POSTERS Poster Session 1 ALLERGY SENSITISATION

Palazzo degli Affari MONDAY, September 29 1 - 19 

POSTERS 

GROUP A 

POSTER DISPLAY: Monday, September 29, 2003 from 9.00 am to 6.00 pm 

POSTER VIEWING AND DISCUSSION: Monday, September 29, 2003 from 12.30 pm to 2.30 pm 

Chairpersons: L.G. Costa (Washington, DC, USA and Bari, Italy) 

E. Fracasso (Verona, Italy) 

A. Meneguz (Rome, Italy) 

H. Tähti (Tampere, Finland) 

Poster Session 1 

ALLERGY SENSITISATION 

Poster board no. abstract no. 

1 IMPROVED RESPONSIVENESS OF LANGERHANS/DENDRITIC CELLS TO 

ALLERGENS 

J. Sheasgreen, S. Ayehunie, S. Lamore, R. Lappen, K. Bellevance, and 

M. Klausner MatTek Corporation, 200 Homer Avenue, Ashland, MA 01721, USA 

2 ANALYSIS OF THE IN VITRO ACTIVATION OF DENDRITIC-LIKE CELLS 

EXPOSED TO POTENTIAL SENSITIZERS 

Pierre Aeby 1 , Christoph Wyss 1 , Heinz Beck 1 and Carsten Goebel 2 , 1 Cosmital SA, 

(Research Company of Wella AG) Marly, Switzerland, 2 Department of Product 

Safety, Toxicology, Wella AG, Darmstadt, Germany 

3 PHENOTYPE ALTERATIONS IN CD34-DERIVED DENDRITIC CELLS AFTER 

EXPOSURE TO CONTACT ALLERGENS AND IRRITANTS 

R.L. Van Den Heuvel, A.C.A. De Smedt, G.E.R. Schoeters, Department of 

Environmental Toxicology, Vito, Mol, Belgium 

4 THE CONTACT SENSITIZER NICKEL SULFATE ACTIVATES THE 

TRANSCRIPTION FACTORS NF-KB AND AP-1 AND INCREASES THE 

EXPRESSION OF THE INDUCIBLE ISOFORM OF NITRIC OXIDE SYNTHASE 

IN SKIN DENDRITIC CELLS 

M. T. Cruz 1,2 , A. L. Vital 1,2 , M. Gonçalo 3 , C.B. Duarte 2 , M. C. Lopes 1,2 , 1 Faculty of 

Pharmacy, 2 Center for Neuroscience and Cell Biology, 3 Faculty of Medicine 

(Department of Dermatology), University of Coimbra, Coimbra, Portugal. 

5 BISPHENOL A SHOWED NO SKIN SENSITIZING OR PHOTOALLERGIC 

POTENTIAL IN A MODIFIED LOCAL LYMPH NODE ASSAY IN MICE 

H.-W. Vohr, H. J. Ahr, G. Stropp, Bayer Health Care, Toxicology, Aprather Weg, 

Wuppertal, Germany 

26 

96 

97 

98 

99 

100

6 ASSESSMENT OF THE SKIN SENSITIZATION POTENCY OF EUGENOL AND 

ITS DIMERS USING A NON-RADIOISOTOPIC MODIFICATION OF THE LOCAL 

LYMPH NODE ASSAY 

M. Takeyoshi1 , S. Noda1 , S. Yamazaki2 , H. Kakishima2 , K. Yamasaki1 and I. Kimber3 1Chemicals Assessment Center, Chemicals Evaluation and Research Institute, Hita, 

Japan, 2Cosmetic Laboratory, Kanebo Ltd., Odawara, Japan and 3Syngenta Central 

Toxicology Laboratory, Macclesfield, UK 

7 THE MOUSE LOCAL LYMPH NODE ASSAY: COMPARISON OF CELLULAR 

PROLIFERATION RESPONSE (CPR) USING VARIOUS VEHICLES (1996-2002) 

E.L. Moore, L.A. Waterson, A.D. Bull, Huntingdon Life Sciences, Huntingdon, 

Cambridgeshire, UK 

8 INCLUSION OF FLOW CYTOMETRIC ENDPOINTS IN THE LOCAL LYMPH 

NODE ASSAY 

D.F. Lanham 1 , M. Wragg 2 , S. Signs 2 , D. Coleman 3 , L.A. Waterson 3 , M.G. Wing 1 , 

1 Department of Experimental Biology, Huntingdon Life Sciences, Cambridgeshire, 

UK, 2 The Lubrizol Corporation, Wickliffe, OH, USA, 3 Department of Short Term 

Toxicology, Huntingdon Life Sciences, Wooleey Road, Alconbury, Huntingdon, 

Cambridgeshire, UK 

9 EXPERIENCE IN THE ROUTINE USE OF THE LOCAL LYMPH NODE ASSAY 

(LLNA) 

B. Griffon, X. Manciaux, S. de Jouffrey, R. Forster, CIT, Evreux, France 

10 A HIGH SENSITIVE DNA ARRAY METHOD FOR THE CHARACTERIZATION 

AND DISCRIMINATION OF DIFFERENT LOCAL IMMUNE REACTIONS IN 

MICE 

Heisler E., Ahr H.-J., Vohr H.-W., Bayer Health Care, Institute of Genetic & 

Molecular Toxicology, Wuppertal, Germany 

11 CYTOKINE PROFILING OF CHEMICAL ALLERGENS: INTER-ANIMAL 

VARIATION 

R.J. Dearman and I. Kimber. Syngenta Central Toxicology Laboratory, 

Macclesfield, Cheshire, UK 

12 ALLERGIC REACTIONS TO TOPICAL CHAMOMILE 

M. Saeedi 1 , K. Morteza-Semnani 2 , 1 Department of Pharmaceutics, Faculty of 

Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran, 2 Department of 

Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical 

Sciences, Sari, Iran 

13 EXPOSURE TO ENZYMES IN DETERGENTS DOES NOT LEAD TO THE 

DEVELOPMENT OF IgE ANTIBODY AMONG CONSUMERS 

K Sarlo 1 , B Kirchner 1 , R Parker 2 , E Troyano 3 , C Rodriguez 3 and R Stachlewitz 4 The 

Procter and Gamble Company, 1 Cincinnati, OH, USA, 2 Egham, UK, 3 Brussels, 

Belgium and 4 Abbott Bioresearch Center, Worcester, MA, USA 

14 DEVELOPMENT OF IgE ANTIBODY TO ENZYMES IN PERSONAL CARE 

PRODUCTS 

K Sarlo 1 , JD Innis 1 , R Parker 2 and G Adamson 3 , 1 The Procter and Gamble 

Company, Cincinnati, OH, USA, 2 Egham, UK, and 3 Avon Products, Suffern, NY, 

USA 

15 SAFETY PROFILE OF A DISH-WASHING LIQUID CONTAINING A BPN’ 

PROTEASE 

E. Troyano 1 , D.A. Page 2 , F. Bielen 1 , K. Sarlo 2 , R. Parker 3 and C. Rodriguez 1 

The Procter and Gamble Company, 1 Brussels, Belgium, 2 Cincinnati, OH, USA and 

3 Egham, UK 

27 

101 

102 

103 

104 

105 

106 

107 

108 

109 

110 

MONDAY

16 A MULTI-LABORATORY EVALUATION OF A COMMON IN VITRO PEPSIN 

DIGESTION ASSAY PROTOCOL USED IN ASSESSING THE SAFETY OF 

NOVEL PROTEINS 

D.J. Esdaile 4 ; G.A. Bannon 1 ; M. Bartels 2 ; R.J. Dearman 3 ; T.J. Fu 5 ; C.M. Glatt 6 ; N. 

Hadfield 3 ; S.L. Hefle 7 ; J.R. Heylings 3 ; R.E. Goodman 1 ; B. Henry 8 ; C. Herouet 4 ; M. 

Holsapple 11 ; G.S. Ladics 6 ; T.D. Landry 2 ; S.C. Maclntosh 8 ; E.A. Rice 1 ; L.S. Privalle 9 ; 

H.Y. Steiner 9 , R. Teshima 10 ; K. Thomas 11 ; R. van Ree 12 ; M. Woolhiser 2 , J. Zawodny 8 , 

1 Monsanto Co., St. Louis, MO, USA, 2 The Dow Chemical Co., Midland, MI, USA, 

3 Syngenta Central Toxicology Laboratory, Alderley Park, UK, 4 Bayer CropScience, 

Sophia Antipolis, France, 5 U.S. Food and Drug Administration, National Center for 

Food Safety and Technology, Summit-Argo, IL, USA, 6 DuPont, Co., Newark, DE, 

USA, 7 University of Nebraska, Lincoln, NE, USA, 8 Bayer CropScience, Research 

Triangle Park, NC, USA, 9 Syngenta Biotechnology, Inc., Research Triangle Park, 

NC, USA, 10 National Institute of Health Sciences, Tokyo, Japan, 11 ILSI Health and 

Environmental Sciences Institute, Washington, DC, USA, 12 Sanquin Research, 

Amsterdam, The Netherlands 

17 THE INDUCTION OF ORAL TOLERANCE TO OVALBUMIN IN BALB/C STRAIN 

MICE 

I. Kimber, C.J. Betts, H.T. Caddick and R.J. Dearman. Syngenta Central 

Toxicology Laboratory, Macclesfield, Cheshire, UK 

18 COMPLEXITY OF THE IMMUNE RESPONSE TO A PROTEASE AND IMPLICA- 

TIONS FOR THE SAFETY ASSESSMENT OF NOVEL ENZYME-CONTAINING 

PRODUCTS 

E.S. Finn, A.C. Pursifull, L.C. Limardi, S. Chapoval, K. Sarlo, B.A. Kirchner, and D. 

N. Rubingh. The Procter & Gamble Co., Cincinnati, OH, USA 

19 STATISTICAL EVALUATION OF CLASSIFICATION METHODS FOR POTENTIAL 

ALLERGENICITY BASED ON LOCAL ALIGNMENT 

D. Soeria Atmadja 1 , A. Zorzet 1 , Å. Björklund 1 , M. Gustafsson 2 , U. Hammerling 1 , 

1 Division of Toxicology, National Food Administration, Uppsala, Sweden, 2 Signal 

and Systems Group, Uppsala University, Uppsala, Sweden 

28 

111 

112 

113 

114


GROUP A 




IMMUNOTOXICOLOGY 


20 DEVELOPMENTAL IMMUNOTOXICOLOGY (DIT) – DEVELOPMENT OF A 

TESTING FRAMEWORK 

M. Holsapple, A. Lavin, Immunotoxicology Technical Committee (ITC), ILSI Health 

and Enironmental Sciences Institute (HESI), Washington, DC, USA 

21 “CELLCHIP” - A NEW TECHNOLOGY FOR IMMUNOTOXICITY SCREENING? 

T. Ringerike 1 , E. Ulleras 2 , G. Nilsson 2 , R. Vandebriel 3 , H. van Loveren 3 , J. Dastych 4 , 

M. Lovik 1 1 National Institute of Public Health, Division of Environmental Medicine, 

Oslo, Norway 2 Uppsala University, Department of Genetics and Pathology, 

Uppsala, Sweden 3 National Institute of Public Health and the Environment, 

Laboratory for Pathology and Immunobiology, Bilthoven, The Netherlands, 

4 International Institute of Molecular and Cell Biology, Laboratory of Molecular 

Immunology, Warsaw, Poland 

22 ASSESSMENT OF THE NONHUMAN PRIMATE IMMUNE SYSTEM BY IMMU- 

NOPHENOTYPING: COMPARISON OF TWO RELEVANT SPECIES WITH THE 

HUMAN 

W. Frings, G.F. Weinbauer, Covance Laboratories GmbH, Münster, Germany 

23 EXPLORATION OF THE PHAGOCYTIC ACTIVITY IN RATS, MONKEYS AND 

DOGS USING TWO HUMAN KITS 

F. Horand 1 , C. Cretinon 1 , F. Condevaux 1 , J. Descotes 2 , 1 MDS Pharma Services, 

L'Arbresle, France, 2 Poison Centre, E Herriot Hospital, Lyon, France 

24 COMPARISON OF NK CELL ACTIVITY MEASUREMENT USING THE 51Cr 

RELEASE ASSAY AND FACS SCAN ANALYSIS: EFFECT OF A SINGLE IV 

DOSE OF ANTI-ASIALO GM1 IN THE RAT 

F. Condevaux 1 , J. Guichard 1 , F.Horand 1 , J. Descotes 2 , 1 MDS Pharma Services, 

L’Arbresle, France, 2 Poison Centre, Edouard Herriot Hospital, Lyon, France 

25 CONTRASTING IMMUNOMODULATION BY MERCURIC CHLORIDE 

FOLLOWING ACUTE AND SUBCHRONIC EXPOSURE 

John Carey 1,2 , Shailendra Anoopkumar-Dukie 2 Peter O’Keeffe 2 , Ashley Allshire 1,2 & 

Frank van Pelt 1,2 1 Environmental Research Institute, 2 Dept. Pharmacology and 

Therapeutics, University College, Cork, Ireland 

26 BIOLOGICAL MARKERS MONITORING Pb IMMUNOTOXICITY; INTER- 

FERENCE WITH ETHANOL 

E. Codorean, C. Tanase, C. Iosif, M. Neagu, G. Manda, D. Popescu, E. Raducan, 

M. Georgescu Laboratory of Biochemie, Department of Pathology, Victor Babes 

National Institute of Pathology, Bucharest, Romania 

29 

115 

116 

117 

118 

119 

120 

121 

MONDAY

27 SAFE DENTAL AMALGAM REMOVAL IN PATIENTS WITH IMMUNOTOXIC 

REACTIONS TO MERCURY 

G. Guzzi 1 , C. Minoia 2 , P. Pigatto 3 , A. Ronchi 2 , A. Gatti 2 , S. Angeleri 2 , O. Formichi 1 , 

1. Italian Association Metal Research and Biocompatibility- A.I.R.M.E.B., Milan, Italy 

2. Laboratory of Environmental Hygiene and Industrial Toxicology “S. Maugeri”, 

Pavia, Italy, 3. Department of Dermatology and IRCCS, University of Milan, Milan, 

Italy 

28 IMMUNOTOXIC EFFECTS OF LEAD ACETATE IN MALE SWISS MICE 

I. Iavicoli, G. Carelli, Centro di Igiene Industriale, Istituto di Medicina del Lavoro, 

Università Cattolica del Sacro Cuore, Rome, Italy 

29 EFFECT OF HEPATITIS B VACCINE IN MERCURIC CHLORIDE-TREATED 

NZBxNZW F1 MICE 

G. Ravel 1 , M. Christ 1 , R. Burnett 1 , J. Descotes 2 , 1 MDS Pharma Services, 

L’Arbresle, France, 2 Poison Centre, Edouard Herriot Hospital, Lyon, France 

30 CYTO- AND CHEMOKINE EXPRESSION IN THE MOUSE MACROPHAGE RAW 

264.7 CELL LINE CELLS EXPOSED TO HARD- AND SOFTWOOD DUSTS 

J. Määttä, M.-L. Majuri, U. Andersson, H. Alenius, K. Savolainen, Finnish Institute 

of Occupational Health, Helsinki, Finland 

31 ROLE OF ACTIVATED NEUROTROPHIC LEUKOCYTES IN PATHOGENESIS OF 

DIFFERENT DISEASES 

A.V. Sorokina, L.P Kovalenko, E.V. Shipaeva, T.A. Gudasheva, R.U. Ostrovskaya, 

S.B. Seredenin, State Zakusov Institute of Pharmacology RAMS, Moscow, Russia 

32 EFFECT OF IL-6 AND IL-15 ON THE NO PRODUCTION AND EXPRESSION OF 

iNOS IN PMN AND PBMC 

J. Jablonski 1 , E. Jablonska 2 , W. Puzewska 2 , M. Marcinczyk 2 1 Department of 

Toxicology, Medical University of Bialystok, Poland, 2 Department of Immunology, 

Medical University of Bialystok, Poland 

33 THE IN VITRO FUNCTIONS OF NORMAL PERIPHERAL LYMPHOCYTES ARE 

INFLUENCED BY LOW MOLECULAR WEIGHT HEPARINES 

M. Neagu 1 , G. Manda 1 , M. Gaghes 1 , C. Constantin 1 , C.Tanaseanu 2 , 1 Immunology 

Department, Victor Babes National Institute, Bucharest, Romania, 2 Sf. Pantelimon 

Emergency Hospital, Bucharest, Romania 

34 RESISTANCE TO IN VITRO INFECTION WITH LEISHMANIA MAJOR IN 

MACROPHAGES FROM ARYL HYDROCARBON RECEPTOR-NULL MOUSE 

L. Vega 1 , M.I. Vázquez 1 , M. Rodríguez 2 , G. Elizondo 1 . 1 Sección Externa de 

Toxicología, Centro de Investigación y Estudios Avanzados-IPN. 2 Instituto Nacional 

de Cardiología, México D. F., México 

35 EFFECT OF PHOSPHODIESTERASE INHIBITORS ON SPLENIC LYMPHOCY- 

TES PROLIFERATION 

G. Dyulgerova, N. Boyadjieva Department of Pharmacology and Toxicology, 

Medical Division, Medical University of Sofia, Sofia, Bulgaria 

36 EFFECTS OF DERIVATIVES OF DITHIOCARBONIC ACID (XANTHATES) ON 

SOME PHAGOCYTE CELLS 

S. Yanev 1 , O. Karagiozova 1 , D. Uzunova 1 , V. Hadzimitova 2 , 1 Department of Drug 

Toxicology, Institute of Physiology, Bulgarian Academy of Sciences, 

2 Dept.Biophysics, Medical School, Sofia, Bulgaria 

37 MOLECULAR MECHANISM OF ACTION OF THE FUNGICIDE MANCOZEB ON 

THE INHIBITION OF CYTOKINE PRODUCTION 

E. Corsini1 , S. Birindelli2 , M. Marinovich1 , C. Colosio2 and C.L. Galli1 1Laboratory of Toxicology, Department of Pharmacological Sciences, University of 

