.S., Lockwood, M.E., Jones, D.L., Bilger, R.C., Lansing, C.R., O'Brien, W.O., Wheeler, B.C. -
System and Methods for Interference-Suppression with Directional Sensing Patterns. US Patent # 7,076,072
issued on July 11, 2006.
5. Feng AS, Jones DL, Wheeler BC, Bilger RC, Lansing CR, O'Brien WD - "Intrabody communication for a
hearing aid" - US patent #7,206,423 B1, issued on 4/17/2007; DE 195 41 648 C2; WO 01/87014 A2.
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6. Jones, D.L., Lockwood, M.E., Bilger, R.C., Feng, A.S., Lansing, C.R., O'Brien, W.D., Wheeler, B.C.,
Elledge, M. and Liu, C. Interference suppression techniques. - US Patent # 7,613,309 B2 (issued on Nov 3,
2009);. European patent #1 312 239 (issued on 12/27/2006).
7. Feng, A.S., Lockwood, M.E., Jones, D.L., Bilger, R.C., Lansing, C.R., O'Brien, W.O., Wheeler, B.C. -
System and Methods for Interference-Suppression with Directional Sensing Patterns. US Patent # 7,577,266
(issued Aug 18, 2009).
Patents Applied For
1. Jones, D.L., Lockwood, M.E., Bilger, R.C., Feng, A.S., Lansing, C.R., O'Brien, W.D., Wheeler, B.C.. -
Refinements of dual-channel extraction algorithm/system for high fidelity interference suppression from nondistinct
sources. PCT patent application filed on May 10, 2001 (Original US Serial number 09/568,430); WO
01/87011 A2.
2. Feng, A.S., Jones, D.L., Wheeler, B.C., Bilger, R.C., Lansing, C.R. and O'Brien, W.D. Wireless Intrabody
Interconnect Technology for Hearing Aids and Acoustic Processing. (UIUC Tech ID- TF00048) - Patent
application filed in May 10, 2000 (US Serial number 09/568,435).
3. O'Brien, W.D., Feng, A.S., Jones, D.L., Wheeler, B.C., Lansing, C.R. and Bilger, R.C. - Wireless Ultrasonic
Intrabody Interconnect Technology for Hearing Aids and Acoustic Processing. US Patent Application
(10/409,970) filed on April 9, 2003.
4. Ratnam, R., Jones, D., Feng, A.S., Lansing, C., O’Brien, W.D., Jr., Wheeler, B.C. "System for Blind
Determination of Reverberation Time in Unknown Acoustic Environments Using Passively Perceived
Sounds,” File date: March 24, 2004, Application No. 10/807,885.
Conference And Other Papers/Abstracts
1. Ide, AN, Andruska , A, Boehler, M, Wheeler, BC, Brewer, GJ. Chronic Network Stimulation Enhances
Evoked Action Potentials, Soc. Neurosci. 2009.
2. Musick, K and Wheeler, BC. Three-Dimensional Microelectrode Array for Recording Dissociated Neuronal
Cultures. MEA 2008 (6th Int. Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, July
2008.
3. Dworak BJ and Wheeler BC. Enhanced Extracellular Recordings from Axons Patterned through PDMS
Microtunnels in a Neuronal Culture. MEA 2008 (6th Int. Mtg., Substrate-Integrated Microelectrode Arrays),
Reutlingen Germany, July 2008.
4. Brewer G, Boehler M, Jones T, Wheeler B. NbActiv4TM, a Novel Improvement to Neurobasal/B27TM
Medium, Increases Activity in Neuronal Networks by Promoting Synaptogenesis. MEA 2008 (6th Int. Mtg.,
Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, July 2008.
5. Brewer G, Boehler, Pearson, R, DeMaris A, Wheeler, B. Neuron Network Activity Scales Exponentially
with Synapse Density. MEA 2008 (6th Int. Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen
Germany, July 2008.
6. Brewer G, Boehler M, Wheeler B, Embryonic Hippocampal Cultures in NbActiv4TM Surpass Spiking
Activity of Embryonic Cortical Cultures in either Serum Medium or NbActiv4TM. MEA 2008 (6th Int.
Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, July 2008.
7. Khatami DB, Brewer GJ, Wheeler BC, Effect of Short- and Long-term Electrical Stimulation on Network
Behavior. MEA 2008 (6th Int. Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, July
2008.
8. Jones, D.L., Lockwood, M.E., Feng , A.S., and Wheeler, B.C., Biologically Inspired Beamforming with
small Acoustic Arrays, BIOSIGNALS 2008, Funchal/Madeira, Portugal, Jan 28-31, 2008.
9. Khatami, D.B., Dworak B.J., Brewer, G.J., and Wheeler, B.C. Functional Connectivity Analysis and
Tracking in Biological Neuronal Networks Patterned on Microelectrode Arrays. BMES Annual Fall
Meeting, Los Angeles, CA., September 26-29, 2007.
10. Dworak, B.J. Scharnweber, R.F., Musick, K.M., Khatami, D.B., Brewer, G.J., and Wheeler, B.C. Multicompartment
neural soma aggregates linked by electrically accessible 3-D axonal microchannels. BMES
Annual Fall Meeting, Los Angeles, CA., September 26-29, 2007.
11. Musick, K.M., and Wheeler, B.C. Three-dimensional microelectrode array for recording dissociated
neuronal cultures, BMES Ann. Conf. Los Angeles, September 26-29, 2007.
12. Wheeler, B.C., Engineering Form and Function in Cultured Neuronal Circuits, Medicon 2007, Ljubljana,
Slovenia, June 2007.
December 2009 Bruce C. Wheeler p. 5/23

13. Kollmar, R, Vieira, M, Christensen, BL, Shah, SM, Kang, Y-J, Wheeler, BC and Feng, AS Promoting
Neurite Outgrowth from Adult Spiral Ganglion Neuron, Age Related Hearing Impairment Conference,
Antwerp, May 2007.
14. Shah, SM, Christensen, BL, Kang, Y-J, Vieira, M, Wheeler, BC, Feng, AS, Kollmar, R. Expression of
Frizzled Genes in the Inner Ear of Adult Mice. Abstract. Ann. Mtg. Assoc. Res. Otolaryng., Feb 2007.
15. Cullen, DK, Vukasinovic, J, Irons, HR, Gleser, A, Wheeler, BC, and Laplaca, MC. Engineered high cell
density three-dimensional constructs, Soc. Neurosci. Ann. Conf., Atlanta, Oct 2006.
16. Wheeler, BC, Khatami, DB, Nam, Y, Boehler, MD, Brewer, GJ, Designed In Vitro Neuronal Networks:
Dependency of Activity on Geometric Pattern, Biomedical Engineering Society Annual Meeting, Chicago,
Oct 2006, featured presentation.
17. Khatami, DB, Nam, Y, Wheeler, BC, Mapping Functional Connectivity in Geometrically Confined Neuronal
Networks, Biomedical Engineering Society Annual Meeting, Chicago, Oct 2006.
18. Brewer, GJ, Boehler, MD, Wheeler, BC, Higher activity with increased connections in patterned
hippocampal neurons, Biomedical Engineering Society Annual Meeting, Chicago, Oct 2006.
19. Brewer, GJ, Fogleman, CN, Boehler, MD, Wheeler, BC. (2006) Neural plasticity in hippocampal neurons by
paired-pulse stimulation on MEA, International MEA Conference, Reutlingen Germany, July 2006.
20. Brewer, G.J., Boehler, M.D., Wheeler, B.C. (2006) Higher activity with increased connections in patterned
hippocampal neurons, International MEA Conference, Reutlingen Germany, July 2006.
21. Brewer, G.J., Boehler, M.D., Wheeler, B.C., (2006) Added astroglia promote greater synapse density and
higher activity in neuronal networks, International MEA Conference, Reutlingen Germany, July 2006.
22. Musick, K., Nam, Y., Wheeler, B.C. (2006) Microstamped electrodes with PDMS insulator: A design
towards inexpensive, single-use microelectrode arrays, International MEA Conference, Reutlingen Germany,
July 2006.
23. Khatami, D.B., Nam, Y., Wheeler, B.C. (2006) Tools for Automated Stimulation and Connectivity Analysis
of Neuronal Networks Grown on Multielectrode Arrays, International MEA Conference, Reutlingen
Germany, July 2006.
24. Brown, E.A., Blum, R.A., Ross, J.D., Nam, Y., Wheeler, B.C., DeWeerth, S.P., (2006) An Integrated System
for Simultaneous Multichannel Stimulation and Recording, International MEA Conference, Reutlingen
Germany, July 2006.
25. Kollmar, R., Vieira, R., Christensen, B., Wheeler, B., Feng, A., (2006) Survival and Stimulation of Neurite
Outgrowth in a Serum-Free Culture of Adult Spiral-Ganglion Neurons. Ann. Mtg. Assoc. Res. Otolaryng.,
Feb, 2006, Baltimore MD.
26. Scharnweber, R.F., Brewer, G.J., and Wheeler, B.C. (2005) Polarized Axon Growth of Hippocampal
Neurons Cultured on Tapered Lines of Laminin, Soc. Neurosci. Ann. Conf., Wash. DC.
27. Nam, Y., Brewer, G.J., Wheeler, B.C. (2005) Glial guidance by neurons in patterned hippocampal cultures in
vitro. Soc. Neurosci. Ann. Conf., Wash DC.
28. Vieira, M, Christensen; BL Wheeler, BC, Kollmar, R, Feng, AS. (2005). Survival and stimulation of neurite
outgrowth in a serum-free culture of adult spiral-ganglion neurons, Soc Neurosci. Conf., Wash DC, Oct.
29. Wheeler, BC (2005) Cultured neuronal networks: past, present, and future. BMES Ann Conf Baltimore.
30. Wheeler, B.C. (2005) Enhancing neuron / electrode interfaces in culture. BMES Ann.Conf. Baltimore, Sept.
31. Khatami,D.B., Brewer,G.J., Ujhelyi, E.,Wheeler, B.C. (2005) Bicuculline application enhances long-term
activity in low density cultured hippocampal neurons, BMES Ann. Conf., Baltimore, Sept.
32. Musick, K., Nam, Y., and Wheeler, B.C. (2005) Microstamp Patterned Electrodes with PDMS Insulator:
Design for Inexpensive Microelectrode Arrays. BMES Ann. Conf. Baltimore, Sept.
33. Wheeler, B.C. (2005) Starting a Bioengineering Department at the University of Illinois. Vietnam Bioeng.
Conf. Ho Chi Minh City. July.
34. Nam, Y., Wheeler, B.C., and Nam, M. H., Technological developments in studying neural information
processing in patterned neuronal
35. Nam, Y. and Wheeler, B.C. Imaging locations of neurons vs. glia in low density culture, 2nd International
IEEE EMBS Special Topic Conference on Neural Engineering, Washington DC, March 2005.
36. Scharnweber, R.F., Brewer, G.J. and Wheeler, B.C., 2004, Cytochalasin treatment disrupts growth cone
guidance on thin laminin lines in culture, Abstract, Society for Neuroscience Annual Meeting, San Diego CA
Oct 2004.
37. Khatami, D.B., Chang, J.C., Brewer, G.J., Wheeler, B.C, 2004, Effects of spatial confinement on the
spontaneous and evoked activity of linearly patterned biological neural networks, Abstract, Society for
Neuroscience Annual Meeting, San Diego CA Oct 2004.
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38. Brewer, G.J., Boehler, M.P., Nam, Y., Wheeler, B.C., 2004, Added astroglia increase spontaneous spiking,
sensitivity to a GABA antagonist and to glutamate on multielectrode arrays in serum-free medium, Abstract,
Society for Neuroscience Annual Meeting, San Diego CA Oct 2004.
