:S-:\s

o
o
a
o
o
0t
5
q
6-
cn
o
U'
o
+
J
:S -:\s
--:-::-\
-\\
-::S
\::_-S
::\S
=s
-\.\\\\\
.:-\\
i-\S
s:s
.\\:
NS
do
a
oF
n
o

--Y>'.-r..
o gl). (
(
,'
e
Applicotion
I Disotcet@ appti:Slion
oeg
()o{}
Disolcer@ can provide excerent properties in majority of formurations. The use
levers are between 0.5 to 3.0% onry. Disorcer@ u. r""J i" ur'iuf,",,ng process
including direct compression and wet granulation. """
In wet granulation, oi"ir"uio
be used intra- or extra_granular or equally divided between the two. ""n
Disolcel@ has been used in pharmaceuticat tablets, capsules and granules to aid in
disintegration of dosage form and drug dissolution.
Disorcer@
arso used in industriar apprications as an absorbent in diapers or
detergents tablet in laundrv.
Specificqtion
l
Basic specification
Appearance
Color
ldentification tests
pH (19 in 100mt)
Loss on drying, 70
Sodium chloride & sodium glycolate, %
Residue on ignition(sulfated ash), %
Heavy metals, ppm
Degree of substitution
Content of water-soluble material, yo
Settling volume, ml
Residual solvents
Free-flowing fibrous powder
White to off-white
Conforms
5.0 - 7.0
< 10.0
< 0.50
14.O - 2A.O

Effects of Disotcel@ on ioblef
disintegrotion time in o model drug formulotion
llTable 1.
Formulation of Hydrochlorothiazide 75mg Tablets
lngredients
Percentage
Hydrochlorothiazide
15.Oo/o
Dicalciumphosphatedihydrate 41.75"/o
Lactose
41.7 sok
Disintegrant 0.50 %
Magnesium Stearate
1.O"/.
Disintegrant
Disolcel@(ccs)
Low-substituted NaCMC (L-CMC)
Sodium starch glycolate(SSG)
Crospovidone(CP)
Pregelatinized starch(PGS)
Disintegration (sec)
27
38
51
470
> 120 min
Hyd roch lorothiazide dissolved, T60% (min)
Disintegrants o-25 ok o.5o '/o 1-o %
Disorcel@(ccs) 13 8 8
a,m
E
Low substitlted
NacMc (L-cMC)
CP
SSG
PGS
Blan k
19 10 9
23
5a
13 11
105 87 21
> 120
Time (mn)
-a- ccs ---.- ssc L.CMC
+ cP ---ra- PGS

.&,r
'4.iilF-
Table 2.
Phenacetin Model System (Direct Gompression)
Ingredients
Phenacetin
Lactose
Disolcel@(ccS)
Magnesium Stearate
Dicalcium Phosphate Dihydrate
Percentage
10.0%
43.750k
0,2.O %
0.5 %
qs 100%
Disolcet@ level
Tablet Hardness(kg)
Disintegration
o% (Blank) 2o/o
5 15 4 86
>72 min 22 sec
'72 mir| 51 sec
z
.q
o
c

llTable 3.
Aluminum Acetylsalicylate Model System (Wet granulation)
Ingredients
Alu minum Acetylsalicylate
PVP
Disolcel-(CCS)
Magnesium Stearate
Lactose
Percentage
50%
3.2"/"
0, 0.5,1.0%
1.O %
qs 100%
Disolcel@ level (%)
0
0.5
1.0
Tablet Hardness (kg) Disintegration (sec)
5.40
>2400
5.38
zv
4 ',.7
18

Different bronds of
Croscqrmellose Sodium comporison
Comporison of Toblet properties using different bronds of
Croscormellose Sodium (Disolcel@ ond other bronds) os disintegront,
$ Utodel Formulation Containing API
(Hydrochlorothiazide 75mg per tablet)
-a-
--_|-
Time (min)

o-,*lf*;
l'
I
l:,
'.: