SCIENTIFIC CURRICULUM - Leitat

4. LINTOP: Optimization of liver and intestine in vitro models for pharmacokinetic and pharmacodynamic
studies. FP6. LIFESCIHEALTH LSH-2005-1.2.3-4.
PUBLICATIONS
1. Quintás G et al. Chemometric approaches to improve PLSDA model outcome for predicting human nonalcoholic
fatty liver disease using UPLC-MS as metabolic profiling tool. Metabolomics 2011 (in press).
2. Kuligowski J et al. Direct determination of polymerized triacylglycerides in deep-frying vegetable oil by
near infrared spectroscopy using Partial Least Squares regression. Food Chemistry 2011 (in press).
3. Schroeder K et al.. Report from the EPAA workshop: In vitro ADME in safety testing used by EPAA
industry sectors. Toxicol In Vitro. 25:589-604, 2011.
4. Vila MR et al. A new ready-to-use concept for in vitro evaluation of biotransformation-mediated toxicity
(Abstract). Toxicology Letters, 2010, 196S, S37-S351.
5. Gombau L et al. Assessment of the inhibition on major human CYP450 isoforms as a predictor of
putative interaction on concomitantly administered drugs for a new compound under development. An
activity of the Melius project (Abstract). Toxicology Letters 2010, 196S, S37-S351.
6. Quintás G et al. Metabolic characterization of PB60 and PB65, two peptidomimetics which notably
facilitate the transport of heparin across the intestinal barrier. An activity of the Melius project (Abstract).
Toxicology Letters 2010, 196S, S37-S351
7. Gómez-Lechón MJ et al. In vitro evaluation of potential hepatotoxicity induced by drugs. Curr Pharm Des.
2010;16(17):1963-77
8. Kuligowski J et al. Sample classification for improved performance of PLS models applied to the quality
control of deep-frying oils of different botanic origins analyzed using ATR-FTIR spectroscopy. Anal
Bioanal Chem. 2011 Jan;399(3):1305-14
9. Dusinska M et al. Testing strategies for the safety of nanoparticles used in medical application.
Nanomedicine. 2009 Aug; 4(6):605-7.
10. Quintás G et al. Use of Fourier transform infrared spectrometry for the on-line study of focusing
mechanism in capillary electrophoresis. Analytical and Bioanalytical Chemistry 2007, 387, 287-292.
11. Lahoz A et al. In Vitro ADME Medium/High-Throughput screening in drug preclinical development. Mini-
Reviews in Medicinal Chemisry 6:1053-62, 2006.
12. Gombau L et al. Polypodium leucotomos extract: antioxidant activity and disposition. Toxicol In Vitro
20:464-71, 2006
13. Lahoz A and Gombau L Alteraciones en la función celular por la acción de fármacos. Las ómicas:
Genómica, Proteómica, Citómica y Metabolómica. Nuevas tecnologías para el desarrollo de fármacos.
Chap 9. Detección de las alteraciones de la función celular en el desarrollo de nuevos fármacos. Pag
229-266, 2005
14. Serradell M et al. Uremic medium causes expression, redistribution and shedding of adhesion molecules
in cultured endothelial cells. Haematologica. 2002 Oct;87:1053-61.
15. Serradell M et al. Uremic media affects hemostatic properties of human endothelial cells in cultureand
increases the production of von Willebrand factor. Nefrologia. 2002;22:33-41.
16. Sitges M et al. Acute and mid-term combined hormone replacement therapy improves endothelial
function in post-menopausal women with angina and angiographically normal coronary arteries. Eur
Heart J. 2001 Nov;22 (22):2116-24.
17. Gálvez A et al. Desmopressin (DDAVP) enhances platelet adhesion to the extracellular matrix ofcultured
human endothelial cells through increased expression of tissue factor. Thromb Haemost. 1997 May; 77
(5):975-80.
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