39. Nam, Y., and Wheeler, B.C., 2004, Micro-stencil based microelectrode array for neuronal cultures, Abstract,
Biomedical Engineering Society Meeting, Oct. 2004, Philadelphia.
40. Chen, H.C., and Wheeler, B.C., Evaluation of algorithms for displaying apparent connectivity in neuronal
networks, Abstract, Biomedical Engineering Society Meeting, Oct. 2004, Philadelphia.
41. Krishnan, B., and Wheeler, B.C., Evaluation of wavelet-based methods for spike sorting, Abstract,
Biomedical Engineering Society Meeting, Oct. 2004, Philadelphia.
42. Khatami, D.B., Nam, Y., Brewer, G.J., and Wheeler, B.C. Effect of bicuculline on the spontaneous and
evoked activity of patterned embryonic hippocampal neurons cultured in vitro. EMBS Annual Conference,
San Francisco, Sept 2004.
43. Nam, Y., and B.C. Wheeler, Multichannel recording and stimulation of neuronal cultures grown on
microstamped poly-D-lysine,EMBS Annual Conference, San Francisco, Sept 2004.
44. Bruce C. Wheeler, Yoonkey Nam, and Gregory J. Brewer, Patterning to Influence in vitro Neuronal
Interfaces, invited talk, EMBS Annual Conference, San Francisco, Sept 2004.
45. Wheeler, B.C., Nam, Y., Khatami, Y., Scharnweber, R.F., Brewer, G.J., 2004, Patterned Neuronal Networks
to Study Information Processing in vitro on Microelectrode Arrays,abstract, SIMEA 2004, Reutlingen
Germany, July 6, 2004.
46. Nam, Y., Wheeler, B.C. Neural recordings of dissociated hippocampal cultures using a 3D tip shaped
microelectrode array, abstract, SIMEA 2004, Reutlingen Germany, July 6, 2004.
47. Choi, Y., Seungkeun Choi, S., Powers, R., Nam, Y., Marr, A., Brewer, G.J., Wheeler, B.C., Allen, M.G.,
2004, Three-Dimensional Tower Structures with Integrated Cross-Connects for 3-D Culturing of Neurons,
poster, 2004 Solid-State Sensor and Actuator Workshop.
48. Ratnam, R., Jones, D.L., Wheeler, B.C., and Feng, A.S., 2003, "Online estimation of room reverberation
time," Journal of the Acoustical Society of America, vol. 113, p. 2269, 2003.
49. Nam, Y., Khatami, D., Brewer, G.J., Wheeler, B.C., Spontaneous and Evoked Electrical Activity in
Patterned, Cultured Neuronal Networks, Ann. Conf., Soc. Neurosci, New Orleans, Nov. 2003.
50. Scharnweber, R.F., Nam, Y., Chang, J.C., Brewer, G.J., Wheeler, B.C., Technique for presenting multiple
guidance cues to cultured embryonic rat hippocampal neurons, Ann Conf., Soc. Neurosci, New Orleans,
Nov. 2003.
51. Larsen, E., Lansing, C.R., O’Brien, W.D., Jr., Wheeler, B.C., Feng, A.S. Acoustic scene analysis using
estimated impulse responses, 37th Asilomar Conf on Signals, Systems and Computers, Nov 6-9, Pacific
Grove CA, 2003.
52. Nam, Y., Khatami, D., Wheeler, B.C., and Brewer, G.J., Electrical stimulation of patterned neuronal
networks in vitro, IEEE EMBS Annual Conference, Cancun, Mexico, October, 2003
53. Mohan, S., Kramer, M.L., Wheeler, B.C., and Jones, D.L., Localization of nonstationary sources using a
coherence test. IEEE Workshop on Statistical Signal Processing. September 2003.
54. Nam, Y., Scharnweber, R., Chang, J.C. Wheeler, B.C., Brewer, G.J., A new MEA design approach for
patterned neuronal circuits, poster presentation at SIMEA, Denton TX, May 2003.
55. Khatami, D., Nam, Y., Wheeler, B.C., Neural characterization of spontaneous activity of spatially confined
neuronal networks, poster presentation at SIMEA, Denton TX, May 2003.
56. Nam, Y., Scharnweber, R., Khatami, D., Wheeler, B.C., Brewer, G.J. Neural networks in vitro – does
function follow the form?, poster presentation at SIMEA, Denton TX, May 2003.
57. Brewer, G.J., Wheeler, B.C., Enhanced synaptogenesis from nutrient support and neuron patterning on
microelectrode arrays, presentation at SIMEA, Denton TX, March 2003.
58. Nam, Y., Wheeler, B.C., Brewer, G.J., Electrical recordings with gold coated microelectrode arrays that
permit alkanethiol control of neuronal attachment, IEEE EMBS Mtg, Houston TX, Oct 2002, on CD ROM
59. Chang JC, Brewer GJ, Wheeler BC. An enhanced microstamping technique for controlled deposition of
proteins. 2nd Annual International IEEE-EMBS Spec. Top. Conf. Microtechnologies in Medicine and
Biology. Proceedings (Cat. No.02EX578). IEEE. 2002, pp.126-31. Piscataway, NJ, USA.
60. B.C. Wheeler, "Designing In Vitro Patterned Neuronal Networks," invited presentation, 49th International
Vacuum Society Meeting, Denver, CO, November 7, 2002.
61. Nam, Y., Wheeler, B. C., and Brewer, G. J., "Electrical recordings with gold coated microelectrode arrays
that permit alkanethiol control of neuronal attachment," IEEE EMBS Mtg, Houston, Oct 2002. On CD.
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62. Chang, J. C., Brewer, G. J., and Wheeler, B. C., "An enhanced microstamping technique for controlled
deposition of proteins," [Conference Paper], 2nd Annual Int.l IEEE-EMBS Special Topic Conf.
Microtechnologies in Medicine & Biology. Proc. Cat. No.02EX578, IEEE, Piscataway, NJ, 126-131, 2002.
63. Nam, Y., Wheeler, B.C., Brewer, G.J. Gold surface microelectrode arrays permit geometrical control of
neuronal networks via thiol linking chemistry, IEEE EMBS Spec. Top. Conf. On Microtechnologies in
Medicine and Biology, Madison, WI, May 2-4, 2002.
64. Nam, Y., Chang, J. C., Wheeler, B. C., Brewer, G. J., "Building Biological Neuronal Networks," presented at
Cambridge Healthtech Conference BioMEMS & Biomedical Nanotechnology World 2001, Columbus Ohio,
and at the NIH Neural Prosthesis Program Annual Meeting, Bethesda, MD, October, 2001.
65. J. Larsen; Lockwood, M. E.; Lansing, C. R.; Bilger, R. C.; O'Brien, Jr., W. D.; Jones, D. L.; Wheeler, B. C.;
and Feng, A.S., "Performance of a frequency-based minimum variance beamforming algorithm for normal
and hearing impaired listeners," ASA Meeting, Chicago, IL 2001. Journal of the Acoustical Society of
America, vol. 109, June, 2001.
66. Berry, M. Lockwood, M.E., Jones, D.L., Bilger, R.C., Lansing, C.R., Liu, C., O'Brien, W.D., Wheeler, B.C.
and Feng, A.S. (2001) Beamformer improvement with increasing number of sensors. J. Acoust. Soc. Am.
109, June, ASA Mtg., Chicago.
67. Lockwood, M.E., Lansing, C.R., Bilger, R.C., O'Brien, W.D., Jones, D.L., Wheeler, B.C. and Feng, A.S.
(2001). Performance of a frequency-based minimum variance beamforming algorithm for normal and
hearing impaired listeners. J. Acoust. Soc. Am. 109, June, ASA Mtg., Chicago.
68. Zheng, Y., Lockwood, M.E., Wheeler, B.C., Jones, D.L., Feng, A.S., O'Brien, W.D., Bilger, R.C., Lansing,
C.R. (2001) Comparison of binaural beamformers for speech extraction in complex auditory scenes. J.
Acoust. Soc. Am. 109, June, ASA Mtg., Chicago.
69. Lockwood, M.E., Yang, K.L., Jones, D.L., Bilger, R.C., Lansing, C.R., Liu, C., O'Brien, W.D., Wheeler,
B.C. and Feng, A.S. (2001) Robustness of the beamforming algorithms with head-related transfer functions.
J. Acoust. Soc. Am. 109, June, ASA Mtg., Chicago.
70. Lockwood, M.E., Elledge, M.E., Yang, K.L., Jones, D.L., Lansing, C.R., Bilger, R.C., Wheeler, B.C.,
O'Brien, W.D. and Feng, A.S. (2000) Simulation and real-time implementation of a new optimum
beamforming technique. Intern. Hearing Aid Research Conference in Lake Tahoe (CA): 32-33.
71. Yang, K.L., Lockwood, M.E., Elledge, M.E. & Jones, D.L. (2000) A comparison of beamforming algorithms
for binaural acoustic processing. Proc. 9th IEEE Digital Signal Processing Workshop. Hunt (TX), Oct. 2000.
72. Larsen, J., Lockwood, M.E., Lansing, C.R., Bilger, R.C., O'Brien, W.D., Jones, D.L., Wheeler, B.C. and
Feng, A.S. (2001) Performance of a frequency-based minimum variance beamforming algorithm for normal
and hearing impaired listeners. Abstr. 24th Annual Midwinter Meeting of the Assoc. Res. Otolaryngol., 174.
73. Elledge, M.E., Lockwood, M.E., Bilger, R.C., Feng, A.S., Jones, D.L., Lansing, C.R. O'Brien, W.D. and
Wheeler, B.C. (2000) Real-time implementation of a frequency-domain beamformer on the TI C62X EVM.
Presented at 10th Ann. DSP Technol. Educ. & Res. Conf., Houston (TX), August 2-4.
74. I. C. Henry, A. B. Kirillov, B. C. Wheeler, and H. W. Wiggins, Jr., "Spike Sorting Performance Metrics,"
conference paper, IEEE EMBS Meeting, Chicago, IL, July 2000. On CD ROM.
75. D. W. Branch, B. C. Wheeler, G. J. Brewer, and D. E. Leckband, "Long-term Stability of Microstamped
Substrates of Polylysine and Grafted Polyethylene Glycol in Cell Culture Conditions," conference paper,
IEEE EMBS Meeting, Chicago, IL, July 2000. On CD ROM.
76. M. E. Elledge; Lockwood, M. E.; Bilger, R. C.; Feng, A. S.; Goueygou; Jones, D. L.; Lansing, C. R.; Liu, C.;
O'Brien, Jr., W. D.; and Wheeler, B. C., "A real-time dual-microphone signal-processing system for hearing
aids," Journal of the Acoustical Society of America, vol. 106, Part 2, no. 2279A, 1999.
77. Lockwood, M. E., Jones, D. L., Elledge, M. E., Bilger, R. C., Feng, A. S., Goueygou, M., Lansing, C. R.,
Liu, C. O'Brien, Jr., W. D., Wheeler, B. C., "A minimum variance frequency-domain algorithm for binaural
hearing aid processing," ASA Meeting, Columbus OH, October 1999. Journal of the Acoustical Society of
America, vol. 106, p. 2278, 1999.
78. M. E. Lockwood, D. L. Jones, M. E. Elledge, R. C. Bilger, A. S. Feng, M. Goueygou, C. R. Lansing, C. Liu,
W. D. O'Brien, Jr., and B. C. Wheeler, "A minimum-variance frequency domain algorithm for binaural
hearing aid processing," ASA Meeting, Columbus OH, October 1999. Journal of the Acoustical Society of
America, vol. 106, p. 2278, 1999.
