Vortrag DDr. Wolfgang Maurer.pdf

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Global Production Potential for Pandemic Influenza Vaccine „Pandemic Vaccine“ Appears to Protect Only at High Doses • Two doses of 90 µg of purified killed virus – 4 weeks apart • Monovalent pandemic vaccine, 2 x 90 µg HA – 75 million doses global production capacity • Monovalent adjuvanted vaccine, 2 x 11.25 µg HA – 0,9 billion doses global production capacity • Adapted from M Enserik Science 309:996 (12.8.2005) Influenza Impfstoffe – Klassische Produktion
Vero Cell Microcarrier Cultures a) before infection : b) after 3 days infection with Influenza : Vero cells microcarrier Influenza induced CPE (cytopathic effect) microcarrier Zellkultur-Technologie MDCK-Zellen (Madin Darby Canine Kidney) Die 1958 aus der Niere eines gesunden Hundes isolierte adhärente Zelllinie wurde von Novartis Behring in eine Suspensionszellkultur weiterentwickelt. MDCK 33016 Suspensionszelle
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