Milan, Milan, Italy; 2ICPS, International Centre for Pesticide Safety, Busto Garolfo, Italy 

30 

122 

123 

124 

125 

126 

127 

128 

129 

130 

131 

132

38 IMMUNOMODULATORY EFFECTS OF EBDTCs ON AGRICOLTURAL 

WORKERS OCCUPATIONALLY EXPOSED TO THE FUNGICIDE MANCOZEB 

S. Birindelli1 , E. Corsini2 , M. Marinovich2 , C. Colosio1 , M. Maroni1 and C.L. Galli2 1 2 ICPS, International Centre for Pesticide Safety, Busto Garolfo, Italy Laboratory of 

Toxicology, Department of Pharmacological Sciences, University of Milan, Milan, Italy 

39 IMMUNE-MORPHOLOGICAL ASPECTS OF ORGANOPHOSPHORUS INDU- 

CED DELAYED NEUROPATHY STUDYING 

A. Pushkin, Y. Rumbal, S. Dvoretskaya, V. Petrunin, State Research Institute of 

Organic Chemistry and Technology (GosNIIOKhT), Moscow, Russia 

40 COMPARATIVE INVESTIGATION OF BEHAVIORAL, NEUROTOXICOLOGICAL, 

AND IMMUNOTOXICOLOGICAL INDICES IN DETECTION OF SUBACUTE COM- 

BINED EXPOSURE WITH METHYL PARATHION AND PROPOXUR IN RATS 

L. Institoris 1 , A. Papp 1 , B. D. Banerjee 2 , O. Siroki 1 1 Department of Public Health, 

Faculty of Medicine, University of Szeged, Hungary, 2 Department of Biochemistry, 

University College of Medical Sciences and Guru Teg Bahadur Hospital, University 

of Delhi, Shahdara, Delhi, India 

41 IMMUNOTOXICITY OF ORGANOPHOSPHOROUS PESTICIDES, METHIDATHION 

AND PIRIMIPHOS-METHYL ON THE IMMUNE SYSTEM OF BALB/C MICE 

Juno H. Eom, Hyung Soo Kim, Seung Tae Chung, Jae Hyun Park, Jung Hyun Kil, 

Jong Kwon Lee, and Hye Young Oh, and, Immunotoxicology Division, Department 

of Specialized Toxicology, National Institute of Toxicological Research, Korea Food 

and Drug Administration, 5 Nokbun-Dong, Eunpyung-Ku, Seoul, South Korea 

42 EVALUATION OF IMMUNOTOXICITY INDUCED BY DIAZINON IN C57bl/6 MICE 

E. Zabihi Neishabouri 1 , Z.M. Hassan 2 , S.N. Ostad 1 , 1 Department of Toxicology 

and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, 

Tehran, Iran, 2 Department of Immunology, Faculty of Medical Sciences, Tarbiat 

Modarres University, Tehran Iran 

43 COMPARISON OF SOME IMMUNE RESPONSES OF TWO GROUPS OF 

WORKERS EXPOSED TO VARIOUS LEVELS OF PAHs 

I. Ates 1 , B. Yucesoy 1 , M. Yilmazer-Musa 2 , A. Karakaya 1 1 Department of Toxicology, 

Faculty of Pharmacy, Ankara University, 06100, Tandogan, Ankara, Turkey, 

2 Department of Toxicology, Faculty of Pharmacy, Gazi University, Ankara, Turkey 

44 PROTECTIVE EFFECTS OF GLUTATHIONE ON 5-FLOROURACIL INDUCED 

MYELOSUPPRESSION IN MICE 

K. Takaba, N. Kimoto, T. Takeda, M. Kakuni, M. Naya, N. Kojima, T. Harada, M. 

Hiura, T. Hara, Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd, 

Yamaguchi, Japan 

45 THE IMMUNOTOXIC ACTIONS OF CYCLOSPORIN A, DEXAMETHASONE 

AND FUROSEMIDE IN THE RAT: A COMPARATIVE STUDY 

R. Forster, C. Mimouni, B. Griffon, J-M. Pavard, M. Attia CIT, Evreux, France 

46 TOXICITY ASSAY TO SINGLE DOSES AND TO REPEATED DOSES OF HUMA- 

NIZED ACMT1HT BY ENDOVENOUS ROUTE IN CENP:SPRD RATS 

Y. González1 , A. Casacó2 , AM. Bada1 , D. Fuentes1 , B. González1 , N. Subiros1 , ME. 

Arteaga1 , O. Hernández1 , J. Hernández1 , 1Center of Experimental Toxicology 

(CETEX), National Center for the Laboratory Animal Breeding (CENPALAB), 

2Department of Clinical Assays, Center of Molecular Immunology, (CIM), Havana 

Cuba 

47 IMMUNE FUNCTION ALTERATIONS INDUCED BY OCHRATOXIN A IN 

EX VIVO AND IN VITRO MODELS OF WISTAR RATS 

A. López de Cerain, L. Alvarez, O. Ezpeleta, A.G. Gil, Laboratory of Toxicology, 

Department of Food Sciences and Toxicology, University of Navarre, Pamplona, 

Spain 

31 

133 

134 

135 

136 

137 

138 

139 

140 

141 

142 

MONDAY

48 RESPIRATORY ALLERGY AND INFLAMMATION DUE TO AMBIENT PARTI- 

CLES (RAIAP) – A EUROPEAN-WIDE ASSESSMENT. ALLERGY SCREENING 

T. Løvdal, E. C. Groeng, E. Dybing and M. Løvik, Norwegian Institute of Public 

Health, Oslo, Norway 

49 POLYMORPHISMS OF DNA REPAIR AND BIOTRANSFORMATION GENES 

AND POSSIBLE RELATIONSHIPS WITH IMMUNOLOGICAL RESPONSE 

M. Kuricova1 , P. Vodicka2 , R. Kumar5 ,L. Vodickova3 , J. Tulinska1 , E.Jahnova1 , A. 

Liskova1 , M. Dusinska1 , P.Soucek3 , L. Fuortes4 , K. Hemminki5 1Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic, 

2Institute of Experimental Medicine, Acad. Sci. Czech Republic, Prague, Czech 

Republic, 3National Institute of Public Health, Prague Czech Republic, 4University of Iowa, Department of Preventive Medicine and Environmental Health, Iowa City, 

IA, USA, 5German Cancer Institute, Heidelberg, Germany 

32 

143 

144


GROUP A 




OCULAR AND SKIN TOXICITY 


50 INCIDENCE OF REFRACTIVE ERRORS IN VICTIMS OF CHEMICAL WEAPONS 

AS A DELAY EFFECTS 

Khosro Jadidi 1 , Abbass Riazi2 , Mostafa Naderi1 , Ali Karimi 2 , 

Mahmod Babaei 1 , Hamid Safabaksh1 , Momamad Manaei 1 

1 Dept of Ophthalmology, Baghyatolla (a.s ) University of Medical Sciences 

2 Dept of Physiology and Biophysics, Baghyatolla (a.s ) University of Medical 

Sciences, Niararan, Araj, Teheran, Iran 

51 ETBE-RELATED EFFECTS ON RAT FIBROBLASTS 

I. Iavicoli, G. Carelli, Centro di Igiene Industriale, Istituto di Medicina del Lavoro, 

Università Cattolica del Sacro Cuore, Rome, Italy 

52 EFFECTS OF LATANOPROST AND GLC756, A NOVEL DOPAMINE D2 AGONI- 

ST AND D1 ANTAGONIST, ON CULTURED NORMAL HUMAN DERMAL FIBRO- 

BLASTS 

U.W. Laengle 1 , R. Markstein 2 , D.Pralet 1 , B. Greiner 1 and D.Roman 1 , 1 Toxicology/ 

Pathology, 2 Ophthalmics, Novartis Pharma AG, Basel, Switzerland 

53 THE EFFECT OF ACETAZOLAMIDE ON EYE DEVELOPMENT 

J. Soleimani Rad, K. Sadegi, A. Alizadeh 

Depts of Anatomical Sciences & Ophthalmology , Faculty of Medicine, Medical 

Sciences University of Tabriz , Tabriz, Iran 

33 

145 

146 

147 

148 

MONDAY


GROUP A 




ALTERNATIVE METHODS 


54 THE CHALLENGE: REDUCING ANIMAL USE 

S. Vaughan, R. Combes, FRAME (Fund for the Replacement of Animals in Medical 

Experiments), Russell and Burch House, 96–98 North Sherwood Street, 

Nottingham, NG1 4EE, UK 

55 SAFETY TESTS FOR COSMETIC FORMULATIONS : POSITIONING, 

CORRELATIONS AND PREDICTIVITY OF IN VITRO AND IN VIVO DATA 

E. Camel, J.P. Guillot, Institut d’Expertise Clinique (I.E.C.), 88, Boulevard des 

Belges, 69006 Lyon – France 

56 SKIN IRRITATION - EVALUATION OF MECHANISMS: DESCRIPTION OF AN 

IL-1α THRESHOLD 

T. Welss, K. Schröder, VTB-Skin Biochemistry, Henkel KGaA, Düsseldorf, 

Germany 

57 A TIERED STRATEGY FOR IN VITRO PHOTOTOXICITY TESTING 

A. King and P. Jones, Safety and Environmental Assurance Centre, Unilever 

Colworth, Sharnbrook, Bedford, MK44 1LQ UK 

58 ASSESSMENT OF THE IN-HOUSE PERFORMANCE OF THE EPIDERM TM AND 

EPISKIN TM IN VITRO CORROSIVITY TESTS 

P. Jones and A. King, Safety and Environmental Assurance Centre, Unilever 

Colworth, Sharnbrook, Bedford, MK44 1LQ UK 

59 DETERMINATION OF PHOTOTOXICITY PROPERTIES OF DIFFERENT 

COMPOUNDS USING A FULL THICKNESS SKIN MODEL (AST-2000) 

J. J. Hoffmann 1 , E. Heisler 2 , P. Peters 1 ; S. Karpinski 1 , H.-W. Vohr 2 , 1 CellSystems 

Biotechnologie Vertrieb GmbH, St. Katharinen, Germany, 2 Bayer Health Care, 

Institute of Genetic & Molecular Toxicology, Wuppertal, Germany 

60 ADVANCED SKIN TEST 2000 (AST-2000) AS A POTENT IN VITRO TOOL FOR THE 

CHARACTERIZATION OF SKIN REACTIONS BY PROTEIN FINGERPRINTING 

E. Heisler 1 , J.J. Hoffmann 2 , P. Peters 2 , H.J. Ahr 1 , H.-W- Vohr 1 , 1 Bayer Health Care, 

Institute of Genetic & Molecular Toxicology, Wuppertal, Germany, 2 CellSystems 

Biotechnologie Vertrieb GmbH, St. Katharinen, Germany 

61 RESULTS OF A SKIN IRRITATION VALIDATION STUDY WITH TOPICAL ACNE 

FORMULATIONS 

Joanna Harvey 1 , Marina Cappadoro 2 , Bart De Wever 2 , Adrian Davis 1 , Stuart 

Freeman 1 . 1 GlaxoSmithKline Consumer Healthcare R&D, Weybridge, Surrey UK. 

2 SkinEthic Laboratories, Nice, France 

34 

149 

150 

151 

152 

153 

154 

155 

156

62 USE OF PROTEOMIC TECHNOLOGIES FOR DISCOVERY OF NEW MARKERS 

OF SKIN IRRITATION 

S.T.Fletcher 1 and V.A. Baker 2 , 1 SEAC, Unilever, Bedfordshire, UK, 2 CuDoS Cellular 

Development Systems Ltd, Nottingham, UK 

63 EPIDERMFULL THICKNESS (EPIDERM-FT), A DERMAL-EPIDERMAL SKIN 

MODEL WITH A FULLY DEVELOPED BASEMENT MEMBRANE 

P. Hayden, J. Kubilus, B. Burnham, G. Jackson, J. Sheasgreen and Mitch 

Klausner, MatTek Corp., Ashland, MA, USA 

64 STRONG REPRODUCIBILITY FOR 50 CHEMICALS TESTED FOR THEIR IN 

VITRO SKIN IRRITATION POTENTIAL ON SKINETHIC RECONSTITUTED 

HUMAN EPIDERMIS USING MULTIPLE END POINT ANALYSIS 

M. Cappadoro, C. Tornier, B. De Wever and M. Rosdy. SkinEthic Laboratories, 

Nice, France 

65 INDUCTION OF CYTOCHROME P450 ENZYME ACTIVITY BY UVB AND 

XENOBIOTICS IN NORMAL HUMAN KERATINOCYTES 

G. Bertazzoni 1 , L. Benassi 1 , C. Magnoni 1 , M. Caselli 2 , S. Seidenari 1 , 1 Department of 

Dermatology, University of Modena and Reggio Emilia, Italy, 2 Department of 

Chemistry, University of Modena and Reggio Emilia, Italy 

66 A HUMAN CORNEAL EQUIVALENT AS IN VITRO MODEL FOR ASSESSING 

OCULAR IRRITATION 

M. Engelke, J. Patzke, S. Tykhonova, M. Zorn-Kruppa, Institute for Biophysics, 

Department of Physics and Electrical Engineering, University of Bremen, Bremen, 

Germany 

67 OCULAR PERMEATION OF TIMOLOL THROUGH EXCISED RABBIT CORNEA 

AND RABBIT CORNEAL EPITHELIAL CELL LAYERS: A COMPARISON 

S. Burgalassi, A. Brignoccoli, P. Chetoni, D. Monti, M.F. Saettone, Dept. 

Bioorganic Chemistry and Biopharmaceutics, University of Pisa, Pisa, Italy 

68 EVALUATING THE OCULAR IRRITATION POTENTIAL OF 54 TEST ARTICLES 

USING THE EPIOCULAR HUMAN TISSUE CONSTRUCT MODEL (OCL-200) 

J. Sheasgreen 1 , M. Blazka 2 , J. Harbell 3 , M. Klausner 1 , P. Hayden, J. Merrill 3 , J. 

Kubilus 1 , C. Kloos 2 and D. Bagley 2 . 1 MatTek Corporation, Ashland, MA, 2 Colgate- 

Palmolive Company, Piscataway, NJ, 3 The Institute for In Vitro Sciences, Inc., 

Gaithersburg, MD, USA 

69 EVALUATION OF THE EFFECTS OF CHRONIC SUBCYTOTOXIC SURFACTANT 

EXPOSURE TO A HUMAN CORNEAL CELL LINE 

P.J. Wilkinson 1 , R.H. Clothier 1 , 1 FRAME Laboratories, School of Biomedical 

Sciences, University of Nottingham, Nottingham, UK 

70 ACUTE TOXICITY: ALTERNATIVES TO THE LD50 TEST 

C. Longobardi, V. Pacelli, A. Argentino Storino, RTC, Research Toxicology Centre 

S.p.A., Pomezia - Rome, Italy 

35 

157 

158 

159 

160 

161 

162 

163 

164 

165 

MONDAY

71 PRELIMINARY (PHASE I) RESULTS OF A VALIDATION STUDY TO EVALUATE 

THE RELIABILITY AND RELEVANCE OF TWO IN VITRO CYTOTOXICITY 

ASSAYS FOR PREDICTING RODENT AND HUMAN ACUTE SYSTEMIC TOXI- 

CITY 

S. Casati 1 , J.A. Strickland 2,3 , M.W. Paris 2,3 , W.S. Stokes 2 , R.R. Tice 2,3 , J. Haseman 4 , 

A.P. Worth 5 , H. Raabe 6 , C. Cao 7 , R. Clothier 8 , J. Harbell 6 , R. Curren 6 , M.L. Wenk 9 , 

M.K. Vallant 4 , G. Mun 6 , M. Clear 6 , G.O. Moyer 6 , J. Madren-Whalley 7 , C. Krishna 7 , 

M.Owen 8 , N. Bourne 8 , 1 European Centre for the Validation of Alternative Methods 

(ECVAM) JRC, Ispra, Italy, 2 NTP Interagency Center for the Evaluation of Alternative 

Toxicological Methods (NICEATM), RTP, NC, USA 27709, 3 ILS, Inc., RTP, NC, USA, 

4 National Institute of Environmental Health Sciences (NIEHS), RTP, NC, USA, 

5 European Chemicals Bureau (ECB) JRC, Ispra, Italy, 6 Institute for In Vitro 

Sciences, Gaithersburg, MD, USA, 7 U.S. Army Edgewood Chemical Biological 

Center, APG, MD, USA, 8 Univ. of Nottingham, Nottingham, UK, 9 BioReliance Corp., 

Rockville, MD, USA 

72 APPROACHES TO THE MINIMISATION OF DOG USE IN THE SAFETY 

ASSESSMENT OF PHARMACEUTICALS: AN INDUSTRY/ ANIMAL WELFARE 

INITIATIVE 

D. Smith1 ; R. Combes2 ; G. Descotes3 ; S. Dyring Jacobsen4 ; R. Hack5 ; J. 

Kemkowski6 ; K. Krauser7 ; L. Lammens8 ; R. Pfister9 ; B. Phillips10 ; Y. 