79. M. E. Elledge, M. E. Lockwood, R. C. Bilger, A. S. Feng, M. Goueygou, D. L. Jones, C. R. Lansing, W. D.
O'Brien, Jr., and B. C. Wheeler, "A real-time dual-microphone signal processing system for hearing aids,"
ASA Meeting, Columbus OH, October 1999. JASA, vol. 106, p. 2279, 1999.
80. Wheeler, B.C. (1999) “Micropattern neural networks in a dish,” invited talk, Cambridge Healthtech Institute
Fourth Annual Conference on Microsystems Technology in Medicine and Biology, Boston MA.
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81. Venkateswar, R. A., Branch, D. W., and Wheeler, B. C. (1999) “A novel method for producing patterned
biomolecule gradients,” Proc. IEEE EMBS 21st Annual Int. Conf., Atlanta, GA, October.
82. Chang, J. C., Wheeler, B. C., and Brewer, G. J. (1999) “Substrate recording of patterned hippocampal
neurons on multielectrode arrays,” Proc. IEEE EMBS 21st Annual Int. Conf., Atlanta, GA, October.
83. Branch, D. W., Wheeler, B. C., Brewer, G. J. (1999) “Long-term maintenance of patterns of hippocampal
pyramidal cells on substrates of polyethylene glycol and microstamped polylysine,” Proc. IEEE EMBS 21st
Annual Int. Conf., Atlanta, GA, October.
84. B. C. Wheeler, G. J. Brewer, D. W. Branch, J. Chang, and K. Venkateswar, "Rational Design Of In Vitro
Neural Networks Using Patterned Self-Assembled Monolayers," American Chemical Society Abstracts, Los
Angeles CA, March 1999.
85. Lockwood, M.E., Jones, D.L., Elledge, M.E., Bilger, R.C., Feng, A.S., Goueygou, M., Lansing, C.R., Liu, C.
O'Brien, W.D. Jr., Wheeler, B.C. (1999) A minimum variance frequency-domain algorithm for binaural
hearing aid processing. J. Acous. Soc. Am. 106 (Pt. 2): 2278A.
86. Elledge, M.E., Lockwood, M.E., Bilger, R.C., Feng, A.S., Goueygou, Jones, D.L., M., Lansing, C.R., Liu, C.
O'Brien, W.D. Jr., Wheeler, B.C. (1999) A real-time dual-microphone signal-processing system for hearing
aids. J. Acous. Soc. Am. 106 (Pt. 2): 2279A.
87. Wheeler, B.C. (1998) “Multineuron Assemblies: Multidimensional Scaling For Visualization”, Symposium
on Developments in Multichannel Extracellular Recording, U. Mich. Center for Neural Communication
Technology, in conjunction with the 28th Soc. Neurosci. Conf., Los Angeles.
88. Branch, D.W. Chang, J., Brewer, G.J., and Wheeler, B.C. (1998) “Micropatterned Neural Networks,” Abstr.
29th NIH Neural Prosthesis Conference Abstracts, 29, Bethesda MD.
89. Wheeler, B.C., Brewer, G.J., and Branch, D.W. (1998) “Micropatterned Neural Networks,”Abstr. Biomed.
Eng. Soc. Conf., Annals of Biomedical Engineering, 26, sup. 1, p. 93, Cleveland OH.
90. Wheeler, B.C. (1998) “Multineuron Assemblies: Multidimensional Scaling For Visualization,” (invited
presentation), Abstracts from the Int. Conf. on Substrate-integrated Microelectrode Arrays: Technology and
Applications, p. 7, Natural and Medical Sciences Instititue at Tubingen in Reutlingen, Germany.
91. Wheeler, B.C. (1998) “Microstamping Proteins For Precise Control Of Nerve Cell Growth In Culture,”
(invited presentation), Abstracts from the Int. Conf. on Substrate-integrated Microelectrode Arrays:
Technology and Applications, p. 45, Natural and Medical Sciences Instititue at Tubingen in Reutlingen,
Germany.
92. Wheeler B.C., & Brewer, G.J. (1998) “Microstamping proteins for precise control of nerve cell growth in
culture,” Cambridge Healthtech Inst. Third Ann. Conf. Microsystems Techn. in Med. & Biol., Boston MA.
93. Liu,C., Feng, A.S., O’Brien, W.D.,Jr., Wheeler,B.C., Bilger, R.C., & Lansing, C.R. (1997) “Improving the
acuity and robustness of localization of multiple sources using ‘stencil’ filters,” JASA, 102(5), 3140.
94. Liu, C., Feng, A.S., Wheeler, B.C., O'Brien, W.D., Bilger, R.C. & Lansing, C.R. (1997) “A binaurally-based
auditory processor effectively extracts speech in the presence of multiple competing sounds,” Hearing Aid
Research and Development Conference, NIH, Bethesda, MD.
95. Corey, J.M., Branch, D.W., Wheeler, B.C., Weyhenmeyer, J.A. and Brewer, G.J. (1997) “Influencing
polarity of hippocampal neurons using micro-stamp patterns of biomolecules,” Abstr. 27th Soc. Neurosci.
Conf., 23, p. 32, New Orleans, LA.
96. Branch, D.W., Corey, J.M., Wheeler, B.C., Weyhenmeyer, J.A. and Brewer, G.J. (1997) “Micro-stamp
patterns of biomolecules for control of neuronal growth,” Abstr. 27th Soc. Neurosci. Conf., 23, p. 32, New
Orleans, LA.
97. Wheeler, B.C., Branch, D.W., Corey, J.M., Weyhenmeyer, J.A. and Brewer, G.J. (1997) “Engineering neural
networks in vitro: microstamping biomolecules to control cell position,” Proc. IEEE EMBS 19th Annual Int.
Conf., Chicago, IL.
98. B. C. Wheeler and G. J. Brewer, "Microstamping Proteins for Precise Control of Nerve Cell Growth in
Culture," Cambridge Healthtech Institute Third Annual Conference on Microfabrication Technology for
Biomedical Applications, San Jose CA, October 1997.
99. B. C. Wheeler, D. W. Branch, J. M. Corey, J. A. Weyhenmeyer, and G. J. Brewer, "Microstamping Proteins
for Precise Control of Nerve Cell Growth in Culture," Abstract, 28th NIH Neural Prosthesis Conference
Abstracts, Bethesda MD, p. 22, October 1997.
100. Liu, C., Feng, A.S., Wheeler, B.C., O'Brien, Jr., W. D., Bilger, R.C., and Lansing, C., "Speech enhancement
via directional hearing based on the 'place' theory," Second Biennial Hearing Aid Research & Development
Conference, Washington DC, vol. 58A, no. II-P-29, September 1997.
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101. C. Liu, A. S. Feng, B.C. Wheeler, W. D. O'Brien, Jr., R. C. Bilger, and C. R. Lansing, "A binaurally-based
auditory processor effectively extracts speech in the presence of multiple competing sounds," Hearing Aid
Research and Development Conference, NIH, Bethesda, MD, September 1997.
102. J. M. Corey, M. S. Chen, A. L. Brunette, D. W. Branch, J. A. Weyhenmeyer, B. C. Wheeler, and G. J.
Brewer, "Influencing neuronal growth with multibiomolecule patterned substrates," 26th Society of
Neuroscience Annual Conference, Washington, D.C., vol. 22, p. 1717, November 1996.
103. Wheeler, B. C. (1996) "Universal access to ECE undergraduate information via the Web," IEEE Frontiers in
Education Conference, Salt Lake City, UT, on CD ROM, November.
104. Wheeler, B. C., Corey, J.M., Brunette, A.L., Chen, M.S., and Weyhenmeyer, J.A. (1996) "Micropatterning
B104 neuroblastoma cells in culture: an assay for neuronal pattern synthesis", IEEE EMBS Annual
Conference, Amsterdam, The Netherlands, on CD ROM.
105. Wheeler, B. C., Chang, J. C., Berke, B. A., Corey, J. M. and Branch, D. W. (1996) "Technology for neuronal
pattern synthesis and recording," Annals of Biomedical Engineering, p. S-68, v. 24, supplement 1, Fall 1996
Meeting, Biomed. Eng. Soc., University Park, PA.
106. Wheeler, B. C., R. L. Magin, M. Osborne, and B. Bruce (1996) "A freshman general education
bioengineering course on the world wide web," ASEE Annual Meeting, on CD ROM, Wash., D.C.
107. Wheeler, B. C., R. L. Magin, M. Osborne, and B. Bruce (1996) "Asynchronous learning in the small
engineering classroom," ASEE Annual Meeting, on CD ROM, Washington D.C., on CD ROM.
108. Wheeler, B.C., Corey, J.M. and Brewer, G.J. (1995), “Micropatterning of neural growth in culture: A
comparison of laser and photoresist based techniques,” 18th Mtg. Electrochem. Soc., Chicago, 1-8.
109. J. M. Corey, B. C. Wheeler, and G. J. Brewer, "Confinement of hippocampal neurons to grid patterns using
three silane-based photolithographic processes," Abstract, 26th NIH Neural Prosthesis Conference Abstracts,
Bethesda, MD, p. 24, 1995.
110. Corey, J.M., Wheeler, B.C. and Brewer, G.J., (1995) “Selective silane removal: A technique for
micropatterning of neurons in culture,” 17th IEEE EMBS Conference, Montreal, 1995, 1731-1732.
111. Bendre, A., Swain, R., Wheeler, B.C., & Greenough, W. (1995). Augmentation of cerebellar responses to
parallel fiber activation following skilled motor acquistion in rats," Soc. Neurosci. Abstr. 21, San Diego, CA.
112. Wheeler, B.C. (1995) “Multineuron assemblies: A generalized clustering approach,” International
Workshop on Measures of Spatio-Temporal Dynamics, Bryn Mawr College.
113. Corey, J. M., Wheeler, B.C., & Brewer, G. J. (1995). “Confinement of hippocampal neurons to grid patterns
using three silane-based photolithographic processes,” NIH Neural Prosthesis Workshop, Bethesda MD.
114. Wheeler, B.C. and Brewer, G.J., (1994), "Selective hippocampal neuritogenesis: axon growth on laminin or
pleiotrophin, dendrite growth on poly-D-lysine", Soc. Neurosci. Abs., 20, p.1292, Miami Beach FL.
115. Stavrakos, N. J., Wheeler, B. C., Gordon, S. H., Wicklow, D. T., Greene, R. V., & Schudy, R. B. (1994)
“Identification of contaminated corn from FTIR spectra: A MATLAB tool for pattern recognition and neural
network studies,” in C. H. Dagli,F. R. Fernandez,J. Ghosh, & R. T. S. Kumara (Ed.), Artificial Neural
Networks in Engineering, 4 (779-784). St. Louis, MO.
116. Wheeler, B. C. (1994). Visualizing multineuron assemblies a generalized clustering approach. In
International Symposium on the Dynamics of Neural Processing, June (79-83). Washington D.C.
117. Wheeler, B.C., Corey, J.M., and Brewer, G.J., (1993), "Patterned microcircuits of hippocampal neurons:
comparisons of photoresist versus laser ablation processes," Soc. Neurosci Abstr. 19, p1292, Wash. DC.
118. B. C. Wheeler, S. H. Gordon, D. R. DeWispeleare, M. A. Jackson, and R. V. Greene, "Neural network
identification of contaminated corn from FTIR spectra," Proceedings of the IEEE EMBS 15th Annual
International Conference, San Diego, CA, pp. 301-302, October 1993.
