Mesothelin-ADC - Molecular Diagnostics for Cancer Drug ...
Mesothelin-ADC - Molecular Diagnostics for Cancer Drug ...
Mesothelin-ADC - Molecular Diagnostics for Cancer Drug ...
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<strong>Mesothelin</strong> positive cells<br />
tumor area (mm²)<br />
<strong>Mesothelin</strong>-specific targeting and<br />
bystander effect<br />
Experimental<br />
design<br />
<strong>Mesothelin</strong> <strong>Mesothelin</strong><br />
-<br />
+ 0 %<br />
20 %<br />
40 %<br />
<strong>Mesothelin</strong><br />
expression<br />
tumor area [mm 2 ]<br />
200<br />
150<br />
100<br />
50<br />
Anti-tumor<br />
efficacy<br />
100% po<br />
100% po<br />
80% pos<br />
60% pos<br />
40% pos<br />
20% pos<br />
0% posi<br />
60 %<br />
80 %<br />
100 %<br />
0<br />
0 10 20 30 40 50 60 70 80<br />
time after Days tumor after tumor cell cell inoculation [days]<br />
100% mesothelin control<br />
0% mesothelin<br />
20% mesothelin<br />
40%mesothelin<br />
60% mesothelin<br />
80% mesothelin<br />
100% mesothelin<br />
Bay 94--9343<br />
10 mg/kg<br />
Increased mesothelin expression translates into increased efficacy of BAY 94-9343<br />
8 • <strong>Mesothelin</strong> <strong>ADC</strong> • Boston, June 2012 • David Henderson
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