Rabemampianina11 ; S. Sparrow12 ; M. Stephan-Gueldner13 ; F. von Landenberg14 1 2 3 4 Astra Zeneca, UK, FRAME, UK, Servier, France, Novo Nordisk, Denmark, 

5 6 7 8 Aventis Pharma, Germany, Altana, Germany, Schering, Germany; Johnson & 

Johnson, Belgium; 9Novartis Pharma AG, Switzerland; 10RSPCA, UK; 11Pfizer, France; 12UK, 12GlaxoSmithKline, UK, 14Merck, Germany 

73 IMPROVED PREDICTION OF THE HUMAN ACUTE TOXICITY BY THE DELAYED 

CYTOTOXICITY OF THE MEIC REFERENCE CHEMICALS IN Fa32 CELLS 

P. J. Dierickx, Instituut voor Volksgezondheid, Laboratorium Biochemische 

Toxikologie, Wytsmanstraat 14, B-1050 Brussel, Belgium 

74 ASSESSMENT OF THE IMPACT OF TOXIC EXPOSURES TO VIABILITY OF 

HIGHER EUKARYOTIC CELLS BY FLUORESCENT CELL METABOLIC AND 

CELL PROLIFERATION ASSAYS 

Marleen Maras 1 , Jurgen del Favero 2 , Bart Naudts 3 , Paul Vanhummelen 4 , Erwin 

Witters 5 , Harry Van Onckelen 5 , Eddy Esmans 5 , Christine Van Broeckhoven 2 , Alain 

Vershoren 6 Ronny Blust1 and Wim De Coen 1 , 1 Laboratory for Ecophysiology, 

Biochemistry and Toxicology, University Antwerp, Groenenborgerlaan 171, B-2020 

Antwerp, Belgium, 2 Department of Molecular Genetics VIB8, University of Antwerp, 

Universiteitsplein 1, B-2610 Antwerp, Belgium, 3 Department of Mathematics and 

Computer Science, University of Antwerp, Middelheimlaan 1, B-2020 Antwerp, 

Belgium, 4 VIB MicroArray Facility, UZ Gasthuisberg, Onderwijs en Navorsing, 

Herestraat 49, B-3000 Leuven, Belgium, 5 Lab. for Plant Biochemistry and 

Physiology, University Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium. 

6 Department of Mathematics and Informatics, University Antwerp, Groenenborgerlaan 

171, B-2020 Antwerp, Belgium 

75 OLFACTORY MUCOSAL TOXICITY SCREENING AND MULTIVARIATE QSAR 

MODELLING FOR CHLORINATED BENZENE DERIVATIVES 

C. Carlsson 1 , M. Harju 2 , F. Bahrami 1 , T. Cantillana 3 , M. Tysklind 2 , I. Brandt 1 , 

1 Department of Environmental Toxicology, Uppsala University, Norbyvägen 18A, 

SE-752 36, Uppsala; and 2 Department of Environmental Chemistry, University of 

Umeå, SE-901 87, Umeå and 3 Department of Environmental Chemistry, Stockholm 

University, SE-106 91 Stockholm, Sweden 

36 

166 

167 

168 

169 

170

76 DEVELOPMENT OF AN IN VITRO BLOOD-BRAIN BARRIER SYSTEM 

T. Toimela 1 , H. Tähti 1 , 1 University of Tampere, Medical School, Tampere, Finland 

77 NEUROPATHY TARGET ESTERASE ACTIVITY REACTIVATION IN 

CHROMAFFIN CELL CULTURES TREATED WITH MIPAFOX 

E. Quesada, M.A. Sogorb, E. Vilanova, V. Carrera. División de Toxicología, 

Universidad Miguel Hernández, Elche (Alicante) Spain 

78 DELAYED NEUROPATHY FORECAST: THE NEUROPATHY ESTERASE 

ACTIVITY IN VITRO AND IN VIVO AS A DELAYED NEUROTOXICITY OF 

ANTICHOLINESTERASE COMPOUNDS (PESTICIDES AND DRUGS) TEST 

N.V. Kokshareva, M.G. Prodanchuk, M.L. Zinovieva, O.V. Gudz Medved Institute 

of Ecohygiena and Toxicology, Kyiv, Ukraine 

79 CYTOTOXIC EFFECTS OF 100 TOXIC COMPOUNDS ON HEP G2 AND HELA 

CELLS 

Willem G.E.J. Schoonen 1 , Walter M.A. Westerink 1 , Jeroen A.D.M. de Roos 1 and 

Eric Débiton 2 , 1 Department of Pharmacology, Research and Development, N.V. 

Organon, Molenstraat 110, 5340 BH Oss, The Netherlands, 1 INSERM UMR 484, 

Rue Montalembert, 63005 Clermont-Ferrand, France 

80 DIFFERENTIAL PROTEOME ANALYSIS OF RAT LIVER FOLLOWING TCDD 

EXPOSURE 

R. Pastorelli 1 , D. Carpi 1 , S. Tavazzi 1 , E. Fattore 1 , C. Chiabrando 1 , L. Airoldi 1 , H. 

Hakansson 2 , R. Fanelli 1 , 

1 Department of Environmental Health Sciences, Istituto "Mario Negri", Milan, Italy, 

2 Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden 

81 ENDPOINT SELECTION FOR HEPATIC CYTOTOXICITY EVALUATION USING 

LIVER SPHEROID MODEL 

Jinsheng Xu and Wendy M. Purcell Centre for Research in Biomedicine, Faculty 

of Applied Sciences, University of the West of England, Bristol, UK 

82 EVALUATION OF THE TOXICITY EFFECT OF ETHANOL ON CACO-2/TC7 

COLON TUMOR CELL CULTURES 

A. Chiusolo and G. Dal Negro. Cellular & Biochemical Laboratory, Safety 

Assessment Department, GlaxoSmithKline R&D, Verona, Italy 

83 VALIDATION OF AN IN VITRO MODEL FOR THE EARLY ASSESSMENT OF 

PHOSPHOLIPIDOSIS IN DRUG DEVELOPMENT 

Alessandro Casartelli, Monica Bonato, Federica Crivellente, Illaria Masotto, Luca 

Vandin and Gianni Dal Negro. Cellular & Biochemical Laboratory, Safety 

Assessment Department, GlaxoSmithKline R&D, Verona, Italy 

84 A NEW METHODOLOGY FOR THE DETERMINATION OF PHOSPHOLIPASE 

ACTIVITY 

F.K. Ticli 1 , J.J. Franco 1 , A.M. Soares 2 , S.A. Uyemura 1 , S.V. Sampaio 1* , 1 Laboratório 

de Toxicologia, Departamento de Análises Clínicas, Toxicológicas e 

Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, 

Universidade de São Paulo, Ribeirão Preto - SP. Brasil, 2 Unidade de Biotecnologia, 

Universidade de Ribeirão Preto, Ribeirão Preto – SP. Brasil 

85 DEVELOPMENT OF MULTIPLEXED COMPETITIVE LUMINEX PROTEIN 

ASSAYS FOR TOXICITY PREDICTION SCREENS 

Rhiannon Lowe 1 , Julie Byard 2 , Samuel L.L. Roberts 1 , Hayley C. Cordingley 1 , 

1 GlaxoSmithKline Ware R&D, Department of Investigational Pathology and 

Toxicology GSK R&D, Ware, Hertfordshire UK, 2 Scientific Generics Limited, 

Harston Mill, Harston, Cambridge, Cambridgeshire UK 

37 

171 

172 

173 

174 

175 

176 

177 

178 

179 

180 

MONDAY


GROUP A 




QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS (QSAR) 


86 DEVELOPMENT OF A DATABASE FOR (Q)SAR IN REPEATED DOSE TOXICITY 

Bitsch A., Wahnschaffe U., Simetska N., Mangelsdorf I. Fraunhofer Institute of 

Toxicology and Experimental Medicine (ITEM), Nikolai-Fuchs-Str.1, 30625 

Hannover, Germany 

87 SAR AND QSAR USED IN A WEIGHT OF EVIDENCE APPROACH FOR EVA- 

LUATING THE EFFECTS ON HUMAN HEALTH OF PESTICIDES 

P. Crettaz, Swiss Federal Office of Public Health, Chemicals Division, 3003 Bern, 

Switzerland 

88 PREDICTION OF ACUTE AQUATIC TOXICITY TO FISH COMPARING 

DIFFERENT QSAR APPROACHES 

A. Roncaglioni 1 , A. Colombo 1,2 , U. Maran 2 , M. Karelson 2 , E. Benfenati 1 , 1 Laboratory 

of Environmental Toxicology and Chemistry, Istituto di Ricerche Farmacologiche 

“Mario Negri”, Milan, Italy, 2 Department of Chemistry, University of Tartu, Tartu 

51014, Estonia 

89 THE COMPARATIVE USE OF QUANTITATIVE STRUCTURAL ANALYSIS RELA- 

TIONSHIPS (QSARs) AND MOLECULAR MODELLING FOR UNDERSTANDING 

RECEPTOR MEDIATED MECHANISMS OF TOXICITY, RECEPTOR CROSS- 

TALK AND IMPLICATIONS FOR ENDOCRINE DISRUPTION 

M. N Jacobs1 , C. Luscombe2 , M. Dickins3 *, S. Hood3 , D.F.V. Lewis1 , 1School of 

Biomedical and Life Sciences, University of Surrey, Guildford, Surrey, UK, 

2Discovery Research, GlaxoSmithKline, Gunnels Wood Rd, Stevenage, UK, 

3 3 DMPK, GlaxoSmithKline, Park Road, Ware, Herts, UK, *now at Pfizer, Sandwich, 

Kent, UK 

38 

181 

182 

183 

184


GROUP A 




TOXICOGENOMICS 


90 THE PREDICTIVE VALUE OF GENE EXPRESSION MICRO ARRAYS IN 

TOXICOGENOMICS 

Hans Gmünder and Andreas Hohn, Genedata AG, Maulbeerstrasse 46, CH-4016 

Basel, Switzerland 

91 LIVER ENRICHED TRANSCRIPTION FACTORS AS PREDICTORS FOR TOXI- 

CITY – IMPLICATIONS FOR TOXICOGENOMIC RESEARCH 

J. Borlak 1 , A. Sowa 1 and M. Niehof 1 , Fraunhofer Institute for Toxicology and 

Experimental Medicine, 1 Drug Research and Medical Biotechnology, Hannover, 

Germany 

92 DEVELOPMENT OF RAT AND FISH LIVER NUCLEOTIDE ARRAYS FOR 

STUDYING GENE EXPRESSION IN RESPONSE TO ESTROGENIC 

COMPOUNDS 

K. Schirmer 1 , J. Wober 2 , A. Schreer 1 , A. Caldarelli 2 , and G. Vollmer 2 , 1 Junior 

Research Group of Molecular Animal Cell Toxicology, UFZ Centre for 

Environmental Research, Leipzig, Germany, 2 Department of Zoology, University of 

Technology Dresden, Dresden, Germany 

93 COMPARING THE TOXICITY AND POTENTIAL CARCINOGENICITY OF TWO 

ANTIESTROGENS. A SHORT-TERM STUDY WITH MICROARRAY ANALYSIS IN 

FEMALE RAT LIVER 

P. Hirsimäki1 , A. Aaltonen2 , A. Flores-Morales3 , L. Kangas2 and G. Norstedt3 1) Turku University Central Hospital, Dept. of Pathology, BioCity, Tykistökatu 6 B 6, 

20520 Turku, Finland, 2) Hormos Medical Corp, PharmaCity, Itäinen Pitkäkatu 4, 

20520 Turku, Finland, 3) Dept. of Molecular Medicine and Cell and Molecular 

Biology, Karolinska Institutet, 17176 Stockholm, Sweden 

94 GENE EXPRESSION CHANGES IN RAT LIVER INDUCED BY TWO HYPOLIPIDE- 

MIC DRUGS; A PPAR-α AGONIST AND A HMG-COA REDUCTASE INHIBITOR 

AND DIETHYLHEXYL PHTHALATE USING AFFYMETRIX GENECHIP ® TECHNO- 

LOGY 

N. Simecek, J. P. Wood, S. L. Margrett, C. J. Waterfield, H. Thakkar, J. Lyon 

Department of Investigative Pathology and Toxicology, GlaxoSmithKline, Welwyn, 

Herts, AL6 9AR, UK 

39 

185 

186 

187 

188 

189 

MONDAY

95 TOXICOGENOMICS: COMPARISON OF IN VITRO AND IN VIVO MODELS 

USING PIQOR TM Tox cDNA MICROARRAYS 

Katrin Buss 1 , Tanja Hansen 2 , Stefan Tomiuk 1 , Kay Hofmann 1 , Frank Hübel 1 , 

Andreas Bosio 1 , Jürgen Borlak 2, 1 Memorec Stoffel GmbH, Stöckheimer Weg 1, D- 

50829 Cologne, Germany, 2 Fraunhofer Institute of Toxicology and Experimental 

Medicine, Nikolai-Fuchs-Str.1, D-30625 Hannover, Germany 

96 APPLICATION OF GENE EXPRESSION TOWARD DISCOVERY OF CANDIDATE 

BIOMARKERS OF NEPHROTOXICITY: A COLLABORATION WITHIN THE 

INTERNATIONAL LIFE SCIENCES INSTITUTE CONSORTIUM 

ILSI/HESI Genomics Nephrotoxicity Working Group 

97 NAPHTHALENE EXPOSURE: EFFECTS ON APOPTOSIS AND GENE EXPRES- 

SION IN HUMAN CORD BLOOD CELLS 

Ilaria Malerba 1 , Cristina Diodovich 1 , Gerard Bowe 1 , Marco G.Bianchi 2 , Francesco 

Acquati 2 and Laura Gribaldo 1 , 1 ECVAM, Institute for Health and Consumer 

Protection, J.R.C., Ispra, Italy, 2 Dipartimento di Biologia Strutturale e Funzionale, 

Universita’ dell’Insubria-Varese, Italy 

98 TOXICOGENOMICS ANALYSIS OF HUMAN UMBILICAL CORDS TO 

ESTABLISH A NEW RISK ASSESSMENT OF HUMAN FETAL EXPOSURE TO 

MULTIPLE CHEMICALS 

M. Komiyama 1,2 , D. Nishimura 1 , K. Takashima 1 , T. Adachi 3 , C. Mori 1,4 , 1 Department 

of Bioenvironmental Medicine, Graduate School of Medicine,Chiba University, 

2 Center for Environment, Health and Field Sciences, Chiba University, Chiba, 

Japan, 3 Center for Research and Development of Bioresources, Research Institute 

for Advanced Science and Technology, Osaka Prefecture University, Sakai, Japan, 

4 Core Research for Evolutional Science and Technology (CREST), Japan Science 

and Technology Corporation (JST), Kawaguchi, Japan 

99 ILSI HESI COMMITTEE ON THE APPLICATION OF GENOMICS TO 

MECHANISM BASED RISK ASSESSMENT 

Peter G. Lord 1 , Syril D. Pettit 2 , and William D. Pennie 3 , 1 Johnson & Johnson, 

Raritan, NJ, USA, 2 ILSI/HESI, Washington DC, USA, 3 Pfizer, Groton, CT, USA 

40 

190 

191 

192 

193 

194


GROUP A 




STEM CELLS IN TOXICOLOGY 


100 CYTOCHROME P450 2E1 IS PRESENT AND ACTIVE IN HUMAN HEMATO- 

POIETIC STEM CELLS 

P. Anzenbacher1 , E. Anzenbacherová2 , L. Kousalová1 , J. Vondráková3 , I. 

Skoumalová3 , 1Institute of Pharmacology and 2Institute of Medical Chemistry and 

Biochemistry, Faculty of Medicine, Palacky University, CZ-775 15 Olomouc, and 

3Department of Hematology, University Hospital, CZ-775 20 Olomouc, Czech 

Republic 

101 IN VITRO PLURIPOTENCY OF HUMAN MARROW MESENCHYMAL STEM 

CELLS 

Sarah Snykers 1 , Tamara Vanhaecke 1 , Peggy Papeleu 1 , Greetje Elaut 1 , Ivan Van 

Riet 2 and Vera Rogiers 1 , 1 Dept. Toxicol., Vrije Universiteit Brussel, Belgium; 2 Dept. 

Med. Oncol.-Hematol.-Stem Cell Lab., Academical Hospital, Vrije Universiteit 

Brussel, Belgium 

41 

195 

196 

MONDAY


GROUP A 




FOOD SAFETY 


102 CANCER CHEMOPREVENTION AND ANTHOCYANINS: INDUCTION OF 

APOPTOSIS AND CELL DIFFERENTIATION PROMOTED BY CYANIDIN 3-O-ß- 

GLUCOPIRANOSIDE IN TWO LEUKAEMIA CELL LINES 

F. Berti1 , C. Fimognari1 , G. Cantelli-Forti1 and P. Hrelia1 1Department of Pharmacology, University of Bologna, Bologna, Italy 

103 EVALUATION OF SAFETY OF TWO NATURAL ANTIOXIDANTS EXTRACTS ON 

CHROMAFFIN CELLS PROTECTION 

M. S. Miranda 1 , E. Q. Paredes 2 , E. S. Blasco 2 , E. Vilanova 2 , 1 Faculty of 

Pharmacy of Federal University of Bahia, Brazil 2 Laboratory Toxicology of Institute 

of Bioengineering of Miguel Hérnandez University, Elche, Alicante, Spain 

104 DNA-DAMAGE REDUCING EFFECTS OF FLAVONOID SUPPLEMENTATION IN 

A HUMAN INTERVENTION STUDY 

L. Wilms 1 , J. Kleinjans 1 , 1 Department of Health Risk Analysis and Toxicology, 

Maastricht University, Maastricht, The Netherlands 

105 REPEATED DOSE ORAL TOXICITY (13 WEEKS) OF 4-HYDROXY-3-METHOXY- 

BENZALDEHYDE (VANILLIN) TO SPRAGUE DAWLEY RATS 

Axel Mancebo 1 , Yoagne M. Trapero 2 , Yana González 1 , Bárbara O. González 1 , 

Dasha Fuentes 1 , Osvaldo Hernández 1 , Juana Hernández 1 , Consuelo González 1 , 

Yasnay Hernández 1 , María E. Arteaga 1 , Nelvys Subirós 1 , Ana M. Bada 1 . 

1 Centro de Toxicología Experimental (CETEX), Centro Nacional para la Producción 

de Animales de Laboratorio (CENPALAB) 2 Centro de Biofísica Médica, Havana, 

Cuba 

106 13-WEEK TOXICITY STUDY OF ESTRAGOLE ADMINISTERED BY GAVAGE TO 

F344/N RATS AND B6C3F1 MICE 

Kamal M. Abdo1 , Ronald Herbert1 , and Jerry D. Johnson2 1NIEHS/NIH, Research Triangle Park, NC, 27709, USA; Battelle, Columbus, OH, 

43201 USA 

107 METABOLISM AND CYTOTOXIC MECHANISMS OF SALICYLALDEHYDE IN 

ISOLATED RAT HEPATOCYTES 

Hossein Niknahad 1 and Peter J. O’Brien 2 , 1 Department of Pharmacology and 

Toxicology, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, 

Fars, Iran, 71345; 2 Department of Pharmaceutical Sciences, Faculty of Pharmacy, 

University of Toronto, Toronto, Ontario, Canada M5S 2S2 

42 

197 

198 

199 

200 

201 

202

108 ASSESSMENT OF EXPOSURE TO FOOD CHEMICALS IN ROMANIA, 

2001–2002 

Carmen Hura 1 ,I.Palamaru 1 , B.A.Hura 2 , 1 Food Toxicology Laboratory, Institute of 

Public Health, Iassy, Romania, 2 Electrotechnic Faculty, Technical University “Gh. 