119. Wheeler, B.C., Fang, L., Zardoshti, M., and Wiggins, H. (1993), "Multiple unit action potential sorting:
investigation of features, algorithms, and parameters for a fully automated system," Proc. IEEE EMBS 15th
Annual Int. Conf., 261-262.
120. Peck, T.L., LaValle, L., Magin, R.L., Adesida, I., and Wheeler, B.C. (1993), "RF Microcoils with Micron-
Scale Feature Sizes for NMR Microscopy," Proc. IEEE EMBS 15th Annual Int. Conf., 174-175.
121. Zardoshti, M., Wheeler B.C., Badie, K. and Hashemi R., (1993) "Evaluation of EMG features for movement
control of prostheses," Proc. IEEE EMBS 15th Annual Int. Conf., 1141-1142.
122. Wiggins, H., Hetzel, G., Wheeler, B.C., and Lupescu, M., (1993) "Real-time sorting of neural action
potentials one hundred channels at a time," NIH Neural Prosthesis Workshop, Bethesda MD, October.
123. Wheeler, B.C., (1993), "Matlab exercises to demonstrate principles of biological modeling and signal
processing," Proc. 100th Annual Conference ASEE, 1789-1790, Champaign IL.
124. Wheeler, B.C. (1993), "Micropatterned neuronal cultures," Proc. 5th Iranian Biomed. Eng. Conf., Teheran.
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125. Wheeler, B.C. and Zardoshti, M., (1993), "Advances in neural spike sorting," Proc. 5th Iranian Biomedical
Engineering Conference, Teheran.
126. O. Ozdamar and B. C. Wheeler, "Real-time processing of neurological signals: neuronal and EEG spike
detection using digital signal processors," IEEE 14th Ann Int. Conf. IEEE EMBS, Paris, France, Nov. 1992.
127. Wheeler, B.C. (1992), "Sorting action potentials one hundred channels at at a time," Proc. IEEE 14th Annual
Int. Conf. IEEE EMBS, 1256-7 (invited paper).
128. Fang, L., and Wheeler, B.C. (1992), "Sorting neural action potentials in extracellular recordings: a
comparison of the effectiveness of popular sorting features," Proc. Comp. Nsci. Symp., Indianapolis.
129. Zardoshti, M., and Wheeler, B.C. (1992), "Finding the number of neurons in extracellular recordings: a
comparison of the effectiveness of popular clustering indices," Proc. Comp. Nsci. Symp., Indianapolis.
130. Smith, S.R., Wheeler, B.C., Dowd, J.P., and Comer, C.M., (1991), "Investigation of multi-cellular neural
code for directed movement," IEEE EMBS Conf., Orlando.
131. Corey, J.M., Wheeler, B.C., and Brewer, G.J., (1991), "Localization of hippocampal neurons to chemically
modified silicon nitride surfaces," Soc. Neurosci. Abstr., 17, p. 210, New Orleans.
132. B. C. Wheeler, S. Boppart, and C. Wallace, "A flexible, perforated microelectrode array for extended neural
recordings," 21st Society of Neuroscience Conference, New Orleans, LA, vol. 17, p. 175, November 1991.
133. Wheeler, B.C. (1991), "Multi-unit neural recording," Abstr. Biomed. Eng. Soc. Conf., Annals of Biomedical
Engineering, 19, 622, Charlottesville.
134. Boppart, S., Wheeler, B.C., and Wallace, C. (1991), "A flexible, porous electrode array improves longevity
in hippocampal slice recordings," 14th Midwest Neuroscientists Conf., Urbana IL.
135. Corey, J.M., Wheeler, B.C., and Brewer, G.J. (1990), "Compliancy of hippocampal neurons grown on
patterned microcircuits," Soc. Neurosci. Abstr., 16, p. 1008, St. Louis.
136. Wheeler, B.C., Eden, G.J., and Brewer, G.J. (1989), "Patterned growth of hippocampal neurons on
microcircuits," Soc. Neurosci. Abstr., 15, p. 1036, Phoenix AZ.
137. Brusnighan, D.A., Strauss, M.G., Floyd, J.M., and Wheeler, B.C., (1989) "Orientation aid implementing the
global positioning system," Proc. NE Bioeng. Conf., Boston.
138. Dowd, J.P., Smith, S.R., Comer, C.M., and Wheeler, B.C. (1988), "Multi-unit analysis of a neural ensemble
controlling directed movement," Soc. Neurosci. Abstr., 14, p. 689, Toronto.
139. Smith, S.R., Dowd, J.P, Wheeler, B.C., and Comer, C.M. (1988), "Analysis of multiunit data from a neural
ensemble controlling directed movement," Proc. 10th IEEE EMBS Conf., 1171-1172, New Orleans, LA.
140. Willming, D.A. and Wheeler, B.C. (1988), "A real-time multichannel DSP-based neural signal analysis
system," Proc. 10th IEEE EMBS Conf., 1169-1170, New Orleans, LA.
141. Wheeler, B.C. and Tang, B. (1988), "A flexible electrode array for brain slice recording," Proc. 10th IEEE
EMBS Conf., 816-817, New Orleans, LA.
142. Wheeler, B.C. and Smith, S.R. (1988), "Neural network models of an escape response," Neural Networks, 1
(Suppl. 1), 281.
143. B. C. Wheeler, "Personal computer based multiunit and multichannel neural data acquisition," 3rd
Symposium on Networks in Brain and Computer Architecture, Denton, TX, 1987.
144. Novak, J.L., Wheeler, B.C., and Chang, F.-L. (1987), "Variations in the delays between peaks within
population bursts in CA1 recorded with a 32 element array," Soc. Neurosci. Abstr., 13, 942, New Orleans.
145. Wheeler, B.C. and Smith, S.R. (1987), "Action potential waveform alignment with cubic splines," Proc. 9th
IEEE EMBS Conf. 1852-3, Boston, MA.
146. Novak, J.L. and Wheeler, B.C. (1986), "Epileptiform activity recorded from the rat hippocampal slice with a
planar microelectrode array," Soc. Neurosci. Abstr., 12, p. 1528, Washington, DC.
147. Smith, S.R. & Wheeler, B.C. (1986), "A digital, real-time action potential detection system," Proc. 8th IEEE
EMBS Conf., 259-262, Fort Worth, TX.
148. Wheeler, B.C. and Novak, J.L. (1986), "Current Source Analysis of Brain Slice Electrode Array Data", Proc.
8th IEEE EMBS Conf., 458-460, Fort Worth, TX.
149. Wheeler, B.C., Novak, J.L., and Smith, S.R. (1986), "32 channel microelectrode array recordings from brain
slices," Proc. 19th ACEMB, 327, Baltimore, MD.
150. Smith, S.R. & Wheeler, B.C. (1985), "Neural signal detection techniques: performance for real-time
applications", Proc. 7th IEEE EMBS Conf., 1274, Chicago, IL.
151. Novak, J.L. and Wheeler, B.C. (1985), "Multi-site stimulation and recording from rat hippocampal slices
using a microelectrode array," Proc. 7th IEEE EMBS Conf., 1275, Chicago, IL.
152. Picus, M.M. and Wheeler, B.C. (1983), "A nine channel probe for multiple neuron recording," Proc. 36th
ACEMB, 224, Columbus OH.
December 2009 Bruce C. Wheeler p. 11/23

153. Wheeler, B.C. and Heetderks, W.J. (1980), "Performance of algorithms for the detection and classification of
waveforms from individual neurons," Workshop Dig. Sign. & Waveform Anal., 5th Int. Conf. Patt. Recog.,
Miami Beach.
154. Wheeler, B.C. and Heetderks, W.J. (1980), "The effects of sampling rate on the signal-to-noise ratio of
biological signals," Proc. 8th New Eng. Bioeng. Conf., 446-450, Cambridge MA.
155. Wheeler, B.C. and Heetderks, W.J. (1979), "Separation of cockroach giant axon action potentials using
multiunit analysis techniques," Proc. 7th New Eng. Bioeng. Conf., 310-313, Troy NY.
156. Kim, M., Shin, K.G., and Wheeler, B.C. (1978), "A systems model of cell kinetics and its application to
cancer chemotherapy," Proc. Joint Automatic Control Conf.
Other Conference and Workshop Presentations (unpublished)
1. Microstamping Proteins for Precise Control of Nerve Cell Growth in Culture, Bruce C. Wheeler, Darren W.
Branch, Joseph M. Corey, James A. Weyhenmeyer and Gregory J. Brewer, Conference on Microfabrication
for Biotechnology, San Jose CA, October 27, 1997.
2. Artificial Patterning of the Growth of Neurons: a Beginning Technology, Lecture to Spinal Cord Injury
Center, Amirkabir University, Tehran, Iran, Jan. 6, 1993.
3. Technology for Recording from Many Individual Neurons, Tutorial, 5th Annual Iranian Biomedical
Engineering Conference, Tehran, Iran, Jan. 5-7, 1993.
4. H. Wiggins, G. Hetzel, B. C. Wheeler, and M. Lupescu, "Real-time sorting of neural action potentials one
hundred channels at time," 24th Annual Neural Prosthesis Workshop, Bethesda, MD, October 13-15, 1993.
5. NCSA Workshop on Real-Time Applications of High Performance Computing for Biological Imaging,
Urbana, IL. , September 1993. (Poster authors: B. C. Wheeler, M. Lupescu, G. Hetzel, and H. Wiggins)
6. Ozdamar, O., and Wheeler, B.C., (1992), "Real-time processing of neurological signals: neuronal and EEG
spike detection using digital signal processors", invited tutorial, IEEE EMBS Ann. Conf. (Paris, France)
7. Multineuron Patterning and Recording, ONR Conference on Controlled Growth and Communication in
Cultured Mammalian Neurons, Elkridge, MD, April 27, 1992.
8. Techniques for Patterning Hippocampal Neurons in Culture, Midwest Hippocampal Mtg. Urbana, July10,
1992.
Invited Lectures
1. Writing Scientific Papers, ISABEL 2009 (bioengineering conference), Bratislava, Slovakia, November 25,
2009.
2. Brain on a Chip: Can We Build One? ISABEL 2009 (bioengineering conference), Bratislava, Slovakia,
November 24, 2009.
3. Meet the Editors. ISABEL 2009 (bioengineering conference), Bratislava, Slovakia, November 24, 2009.
4. Meet the Editors. IEEE Eng. Med. Biol. Conf, Minneapolis MN Sept 3, 2009.
5. Writing Scientific Papers: Preparing your manuscript – what are the editors and reviewers looking for? IEEE
Eng. Med. Biol. Conf, Minneapolis MN Sept 3, 2009.
6. Developments in Biomedical Engineering. Talk to Gainesville Chapter of the IEEE EMBS. March 25, 2009.
7. Brain on a Chip: Can We Build One? Los Alamos National Laboratory, February 27, 2009.
8. Faculty for “Neuro-Electronic Hybrid School, Institute for Advanced Studies, the Hebrew University of
Jerusalem, Israel, March 15-20, 2009. Invited but withdrew for health reasons.
9. Brain on a Chip: Progress in its Design and Construction", Workshop on Nanotechnology as an Enabler for
Neuroscience, Neuroengineering and Neural Prostheses, Stanford University, Dec 11, 2008.
10. Brain on a Chip: If We Build One, What Will It Say? Distinguished Lecture Series, invited talk, Institute for
Computing, Information and Cognitive Systems, University of British Columbia, October 23/24, 2008.
11. Brain on a Chip. U Florida Biomedical Engineering Dept Seminar, Sept 2009.
12. Brain on a Chip: Can We Build One? IEEE EMBS Annual Conference, Neural Engineering Symposium,
Vancouver, British Columbia, Aug 2008.
