Strategies for the Prevention of Postherpetic Neuralgia - immpact

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Amitriptyline + acyclovir (n = 9) Placebo + acyclovir (n = 17) Dworkin RH. Prevention of postherpetic neuralgia. Lancet, 1999;353:1636-1637.
Preventing PHN by attenuating nerve damage and acute pain in herpes zoster VZV reactivation Peripheral nerve damage and dysfunction Acute neuropathic pain VZV replication ANTIVIRAL THERAPY ANALGESIA Acute nociceptive pain Central functional and structural changes (e.g., central sensitization, damage from excitotoxicity) PHN Tissue damage and inflammation VZV = varicella-zoster virus Dworkin RH, et al. Clinical Journal of Pain, 2000;16:S90-S100.
Page 1 and 2: Strategies for the Prevention of Po
Page 3 and 4: Proportion of patients developing P
Page 5 and 6: Greater acute pain is a risk factor
Page 7 and 8: If you come to a fork in the road,
Page 12 and 13: Pain, 2009;142:209-217
Page 14 and 15: Table 2. Corticosteroid and analges
Page 16 and 17: BOTTS (blockers of the transition s
Page 18 and 19: Shingles Trial of Oral Medication t
Page 20 and 21: 1. Topical local anesthetics 2. Sub
Page 24 and 25: van Wijck AJM, et al. Lancet, 2006;

Strategies for the Prevention of Postherpetic Neuralgia - immpact

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