Asachi” Iassy, Romania 

109 CYTOTOXIC EFFECTS OF MALACHITE GREEN IN TWO HUMAN CELL LINES 

I. De Angelis 1 , A. Giuliano Albo 2 , C. Nebbia 2 , A. Stammati 1 , F. Zampaglioni 1 and M. 

Dacasto 2 1 Dipartimento Ambiente e Prevenzione Primaria, Istituto Superiore di 

Sanità, Roma, Italia. 2 Dipartimento di Patologia Animale, Sezione di Farmacologia e 

Tossicologia, Università di Torino, Italia 

110 STRATEGY OF FOOD SAFETY IN THE REPUBLIC OF UZBEKISTAN 

ACCORDING TO THE INTENTION OF ENTRY TO THE WORLD TRADE 

ORGANIZATION 

A.S. Khudaiberganov, Laboratory of Toxicology, Academy of the Ministry of 

Internal Affairs of the Republic of Uzbekistan, Tashkent, Uzbekistan 

111 SEVERE ALLERGIC REACTIONS TO FOOD - THE NORWEGIAN NATIONAL 

REPORTING SYSTEM AND REGISTER 

M. Løvik1 , H.G. Wiker1 , R. Kjelkevik2 , E. Egaas3 , B.A. Stensby1 , B. Gondrosen2 1 2 Norwegian Institute of Public Health, Oslo, Norwegian Food Control Authority, 

Oslo, and 3Veterinary Institute, Oslo, Norway 

112 THE NORWEGIAN FISH AND GAME STUDY DESCRIPTION OF A DIETARY 

SURVEY FOCUSING ON FOODS CONTAINING ENVIRONMENTAL 

CONTAMINANTS 

H.M.Meltzer 1 , C. Bergsten 2 , H.Stigum 1 , M.L.Wiborg 2 , K. Færden 2 , J.Alexander 1 . 

1 Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, 

Norway, 2 Norwegian Food Control Authority, Oslo, Norway 

113 THE DEVELOPMENT OF A FOOD FREQUENCY QUESTIONNAIRE TO ESTI- 

MATE THE INTAKE OF FOODS, NUTRIENTS AND NON-NUTRIENTS IN THE 

NORWEGIAN MOTHER AND CHILD COHORT STUDY 

Haugen M 1 , Ydersbond T 2 , Meltzer HM 1 , and Alexander J 1 , 1 Division of 

Environmental Medicine, Department of Food Toxicology, Norwegian Institute of 

Public Health, Oslo, 2 Statistics Norway, Oslo, Norway 

114 PROBABILISTIC EXPOSURE ASSESSMENT FOR ACRYLAMIDE IN FLEMISH 

ADOLESCENTS 

M. Bilau 1 , C. Matthys 1 , C. Vinkx 2 , S. De Henauw 1 and J.L. Willems 1 , 1 Ghent 

University, Departement of Public Health, 2 Blok A, De Pintelaan 185, B-9000 

Ghent, Belgium, 2 Health, Food Chain Safety and Environment PPS, State 

Administrative City, B-1010 Brussels, Belgium 

115 EFFECT OF DIFFERENT STORAGE CONDITIONS ON NITRATE/NITRITE 

LEVELS, MICROBIOLOGICAL QUALITY AND N-NITROSAMINES CONTENT IN 

POLISH EDIBLE OFFALS PROCESSED MEAT PRODUCTS 

K. Domańska 1 , B. Kowalski 2 , 1 Department of Poultry Diseases, 2 Laboratory of 

Radiological Protection and Isotopic Research, National Veterinary Research 

Institute, Pulawy, Poland 

116 OCCURRENCE OF NITROSAMINES IN RUBBER BABY TEATS IN SLOVENIA 

L. Perharic 1 , V. Golja 1 , M. Gabrijelcic 1 , M. Seljak 1 , S. Barlow 2 , 1 Institute of Public 

Health of the Republic of Slovenia (IPHRS), Trubarjeva 2, 1000 Ljubljana, Slovenia, 

2 8 Harrington Rd, Brighton, BN1 6RE, UK 

117 DETERMINATION OF Pb AND Cd IN SOME SERBIAN WHITE WINES BY 

DPSV 

Z. Basić 1 , V. Kilibarda 1 , S. Razˇić 2 , 1 Military Medical Academy, Belgrade, 2 Faculty of 

Pharmacy, University of Belgrade, Serbia and Monte Negro 

43 

203 

204 

205 

206 

207 

208 

209 

210 

211 

212 

MONDAY

118 FLUORIDE LEVELS IN SOFT DRINKS CONSUMED IN THE AUTONOMOUS 

COMMUNITY OF THE CANARY ISLANDS, SPAIN 

C. Rubio 1 , M. I. Rodríguez 1 , A. Hardisson 1 and A. Burgos 2 , 1 Toxicology 

Department. University of La Laguna, School of Medicine, 38071 La Laguna, S/C 

de Tenerife, Spain, 2 Preventive Medicine and Public Health Department. University 

of La Laguna, School of Medicine, 38071 La Laguna, S/C de Tenerife, Spain 

119 A SIMPLE AND RAPID METHOD FOR SCREENING IRRADIATED FOOD 

B. Di Carlo, A. Maggi and O. Sapora, Dipartimento Ambiente e Salute, Istituto 

Superiore di Sanità, Via Regina Elena 299, 00161 Rome, Italy 

120 RADIATION BIOTECHNOLOGY. INFLUENCE OF GAMMA-IRRADIATION ON 

STABILITY OF ORGANOCHLORINATED PESTICIDES CONTAMINATING FOOD 

Tatyana V. Melnikova 1 , Lyudmila P. Polyakova 1 and Gennady V. Kozmin 1 , 1 State 

University of Nuclear Power Engineering, Obninsk, Russia 

121 NATURAL CO-OCCURRENCE OF DEOXYNIVALENOL AND OCHRATOXIN A 

IN BEER 

E.K. Tangni and Y. Larondelle Unité de Biochimie de la Nutrition, Place Croix du 

Sud 2 Bte 8, Faculté d’Ingénierie biologique, agronomique et environnementale, 

Université catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium 

122 AN IN VITRO INVESTIGATION ON THE VARIABLES CONTROLLING THE 

BIOACCESSIBILITY AND ADSORPTION OF CADMIUM TO/FROM LETTUCE 

(LACTUCA SATIVA L. CV. OSTINATA): HELPFUL FOR PREDICTING 

BIOAVAILABLE CD IN FOODS? 

1 M.Waisberg, 2 W.D. Black and 1 Hale, B. 1 Department of Land Resource Science, 

and 2 Department of Biomedical Sciences, University of Guelph, Guelph, ON, 

Canada 

123 THE NECESSITY OF ADDITIVES DETERMINATION IN PLASTIC CONTAINERS 

S. Honary, Mazandaran University of Medical Sciences, School of Pharmacy. Sari, 

Iran 

124 EFFECT OF TORTILLA PROCESSING ON FUMONISIN B1 DESTRUCTION 

H.A. Amra1 , A. Aboul Enein, 2 A.A. Ragab2 , A.M. Ayesh1 and M.I. Mohamed1 1Food Toxicology and Contaminates Dept., National Research Center, Dokki, 

Cairo, Egypt 2Biochemistry Dept., Faculty of Agriculture, Cairo University, Cairo, 

Egypt 

125 A STANDARDIZED AND RELIABLE APPROACH TO THE ASSESSMENT OF 

SAFETY AND EFFICACY OF NUTRACEUTICALS 

F. Pizzocheri 1 , A. Conto 2 , N. Corsico 1 , 1 Pharmasafe sas, Milan – Italy , 2 Chemsafe 

sas Colleretto Giacosa-Italy 

126 THE STUDY OF ACUTE TOXICITY OF BIEBERSTEINIA MULTIFIDA TOTAL 

EXTRACT IN MICE 

S.N.Ostad 1 , H. Montazeran 1 , B. Minaee 2 , H.R. Monsef 3 , Dept. Toxicology & 

Pharmacology 1 , Dept. Pharmacognosy 2 Faculty of Pharmacy & Dept Histology 

Faculty of Medicine 3 , University of Tehran Medical Sciences, Tehran, Iran 

127 TOXO-PATHOLOGICAL EFFECTS INDUCED BY UREA IN BROILER CHICKS 

A. A. Sharkawy 1 , M. Mubar ak 2 . 1 Department of Forensic Medicine and 

Toxicology, Fac. Vet. Med., Assiut Uni., Assiut, Egypt. 2 Department of Pathology 

and Clinical Pathology, Fac. Vet. Med., Assiut Uni., Assiut, Egypt 

44 

213 

214 

215 

216 

217 

218 

219 

220 

221 

222


GROUP A 




GASTROINTESTINAL TOXICOLOGY 


128 ASSESSMENT OF GASTROTOXIC EFFECTS OF NIMESULIDE, A COX2- 

SELECTIVE NSAID, AFTER SINGLE AND MULTIPLE OVERDOSAGE IN RATS 

S. Dobric 1 , V. Cupic 2 , Z. Milovanovic 1 , V. Jacevic 1 , R. Velev 3 , D. Bokonjic 1 . 

1 National Poison Control Centre, Military Medical Academy, Belgrade, Serbia and 

Montenegro, 2 Faculty of Veterinary Medicine, Belgrade, Serbia and Montenegro, 

3 Faculty of Veterinary Medicine, Skopje, FYR Macedonia 

129 TOXICITY TESTING PROTOCOL OPTIMIZATION WITH CACO-2 CELLS: A 

CASE-STUDY ON HEAVY METALS 

A. Stammati 1 , L. Turco 1 , F. Zucco 2 and I. De Angelis 1 , 1 Dipartimento Ambiente e 

Prevenzione Primaria, Istituto Superiore di Sanità, Roma, Italy. 2 Istituto di 

Neurobiologia e Medicina Molecolare, Consiglio Nazionale delle Ricerche, Rome, 

Italy 

130 VALIDATION OF PEPSINOGEN MEASUREMENT IN THE STOMACH AND 

SERUM OF SPRAGUE DAWLEY RAT 

Elena Giannotti, Luca Vandin and Gianni Dal Negro. Cellular & Biochemical 

Laboratory, Safety Assessment Department, GlaxoSmithKline R&D, Verona, Italy 

45 

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224 

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GROUP A 




NATURAL TOXINS 


131 SCREENING FOR FUMONISINS B1 AND B2 IN CORN COLLECTED IN 

REPUBLIC OF CROATIA 

A-M. Domijan1 , M. Peraica1 , R. Fuchs1 , A. Lucić 1 , B. Radić 1 , Ć. Jurjević 2 , B. 

Cvjetković 2 

1Unit of toxicology, Institute for Medical Research and Occupational Health, 

Ksaverska c. 2, 10000 Zagreb, Croatia, 2 Department of Phytopathology, Faculty of 

Agriculture, University of Zagreb, Svetosˇ imunska 25, 10000 Zagreb, Croatia 

132 CYCLODEPSIPEPTIDE TOXICITY ON ISOLATED CARDIOMYOCYTES OF THE 

GUINEA PIG 

K. Kouri, M. Kamyar, A. Rapp, R. Lemmens-Gruber Dept. of Pharmacology and 

Toxicology, University of Vienna, Althanstr. 14, A-1090 Vienna, Austria 

133 CYTOTOXICITY, INHIBITION OF PROTEIN SYNTHESIS AND INDUCTION OF 

STRESS PROTEIN EXPRESSION IN HEP G2 CELL LINE IN RESPONSE TO 

ZEARALENONE 

Wafa Hassen 1 , Isabelle Baudrimont 2 , M. Moncef Ladjimi 3 , Edmond Creppy 2 and 

Hassen Bacha 1 1 Laboratoire de Recherche sur les Substances Biologiquement 

Compatibles, Faculté de Médecine Dentaire. Monastir 5019, Tunisia ; 2 Laboratoire 

de Toxicologie et d’Hygiène Appliquée, UFR Sciences Pharmaceutiques, 

Université Victor Ségalen. Bordeaux II 33000, France and 3 Laboratoire de 

Biochimie des Signaux Régulateurs Cellulaires et Moléculaires, UMR 7631, CNRS- 

Université Pierre et Marie Curie, Paris, France 

134 LEVELS OF OCHRATOXIN A AND IGG AGAINST CONIDIA FROM PENICIL- 

LIUM VERRUCOSUM IN BLOOD SAMPLES FROM HEALTHY FARM 

WORKERS AND BLOOD DONORS 

M.A. Skaug, Faculty of Health Studies, Hedmark University College, Elverum, Norway 

135 OXIDATIVE DNA DAMAGE INDUCED BY THE CARCINOGENIC MYCOTOXIN 

OCHRATOXIN A IN VITRO AND IN VIVO 

H.G. Kamp 1 , R. Turesky 2 , J. Schlatter 3 , G. Eisenbrand 1 , C. Janzowski 1 , 1 Dept. of 

Chemistry, Div. of Food Chemistry & Environmental Toxicology, University, 

Kaiserslautern, Germany, 2 National Center for Toxicology Research, Jefferson, USA 

and 3 Swiss Federal Office of Public Health, Bern, Switzerland 

136 MODIFICATION OF TOXICITY MARKERS BY OCHRATOXIN A IN RAT 

HEPATOCYTES PRIMARY CULTURE AND HK-2 CELL LINE 

O. Ezpeleta, L. Alvarez, L. Arbillaga, A. López de Cerain, Laboratory of Toxicology, 

Department of Food Sciences and Toxicology, University of Navarre, Pamplona, 

Navarre, Spain 

46 

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227 

228 

229 

230 

231

137 OCHRATOXIN A TOXICITY AND CARCINOGENICITY 

D. Holzhäuser, T. Delatour, M. Marin-Kuan, S. Junod, G. Guignard, D. Piguet, J. 

Richoz, C. Bezencon, B. Schilter, C. Cavin, QS Department , Nestlé Research 

Center, Lausanne, Switzerland 

138 HISTOPATHOLOGICAL ALTERATIONS IN LIVER AND KIDNEY BROILERS 

TREATED WITH INCREASED DOSES OF OCHRATOXIN A 

Jelena Nedeljkovic Trailovic, Snezana Sinovec and Z. Sinovec, Faculty of 

Veterinary Medicine, University of Belgrade, Bulevar JNA 18, 11000 Belgrade, 

Yugoslavia 

139 ANTIOXIDANT PROPERTY OF ESSENTIAL OIL ISOLATED FROM BLACK 

COMIN SEEDS (NAGILLA SATIVA) AND CLOVE BUDS (SYZYGIUM AROMATI- 

CUM) IN RATS DURING AFLATOXICOSIS 

Mosaad A. Abdel-Wahhab and Soher E. Aly Food Toxicology and Contaminants 

Dept. National Research Center, Dokki, Cairo, Egypt 

140 CORRELATION BETWEEN DNA ADDUCT FORMATION AND OTA METABOLI- 

TES IN OPPOSUM KIDNEY CELLS 

V. Faucet 1 , C.Lebeau 2 , M.Castegnaro 1 , A.Pfohl-Leszkowicz 1 , 1 Unit of Toxicology & 

Food Safety, Ecole Nationale Supérieure Agronomique Toulouse, F-31326, 

2ULB-Erasme, Bruxelles, B61070, Belgium 

141 DETERMINATION OF α – AMANITIN IN HUMAN BIOLOGICAL FLUIDS BY 

LIQUID CHROMATOGRAPHY – CID – MASS SPECTROMETRY AFTER SOLID 

PHASE EXTRACTION 

M.Vujovic 1 , V.Kilibarda 2 , S.Cusic 2 , 1 Laboratory of Toxicology, Institute of Forensic 

Medicine, Nis, Serbia and Montenegro, 2 Institute of Toxicology and Pharmacology, 

Military Medicine Academy, Belgrade, Serbia and Montenegro 

142 VALIDATION OF THE ELISA TEST FOR URINARY α-AMANITIN ANALYSIS IN 

HUMAN AMANITA PHALLOIDES POISONING 

T. Coccini, G. Randine, C. Locatelli, R. Butera, L. Manzo, Toxicology Division- 

Poison Control Center, IRCCS Maugeri Foundation and University of Pavia, Pavia, 

Italy 

143 ACONITE POISONING IN WESTERN COUNTRIES: DIFFERENT CLINICAL 

PICTURES 

M.L. Colombo 1 , P.A. Moro 2 , F. Zoppi 3 , , S. Primavera 4 , C. Potì 5 , F. Assisi 2 , A. 

