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Strategies for the Prevention of Postherpetic Neuralgia - immpact

Strategies for the Prevention of Postherpetic Neuralgia - immpact

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Preventing PHN by attenuating nerve<br />

damage and acute pain in herpes zoster<br />

VZV<br />

reactivation<br />

Peripheral nerve damage and dysfunction<br />

Acute neuropathic pain<br />

VZV<br />

replication<br />

ANTIVIRAL<br />

THERAPY<br />

ANALGESIA<br />

Acute nociceptive pain<br />

Central<br />

functional and<br />

structural<br />

changes (e.g.,<br />

central<br />

sensitization,<br />

damage from<br />

excitotoxicity)<br />

PHN<br />

Tissue damage and inflammation<br />

VZV = varicella-zoster virus<br />

Dworkin RH, et al. Clinical Journal <strong>of</strong> Pain, 2000;16:S90-S100.

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