13. Meet the Editors. IEEE Eng. Med. Biol. Conf, Vancouver, British Columbia, Aug 2008..
14. Brain on a Chip: Can We Build One? ECE Dept., Southern Methodist University, April 30, 2008.
15. Brain on a Chip: Can We Build One? Brain and Bio Engineering Department, KAIST, November 14, 2007.
16. Biologically inspired binaural hearing aid algorithms: Design principles and effectiveness, Seoul National
University, November 13, 2007
17. Brain on a Chip: Can We Build One? Seoul National University, November 12, 2007.
18. Brain on a Chip: Can We Build One? Biomedical Engineering Department, Yale University, Oct. 18, 2007.
December 2009 Bruce C. Wheeler p. 12/23

19. From Engineered Neural Networks to Biologically Inspired Hearing Aids, Samples of Bioengineering and
Neural Engineering Research, University of New Mexico, Sept. 13, 2007.
20. Meet the Editors. IEEE Eng. Med. Biol. Conf, Lyon France, August 2007.
21. Brain on a Chip: Can We Build One? Tutorial, Workshop on Advances in Cognitive and Neural Engineering,
IEEE EMBS Conf, Lyon, August 2007.
22. Brain on a Chip: An Engineer's Challenge, ECE Department seminar, Univ. New Mexico, June 19, 2007.
23. Brain on a Chip: Can We Build One? Plenary Address, IEEE Neural Engineering Conf., Hawaii, May 2007.
24. Brain on a Chip: An Engineer's Challenge, Department seminar, Michigan State University, April 5 2007.
25. Engineering Form & Function in Cultured Neuronal Networks, Univ. Central Florida, March 22, 2007.
26. Department of Biomedical Engineering Department, University of Florida, March 20, 2007.
27. Engineering Form and Function in Cultured Neuronal Networks, Department seminar, Department of
Molecular Pharmacology, Physiology, and Biotechnology, Brown University, March 16, 2007.
28. Brain on a Chip: An Engineer's Challenge. Colloquium Speaker, Electrical and Computer Engineering
Department, Montana State University, Jan 26, 2007.
29. Engineering Form and Function in Cultured Neuronal Circuits, Bioengineering Department Seminar, UC
Irvine, January 25, 2007
30. Engineering Form and Function in Cultured Neuronal Circuits, Workshop on the Frontiers in Quantum and
Biological Information Processing, U. Central Florida, Orlando, Nov 17, 2006.
31. Progress and Challenges for Engineering Form and Function in Cultured Neuronal Networks, Bioengineering
Department Seminar, Penn State University, Nov 3, 2006.
32. An Introduction to the Use of Microelectrode Arrays, invited talk, International MEA Conference, Reutlingen
Germany, July 2006. (not delivered due to emergency)
33. Engineering Form and Function in Cultured Neuronal Circuits, University of Texas at Dallas, June 26, 2006.
(not delivered due to emergency)
34. Progress and Challenges for the Engineering Design of In Vitro Neuronal Networks, Duke University,
Biomedical Engineering Dept., June 20, 2006.
35. Engineering Form and Function in Cultured Neuronal Networks, Bioeng. Dept., U. Utah, Apr 28, 2006.
36. Engineering Cultured Neuronal Networks. University of Louisville School of Medicine, Neuroscience
Department Seminar, Jan 26, 2006.
37. Engineering Cultured Neuronal Networks. Center for Nano Science and Technology, U Illinois, Nov 2, 2005.
38. Engineering Cultured Neuronal Networks. Biocomplexity Institute, University of Indiana, Oct. 4, 2005.
39. Advances in Neural Interfaces From In Vitro Models, Neural Interfaces Workshop, Bethesda, Sept 9, 2005.
40. Starting a Bioengineering Department at the University of Illinois, invited talk, First International Conference
on the Development of Biomedical Engineering in Vietnam, Ho Chi Minh City, July 27, 2005
41. Cultured Neuronal Networks: Design, Function, Interfaces, Analyses. Presentation to the Bioengineering and
Bioinformatics Summer Institute, Clemson University, June 30, 2005.
42. Cultured Neuronal Networks: Design, Function, Interfaces, Analyses. Presentation to Bioelectrode Interfaces
Short Course, University of Illinois at Chicago, June 3, 2005.
43. Micropatterned Neuronal Networks in Culture: Simplicity or Complexity? Invited talk, 5th Understanding
Complexity Symposium, Department of Physics, University of Illinois at Urbana-Champaign, May 17, 2005
44. Cultured Neuronal Networks: Design, Function, Interfaces, Analyses. Invited talk, Bioengineering
Department, University of Minnesota, Feb 28, 2005.
45. Patterning to Enhance Activity of Cultured Neuronal Networks. Invited Talk. Indiana University Purdue
University at Indianapolis, November, 2004.
46. Patterning to Enhance Activity of Cultured Neuronal Networks. Invited Talk. Bioengineering Department,
University of California at San Diego, October 22, 2004.
47. Patterning to Influence in vitro Neuronal Interfaces, Bruce C. Wheeler, Yoonkey Nam, and Gregory J.
Brewer, invited talk, EMBS Annual Conference, San Francisco, Sept 2004.
48. Cultured Neuronal Networks: Design, Function, Interfaces, Analyses. Invited talk, Bioengineering
Department, Arizona State University, April 2, 2004.
49. Patterning to Enhance Activity of Cultured Neuronal Networks. Invited Talk. Biomedical Engineering
Department, Northwestern University, Mar. 11, 2004.
50. Future of Bioengineering at UIUC, informal presentation to the Dean of Engineering and key staff at the
University of Texas at Dallas, Feb 20, 2004.
51. Multineuron Assemblies: Multidimensional Scaling For Visualization, invited talk, Center for Computational
biology, Montana State University, Bozeman MT, January 16, 2004.
December 2009 Bruce C. Wheeler p. 13/23

52. Patterning to Enhance Cultured Neuronal Networks. Invited talk, Center for Computatonal Biology, Montana
State University, Bozeman MT, January 16, 2004.
53. Cultured Neuronal Networks: Design, Function and Interfaces. Invited talk, Fifth International Workshop on
Future Information Processing Technologies, Miyazaki, Japan, November 11, 2003.
54. Patterning to Enhance Activity of Cultured Neuronal Networks, invited talk, Cornell University
Nanofabrication Center, October 28, 2003.
55. Patterning to Enhance Activity of Cultured Neuronal Networks, invited talk, Annual Provost’s Neuroscience
Symposium, University of Southern California, October 9, 2003.
56. Patterning to Enhance Activity of Cultured Neuronal Networks, invited talk, School of Engineering,
University of California at Santa Cruz, August 21, 2003.
57. Taking Neurons to the Electrode, invited talk to the Asilomar Conference on Implanted Auditory Prostheses,
Pacific Grove CA, August 20, 2003.
58. Patterning to Enhance Activity of Cultured Neuronal Networks, invited talk at Session on Neural Engineering
at Gordon Conference on Biomaterials: Biocompatibility & Tissue Engineering, July 20-25, 2003.
59. Patterning to Enhance Activity of Cultured Neuronal Networks, invited presentation at workshop on
Nonlinear Dynamics, Control and Guidance of Unmanned Autonomous Vehicles (UAV), ONR and
University of Florida, Gainesville, May 29, 2003.
60. Neurons on Chips as Signaling and Control Devices, tutorial presentation at workshop on Nonlinear
Dynamics, Control and Guidance of Unmanned Autonomous Vehicles (UAV), ONR and University of
Florida, Gainesville, May 29, 2003.
61. Designing In Vitro Patterned Neuronal Networks, seminar, Biomedical Engineering Department, University
of Twente, Netherlands, May 20, 2003.
62. Patterning to Enhance Activity of Cultured Neuronal Networks, invited talk at Workshop on Biology and
Physics at Interfaces: From Single Molecules to Cells, Research Center at Julich, Germany, May 21, 2003.
63. Designing In Vitro Patterned Neuronal Networks, invited seminar, BioEngineering Department, RPI, Troy
NY, March 24, 2003.
64. Designing In Vitro Patterned Neuronal Networks, invited seminar, Chemical Engineering Department,
University of California at Santa Barbara, Feb 20, 2003.
65. Interdisciplinary Bioengineering Research and Programs at the University of Illinois. Invited talk, McMaster
University, Workshop, Adapative Systems Laboratory, Dec. 2, 2002.
66. Biologically inspired binaural hearing aid algorithms: Design principles and effectiveness. Invited talk,
McMaster-Gennum Workshop on Intelligent Hearing Instruments, Kimberley, Ontario, Canada, Oct 1, 2002.
67. Designing In Vitro Patterned Neuronal Networks, invited seminar, Bioengineering Department, Case Western
Reserve University, Cleveland OH Sept 20, 2002.
68. Designing In Vitro Patterned Neuronal Networks, invited talk, 60 th Device Research Conference, Emerging
Technologies Session, June 24, 2002.
69. Designing In Vitro Patterned Neuronal Networks, invited talk, Bioeng Dept, U. Southern Cal., June 25, 2002.
70. Designing In Vitro Patterned Neuronal Networks, invited talk, Rutgers University Bioengineering
Department, April 1, 2002.
71. Designing In Vitro Patterned Neuronal Networks, invited talk, Complex Systems Symposium, University of
Illinois, Urbana, May 14, 2002.
72. Designing In Vitro Patterned Neuronal Networks, invited talk, Materials Research Society Annual
Conference, Boston, November 26, 2001.
73. Rational Design of Neural Networks with Real Neurons, graduate seminar, Bioengineering Department, Penn
State University, State College PA, Nov 8, 2001.
74. Novel Algorithms for Binaural, Directionally Selective Microphones for Hearing Aid Applications, graduate
seminar, Bioengineering Department, Penn State University, State College PA, Nov 8, 2001.
75. Designable Neuronal Networks in Vitro, invited dinner symposium technical talk, Conference on Artificial
Neural Networks In Engineering (ANNIE 2001), St. Louis, MO, Nov 6, 2001.
76. Surface Micro-Nanotech Symposium Chair, BioMEMS and Biomedical Nanotechnology Conference,
Columbus Ohio, September 22-25, 2001.
77. Progress toward the Design of In Vitro Neural Networks, invited talk, Conference on Assembly and Self-
Assembly at the Interface of Biology, Chemistry and Physics, Il Ciocco, Italy, Aug. 20-25, 2001.
78. Progress and Challenges for the Design of In Vitro Neural Networks, International Workshop on Cell-
Substrate Coupling, Munich, Germany, June 2001.
December 2009 Bruce C. Wheeler p. 14/23

79. Rational Design of Neural Networks, seminar to the Max Planck Institute for Polymer Research, Mainz,
Germany, March 20, 2001.
80. Microcontact Printing of Biomolecules on Glassy Substrates, lecture to Samsung Central Research
Laboratory, Seoul Korea, Feb 9, 2001.
81. Neural Signal Processing Techniques, II. Tutorial to the Nano-Bio Engineering Research Center Workshop,
Seoul National University, Korea, Feb 9, 2001.
82. Bioengineering Opportunities for Electrical Engineers, graduate seminar to Konkuk University, Seoul, Korea,
Feb 8, 2001.
83. Neural Signal Processing Techniques, I. Tutorial to the Nano-Bio Engineering Research Center Workshop,
Seoul National University, Korea, Feb 8, 2001.
84. Rational Design of Neural Networks with Real Neurons, lecture to the Nano-Bio Engineering Research
Center Workshop, Seoul National University, Korea, Feb 5, 2001.