Martella 1 , C. Zanardini 1 , 1 Dept. Plant Biology, Faculty of Pharmacy, University of 

Torino, Italy, 2 Poisoning Control Centre of Milan, Niguarda Ca’ Granda Hospital, 

Milan, Italy, 3 Lab. Clinical Analysis, Niguarda Ca’ Granda Hospital, Milan, Italy, 

4 Dept. Anaesthesiological Reanimation , Desenzano del Garda Hospital, Brescia, 

Italy, 5 Forensic Medicine, Mestre Hospital, Venice, Italy 

144 EFFECTS OF LAUREL (Laurus nobilis L.) LEAVES AND BERRIES ETHER OIL, 

PCBs AND CCl 4 ON PRODUCTION OF OXYGEN RADICALS 

M. Popovic 1 , B. Kaurinovic 1 , T. Cebovic 2 , M. Vojinovic-Miloradov 1 , 1 Faculty of 

Sciences, Department of Chemistry, University of Novi Sad, Novi Sad, Serbia and 

Montenegro, 2 Faculty of Medicine, Department of Biochemistry, University of Novi 

Sad, Clinical Centre Novi Sad, Novi Sad, Serbia and Montenegro 

145 EFFECTS OF LAUREL (Laurus nobilis L.) LEAVES AND BERRIES ETHER OIL 

AND FULERENE DERIVATIVES ON PRODUCTION OF OXYGEN RADICALS 

AND LIPID PEROXIDATION OF LIPOSOMES 

B. Kaurinovic 1 , M. Popovic 1 , T. Cebovic 2 , A. Djordjevic 1 , 1 Faculty of Sciences, 

Department of Chemistry, University of Novi Sad, Novi Sad, Serbia and 

Montenegro, 2 Faculty of Medicine, Department of Biochemistry, University of Novi 

Sad, Clinical Centre Novi Sad, Novi Sad, Serbia and Montenegro 

47 

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234 

235 

236 

237 

238 

239 

240 

MONDAY

146 STUDY EFFECT PEGANUM HARMALA PLANT ON SKELETAL SYSTEM 

M.T.Goghataei, F. Kermanian, M. Mehdizadeh Anatomy Department, Iran 

University, Tehran, Iran 

147 MICROCYSTIN-LR CAUSES REORGANIZATION OF ACTIN FILAMENTS AND 

MICROTUBULES IN RABBIT WHOLE EMBRYO CULTURES 

M.C. Zˇ uzˇek 1 , M. Kosec 1 , J. Mrkun 1 , D. S ˇ uput 3 , B. Sedmak 2 , R. Frangezˇ 1 , 

1 Veterinary faculty, Institute of physiology, pharmacology and toxicology, University 

of Ljubljana, Slovenia, 2 National Institute of Biology, University of Ljubljana, 

Slovenia, 3 Medical faculty, University of Ljubljana, Slovenia 

148 EFFECT OF CROTAPOTIN ON THE BIOLOGICAL ACTIVITY OF D49 AND K49 

BOTHROPS PLA2 E.C. Arantes1 ; A.L. Cecchini1,2 , A.M. Soares3 , R. Cecchini4 , C.A.Vieira2 , J.R. Giglio2. 1 2 Depto. Física e Química, FCFRP-USP; Depto. Bioquímica e Imunologia, FMRP- 

USP; 3Unidade de Biotecnologia, UNAERP; 4 Depto. Patologia General, Centro de 

Ciências Biológicas, UEL; 5 Depto. Química, FFCLRP, USP; Ribeirão Preto, SP, 

Brazil 

149 NORADRENERGIC AND NITRERGIC EFFECTS INDUCED BY Tityus serrulatus 

VENOM ON THE RAT ISOLATED RETRACTOR PENIS MUSCLE. 

E.C. Arantes 1 , J.H.G.G. Bomfim 1 , M.A.F. de Godoy 2 , J. R. Giglio 3 , A.M. de 

Oliveira 1 . 1 Depto. Física e Química, FCFRP-USP, 2 Depto Farmacologia, FMRP- 

USP, 3 Depto. Bioquímica e Imunologia, FMRP-USP, Ribeirão Preto, SP, Brazil 

150 PURIFICATION AND CHARACTERIZATION OF A METALLOPROTEASE FORM 

KOREA SNAKE VENOM (AGKISTRODON BREVICAUDUS) 

245 

Sook-Jim Hur1 , Hye-Jin Won1 , Myung-Sook Lee1 , Ji-Yun Kim1 , Motohide Takahashi2 , Sook-Ho 

Lee1 , 1Division of Bacterial Products, Center for Biologic Evaluation, Korea Food & Drug 

Administration, Korea, 2 National Institute of Infectious Disease, Japan 

151 INHIBITION OF THE MYOTOXIC AND EDEMATOGENIC ACTIVITY OF CRUDE 

BOTHROPS JARARACUSSU VENOM AND OF THE BthTX-I AND II TOXINS BY 

ROSMARINIC ACID ISOLATED FROM THE PLANT CORDIA VERBENACEA 

(BORAGINACEAE) 

F.K. Ticli 1 , A.M. Soares 2 , P.S. Pereira 2 , S.V. Sampaio 1 , 1 Laboratório de Toxicologia, 

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de 

Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão 

Preto - SP. Brasil, 2 Unidade de Biotecnologia, Universidade de Ribeirão Preto, 

Ribeirão Preto - SP. Brasil 

152 THE BLOCKING ACTIVITY OF DIFFERENT TOXINS AGAINST POTASSIUM 

CHANNELS Kv3.4 IN RLE CELLS 

Mehdi Saberi 1 , Edward Rowan 2 , Alan Harvey 2 , 1 Department of Pharmacology, 

Faculty of Medicine, Baghiyatollah (a.g) University of Medical Sciences, Tehran, 

Iran, P.O. Box 19568, Tehran, Iran, 2 Department of Physiology and Pharmacology, 

Strathclyde University, Glasgow, Scotland 

153 CHANGE IN DISTRIBUTION OF TETRODOTOXIN IN THE OVARY OF A MARI- 

NE PUFFERFISH TAKIFUGU VERMICULARIS DURING SPAWNING SEASON 

O. Arakawa 1 , K. Okada 2 , Y. Mahmud 2 , T. Takatani 1 , K. Kawatsu 3 , Y. Hamano 3 , T. 

Noguch i 4 , 1 Faculty of Fisheries, Nagasaki University, Nagasaki 852-8521, Japan, 

2 Graduate School of Science and Technology, Nagasaki 852-8521, Japan, 

3 Department of Food Microbiology, Osaka Prefectural Institute of Public Health, 

Osaka 537-0025, Japan, 4 Japan Frozen Foods Inspection Corporation, Minato, 

Tokyo 105-0012, Japan 

48 

241 

242 

243 

244 

246 

247 

248

154 IMMUNOENZYMATIC VISUALIZATION OF TETRODOTOXIN (TTX) IN THE 

SKIN CELLS OF A PUFFERFISH TETRAODON NIGROVIRIDIS 

Y. Mahmud 1 , O. Arakawa 2* , A. Ichinose 3 , M. B. Tanu 2 , T. Takatani 2 , K. Tsuruda 1 , K. 

Kawatsu 4 , Y. Hamano 4 , T. Noguchi 5 , 1 Graduate School of Science and Technology, 

Nagasaki University, Japan, 2 Faculty of Fisheries, Nagasaki University, Japan, 

3 Institute of Tropical Medicine, Nagasaki University, Japan, 4 Department of Food 

Microbiology, Osaka Prefectural Institute of Public Health, Japan, 5 Japan Frozen 

Foods Inspection Corporation, Tokyo, Japan 

155 HISTOPATHOLOGICAL, HEMATOBIOCHEMICAL AND URINALYSIS CHANGES 

IN EXPERIMENTAL OAK (Quercus brantii) POISONING IN SHEEP 

M. Pourjafar and A. Derakhshanfar and H. Talebanfard, School of Veterinary 

Medicine, Shahrekord University, Shahrekord, IRAN 

49 

249 

250 

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GROUP A 




CLINICAL TOXICOLOGY 


156 FATAL POISONING BY AMANITA PHALLOIDES MUSHROOMS 

D. Chaparoska 1 , E. Masin 2 , N. Becarovski 1 , L. Melovska 1 , Department of 

Toxicology 1 and Department of Nephrology 2 , University Clinical Center, Skopje, 

R.Macedonia 

157 PROTHROMBINE TIME-USEFUL PROGNOSTIC MARKER IN AMANITA 

PHALLOIDES POISONING 

L. Petkovska, Z. Pereska, Dz. Naumovski, C. Bozinovska, D. Petrovski, F. 

Licoska, A. Babulovska Clinic of Toxicology and Urgent internal medicine, Clinical 

Centre-Skopje, Macedonia 

158 A CASE REPORT OF A STRYCHNINE INDUCED ACUTE POISONING AND ITS 

SUCCESSFUL 

Abdolkarim Pajoumand1 , Nasser Jalali1 , Shahin Shadnia1,2 , Mahsa Moinosadat1 1 Poisoning Ward, Loghman Hakim Hospital, Faculty of Medicine, Shaheed 

Beheshti University of Medical Science, Tehran-IRAN 

2 Department of Toxicology, Faculty of Pharmacy, Tehran University of Medical 

Science, Tehran-Iran 

159 LATE COMPLICATIONS OF CAUSTIC INJURIES 

F. Licoska, C. Bozinovska, J. Naumovski, B. Pavlovski, L. Petkovska, Z. Pereska, 

A.Cibisev, Clinic of toxicology and Urgent Internal Medicine, Skopje, Macedonia 

160 CHILD POISONING WITH CAUSTIC CORROSIVES IN CROATIA 1997-2001 

I. Vidic´ Sˇ trac, A. Barisˇin, Croatian National Institute of Public Health, Department 

of Health ecology 

161 TREATMENT OF MERCURY OXIDE INTOXICATION WITH N-ACETYL 

CYSTEINE 

D. Pasqualatto 1 , M. Pachón 2 , D. Rodríguez 2 , M. Albarrán 2 1 Servicio de 

Información de Medicamentos y Tóxicos, Facultad de Farmacia, Universidad 

Central de Venezuela; 2 Hospital "Dr. M. Pérez Carreño " Caracas, Venezuela 

162 N-ACETYLCYSTEINE IN ZINC CHLORIDE POISONING 

D. Pasqualatto, M.C. Fernández. Servicio de Información de Medicamentos y 

Tóxicos. Facultad de Farmacia, Universidad Central de Venezuela, Caracas, 

Venezuela 

50 

251 

252 

253 

254 

255 

256 

257

163 ADVERSE EFFECTS OF INTRAVENOUS N-ACETYL CYSTEINE IN ACETAMI- 

NOPHEN POISONING TREATMENT 

N. Jalali 1 , F. Taghaddosinejad 2 , H. Sanaei Zadeh 2 , Sh. Shadnia 1 , 1 Poison center, 

Loghman-Hakim Hospital, Faculty of Medicine, Shaheed-Beheshti University of 

Medical Science, Tehran, Iran, 2 Department of Forensic Medicine, Faculty of 

Medicine, Tehran University of Medical Science, Tehran, Iran 

164 CLINICAL COURSE IN ACUTE PERORALLY MERCURY SALTS 

D. Petrovski, Dz Naumovski, Z. Pereska, L. Petkovska, A. Cibisev A., E. 

Kovkarova, F. Licoska, Clinic of Toxicology and Urgent Internal Medicine, Clinic 

Centre, Skopje, Macedonia 

165 LONG-LASTING POLYNEUROPATHY AND PSYCHIATRIC DISORDERS IN 

THALLIUM POISONING. STUDY OF SIX CASES 

C. Locatelli, V. Petrolini, R. Butera, G. Bernareggi, S. Arrigoni, M. Carli, L. Manzo. 

Pavia Poison Center, IRCCS Maugeri Foundation Hospital and University of Pavia, 

Pavia, Italy 

166 INTERMEDIATE SYNDROME IN ORGANOPHOSPHOROUS POISONING, A 

CLINICAL STUDY TO CORRELATE ITS PREVALENCE WITH RBC CHOLINE- 

STERASE 

Shah A.H., Shah A.R., New Civil Hospital, Ahmedabad, India 

167 OTC - PROGNOSTIC PARAMETER IN ACUTE ORGANOPHOSPHATE 

POISONINGS 

Z. Pereska, L. Petkovska, Dz. Naumovski, C. Bozinovska, Gj. Pilovski, D. 

Petrovski, A. Babulovska, Clinic of toxicology and Urgent Internal Medicine, 

Clinical Center, Skopje, Macedonia 

168 SIDE EFFECTS OF ANTIDOTAL THERAPY WITH PRALIDOXIME IN HUMAN 

ORGANOPHOSPHATE POISONING 

C. Locatelli, R. Butera, V. Petrolini, A. Bove, J. Georgatos, A. Agazzi, L. Manzo. 

Poison Control Center, IRCCS Maugeri Foundation and University of Pavia, Pavia, 

Italy 

169 ELECTROCARDIOGRAPHIC CHANGES OBSERVED IN ACUTE INHALATORY 

IRRITATIVE POISONINGS 

J. Naumovski, Z. Pereska, L. Petkovska, C. Bozinovska, C.I. Naumov, E. 

Kovkarova, Clinic of Toxicology and Urgent Internal Medicine, Clinical Centre, 

Skopje, Macedonia 

170 ASTHMA AFTER EXPOSURE TO GLUTARALDEHYDE 

GF. Desogus, Study Reports of Toxicology, Azienda USL 7, Carbonia, Italy 

171 COMPREHENSIVE SCREENING OF ABUSED DRUGS IN TRAFFIC ACCI- 

DENTS AND TRAUMA VICTIMS 

T. Söylemezogˇlu 1 , B. Yücesan 2 , S¸.S¸. Çeçen 1 , 1 Ankara University, Institute of 

Forensic Medicine, Dikimevi, Ankara / TURKEY, 2 Ministry of Health, Ankara 

Education and Research Hospital, Dr. Nilgün Sönmez Acar Blood Bank, Cebeci, 

Ankara / Turkey 

172 FATAL METHANOL POISONING 

1 A. Dip, 2 A. Demircan, 2 A. Keles¸, 3 B. Demirel, 3 A.F. Is¸ ık, 1 T. Söylemezogˇlu, 1 Institute 

of Forensic Medicine, Ankara University, 2 Department of Emergency, Faculty of 

Medicine, Gazi University, 2 Department of Forensic Medicine, Gazi University, 

Turkey 

51 

258 

259 

260 

261 

262 

263 

264 

265 

266 

267 

MONDAY

173 LONG QT SYNDROME INDUCED BY OXATOMIDE OVERDOSE IN CHILDREN 

C. Locatelli 1 , V. Petrolini 1 , R. Butera 1 , D. Lonati 1 , S. Mannarino 2 , E. Stacul 3 , E. Fufi 3 , 

A. Valli 4 , P. Papa 4 , L. Manzo 1,5 , 1 Pavia Poison Center, IRCCS Fondazione Maugeri, 

Pavia; 2 Pediatric Cardiology Division, 3 Department of Pediatrics and 4 Laboratory of 

Clinical Toxicology, IRCCS Policlinico San Matteo, Pavia; 5 University of Pavia, 

Pavia, Italy 

174 APPLICATION OF COTININE DETERMINATION FOR EVALUATION OF 

EFFECTIVENESS OF BUPROPIONE THERAPY 

D. Zuba 1 , E. Florek 2 , W. Piekoszewski 1,3 , E. Gomółka 3 , A. Kamenczak 4 , B. Jenner 3 , 

1 Institute of Forensic Research, Krakow, Poland, 2 Laboratory of Environmental 

Research, Department of Toxicology, University of Medical Sciences, Poznan, 

Poland, 3 Department of Clinical and Industrial Toxicology, Jagiellonian University, 

Krakow, Poland, 4 Toxicology Clinic, Jagiellonian University, Krakow, Poland 

175 TOXICITY AND SEIZURE CAUSED BY INJECTION OF LIDOCAINE 

Ebrahim Nasiri, H. Samadae, Faculty member Mazandaran University of Medical 

Sciences, Sari, Iran 

176 DRUG-INDUCED COMAS 

C. Bozinovska, Z. Pereska, J. Naumovski, L. Petkovska, N. Popovski A. 

Babulovska Clinic of Toxicology and Urgent Internal Medicine, Clinical Center, 

Skopje, Macedonia 

177 A TOXIC EVENT SURVEILLANCE SYSTEM IN THE EMERGENCY DEPART- 

MENT: A USEFUL TOOL TO ASSESS ACUTE CHEMICAL RISK IN HUMANS 

A. Ferrer Dufol 1 , S. Nogué Xarau 2 , R. Royo Hernandez 1 , E. Civeira Murillo 1 , F. 

Vargas Marcos 3 , O. Castillo Soria 3 and the members of the Toxic Surveillance 

System Program. 1 Unit of Toxicology, University Clinic Hospital, Zaragoza, Spain, 

2 Toxicology Unit, Clinic Hospital, Barcelona, Spain, 3 Ministry of Health, Madrid Spain 

52 

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DRUG TOXICOLOGY 


178 ASSESSMENT OF LABRASOL“/LABRAFIL“/TRANSCUTOL“ (4/4/2, V/V/V) AS 

A VEHICLE FOR HYDROPHOBIC COMPOUNDS AFTER 4-WEEK ORAL TOXI- 

CITY STUDY IN WISTAR RATS 

C. Spire 1 , J.F. Lepage 2 , G. Vermeil de Conchard 1 , A. Beamonte 1 , H. Bertheux 1 , F. 

Goldfain-Blanc 1 , J.L. Delongeas 1 and N. Claude 2 . 1 Drug Safety Assessment, 

Servier, Orléans-Gidy, France, 2 Institut de Recherches Internationales Servier, 

Courbevoie, France 

179 IMPLICATION OF THE NITROGEN MONOXIDE SYSTEM IN ANTI-ATHERO- 

SCLEROTIC POTENTIAL OF LACIDIPINE IN THE APOE-DEFICIENT MICE 

P. Cristofori1 , A. Lanzoni1 , D. Spagnolo1 , V. Zantedeschi, M. Andreoli2 , F. Crespi2 1Safety Assessment Dept. Pathology Research Centre Glaxo Smith Kline Verona, 

