Multicenter Study for Adult ALL – GMALL 07/2003 Overview Total ...
Multicenter Study for Adult ALL – GMALL 07/2003 Overview Total ...
Multicenter Study for Adult ALL – GMALL 07/2003 Overview Total ...
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<strong>Overview</strong><br />
17-Dec-04<br />
KI<br />
Induction<br />
CNS<br />
SZ collection<br />
� � � �<br />
BM/MRD<br />
Stratification I<br />
according to risk factors<br />
SR<br />
HR<br />
VHR<br />
No Donor<br />
Donor<br />
HD-MTX<br />
ASP<br />
6 MP<br />
T-Lin:<br />
CLAEG<br />
B-Lin:<br />
FLAG-IDA<br />
Allo SCT*<br />
i.th. MTX i.th. triple prophylaxis<br />
(HR/VHR)<br />
<strong>Study</strong> Protocol – Short Version<br />
Reind.<br />
6MP/MTX<br />
Auto SCT*<br />
VM26<br />
ARAC<br />
1 4 8 12 16 20 24 28 32 36 40 44<br />
* If donor or autologous stem cells available<br />
<strong>Multicenter</strong> <strong>Study</strong> <strong>for</strong> <strong>Adult</strong> <strong>ALL</strong> – GM<strong>ALL</strong> <strong>07</strong>/<strong>2003</strong><br />
<strong>Overview</strong> <strong>Total</strong> Therapy<br />
HD-MTX<br />
ASP<br />
MRD-HR<br />
CYCLO<br />
ARAC<br />
HD-MTX<br />
ASP<br />
6MP/MTX<br />
Stratification II<br />
according to MRD<br />
48 52<br />
weeks<br />
MRD<br />
HR<br />
MRD<br />
NR<br />
MRD<br />
IMR<br />
End of Therapy<br />
©2004 European LeukemiaNet; www.leukemia-net.org<br />
SCT (allo sibling, MUD or auto)*<br />
CYCLO<br />
ARAC<br />
VM26<br />
ARAC<br />
Intensified Maintenance<br />
HD-MTX<br />
ASP<br />
CYCLO<br />
ARAC<br />
VM26<br />
ARAC<br />
HD-MTX<br />
ASP<br />
58 66 74 82 90 98 104<br />
4
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