85. Micropatterned Neural Networks in a Dish, graduate seminar, Dept. of Bioengineering, Clemson University,
Dec. 8, 2000, Clemson SC
86. Rational Design of Neural Networks in Vitro by Micropatterning, IEEE Solid State Circuits and Technology
Workshop on Biomedical Electronics, October 12, 2000, Arlington VA
87. Micropatterned Neural Networks in a Dish, seminar to Johns Hopkins University Department of
Bioengineeirng, Sept 22, 2000, Baltimore MD.
88. Hybrid Systems, talk to NSF Workshop on Biocomputation, Sept 21, 2000, Arlington VA
89. Biological/Electronic Interface Panel Presenter, NIH BECON Symposium on Nanoscience and
Nanotechnology: Shaping Biomedical Research, Bethesda MD, June 25-26, 2000.
90. Patterned Neural Networks in a Dish. Seminar at University of Illinois at Chicago. February 2, 2000.
91. Neural Networks in a Dish, Southern Illinois University, Springfield, Jan 19, 1999.
92. Micropatterned Neural Networks in a Dish. invited talk, Cambridge Healthtech Institute Fourth Annual
Conference on Microsystems Technology in Medicine and Biology, Boston MA, December 3, 1999.
93. Cochlear Prostheses. Seminar at University of Illinois at Chicago. November 29, 1999.
94. Multiple Neuron Signal Processing: Spike Sorting and Multidimensional Scaling For Visualization,Seminar
to the Inter-University Semiconductor Research Center, Seoul National University, Seoul Korea, Sept, 1999.
95. Undergraduate Electrical and Computer Engineering Education: Trends at the University of Illinois at
Urbana-Champaign. ECE Department Seminar Seoul National University, Seoul, Korea, Sept, 1999.
96. Applications of Cellular Microlithography: The Creation of a Neural Network in a Culture Dish. Seminar to
the Korea Advanced Institute for Science and Technology (KAIST), Taejon, Korea, Sept., 1999.
97. Applications of Cellular Microlithography: The Creation of a Neural Network in a Culture Dish. Seminar to
the Inter-University Semiconductor Research Center, Seoul National University, Seoul Korea, Sept., 1999.
98. Microstamping Deposition for Patterned Nerve Cell Culture. Cambridge HealthCare Institute Conference on
Microsystems Technology in Medicine and Biology, Boston MA, April 16, 1998.
99. Micropatterned Neuronal Networks, Workshop on Novel Applications of VLSI Methodology, Defense
Sciences Research Council, LaJolla CA, July 23, 1997.
100. Can We Use Neural Networks to Understand Neural Networks? Neural Spike Waveform Separation and
the Understanding of Multiple Spike Trains, Physiology Department, Northwestern University, Chicago, IL
June 18, 1993.
101. Signals, Sensors, and Structures for Neural Pattern Analysis, Sangamon County Chapter of the Society
for Neuroscience, Southern Illinois University, Springfield, IL, December 15, 1992.
102. Microelectrode Arrays for Neuroscience, Delaware State College, Minority Access to Research Careers
Seminar, March 20, 1992
DEPARTMENT PROPOSALS
University of Florida Biomedical Engineering Department
Proposal for an undergraduate degree program in Biomedical Engineering. PI. To be submitted Fall 2009.
University of Illinois Bioengineering Department
Bioengineering Department proposal; BS Bioengineering proposal; MS, PhD Proposal. Approved by the Urbana-
Champaign Campus, the University of Illinois, and the Illinois Board of Higher Education, 2003. PI: B.
Wheeler. (Campus proposal for funding written by Dean David Daniel.)
December 2009 Bruce C. Wheeler p. 15/23

NCI Siteman Center of Cancer Nanotechnology Excellence (Wickline, Wash. U., overall PI; Adesida, UIUC
subcontract PI; Wheeler, co-PI for nanofabrication module). 1/6 summer month for the Bioengineering
Department. Funded. 2006-2011. Acted as PI from 2006-2008.
GRANTS
Active Support as PI
NIH. PI: Wheeler. Engineering Form and Function in Neuronal Networks. R01. 2006-2011. Direct/Indirect
$931k, $380k; subcontract to SIUSM Direct/Indirect $670/270k.
Previous External Funding as PI or with Substantial Involvement as Co-PI
NIH: R01 EB 000786 BRP program, 2002-2007, Development and Information Processing in 3-D Patterned
Neural Circuits, subcontract from Georgia Tech, DeWeerth PI; UIUC component: Wheeler, PI approx $500k
direct over 5 years.
Information Processing in Designed Neuronal Circuits, PI: Wheeler, Co-PI: Brewer. 2002-2006, NSF. $1,156,000
total direct+indirect.
Project FROG (for hearing aid algorithm development). Phonak. PI: Feng. Co-PIs: Wheeler, Jones, 10% effort.
$330,000 annual, 11/00-6/01; $550,00 annual, 6/01-6/03.
NIH: PHS 1 F30 MH12397-02 PI: Wheeler, 2000-2005. Studies of living, sparse, patterned neural network.
Support for pre/post doctoral student John Chang.
Real Time Implementation of Intelligent Hearing Aids. NIH. $150,000 total direct, two years plus extension. PI:
Wheeler. 7/00-6/03.
DARPA Subcontract from SUNY Binghamton. Development of a Biomimetic Acoustic Microsensor. 9/29/00-
9/28/03. $179,525 annual. (PI: Jones; coinvestigator: Feng, Wheeler, O’Brien, 5% effort).
Micropatterned Neural Networks. NIH. $150,000. 10/99-4/02. PI: BC Wheeler (10% time)
Microstamping Proteins and Micropatterning Neurons. NIH. $100,000. 10/98-10/00. PI BC Wheeler (10% time)
U.S.-Korea Cooperative Research: Micropatterned Neural Networks and Microelectrode Arrays. NSF: PI: BC
Wheeler. $16, 504 direct costs, 1999-2001 (travel support).
Optimizing Data Processing Systems for Grain Evaluation. US Dept. Agriculture, Northern Regional Research
Center, Peoria IL. 07/95-07/99. PI: BC Wheeler. $18,000.
Bioengineering Curriculum Development at UIUC: Engaging Non-Science Majors and Future Teachers.
Whitaker Foundation. 8/93-8/96. PIs: RL Magin, B Bruce. Duration: 3 years. Total: $452,568. Role:
coinvestigator.
Novel Sensors to Monitor Solid-Substrate Fermentations, Biotechnology Research and Development Corporation,
PI: BC Wheeler. 6/89-7/94. Total: $169,656.
Investigation Of Neuronal Spike Recognition Algorithms, PI BC Wheeler. (Subcontract to NIH SBIR Phase II
Program, Spike Detector for Multichannel Neuronal Data Acquisition, PI: Harvey Wiggins, Spectrum
Scientific, Dallas.) 4/91-3/93. $77,593 total.
Investigation Of Neuronal Spike Recognition Algorithms, $4270, UIUC Research Board, 1 year, 1992.
Patterned Neuronal Networks, NIH. PI: Bruce C. Wheeler. 10% effort. 4/91-3/93. Direct Cost: $70,000.
Spike Detector For Multichannel Neuronal Acquisition, consultant, (PI H. Wiggins, Spectrum Scientific, Dallas,
$45,600, 1 year.)
Spatial Description Of Epileptiform Activity In The Hippocampal Slice With A Microelectrode Array, $25,000, 1
year, Epilepsy Foundation of America, 1987-8.
3M Faculty Award, $20,000, 1984-6. Research Gift For Electrode Array And Microsensor Studies.
Fabrication Of Buried Membrane Ion-Selective Field Effect Transistors,$39,000,NSF ECS83-07399,1983-6.
Fabrication And Use Of Microelectrode Arrays For Neural Recording, $114,882, Whitaker Found., 1982-4.
Other Previous Funding
Experience Dependent Changes in Brain. NIH. $782.964. 3/99-2/04. PI: D. Clayton. Co-PIs: Volman, Wheeler
(2% time – primarily consultative)
Physical exercise, mental activity, and brain plasticity. NIH 2 R01 AG10154-10A2. PI WT Greenough. Co-PI
BC Wheeler. 7/1/00-6/30/03. (consultative)
Physical Exercise, Mental Activity, And Brain Plasticity. NIH. PI WT Greenough. Co-PI BC Wheeler. 7/1/95-
6/30/98. $304,073 (consultative).
A Database System for Neuronal Pattern Analysis. NSF. 9/98-8/03. PI M. Gabriel. CoPIs: M Nelson, BC
Wheeler and 5 others. Total: $480,836. (2% – primarily consultative)
December 2009 Bruce C. Wheeler p. 16/23

A Database System for Neuronal Pattern Analysis. NSF. 6/92-5/98. PI M. Gabriel. CoPIs: M Nelson, BC
Wheeler and 5 others. (consultative) Total: $103,402.
Development of Microdomain RF Coils for NMR Microscopy, NSF:. PI: R.L. Magin. Co-PIs: BC Wheeler, P
Lauterbur. 9/1/91-8/31/94. Total cost: $295,000
Center for the Neurobiology of Learning and Memory, NSF BNS 88-21219, PI: W.T. Greenough. Co-PIs: Feng,
Gabriel, Wheeler. Entire period of support: 5/89-5/94. Total: $593,566
Chemical Communication Between Cells and Engineered Bioscaffold Materials. University of Illinois Critical
Research Initiative. $200,000. 6/98-6/00. PI: D. Leckband. Co-PIs: Wheeler, Gross, Eurell. (10% time)
Fabrication of Micro-Miniature Devices and Micro-Electrical-Mechanical Systems. PI: MA Shannon. One of
seven co-PIs. University of Illinois, Critical Research Initiative Program. 6/95-5/97. $200,000.
Surface Modification to Enhance Selective Neuronal Growth. 7/95-8/96. UIUC Research Board. $19,600. PI: BC
Wheeler.
Precise Control of Neuronal Growth: An Enabling Technology for Neural Prosthetics; University of Illinois, Mary
Jane Neer Fund; $15,000; 1997-1998. PI: BC Wheeler.
Micropatterned substrates as an aid to spinal cord regrowth, $13,000, 1 year, with T. Khan, co-PI, UIUC-Hines
VA Satellite Research Program, 1990-1.
A proposal to develop a global navigation system for the visually impaired, co-investigator with M.G. Strauss,
$6,394, UIUC Research Board, 1988.
Neurobiological and ultrasonic applications of neural networks, with C.M.W. Daft, $7872, 1 year, UIUC
Research Board, 1988.
Initial microsensor investigations of fundamental properties of biological films, with B.E. Rittmann.
Data acquisition system for brain slice studies with microelectrode arrays, $4332, NIH Biomedical Research
Support Grant, UIUC, and Bioengineering Faculty Grant, UIUC, 1984.
Fabrication and use of a planar microelectrode array in brain slice recording, NIH Biomedical Research Support
Grant, UIUC, and Bioengineering Faculty Grant, UIUC, 1984.
A Prototype Biomedical Ion-Specific Sensor For Incorporation Into A Miniature Array, $3000, NIH Biomedical
Research Support Grant, UIUC, 1982.
A multiple miniature electrode array for insertion into neural tissue, $3500, NIH Biomedical Research Support
Grant, UIUC, 1981.
Neural systems laboratory development, with Burks Oakley; $37,500; UIUC Research Board, 1981.
Request for Test and Measurement Equipment. PI: BC Wheeler, RB Uribe, PT Krein. Hewlett Packard University
Grants Program. $130,000. (As department representative)
Learning Technology Infrastructure Development for the ECE Department. $24,500. 11/95-12/96. University of
Illinois, Learning Technology Initiative. PI: BC Wheeler.