Italy 2Biology Dept.Psychiatry C.E.D.D.- Research Centre Glaxo Smith Kline 

Verona, Italy 

180 TOXICOLOGICAL EVALUATION OF A NOVEL ACAT INHIBITOR VULM 1457 

M. Zemánek 1 , I. Sadloňová 2 , E. Ujházy 3 , M. Dubovicky´ 3 , V. Faberová 2 , Sˇ . Bezek 1 , 

1 Slovakofarma, JSC., Hlohovec, 2 Drug Research Institute, JSC., Modra, 3 Institute of 

Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovakia 

181 SEVEN-DAY REPEATED-DOSE ORAL COMPARATIVE METABOLISM STUDY 

WITH THREE ANTIPSYCHOTIC AGENTS 

G. Szücs, M. Albert, D. Dányi, Department of Toxicology, EGIS Pharmaceuticals 

Ltd., Budapest, Hungary 

182 EFFECT OF ACUTE HEROIN ON BASAL AND ELECTRICAL VAGAL 

STIMULATION ACID AND PEPSIN SECRETION IN RAT 

Nabavizadeh Rafsanjani Fatemeh, Najafi Ali, Esmaeili Farzaneh 

Department of Physiology, Kerman University of Medical Sciences, Tehran, Iran 

183 GLUCOSE UPTAKE BY THE NEURONAL CELL LINES, SH-SY5Y AND U-373 

MG MAY BE MODULATED BY SELECTED NEUROLOGICAL DRUGS 

M. Mannerström, H. Tähti, Medical School, Department of Toxicology, University 

of Tampere, Tampere, Finland 

184 TERATOGENIC EFFECTS OF DIAZEPAM INTAKE DURING PREGNANCY 

TO CLEFT PALATE & CLEFT LIP 

N. Takzaree, K. Yarmohammadi, A.R. Takzaree, A. Bakhtiarian. Dept. of 

Embryology, Tehran University of Medical Sciences, Faculty of Medicine, Tehran, 

Iran 

53 

273 

274 

275 

276 

277 

278 

279 

MONDAY

185 SAFETY ASSESSMENT OF CARGLUMIC ACID IN JUVENILE RATS 

R. Forster1 , G. Chevalier1 , M. Attia1 , , L. Martin2 and M-C Fortun2 1 2 CIT, Evreux, France and Orphan Europe, Paris, France 

186 INFLUENCE OF VERAPAMIL ON THE ANALGESIC EFFECT AND TOXICITY OF 

INDOMETHACINE 

L. Tantcheva, E. Stoeva and M. Nikolov, Department of Drug Toxicology, Institute 

of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria 

187 EFFECTS OF NIFEDIPINE ON HISTOPATHOLOGICAL CHANGES OF KIDNEY 

IN DIABETIC RAT 

H. Mahdavinasab 1 , H. Mehrani 2 , H. Imani 1 , H. Sadrai 1 , H. Dashtnavard 1 , M. Mofid 1 , 

M. Ahmadian 1 , 1 Department of Anatomy, Faculty of Medicine, Baghyiatallah 

University, Tehran-Iran, 2 Department of Biochemistry, Faculty of Medicine, 

Baghyiatallah University, Tehran-Iran 

188 EVALUATION OF ANTISECRETORY EFFECT OF GLYCERYL TRINITRATE IN 

RATS TREATED WITH CYCLOOXYGENASE NON-SELECTIVE AND 

SELECTIVE NSAIDs 

R. Velev1 , S. Dobrić 2 , V. Ćupić 3 , Z. Milovanović 2 , D. Bokonjić 2 

1Faculty of Veterinary Medicine, Lazar Pop Traajkov 5-7, 1000 Skopje, Republic of 

Macedonia, 2National Poison Control Center, Military Medical Academy, Belgrade, 

Yugoslavia and 3Faculty of Veterinary Medicine, Belgrade, Yugoslavia 

189 BENZAMIDE-BASED TRICHOSTATIN A ANALOGUES ARE POTENT AND 

METABOLICALLY STABLE INHIBITORS OF HISTONE DEACETYLASE 

G. Elaut 1 , G. Laus 2 , P. Papeleu 1 , V. Breckx 2 , J. Van Hemel 2 , M. Erra 3 , G. Brosch 3 , S. 

Snykers 1 , T. Vanhaecke 1 , D. Tourwé 2 and V. Rogiers 1 , Departments of Toxicology 1 

and Organic Chemistry 2 , Vrije Universiteit Brussel, Brussels, Belgium, 3 Department 

of Microbiology, University of Innsbruck, Innsbruck, Austria 

190 PL 14736: A 4-WEEK INTRAVENOUS TOXICITY STUY IN RATS FOLLOWED 

BY A 4-WEEK RECOVERY PERIOD AND A 4-WEEK INTRAVENOUS TOXICITY 

STUDY IN DOGS 

M. Veljača 1 , Zˇ . Krnič 1 , Ć. Ferenčić 1 , M. Kolega 1 , 1 PLIVA Pharmaceutical Industry 

Inc., Zagreb, Croatia 

191 FLOW CYTOMETRIC MONITORING OF IMMUNE-MEDIATED TOXICITY 

INDUCED BY LONG-TERM ANTIGLAUCOMA TREATMENTS ON 

CONJUNCTIVAL EPITHELIAL CELLS USING THREE INFLAMMATORY 

MARKERS : HLA-DR, IL-6 AND IL-8 

F. Brignole 1,3 , C. Blondin 3 , L. Bensoussan 3 , P. Hamard 3 , G. Sabeh Afaki 1 , C. 

Baudouin 2,3 , C. Creuzot-Garcher 4 , J.-M. Warnet 1,3 . 1 Laboratoire de Toxicologie, 

Faculté des Sciences Pharmaceutiques et Biologiques, Université René Descartes 

- Paris 5. 2 Hôpital Ambroise Paré, AP-HP, Boulogne. 3 Centre Hospitalier National 

d’Ophtalmologie des Quinze-Vingts, EA 3123 Pierre et Marie Curie University, Paris 

6. 4 Centre Hospitalo-Universitaire de Dijon, France 

192 INHIBITION KINETICS AND EXPRESSION OF GLUTAMATE TRANSPORTERS 

IN RETINAL PIGMENT EPITHELIAL CELLS 

H. Mäenpää and H. Tähti, Medical School, University of Tampere, Finland 

193 OCULAR SURFACE TOXICITY OF PRESERVED ANTIGLAUCOMA TREAT- 

MENTS : AN EX VIVO AND IN VITRO COMPARISON OF PROSTAGLANDINS 

AND BETA-BLOCKERS USING CYTOFLUORIMETRIC ASSAYS 

F. Brignole 1,3 , P.-J. Pisella 1,2, C. Debbasch 1 , P. Hamard 1,3 , V. Parier 2 , P. Rat 1 , Ch. 

Baudouin 3 , J.-M. Warnet 1 . 1 Dpt of Toxicology, Faculty of Biological and 

Pharmacological Sciences, Paris 5 University René Descartes, Paris, France, 2 Dpt 

of Ophthalmology, University Hospital of Tours, Tours, France, 3 Dpt of 

Ophthalmology Quinze-Vingts National Ophthalmology Hospital and Ambroise 

Paré Hospital, APHP, Paris Ouest, Paris, France 

54 

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281 

282 

283 

284 

285 

286 

287 

288

194 IN VITRO EFFECTS OF PRESERVED OR UNPRESERVED ANTIGLAUCOMA 

DRUGS ON APOPTOTIC MARKER EXPRESSION BY HUMAN TRABECULAR 

CELLS 

F. Brignole 1,2 , P. Hamard 1,2,3 , C. Blondin 2 , C. Debbasch 1 , Ch. Baudouin 2,3 , J.-M. 

Warnet 1 1 Laboratory of Toxicology, Faculty of Pharmacological and Biological 

Sciences, René Descartes University, Paris 5. 2 Immuno-Ophthalmology Unit, 

EA3123, Pierre and Marie Curie University, Paris 6. 3 Departments of 

Ophthalmology, Quinze-Vingts National Hospital and Ambroise Paré Hospital, AP- 

HP, Paris, France 

195 ANATOMOPATHOLOGIC CHANGES IN SPRAGUE DAWLEY RATS AFTER 14 

DAYS REPEATED ADMINISTRATION OF HUMAN RECOMBINANT ERYTHRO- 

POIETIN 

D. Fuentes 1 , M. Arteaga 1 , O. Hernández 1 , A. Casacó 2 , A. Thomas 1 , Y. Rivero 1 , Y. 

Torres 1 , N. Subirós 1 , B. González 1 1 División de Toxicología y Experimentación 

Animal del Centro Nacional para la Producción de Animales de Laboratorio, La 

Habana, Cuba. 2 Departamento de Ensayos Clínicos del Centro de Inmunología 

Molecular, La Habana, Cuba 

196 DOSE REPEATED TOXICITY STUDY OF THE HUMANIZED ANTI-EPIDERMAL 

GROWTH FACTOR RECEPTOR MONOCLONAL ANTIBODY h-R3 (THERACIM) 

BY ENDOVENOUS ROUTE IN CERCOPITHECUS AETHIOPS SABAEUS 

MONKEYS 

A. Casacó 1 , M. Arteaga-Pérez 2 , M. Maceira 1 , O. Hernández-Sosa 2 , A. Bada- 

Barro 2 , A. León-Goñí 2 , R. Orpheé-Suárez 2 , A. Cuevas-Fiallo 2 , D. Moreno-Díaz 2 , 

P. Padro-Gutiérrez 3 , F. Baro-González 3 , V. Rodríguez-Rodríguez 3 , L. Charro-Ruiz 3 , 

F. Vázquez-Castro 4 , A. Ballester-Labrada 5 , 1 Centro de Inmunología Molecular, 

2 Centro Nacional para la Producción de Animales de Laboratorio, 3 Centro de 

Neurociencias, 4 Centro de Investigaciones Médico Quirúrgicas, 5 Centro de 

Investigaciones Clínicas, Havana, Cuba 

197 ACUTE AND REPEATED DOSE INTRAMUSCULAR TOXICITY OF N-ACE- 

TILGM3 CANCER VACCINE IN SD RATS 

A. Bada 1 , A. Casacó 2 , A. Mancebo 1 , O. Hernández 1 , D. Fuentes 1 , J. Hernández 1 , N. 

Subirós 1 , B. González 1 , ME. Arteaga 1 1 División de Toxicología y Experimentación 

Animal del Centro Nacional para la Producción de Animales de Laboratorio, 

Habana, Cuba, 2 Departamento de Ensayos Clínicos, Centro de Immunología 

Molecular, Habana, Cuba 

198 THE EFFECT OF ANABOLIC - ANDROGENIC STEROID ON THE BODY, 

TESTIS AND EPIDIDYMIS WEIGHT IN ADULT MALE RAT 

F. Mesbah 1 , H. Mirkhani 2 , S. Karbalaei doust 1 , S. Shokri 1 Anatomy 1 & 

Pharmacology 2 Departments, Shiraz Medical School, Shiraz, Iran 

199 THE EFFECT OF ANABOLIC-ANDROGENIC STEROID ON THE SPERM 

COUNT, MOTILITY AND MORPHOLOGY IN ADULT MALE RATS 

S. Karbalay Doust 1 ., H. Mirkhani 2 , F. Mesbah 1 , S. Shokri 1 . Anatomy 1 & 

Pharmacology 2 Departments. Shiraz Medical School, Shiraz, Iran 

200 RISK CRITERIA OF TOXIC EFFECTS ADVANCEMENT UNDER IMPACT OF 

SEVERAL HORMONAL MEDICINES 

M. Kudrya 1 , I. Palagina 1 , L. Mogilat 1 , A. Gladkova 1 , 1 Laboratory of Drug Toxicology, 

Ukrainian Institute of Endocrine Pathology Problems, Kharkov, Ukraine 

201 MORPHOLOGICAL CHANGES IN MOUSE TESTS AFTER TREATMENT WITH 

FLUTAMIDE 

R. Anahara 1 , Y. Ono 1 , Y. Toyama 2 , C. Mori 1 , 3 , 1 Department of Bioenvironmental 

Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan, 

2 Department of Anatomy and Developmental Biology, Graduate School of Medicine, 

Chiba University, Chiba, Japan, 3 Core Research for Evolutional Science and 

Technology (CREST), Japan Science and Technology Corporation, Kawaguchi, Japan 

55 

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291 

292 

293 

294 

295 

296 

MONDAY

202 LONG-TERM METABOLIC AND ENDOCRINE ACTIVITY CHANGES IN 

RESPONSE TO CLENBUTEROL IN MATURE FEMALE PIGS 

T. Gojmerac 1 , B. Mandić 2 , M.Korsˇić 3 , A. Tomasˇić 1 , B. Vinković 1 , 

1 Croatian Veterinary Institute, Zagreb, Croatia; 

2 Vuk Vrhovac Institute for Diabetes, Endocrinology and Metabolic Diseases, School 

of Medicine, University of Zagreb, Croatia; 3 University Department of Medicine- 

Rebro, Zagreb, Croatia 

203 A STUDY OF HEPARIN EFFECTS ON HEMATOBIOCHEMICAL FACTORS AND 

BILIARY BILIRUBIN SECRETION IN SHEEP 

Pourjafar M. and Mostaghni K School of Veterinary Medicine, Shahrekord 

University, Shahrekord, Iran 

204 TOLERANCE DEVELOPES TO ANTI-INFLAMMATORY EFFECT OF MORPHINE 

P. Hassanzadeh, Ph. D. A. Ahmadiani,* Ph. D., M. Alebouyeh, Ph. D. Department 

of pharmacology, Faculty of Medicine, Shahid Beheshti University of Medical 

Sciences, Tehran, Iran 

205 A SELECTIVE COX-2 INHIBITOR, NIMESULIDE, AS GASTROENTEROPRO- 

TECTIVE AGENTS IN T-2 TOXIN POISONED RATS 

V. Jac´evic´ 1 , L. Zolotarevski 2 , K Jelić 2 , V. Kilibarda 1 , J. Dimitrijević 2 , M.P. 

Stojiljković 1 , 1 National Poison Control Centre, Military Medical Academy, Belgrade, 

Serbia and Montenegro, 2 Institute for Pathology and Forensic Medicine, Military 

Medical Academy, Belgrade, Serbia and Montenegro 

206 EFFECT OF ROLIPRAM ON NATURAL KILLER CELLS ACTIVITY 

G. Dyulgerova, N. Boyadjieva Department of Pharmacology and Toxicology, 

Medical Division, Medical University of Sofia, Sofia, Bulgaria 

207 EFFECTS OF CAFFEINE ON INDUCTION OF APOPTOSIS IN BLOOD 

MONOCYTE AND ALVEOLAR MACROPHAGE CELLS 

M. Jafari 2 , A. Rabbani 1 , 1 Institute of Biochemistry and Biophysics, 

University of Tehran, Tehran, Iran, 2 Department of Biochemistry, Faculty 

of Medicine, Baghiyatollah University, Tehran, Iran 

208 DNA DAMAGE AND REPAIR INDUCED BY PHOTOSENSITIZING DRUGS: 

FLUOROQUINOLONES 

O. Sapora, G. La Sala, B. Di Carlo, and A. Maggi, Dipartimento Salute e Ambiente, 

Istituto Superiore di Sanità, Via Regina Elena 299, 00161 Rome, Italy 

209 SERUM CALCIUM , MAGNESIUM AND PHOSPHORUS LEVELS IN RATS 

TREATED BY SOME AMINOGLYCOSIDE, QUINOLONE ANTIBIOTICS, 

GLICLAZIDE, PIRETANIDE AND VERAPAMIL 

N. M. Abdel- Hamid 1 ; F.R. Abdallah 2 and R.S. Amin 1 1 Biochemistry Department, 

Faculty of Pharmacy, El-Minia University, 2 Egypt Biochemistry Department , Faculty 

of Pharmacy, Zagazig University, Egypt 

210 CHANGES IN CONCENTRATION OF ZINC IN URINE, SERUM, AND SALIVA AS 

INDICES OF GENTAMICIN NEPHROTOXICITY IN MALE WISTAR RATS 

M. Roohi Azizi 1 , N. Rezvan 2 , A.R. Dehpour 3 , S.Sh. Sadr 2 , A. Norouzy 2 , B. Minaee 4 , 

1 Laboratory of Clinical Neuro-Physiology, Department of Basic Sciences, Faculty of 

Rehabilitation, Iran University of Medical Sciences,Tehran, Iran, 2 Department of 

Physiology and 3 Pharmacology and 4 Histology, Faculty of Medicine, Tehran University 

of Medical Sciences, Tehran, Iran 

211 ISONIAZID INDUCES A HEPATIC MICROSOMAL CYTOCHROME P-450- 

DEPENDENT ACTIVITY IN ETHANOL CONSUMPTION RATS 

A. Voronina, Department of General Toxicology, Institute of Pharmacology & 

Toxicology, Kyiv, Ukraine 

56 

297 

298 

299 

300 

301 

302 

303 

304 

305 

306

212 CONTINUOUS INTRAVENOUS INFUSION IN NEW ZEALAND WHITE RABBITS 

R. Cicalese, R. Sisti, J. Brightwell, RTC, Research Toxicology Centre S.p.A., 

Pomezia - Rome, Italy 

213 DRUGMATRIX TM PROVIDES PREDICTIVE CHEMOGENOMICS SOLUTIONS 

FOR SAFETY ASSESSMENT IN DRUG DISCOVERY AND DEVELOPMENT 

Pauline Gee, and Richard Mitchell, MDS Pharma Services Bothell, Washington, 

USA, Leslie Browne, Ph.D., Kyle Kolaja, PhD., Kurt Jarnagin, Ph.D., George Natsoulis, 

Ph.D. and Alan Roter, Ph.D. Iconix Pharmaceuticals, Inc. Mountain View, CA, USA 

214 MECHANISMS OF TOXIC DAMAGE IN ORGANISM UNDER THE IMPACT OF 

ANTI-DIABETIC MEDICINES (ADMs) – DICARBOXYLIC ACIDS DERIVATIVES 

I. Palagina 1 , M. Kudrya 1 , F. Kolodub 1 , N. Ustenko 1 , 1 Laboratory of Drug Toxicology, 

Ukrainian Institute of Endocrine Pathology Problems, Kharkov, Ukraine 

215 BLOCKERS OF VOLUME REGULATED Cl-CHANNELS – A NEW GROUP OF 

ANTI-CANCER DRUGS EXHIBITING LOW TOXICITY 

Jens Lichtenberg and Palle Christophersen NeuroSearch A/S, Pederstrupvej 93, 

2750 Ballerup, Denmark 

216 AMIFOSTINE PROTECTION AGAINST DOXORUBICIN-INDUCED RAT HEART 

MAST CELL ACCUMULATION 

S. Dobric 1 , V. Dragojevic-Simic 1 , V. Jacevic 1 , D. Bokonjic 1 , L. Zolotarevski 2 , K. Jelic 2 , 

1 National Poison Control Centre, Military Medical Academy, 2 Institute for Pathology 

and Forensic Medicine, Military Medical Academy, Belgrade, Serbia and Montenegro 

217 SAFETY PHARMACOLOGY STUDY OF CKD-732, A NEW FUMAGILLIN 

ANALOGUE ANTICANCER AGENT 

Eun-Joo Kim 1 , Hyun-Jin Kim 1 , Sun-Hee Do 1 , and Joon-Kyum Kim 2 , 1 Korea 

Institute of Toxicology, KRICT, P.O.Box 107, Yuseong-gu, Daejoen, Korea, 2 Medical 

Research center, Jong Kun Dang Co. Kuro, Seoul, Korea 

218 CYTOTOXICITY EVALUATION OF THREE PHTHALOCYANINE PHOTOSENSI- 

TISERS ON HUMAN CORNEAL EPITHELIUM CELL CULTURES 

D. Monti 1 , S. Burgalassi 1 , P. Chetoni 1 , G. Roncucci 2 , S. Tampucci 2 , M.F. Saettone 1 , 

1 Dept. Bioorganic Chemistry and Biopharmaceutics, University of Pisa, Pisa, Italy, 

2 Molteni Farmaceutici S.p.A., Firenze, Italy 

219 NONSPECIFIC EFFECT OF NARCOTIC ANALGESICS ON THE MODELS OF 

CELL MEMBRANES 

S.M. Rogacheva1 , P.E. Kuznetsov2 , V.A. Zlobin2 , G.V. Nazarov2 , N.B. Kuznetsova2 , 

1Department of Ecology, Saratov State Technical University, Saratov, Russia, 

2Department of Biochemistry and Biophysics, Saratov State University, Saratov, 

Russia 

220 PL 14736: 14-DAY INTRACOLONIC TOXICITY STUDIES IN RATS AND DOGS 

Z. Krnić 1 , M. Veljača 1 , M.K. Prinsen 2 , 1 PLIVA Pharmaceutical Industry Inc., Zagreb, 

Croatia, 2 Departments of General Toxicology and Analytical and Molecular 

Phamacology, TNO Nutrition and Food Research, Zeist, The Netherlands 

221 COMPARATIVE STUDY OF DEXTROMETORPHAN ASSAY BY UV SPECTRO- 

PHOTOMETRY AND SPECTROFLUORIMETRY 

A. Florea 1 , D.L. Baconi 2 , A. Popa 2 , M. Ilie 2 , D. Balalau 2 , 1 National Medicines 

Agency, Bucharest, Romania 2 “Carol Davila” University of Medicine and Pharmacy, 

Faculty of Pharmacy, Bucharest, Romania 

222 SAFETY OF PANAX GINSENG AQUA-ACUPUNCTURES SOLUTION ON P450- 

DEPENDENT DRUG METABOLISM IN CULTURE OF ADULT RAT HEPATOCYTES 

Boo Hyeong Byun 1 , Eun-Joo Kim 2 and Sun-Hee Do 2 , 1 Dept of Oriental Medicine 

Kyungsan Univ., Daegu, Korea, 2 Korea Institute of Toxicology, KRICT, P.O.Box 107, 

Yuseong-gu, Daejoen, Korea 

57 

307 

308 

309 

310 

311 

312 

313 

314 

315 

316 

317 

MONDAY

223 STUDY ON SINGLE DOSE TOXICITY OF PANAX GINSENG AQUA-ACUPUNC- 

TURE SOLUTION IN RATS 

Boo-Hyeong Byun 1 , Bu-il Seo 1 , Soon-Jae Rhee 2 , Eun-Joo Kim 3 and Sun-Hee Do 3 , 

1 Dept of Oriental Medicine Kyungsan Univ., Daegu, Korea, 2 Dept of Food and 

Nutrition, Dae-gu Catholic Univ., Korea, 3 Korea Institute of Toxicology, KRICT, 

P.O.Box 107, Yuseong-gu, Daejoen, Korea 

224 TOXICOLOGICAL STUDY ON THREE HERBAL FORMULATIONS IN IRAN 

M. R. Heidari, M. Hassibi, A. Mondegari, Department of toxicology and 

pharmacology, Kerman University of Medical Sciences, Kerman, Iran 

225 BIOLOGICAL ACTIVITY OF ARNEBIA EUCHROMA ROYLE 

K. Javidnia 1 , R. Bahri Najafi 1 , A. Jafari 2 , 1 Faculty of Pharmacy, Shiraz University of 

Medical Sciences, Shiraz, Iran, 2 Research center of Natural Resource and Animal 

Husbandry, Yasuje, Iran 

226 STUDY ON ADSORPTION OF ET-743 TO MATERIALS USED IN INTRAVENOUS 

RODENT INFUSION STUDIES 

J. Verbeeck 1 , A. Looszova 1 , T. Verhaeghe 1 , L. Diels 1 , L. Lammens 1 , R. De Coster 1 , 

I. Manzanares 2 , P. Aviles 2 , W. Coussement 1 1 Johnson and Johnson Pharmaceutical 

Research and Development, a division of Janssen Pharmaceutica N.V., 

GPCD/PCDE, Beerse, Belgium 2 PharmaMar, Madrid, Spain 

227 SUBSTATIONAL OF HEPATOPROTECTIVE ACTION OF BIOMELAN PREPARA- 

TION IN EXPERIMENT 

A. Shayakhmetova, G. Saifetdinova , V. Kovalenko, O.Voloshina, Institute of 

Pharmacology and Toxicology, Kyiv, Ukraine, Pharmacological Centre, Ministry of 

Health, Kyiv, Ukraine 

228 CYTOTOXICITY AND ANTIMICROBIAL ACTIVITY OF EUPHORBIA 

HEBECARPA BOISS 

R. Miri 1 , K. Javidnia 1 , A. Jafari 2 , 1 Faculty of Pharmacy, Shiraz University of 

Medical Sciences, Shiraz, Iran, 2 Research center of Natural Resource and Animal 

Husbandry, Yasuje, Iran 

229 ANALGESIC ACTIVITY OF IRANIAN HYPERICUM PERFORATUM 

K. Morteza-Semnani 1 , M. Mahmoudi 2 , M. Saeedi 1 , A. Javanmardi 1 , 1 Department of 

Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical 

Sciences, Sari, Iran, 2 Department of Pharmacology, Faculty of Medicine, 

Mazandaran University of Medical Sciences, Sari, Iran 

230 ANTI-INFLAMMATORY ACTIVITY AND ACUTE TOXICITY OF IRANIAN 

HYPERICUM PERFORATUM 

M. Mahmoudi 1 , K. Morteza-Semnani 2 , M. Saeedi 2 , A. Javanmardi 2 , 1 Department of 

Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, 

Sari, Iran, 2 Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran 

University of Medical Sciences, Sari, Iran 

231 ISOLATION AND CHARACTERIZATION OF ROSMARINIC ACID FROM THE 

PLANT CORDIA VERBENACEA 

F.K. Ticli 1 , S.M.C. da Costa 1 , J.O. da Silva 1 , P.S. Pereira 2 , S.V. Sampaio 1 , 

1 Laboratório de Toxicologia, Departamento de Análises Clínicas, Toxicológicas e 

Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, 

Universidade de São Paulo, Ribeirão Preto - SP. Brasil, 2 Unidade de Biotecnologia, 

Universidade de Ribeirão Preto, Ribeirão Preto - SP. Brasil 

232 ANTI-INFLAMMATORY AND ANTIOXIDANT PROPERTIES OF C-PHYCOCYA- 

NIN 

Diadelis Remirez 1 , Ricardo Gonzalez 2 , Cheyla Romay 2 , and Nuris Ledon 3 . 

1 National Center for the Quality Control of Drugs and Vaccines, 2 Center of Ozone 

Investigations, 3 Molecular Immunology Center, Toronto, Canada 

58 

318 

319 

320 

321 

322 

323 

324 

325 

326 

327

233 DETERMINATION OF LEAD AND CADMIUM CONTENTS IN MEDICINAL 

HERBAL RAW MATERIALS 

Z. Nazari, N. Poorreza Dept. of toxicology & Pharmacology, Pharmacy school, 

Ahvaz University of Medical Sciences, Ahvaz, Iran 

234 INVESTIGATION OF SYSTEMIC TOXICITY AND LOCAL TISSUE TOLERANCE 

OF A NEW MICROPOROUS IMPLANT 

Lj. Pitic 1 , J. Markov 1 , D. Jeremic 1 , D. Djukanovic 2 , 1 Biomedical Research Center, 

Institute, Galenika a.d., Belgrade, Serbia and Montenegro, 2 Clinic for Peridontology 

and Oral Medicine, Faculty for Stomatology, University of Belgrade, Serbia and 

Montenegro 

235 EVALUATION OF CYTOTOXICITY AND BIOCOMPATIBILITY OF BIOCERAMIC 

MICROPOROUS IMPLANT 

J. Markov 1 , Lj. Pitic 1 , D. Djukanovic 2 , 1 Biomedical Research – Institute, Galenika 

a.d. Belgrade, Serbia and Montenegro, 2 Clinic for Periodontology and Oral 

Medicine, Faculty for Stomatology, University of Belgrade, Serbia and Montenegro 

236 PHARMACOLOGY AND TOXICOLOGY OF OXIME REACTIVATORS OF 

CHOLINESTERASE 

C. Dishovsky, Department Experimental Toxicology, Military Medical Academy, 

Sofia, Bulgaria 

237 STORAGE OF UNUSED MEDICATIONS IN A SAMPLE OF TEHRAN'S HOU- 

SEHOLDS 

H.R. Rasekh and F. Roshan-Zamir, Department of Pharmacology/Toxicology, 

Shaheed Beheshti School of Pharmacy, Tehran, Iran 

238 EFFECTS OF NALOXONE AND YOHIMBINE ON MORPHINE AND CLONIDINE 

ANALGESIA IN MICE 

I. Ebrahimi, M. Roohi Azizi , M. R. Keyhani, Laboratory of Clinical 

Neurophysiology, Department of Basic Sciences, Faculty of Rehabilitation, Iran 

University of Medical Sciences, Tehran, Iran 

59 

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329 

330 

331 

332 

333 

MONDAY


GROUP A 




CARDIOVASCULAR TOXICOLOGY 


239 EFFECTS OF ARTESUNATE, AN ANTIMALARIAL AGENT, ON hERG CHANNEL 

CURRENTS EXPRESSED IN CHO CELLS 

Eun-Joo Kim 1 , Ki-Suk Kim 1 , Sun-Hee Do 1 , Sang-Seop Han 1 , Boo-Hyeong Byun 2 , 

1 Korea Institute of Toxicology, KRICT, P.O.Box 107, Yuseong-gu, Daejoen, Korea, 

2 Dept of Oriental Medicine Kyungsan Univ., Daegu, Korea 

240 METABOLISM IS REQUIRED FOR THE EXPRESSION OF ECSTASY-INDUCED 

CARDIOTOXICITY IN VITRO 

Márcia Carvalho 1 , Fernando Remião 1 , Nuno Milhazes 2 , Fernanda Borges 2 , 

Eduarda Fernandes 3 , Félix Carvalho 1 , Maria Lourdes Bastos 1 . 1 REQUIMTE, 

Toxicology Department, 2 CEQOFFUP, Organic Chemistry Department, 3 REQUIM- 

TE, Physical-Chemistry Department, Faculty of Pharmacy, University of Porto, Rua 

Aníbal Cunha, 164, 4050/047 Porto, Portugal 

241 THE EFFECTS OF ACUTE AND SUBACUTE LEAD ACETATE EXPOSURE ON 

THE RESPONSIVENESS OF ADRENERGIC SYSTEM IN RAT AORTA 

Ali Khoshbaten 1 , R. Dehpour 3 , GR. Karimi 3 , S. Tabaei 2 , MR. Zarrindast 3 , M. 

Fahim4, A. Asgari 1 , A. Noroozzadeh 1 , A. Heydari 1 , 1 Department of Physiology and 

Biophysics, University of Baghiyatollah (A.S.) Medical Sciences, 2 Department of 

Physiology, Azad University, 3 Department of Pharmacology, Tehran University of 

Medical Sciences, 4 Department of Physiology, Delhi University of Medical 

Sciences, India 

242 TRANSCRIPTOMIC ANALYSIS OF VASCULITIS INDUCED IN RAT 

MESENTERIC ARTERIES BY A PHOSPHODIESTERASE INHIBITOR 

Stephan Chevalier 1 , Nicolas Dagues 1 , Claudia Garcia-Allen 2 , Valérie Pawlowski 1 . 

PFIZER Global R&D 1 Molecular and Cellular Toxicology Laboratory, Amboise, 

France and 2 Genetic Technologies, Sandwich 1 UK 

243 DOXORUBICIN TREATMENT LEADS TO REPRESSION OF CERTAIN 

TRANSCRIPTION FACTORS IN RAT HEARTS – A MICROARRAY GENE 

EXPRESSION STUDY IN AID FOR HYPOTHESIS GENERATION 

J. Borlak 1 , J. Wagener 1 and T. Thum 1 , Fraunhofer Institute for Toxicology and 

Experimental Medicine, 1 Drug Research and Medical Biotechnology, Hannover, 

Germany 

244 DYNAMICS OF CARDIOVASCULAR EFFECTS OVER A 5 YEAR FOLLOW-UP 

OF CS2 EXPOSED WORKERS 

A. Bortkiewicz, E. Gadzicka, Nofer Institute of Occupational Medicine, Lodz, 

Poland 

60 

334 

335 

336 

337 

338 

339

245 FOLLOW-UP STUDY ON BLOOD PRESSURE IN WORKERS EXPOSED TO 

CARBON DISULFIDE 

E. Gadzicka, A. Bortkiewicz, Nofer Institute of Occupational Medicine, Lodz, Poland 

246 MICROARRAY ANALYSIS REVEALS COMPLEX DEREGULATION OF GENE 

EXPRESSION IN HEART TISSUE UPON AROCLOR 1254 TREATMENT – 

IMPLICATIONS FOR CARDIOTOXICITY 

T. Thum and J. Borlak Fraunhofer Institute for Toxicology and Experimental 

Medicine, Drug Research and Medical Biotechnology, Hannover, Germany 

247 CARDIOVASCULAR TOXIC EFFECTS OF ACUTE EXPOSURE TO HIGH 

GLUCOSE CONCENTRATIONS IN RATS 

C. Di Filippo 1,3 , R. Marfella 2,3 , A. Ceriello 4 , L. Berrino 1 , D. Giugliano 2,3 , A. Filippelli 1,3 , 

F. Rossi 1,3 , M. D’Amico 1,3 , 1 Department Experimental Medicine, 2 Department 

Geriatrics and Metabolic Diseases and 3 Excellence Centre for Cardiovascular 

Disease, Second University of Naples, Italy. 4 Department Pathology and Medicine, 

University of Udine, Italy 

248 OXIDIZED LDL IS A MAJOR REGULATOR OF METABOLIC PATHWAYS IN 

HUMAN ENDOTHELIAL CELLS 

T. Thum and J. Borlak Fraunhofer Institute for Toxicology and Experimental 


249 MODULATION OF PLASMA LIPID LEVELS AFFECTS B[A]P-INDUCED DNA 

DAMAGE IN TISSUES OF TWO HYPERLIPIDEMIC MOUSE MODELS 

D.M.J. Curfs 1 ; L. Beckers 1 ; R.W.L. Godschalk 1,2 ; M.J.J. Gijbels 3,4 ; F.J. van 

Schooten 1 1 Departments of Health Risk Analysis and Toxicology, 3 Molecular 

Genetics and 4 Pathology, University of Maastricht, Maastricht, The Netherlands. 