Virtual Computer Laboratory and Guided Engineering Design in Modeling of Biological Systems. 6/95-6/96.
SCALE (Sloan Center for Asynchronous Learning Environments.) $19,500. PI: BC Wheeler
Enhancement of Freshman Discovery Course: Bioengineering in Biology and Medicine -- Focus on Medical
Imaging. 6/95-6/96. SCALE (Sloan Center for Asynchronous Learning Environments.) $12,000. PI: BC
Wheeler
THESES SUPERVISED
Ph.D.
Novak, J.L. "Two-dimensional electrode array studies of propagating epileptiform neural activity in the rat
hippocampal slice," Ph.D., 1988, Electrical Engineering. Dr. Novak is a senior project manager at Sandia. He
almost succeeded with his own startup for integrated sensors. He began as a research scientist at Sandia.
Smith, S.A. "Extraction, processing, and analysis of multineuron data, analysis, and network simulation," Ph.D.,
1991, Electrical Engineering. Dr. Smith is an EE faculty member at Southern Illinois University at
Edwardsville.
Corey, J.L. " Cell Patterning: Building Living Neural Networks," Ph.D. 1997, Neuroscience, MD UIUC, 1999.
Dr. Corey is an Assistant Professor at the University of Michigan School of Medicine.
Branch, D. “Elastomeric stamping : design considerations for long-term maintenance of neuronal networks”, PhD
1999, Biophysics. Dr. Branch is a Senior Research Scientist at Sandia.
Chang, J. “Technologies for and electrophysiological studies of structured, living, neuronal networks on
microelectrode arrays,” Ph.D., Electrical and Computer Engineering, 2002, MD UIUC 2004. He began a
residency at Stanford in 2005.
December 2009 Bruce C. Wheeler p. 17/23

Nam, Y. “Engineering principles to design and analyze patterned neuronal cultures using multielectrode
array,” PhD Electrical Engineering, September 2005. Dr. Nam is an Asst Prof. Korean Advanced Institute for
Science and Technology.
Musick, K. PhD Electrical Engineering, “Three-dimensional microelectrode array for recording dissociated
neuronal cultures,” June 2008.
Scharnweber, R., Neuronal polarization and axonal mRNA localization on microfabricated substrates, PhD,
Neuroscience, 2009, MD expected 2009.
Khatami, D. Design, Considerations For Electrical Stimulation And Functional Connectivity Analysis Of
Neuronal Networks Patterned On Microelectrode Arrays, PhD, Elect. Eng. 2008. MD expected 2010.
M.S.
Picus, M.M. "Fabrication of a nine-channel probe-type microelectrode array," M.S. 1983, EE.
Harvath, A.R. "Fabrication of a covered chamber in silicon," M.S. 1984, EE..
Valesano,W.R. "Multichannel neural data acquisition system with real-time digital filtering," M.S. 1984, EE..
Baillargeon, J.B. "Fabrication of a field effect transistor for use in aqueous environments," M.S. 1984, EE.
Novak, J.L. "Simultaneous neural recording with a durable, easily reproducible multimicroelectrode array," M.S.
1985, EE.
Boggs, B.A. "Fabrication of a potassium sensor based on an insulated gate FET," M.S. 1985, EE.
Smith,S.A. "Performance of neural signal detection techniques for real-time data acquisition," MS. 1985, EE.
Stevenson, P.E. "Fabrication of a silicon based microelectrode," M.S. 1985, EE.
Hula, D.L. "A PMOS process for the Illinois Fab II lab", M.S. 1986, EE.
Ficht, D.A.,"Electrode array development for advanced brain slice recordings," M.S. 1987, EE.
Valenti, A."An automated learning phase system for multiunit neural classification," M.S. 1987, EE.
Bhyrabvhotla, U. "Hybrid circuit impedance monitoring device for estrus detection," M.S. 1988, EE.
Willming, D., "Performance of a real-time neural signal analysis system based upon the TMS320C25 digital
signal processor," M.S. 1988, EE.
Tang, B. "Fabrication of a perforated multichannel microelectrode array," M.S. 1989, EE.
Chapman, D. "A competitive neural network model of the cockroach escape response," M.S. 1989, EE.
Brown, S. "Multichannel spike simulation package," M.S. 1989.
Boppart, S. "An approach toward a flexible microelectrode array net for extended neural recordings," M.S. 1991,
EE.
Katz, J., "Neural network analysis of FTIR-PAS spectral data from infected corn," M.S. 1991, EE.
Fang, L. "Multiple unit action potential sorting: investigation of features, algorithms, and parameters for a fully
automated system," M.S., 1994, EE.
Chang, J. “A novel, thin silicon oxide coating for multielectrode array surface modification,” MS., 1997, EE.
Venkateswar, R. “A method for microstamping gradients of biomolecules,”M.S., 1998, EE.
Shah, M. “Using optical tweezers to position cells on patterned substrates,” M.S. 1999, EE.
Henry, I., “Spike detection metrics: error estimation for an automated spike sorting system,” MS, 2000, EE.
Zheng, Yang, “Real-time realization issues of the localization and the extraction algorithm,” MS, 2002, EE.
Nam, Y., “Implementation of alkanethiol based linking chemistry on microelectrode arrays for neural
engineering,” MS, 2003, ECE.
Phatak, Sandeep, “Analysis of acoustics of environment and effect of a reflector on localization,” M.S., 2003,
ECE.
Lam, L. 2003. “Evaluation of feature extraction techniques for classification of tetrode recordings of action
potentials”, MS, 2003, ECE.
Krishnan, B., “Evaluation of wavelet-based methods for spike sorting, M.S. 2004, ECE.
Khatami, D., “Effects of spatial confinement on the spontaneous and evoked activity of linearly patterned
biological neural networks,” MS, 2004, ECE.
Chen, H., “Evaluation of algorithms for displaying apparent connectivity in neuronal networks”, MS, 2004, ECE.
Musick, Katherine, “Microstamped electrodes with pdms insulator: a design towards disposable and inexpensive
microelectrode arrays,” MS ECE, 2005.
Wang, M., comparison of multichannel neural signal processing techniques, MS expected 2010.
Thalji, S., signal processing for neural studies, MS expected 2010.
Subramaniam, S. Patterned neural culture leads to enhanced learning. MS expected 2010
Joag, C. Standalone stimulator for neural cultures for long term use in incubators. MS expected 2010.
December 2009 Bruce C. Wheeler p. 18/23

Undergraduate Research and Special Topics Projects: approximately 120 students in 27 years of teaching.
Other Training Activities
Pan, Liangbin. Postdoctoral Research Scientist, May 2009 – present.
Varghese, Kucku. Postdoctoral Research Scientist. April 2009 – present.
Dworak, Bradley, Postdoctoral Research Scientist, December 2006-August 2009. Now Electrical Engineer, FAA,
Oklahoma City.
Nam, Yoonkey, Postdoctoral Research Scientist, Fall 2005-Fall 2006. Now Asst Prof. Korean Advanced Institute
for Science and Technology.
Vieira, Mauricio, Postdoctoral Research Student, 2005-2007. Now Research Associate, U. Illinois.
Liu, Chang, Postdoctoral Scientist (cosupervised with A. Feng) 1996-2000. Now Research Engineering,
Motorola.
Brandt, Robert L. Visiting Research Scientist, Beckman Insitute, 1994-6.
Berke, Bret. Non-Degree Graduate Neuroscience Student, 1995-6.
Young, Wendy. Research Engineer, 1991-2.
Zardoshti-Kermani, Mayhar. Visiting Research Scholar. 1992-1993.
Doctoral Committee Service: 54 students.
TEACHING ACTIVITIES
At Illinois: Courses
BIOEN199--Introduction to Bioengineering: Focus on Medical Imaging. UIUC Freshman Discovery Course. 5
semesters -- 8 to 20 students. Course creator. Integrate computer exercises, electronic conferencing, World
Wide Web based course.
BIOEN 298BW- Circuits for Bioengineering Majors. 20/30 students, 2 semesters. Created course to become
required for BioE majors.
BIOEN 398 – Fundamentals of Bioengineering. Pilot of required course for BioE majors. 5 students, 1 semester.
ECE200--Honors Undergraduate Seminar--20 semesters, 10 to 100 students. Coordinate student/faculty
presentations
EE244--Introductory Laboratory; 9 semesters; 300 students; introduced lab practical exams, computer lecture
demonstrations.
EE260--Introduction to Circuit Analysis; 1 semester; 250 students.
EE270--Introduction to Circuit Analysis; 2 semesters; 80 students. Course Director: 1 semester.
EE310--Digital Signals and Systems; 1 semester; 90 students.
ECE314/BIOEN314--Biomedical Instrumentation; 2 semesters; 60 students.
EE315--Biomedical Instrumentation Laboratory; 1 semester, 45 students.
EE324--Analog Filter Design; 1 semester; 150 students.
ECE342-- Electronic Circuits; 1 semester, 80 students
EE344--Theory and Fabrication of Solid State Devices; lab instructor; 2 semesters; UIUC "Incomplete List of
Excellent Instructors."
EE371WA/BIOEN370D--Medical Image Processing; created new curriculum, computer exercises; 2 semesters;
20 students; UIUC "Incomplete List of Excellent Instructors"; paper in IEEE Transactions on Education.
EE371WH--Integrated Circuit Fabrication Laboratory; course creator; 1 semester; 8 students; designed exercises,
fabrication processes, devices.
ECE375/BIOEN375--Modeling of Biological Systems; 13 semesters; 15--40 students. Rewrote entire course,
introduced computer exercises, team building exercises, conferencing, WWW materials.
BIOEN120--Introduction to Bioengineering; 5 semesters; 60 students.
EE272/BIOEN270--Special Projects; 2 students per semester average. Currently: 1 student working on laboratory
fabrication, neuronal culture, and on computer pattern recognition and neural network projects.
Bioengineering Faculty Advisor--supervised student Open House projects, presentations for eight years;
supervised student editing of international IEEE EMBS student magazine; received Pierce Award for
student/faculty interactions. Faculty advisor to UIUC edited, internationally distributed student newsletter.
BIOL 420--Neurobiology Seminar. Coordinator. 6 semesters. 20 students.
ADMINISTRATIVE DUTIES -- SUMMARY
December 2009 Bruce C. Wheeler p. 19/23

Interim Chair, Department of Biomedical Engineering, University of Florida, Jan 2009-present. Budgeting,
advising assistant professors, initiate faculty search. Unexpected development with abrupt departure of
previous Chair.
Interim Head, Department of Bioengineering, University of Illinois, Jan 2004-Jan 2008
Establishing department, hiring faculty, implementing undergraduate curriculum, overseeing grad admissions,
external affairs, admitting undergraduates.
Director, Bioengineering Program, Mar 2002 – Jan 2004.
Appointed Director to establish a Bioengineering Department
Proposals written: Undergraduate Curriculum, Graduate Program Guide and Curriculum, Departmental Creation;
approved by College of Engineering Executive Committee, Graduate College and UIUC Faculty Senate.
Approved by the Illinois Board of Higher Education December 9, 2003. Steady state budget: approximately
$20M startup and $3M recurring.
Associate Department Head for Undergraduate Affairs and Chief Academic Advisor, Electrical and
Computer Engineering Department, 1995 - 2001
Major Initiatives: Aggressive intervention with students on probation and poor grades in key technical courses is
correlated with 50% decline (from 4% to 2%) in number students dropped each semester from the ECE
Department and a decrease in probation levels from 10% to 8% of ECE students; initiated undergraduate
seminar series; rewrote the entire undergrad advising manual for print and the web.
Coordinate Advising Activities of 90 faculty and 1600 Undergraduate Students ECE
Schedule advising activities. Interface with Engineering College advisors.
Advisor of last resort for students on academic probation, drop status, readmits, and transfers.
Arbiter of transfer credit and curriculum substitutions.
Development of new honors program activities.
Oversight of undergraduate ECE organizations.
Initiated Freshman Scholarship Program (1996-present)
Initiated ECE Explorations -- department wide undergraduate seminar
Rewrote Undergraduate Advising Manual
Development of ECE Department World Wide Web activities
Revision and WWW publication of all advising documents relevant to undergraduate advising
Developed financial support to ECE faculty for course WWW pages (1995-6)
Development of WWW support for student activities, job postings, etc.
Development of targeted email capabilities for ECE Department communication with students
Development of WWW assisted scheduling of advising appointments
Advise Department Head on policies related to undergraduate programs.
Coordination of campus presentation of proposals for revision of undergraduate curricula
Public Representation of the ECE Department
Advising and outreach to prospective students, transfer students, and parents.
Develop ECE activities for on-campus WYSE (Worldwide Youth in Science and Engineering) students
(junior/seniors in high school).
Develop WWW pages for outreach to high schools.
Chair, Neuroscience Graduate Program, 1990-1993
Oversight of All Program Activities
Reported to the Director of the School of Life Sciences
65 affiliated faculty from 5 colleges and 10 departments, 35 (on average) graduate students.
Managed support for continuing graduate students and supervised recruitment of new students
$70,000 / year direct budget (no faculty lines)
Member, Neuroscience Faculty Search Committees for Computational and Molecular Neuroscience
Wrote proposals for training grants.
Chair, Bioengineering Program, 1989-1990
Substituted for RL Magin, who was on sabbatical leave. Managed $100,000 / year budget (no direct faculty
December 2009 Bruce C. Wheeler p. 20/23

lines) Developed seminar series. Developed first draft mission statement and proposal for PhD program.
PROFESSIONAL, SERVICE, AND REVIEWING ACTIVITIES
University of Texas at Dallas Review of Graduate Degree Proposal for the Texas Higher Education Coordinating
Board. April 2009.
Departmental Review Panel, Biomedical Engineering Department, University of Miami, Sept. 2008.
External Advisory Board, UC Davis / Lawrence Livermore Point of Care Technologies Center. 2008.
MIT Educational Counselor, since 1978 (Interview approx. 6 MIT applicants each year.)
Member, Bioengineering Faculty, 1981-; Neuroscience Program, 1984-.
Bioengineering Student Society Advisor - 1983 to1995; 2001-
AAAS Advisory Panel for Louisiana EPSCOR Grant on Bio/Nano Technologies, 2001-3 (four visits)
IEEE Senior Member, 2003.
IEEE EMBS Student Advisory (International) Committee - 1992-Present
IEEE Central Illinois Section: Member-at-Large, 1982-3; Vice-Chair, 1983-4; Chair, 1984-5.
IEEE Engineering in Medicine and Biology Society, Editorial Advisor for internationally distributed student
newsletter, 1992-5.
IEEE EMBS Technical Program Committee, 1997 Annual Conference
NIH Site Visit Team, Program Project, 1990, 1991, 1995, 1999.
NIH Ad Hoc Reviewer, since 1993.
NIH Neural Prostheses Program Proposal Concept Reviewer, 1993, 1994, 2000, 2004.
NIH Neural Prosthesis Program Progress Report Evaluator, 2006.
NIH:Special Study Sections: 1991-4 SBIR Applications in Rehabilitation Engineering; 1992-3 Neuroscience &
Engineering proposals; 2001 Molecular, Cellular and Developmental Neurosciences 7 Study Section, 2001;
1999 (twice), 2002, Bioengineering. 2003, 2004, 2005 Neural/Bioengineering.
NIH Study Sections: Apr 03 MDCN1; Aug 03 ZRG1 MDCN-4; Jan 04 MDCN-A(06); Feb 04 NDPR; Mar 04
ZRG1 MDCN-C(55); May 04 MDCN-A(55); Jul 04 MDCN-G(56), MDCN-A (55), July 04 NINDS TMR RFP-
NIH-NINDS-04-04; Aug 04 ZRG1 MDCN-C(55); Feb 05 MDCN-K(55); Dec 04 2005/01 ZRG1 BST-A(50);
Jun 05 2005/10 ZRG1 BDCN-G(02); Aug 05 ZRG1-MDCN-C(41); Sep 05 ZDC1 SRB-W(49); Feb 05 BDCN
K10, BDCN K50; Jul 06 ZRG1 BDCN-K (50); Jul 06 Nanomedicine Development Centers. Jan08
NIHOD2007035 (Electrode Fab).
NSF: Ad Hoc Reviewer, since 1990 (34 proposals). Panel reviewer 1994.
NSF Panel on Biosystems at the Nanoscale. 1999.
NSF Panel Review on Information Technology (preproposals), 2000.
NSF Panel Review on Information Technology, 2001.
NSF Engineering Research Center Reviewer, 2000, 2002, 2003, 2003.
NSF EPSCOR Advisory Committee, 2001, 2002, 2003.
NSF Biological Computation Workshop Presenter, 2001.
IEEE Trans. Biomed. Eng. Associate Editor – 2001-
IEEE Press book series Emerging Technologies in Biomedical Engineering, Member Ed. Board, 1995-
J. Neuroscience Methods. Member of Editorial Board, 1996-present.
Memberships: AAAS, IEEE, ASEE, Society for Neuroscience
Journal Reviewer (# reviews 1990-2008 in parentheses): Advanced Materials (4), Analyt. Chemi (1), Annals
Biomed. Eng. (10), Appl. Phys. Lett. (1), Audiology-Neurology (1), Biomaterials (4), Biomed. Micro Devices
(2), Biophysical J. (1), Biosensors and Bioelectronics (1), Biotech. & Bioeng. (3), Biotech. Progress (2), Euro.
Biophysics J. (2), Euro. J. Neurosci. (3); Exp. Cell Res. (2), IEE Proc. (1), IEEE EMBS Magazine (1), IEEE
Sensors J. (4), IEEE Trans. Biomed. Eng. (~100), IEEE Trans. Education (2), IEEE Trans. Nanotech (1), IEEE
Trans. Neural Sys. & Rehab Eng. (1), IEEE Trans. Rehab. Eng. (8), J. Applied Bionics & Biomech. (1), J.
Biomaterials (1), J. Biomat. Sci, Polymer (1), J. Biomed Mat. Res. Part A (2), J. Nanosci. & Nanotech. (1), J.
Neuroeng. (5), J. Neurobiol. (1), J. Neurophysiol. (2), J. Neurosci. (3), J. Neurosci. Methods (31), J. Neurotox.
(1), J. Smart Engrg. (1), Langmuir (12), Med. & Biol. Eng. & Comp. (5), Med. Sci. Monitor (2), NanoLetters
(2), NASA (1), Nature Methods (1), Nature Physics (1), Nature Protocols (1), Neural & Behav. Biol. (1),
Neurosci. (2), Neurosci. Letters (3), Physiol. Measure. (1), Physica A (1), Science (1), Sensors & Actuators (1),
Tissue Engrg (1)
December 2009 Bruce C. Wheeler p. 21/23

Proposal Reviewer: NSF (many), NIH (many), Army Research Office (1), Canadian Research Council (1), DOE
(2), Engineering Foundation (1), Human Frontier Science Program (2), Indiana 21 st Cent. R&D Fund (1), Keck
Fdn (1), Louisiana Board of Regents (1), South Carolina DoD EPSCOR (1), Spinal Cord Foundation (2), US-
Israel Binational Science Found (2), UIUC (14), US Army Med RsrchCommand (panel).
German Federal Ministry Of Education and Research. Review of Centers for Comp. Neurosci. Fall 07, Jan 08.
Book Proposals: Academic Press (1),Elsevier (1), Prentice Hall (2), West Educational Publishing (1).
Promotion Reference Letter Writer: Boston U., UC Irvine, Case Western, Drexel, U. Wash, Rutgers (2), UCSD
(2), USC, Georgia Tech (3), Brown, Yale, Purdue, U. Missouri, Stanford, Tel Aviv U., New Jersey Inst. Tech.,
Michigan State, University of Macao.
Award Reference Letters: IEEE Fellow (6), U Minn (3), Drexel (1)
FLORIDA SERVICE AND COMMITTEE ASSIGNMENTS
Interim Chair, Biomedical Engineering, 2009-
Co-Chair, College of Engineering Strategic Planning Committee on Health Care and Biotechnology, 2009-10.
Reviewer, UF Planning Grants for Collaborative Research Projects, 2009.
ILLINOIS SERVICE AND COMMITTEE ASSIGNMENTS
Interim Head, Bioengineering, 2004-2008.
Campus Health and Wellness Research Initiatives Committee, 2006-7
Campus Translational Research Advisory Committee, 2004-7.
Faculty Search Committee, College of Applied Life Studies, 2004-5.
Faculty Search Committee, Department of Agricultural and Biological Engineering, 2004-5.
Director, Bioengineering Program, 2002-3
Bioinformatics Committee, 2002-2005
ECE Department Advisory Committee (elected), 2001-2003.
ECE Department Curriculum Committee, 1994-2005.
Assoc. Head, ECE Department, 1995-01
Dean’s Committee to Propose a Bioengineering Department, 2000-01
Chairman, Neuroscience Graduate Program, 1990-93
Chairman, Bioengineering Faculty, 1989-90
Committee Assignments: Chair, Bioeng. Curr & Courses, 1982-4; Eng. Coll. Teach. & Eval., 1988-90, Chair,
1989-90; Grad. College Eng. & Phys. Sci., 1983-5; Bioproc. Tech., 1984-5; Neurosci. Exec. Comm., 1988-01;
ECE Curric., 1984-01; ECE Grad. Comm. 1989-1990; Chair ECE Teach. Eval. & Awards, 1989-90; ECE
Honors Comm. Chair, 1992-96, 1997-9.
UIUC Biotechnology Council, 1999.
UIUC International Programs Committee, 1997-0.
Graduate Dean Search Committee, 1999-2000.
Severns Chair Search Committee, 1999.
Medical Scholars Program Steering Committee, 1997-2003; Subcommittee on Educational Policy, 1992-93, 97-
98; Admissions Committee, 1997-00.
Beckman Program Subcommittee on Office Space Utilization, 1992-93
Beckman Library Committee, 1992-93
Engineering College Honors Committee, 1992-96, 97-99; EOH and SITE Committee, 1992-96
Engineering College Knights of St. Pat Selection Committee, 2000
ECE Department Open House Advisor, 1989-95
Bioengineering Student Society (IEEE EMBS) Advisor, 1982-95, 01-; Open House Advisor, 1982-95
School of Life Sciences Fellowships Committee, 1990-93
Markey Foundation Grant Steering Committee, 1991-93
Computational Neuroscience Faculty Search Committee, 1989-92
UIUC Admissions - Wrote Recruiting Letters to High School Seniors, 1991-98
UIUC Admissions Honors Symposium Presentation to High School Seniors at UIUC, 1991-93
Council on Undergraduate Education 1994-95. Educational Technology Board 1995-98
UIUC Study Abroad Advisory Committee, 1997-8.
December 2009 Bruce C. Wheeler p. 22/23

Women in Engineering: Camp 21st presentation, August 1998; Bioengineering Presenter, 2001
Summer Orientation Faculty Group Leader, 1997-00.
Campus Translational Research Activities Committee. 2004-2006.
December 2009 Bruce C. Wheeler p. 23/23