2 Division of Toxicology and Cancer Risk Factors, German Cancer Research Centre 

(DKFZ), Heidelberg, Germany 

250 CIGARETTE SMOKE-INDUCED ENDOTHELIAL DYSFUNCTION IN VITRO: 

ROLE OF THE CYCLOOXYGENASE PATHWAY 

R. Schleef and K.von Holt, Philip Morris Research Laboratories GmbH, Koeln, 

Germany 

251 INHIBITION OF MACROPHAGES AND ATHEROGENESIS BY BISPHOSPHO- 

NATES 

P. Ylitalo, O-M. Tuominen, A. Lepoluoto, R. Ylitalo, Department of Pharmacological 

Sciences, Medical School, University of Tampere, Tampere, Finland 

252 A VALIDATED METHOD FOR THE DETERMINATION OF EPOXYEICOSATRIE- 

NOIC ACIDS (EETS) USING HIGH PERFORMANCE LIQUID CHROMATO- 

GRAPHY – ELECTROSPRAY IONISATION / MASS SPECTROMETRY (HPLC- 

ESI/MS N) 

J. Borlak , V. Zelinski and T. Thum, Fraunhofer Institute for Toxicology and 

Experimental Medicine, Drug Research and Medical Biotechnology, Hannover, 

Germany 

253 DIMETHYLBENZ(A)ANTRACENE (DMBA) BINDING CORRESPONDS TO 

CYP1A1 EXPRESSION IN ENDOTHELIAL CELLS OF THE BLOOD-BRAIN 

INTERFACES 

Anna Östergren 1 , Lizette Granberg 2 , Ingvar Brandt 2 and Eva Brittebo 1 , 1 Dept. of 

Pharmaceutical Biosciences, Biomedical Centre, Uppsala University, Box 594, SE- 

751 24 Uppsala, Sweden, 2 Dept. of Environmental Toxicology, Evolutionary Biology 

Centre, Uppsala University, Norbyvägen 18 A, SE-752 36 Uppsala, Sweden 

254 HALLMARKS OF ION CHANNEL GENE EXPRESSION IN END-STAGE HEART 

FAILURE 

J. Borlak and T. Thum, Fraunhofer Institute for Toxicology and Experimental 


61 

340 

341 

342 

343 

344 

345 

346 

347 

348 

349 

MONDAY


GROUP A 




KIDNEY TOXICOLOGY 


255 EFFFECT OF LONG-TERM CADMIUM TREATMENT ON APOPTOSIS AND 

PROLIFERATION OF RAT KIDNEY CELLS 

A. Plewka, G. Nowaczyk, D. Plewka, M.M. Brzóska 1 , M. Kamiń ski, J. Moniuszko- 

Jakoniuk 1 , Department of Histology and Embryology, Medical University of Silesia, 

Katowice, 1 Department of Toxicology, Medical University of Białystok, Poland 

256 ULTRASTRUCTURAL FEATURES OF CELL DEATH BY HgCl2 IN RAT 

PROXIMAL TUBULES 

A. Stacchiotti 1 , A. Lavazza 2 , L. Rodella 1 , R. Rezzani 1 , R. Bianchi 1 , 1 Division of 

Human Anatomy, Department of Biomedical Sciences and Biotechnology, 

University of Brescia, Brescia, Italy, 2 Istituto Zooprofilattico Sperimentale della 

Lombardia ed Emilia-Romagna, Brescia, Italy 

257 THE INFLUENCE OF PYRETHROIDS ON HISTOPATHOLOGICAL CHANGES IN 

KIDNEYS: ANTERIOR (HAEMATOPOIETIC TISSUE) AND POSTERIOR 

(NEPHRON SYSTEM AND HAEMATOPOIETIC TISSUE) IN FISH 

H. Lutnicka, Department of Fish Diseases and Biology, Faculty of Veterinary 

Medicine, Agricultural University, Lublin, Poland 

258 EFFECT OF STATINS ON PROTEIN UPTAKE AND CHOLESTEROL BIO- 

SYNTHESIS IN KIDNEY PROXIMAL TUBULE CELLS 

James E Sidaway 1 , Robert G Davidson 2 , Fergus McTaggart 2 , Terry C Orton 1 , 

Robert C Scott 1 , Graham J Smith 2 and Nigel J Brunskill 3 , AstraZeneca, 1 Safety 

Assessment and 2 Cardiovascular and Gastrointestinal Discovery, Alderley Park, 

Macclesfield, Cheshire, SK10 4TG, UK, 3 Department of Nephrology, Leicester 

General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK 

259 DOES NTBC MODULATE D-SERINE-INDUCED NEPHROTOXICITY? 

R.E. Williams & E.A.Lock, Syngenta Central Toxicology Laboratory, Alderley Park, 

Macclesfield, Cheshire, SK10 4TJ, UK 

260 THE EFFECTS OF AN INCREASE IN TIME BETWEEN SACRIFICE AND TISSUE 

FIXATION ON IMMUNOHISTOCHEMICAL STAINING FOR PROLIFERATING 

CELL NUCLEAR ANTIGEN IN THE RAT KIDNEY 

W. Roosen, L. Lammens, J. Vandenberghe, M. Desmidt, J. Verbeeck, W. 

Coussement Johnson and Johnson Pharmaceutical Research and Development, a 

division of Janssen Pharmaceutica N.V., GPCD/PCDE, Beerse, Belgium 

261 TOXIC EFFECT OF AQUEOUS COFFEE EXTRACT ON MALE RAT KIDNEY 

(STEREOLOGICAL STUDY) 

M.R. Panjehshahin, F. Dehghani, R. Dezfullian, Shiraz Medical School, Shiraz, Iran 

62 

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351 

352 

353 

354 

355 

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LIVER TOXICOLOGY 


262 DETERMINATION OF CARBAMYLE PHOSPHATE SYNTHETASE-1, GLUTAMINE 

SYNTHETASE AND ARGINASE ENZYME ACTIVITIES AS MARKERS OF ACETA- 

MINOPHEN HEPATOTOXICITY IN RATS 

Hoda Fouad 1 , Nadia Barghash 2 , FairouzEl-Sayed 2 , Mervat Barakat 3 1 Departments 

of Forensic Medicine and Toxicology, 2 Medical Biochemistry, and 3 Pharmacology 

and Drug Toxicology, Faculty of Medicine, University of Alexandria, Egypt 

263 PROTECTIVE EFFECTS OF CALCIUM ANTAGONISTS ON ACUTE ACETAMI- 

NOPHEN HEPATOTOXICITY IN ADULT MALE ALBINO RATS 

Usama M. El-barrany 1 , Ashraf M.F. Kamel 2 and Ashraf M. Emara 3 Departments of 

Forensic Medicine & Toxicology1 & 3 ; and Histology2 1 & 2 

, Faculty of Medicine, Cairo 

and Tanta 3 Universities, Tanta, Egypt 

264 HEPATOTOXICITY OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN 

FRESHLY ISOLATED RAT HEPATOCYTES 

Akram Jamshidzadeh, Hossein Niknahad, Behrokh Eskandari, Mansooreh 

Mohammadi, Department of Pharmacology and Toxicology, Faculty of Pharmacy- 

Shiraz University of Medical Sciences, Shiraz, Iran 

265 THE PROTECTIVE EFFECT OF SILYBUM MARIANUM AND VITAMIN E ON 

LIVER TOXICITY INDUCED BY SODIUM VALPROATE 

H. Kalantari and F. Talibi Depart. of Pharmacology &Toxicology, Pharmacy 

School, Ahvaz University of Medical Sciences, Iran 

266 PROBIOTICS EFFECTS ON ACETAMINOPHEN-INDUCED HEPATOTOXICITY 

IN RAT 

M. Rezayat, H.R. Varmazyar, B. Djhangiurir, A. Mohammadie, M. Ghazi-Khansari, 

Depatment of Pharmacology School of Medicine, Tehran University of Medical 

Sciences, Theran, UIran 

267 HEPATOTOXICOLOGICAL DIFFERENCES WITH ET 743 BETWEEN SPRAGUE 

DAWLEY RATS AND CYNOMOLGUS MONKEYS 

J. Verbeeck 1 , A. Vynckier 1 , A. Looszova 1 , K. Anciaux 1 , N. Bode 1 , R. De Coster 1 , L. 

Lammens 1 , P. Aviles 2 , I. Manzanares 2 , W. Coussement 1 1 Johnson and Johnson 

Pharmaceutical Research and Development., GPCD/PCDE, Beerse, Belgium 

2 PharmaMar, Madrid, Spain 

268 TOXICITY EFFECTS OF VITAMIN A ON THE LIVER AND BONE IN RATS 

M. Taheri Moghadam, I. Rashidi, Department of Pathology, Medical University, 

Ahvaz, Iran 

63 

357 

358 

359 

360 

361 

362 

363 

MONDAY

269 HEPATOTOXIC EFFECTS OF 3,4-METHYLENEDIOXYAMPHETAMINE AND α- 

METHYLDOPAMINE IN FRESHLY ISOLATED RAT HEPATOCYTES 

Márcia Carvalho 1 , Nuno Milhazes 2 , Fernando Remião 1 , Fernanda Borges 2 , Eduarda 

Fernandes 3 , Terrence J. Monks 4 , Félix Carvalho 1 , Maria Lourdes Bastos 1 . 

1 REQUIMTE, Toxicology Department, 2 CEQOFFUP, Organic Chemistry 

Department, 3 REQUIMTE, Physical-Chemistry Department, Faculty of Pharmacy, 

University of Porto, Rua Aníbal Cunha, 164, 4050/047 Porto, Portugal. 4 Center for 

Molecular and Cellular Toxicology, College of Pharmacy, University of Texas at 

Austin, Austin, TX 78712/1074, USA 

270 THE METABOLISM OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE (ECSTA- 

SY) INTO N-METHYL-α-METHYLDOPAMINE DRASTICALLY INCREASES ITS 

IN VITRO TOXICITY 

Márcia Carvalho 1 , Nuno Milhazes 2 , Fernando Remião 1 , Fernanda Borges 2 , Eduarda 

Fernandes 3 , Félix Carvalho 1 , Maria Lourdes Bastos 1 . 1 REQUIMTE, Toxicology 

Department, 2 CEQOFFUP, Organic Chemistry Department, 3REQUIMTE, Physical- 

Chemistry Department, Faculty of Pharmacy, University of Porto, Rua Aníbal 

Cunha, 164, 4050/047 Porto, Portugal 

271 EARLY CHANGES IN RAT LIVER INJURED BY ORAL ADMINISTRATION OF 

FURAN 

K.C. Hickling1 , J.M. Hitchcock2 , J.K. Chipman2 , J.G. Evans1 and T.G. Hammond1 1AstraZeneca R&D Charnwood Safety Assessment, Bakewell Road Loughborough 

Leics, LE11 5RH. 2School of Biosciences, The University of Birmingham, 

Edgbaston, Birmingham, B15 2TT UK 

272 HEPATIC P450-DEPENDENT MONOOXYGENASES AND GLUTATHIONE 

LEVELS IN PARACETAMOL AND N-ACETYLCYSTEINE TREATED RATS 

AFTER CHRONIC OF TRICHLOROETHYLENE EXPOSITION 

A. Plewka1 , G. Nowaczyk1 , D. Plewka1 , B. Zielińska-Psuja2 , J. Kowalówka- 

Zawieja2 , M. Kamiński1 , J. Orłowski2 1Department of Histology & Embryology, Silesian School of Medicine, Katowice- 

Ligota, 2Department of Toxicology, Karol Marcinkowski University of Medical 

Sciences, Poznań, Poland 

273 m-DINITROBENZENE-INDUCED HEPATIC CYTOTOXICITY IN RAT LIVER 

SPHEROIDS 

Jinsheng Xu and Wendy M. Purcell Centre for Research in Biomedicine, Faculty 

of Applied Sciences, University of the West of England, Bristol, UK 

274 THE EFFECTS OF THE SMOKE PRODUCED FROM CIGARETTES EXPOSED 

TO SPECIFIC PULSED ELECTROMAGNETIC FIELD ACCORDING TO NIKO- 

LAOU TECHNOLOGY IN RATS AFTER 60-DAYS RESPIRATORY EXPOSURE 

M. Jokanovic 1 , P. Stukalov 2 , D. Angelopoulos 3 , T. Nikolaou 3 , V. Bajic 2 , 1 Faculty of 

Pharmacy, Department of Toxicology, Vojvode Stepe 450, Belgrade, Serbia and 

Montenegro, 2 Clinical Center of Serbia, Pasterova 2, Belgrade, Serbia and 

Montenegro, 3 Fenomeno Electronic Technologies, Athens, Greece 

275 CAN SHORT-WAVE DIATHERMY MAKE HISTOLOGICAL CHANGES IN THE 

RAT LIVER? 

H. Bhadoran, Gh. Kaka, SH. Sadraei, H. Dashtnavard, MH. Asadi 

Departement of Anatomy, Baghyatallah University of Medical Sciences, Tehran, Iran 

276 THE EFFECT OF FRITILLARIA IMPERIALIS BULB EXTRACT ON THE MICE 

LIVER 

H. Kooshapur 1 , H. Kalantari 2 , F. Skandari 2 , 1 Department of Pharmacognosy, 

2 Department of Pharmacology and Toxicology, Ahwaz University of Medical 

Sciences and Health Services, Ahwaz, I.R. Iran 

64 

364 

365 

366 

367 

368 

369 

370 

371

277 HEPATIC STIMULATOR SUBSTANCE PROTECTS AGAINST ACUTE 

CADMIUM-INDUCED LIVER INJURY 

G.I. Panoutsopoulos 1 , K.N. Tzirogiannis 1 , M.D. Demonakou 2 , A.I. Papadopoulos 1 , 

R.I. Hereti 1 , V.G. Kondili 1 , G.K. Papadimas 1 , K.T. Kourenzi 1 , L.A. Euliati 1 , 

1 Department of Experimental Pharmacology, Medical School, Athens University, 75 

Mikras Asias St., Athens 115 27, Greece, 2 Histopathology Laboratory, 

Sismanoglion G.D. Hospital, Sismanogliou 1, Marousi, Attiki 151 27, Greece 

278 THE ROLE OF PUTRESCINE IN ACUTE CADMIUM HEPATOTOXICITY 

K.N. Tzirogiannis 1 , G.I. Panoutsopoulos 1 , M.D. Demonakou 2 , C.C. Vlachos 1 , A.C. 

Basayiannis 1 , R.I. Hereti 1 , K.N. Alexandropoulou 1 , A.I. Papadopoulos 1 , 1 Department 

of Experimental Pharmacology, Medical School, Athens University, 75 Mikras Asias 

St., Athens 115 27, Greece, 2 Histopathology Laboratory, Sismanoglion G.D. 

Hospital, Sismanogliou 1, Marousi, Attiki 151 27, Greece 

279 INFLUENCE OF SOME DERIVATIVES OF PYRIDINE CARBOXYLIC ACIDS ON 

STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF ENDOPLASMIC 

RETICULUM MEMBRANES AND FRACTIONATED NUCLEAR CHROMATIN OF 

A LIVER OF EXPERIMENTAL ANIMALS UNDER POISONING WITH TETRA- 

CHLOROMETHANE AND 1,2-DICHLOROETHANE 

P.G. Zhminko 1 , Yu.I. Gubskiy 2 , A.N. Marchenko 2 , E.L. Levitsky 2 , N.V. Litvinova 2 , 

A.G. Goriushko 2 , A.V. Matvienko 3 , V.Ph. Danilenko 4 , T.N. Kurapova 2 , A.N. Velichko 2 , 

L.P. Babenko 2 , N.M. Kurskaya 2 , 1 Laboratory of General Toxicology, L.I. Medved 

Institute of Ecohygiene and Toxicology, Kiev, Ukraine; Departments of 1 Biochemical 

Pharmacology, 3 Pathomorphology, 4 Synthesis of Physiologically Active 

Substances, 1 Institute of Pharmacology and Toxicology, Kiev, Ukraine 

280 GENE EXPRESSION ANALYSIS OF GALACTOSAMINE-INDUCED HEPATO- 

TOXICITY IN-VIVO AND IN-VITRO 

H. Hildebrand 1 , G. Kempka 1 , H. Ellinger 1 , B. Stuart 2 , B. Wahle 2 , H.J. Ahr 1 Bayer 

AG, 1 Toxicology, 42096 Wuppertal, Germany and 2 Toxicology, Stilwell (USA) 

281 HEPATOCELLULAR INJURY IN OFFSPRINGS OF RATS UNDER LONG TERM 

CHOLINE-DEFICIENT DIET 

C. Liapi 1 , N. Kambas 1 , P. Galanopoulou 1 , S. Theocharis, 1,2. Departments of 

1 Experimental Pharmacology and 2 Forensic Medicine-Toxicology, University of 

Athens, Medical School, Athens, Greece 

282 NUCLEAR MAGNETIC RESONANCE DETECTION AND CHARACTERISA- 

TION OF LIVER STEATOSIS IN RATS 

A. Suozzi 1 , S. Davalli 1 , P. Marzola 2 , D. Benati 2 , C. Zancanaro 2 , C. Marchioro1, L. 

Marocchio 1 , P. Cristofori 1 , 1 Research Centre, GlaxoSmithKline, Verona, Italy, 2 NMR 

Laboratory, DSMB, University of Verona, Verona, Italy 

283 HEPATIC STIMULATOR SUBSTANCE (HSS) ADMINISTRATION MODULATES 

CELL CYCLE RELATED MOLECULES EXPRESSION IN AN ANIMAL MODEL 

OF FULMINANT HEPATIC FAILURE AND ENCEPHALOPATHY 

A.P. Margeli 1 , E.Manolis 2 , L. Papadimitriou 2 , J. Stamoulis 1 , G. Gribilas 1 , 

S. Theocharis 1 . Departments of 1 Forensic Medicine-Toxicology, Medical School, 

and 2 Anatomy-Histology, Nursing School, University of Athens, Athens, Greece 

284 PROTEOMIC INVESTIGATION INTO N-NITROSOMORPHOLINE MEDIATED 

CHANGES IN RAT LIVER 

A. Oberemm 1 , N. Querfurth 1 , C. Meckert 1 , L. Brandenburger 1 , A. Herzig 1 , K. 

Kalenberg 2 , E. Krause 2 , C. Ittrich 3 , A. Kopp-Schneider 3 , J. Hellmann 4 , P. Bannasch 3 , 

H.-B. Richter-Reichhelm 1 , U. Gundert-Remy 1 , 1 Department of Assessment of 

Chemicals, Federal Institute for Risk Assessment, Berlin, Germany, 2 Institute of 

Molecular Pharmacology, Berlin, Germany, 3 German Cancer Research Institute, 

Heidelberg, Germany, 4 Institute of Toxicology,, Merck KGaA, Darmstadt, Germany 

65 

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375 

376 

377 

378 

379 

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GROUP A 




LUNG TOXICITY 


285 COMPARATIVE INHALATION STUDY OF THE STANDARD REFERENCE CIGA- 

RETTES 1R4F AND 2R4F 

E. Van Miert 1 , A. Teredesai 2 , G. Schepers 2 , B. Friedrichs 2 , P. Vanscheeuwijck 1 , 

1 Philip Morris Research Laboratories bvba, Leuven, Belgium, 2 Philip Morris 

Research Laboratories GmbH, Germany, Hannover, Germany 

286 CYTOCHROME P450 GENE EXPRESSION AND PROTEIN ACTIVITY IN BRON- 

CHOALVEOLAR MACROPHAGES AND BRONCHIAL EPITHELIAL CELLS OF 

SMOKERS AND NON-SMOKERS 

T. Thum 1 , V. Erpenbeck 2 , J. Möller 1,2 , N. Krug 2 and J. Borlak 1 , Fraunhofer 

Institute for Toxicology and Experimental Medicine, 1 Drug Research and Medical 

Biotechnology, 2 Immunology/Allergology and Clinical Inhalation 

287 EVALUATION OF CIGARETTE SMOKE-INDUCED INTERMEDIATE CHRONIC 

OBSTRUCTIVE PULMONARY DISEASE (COPD) BIOMARKER RESPONSES IN 

MICE 

C.J. Obot 1 , K.M. Lee 2 , A.F. Fuciarelli 2 , R.B. Westerberg 2 and W.J. McKinney 1 , Philip 

Morris USA, Richmond, VA; 2 Battelle Toxicology Northwest, Richland, WA, USA 

288 INVESTIGATION OF COMBINED EFFECT OF AMOSITE AND TOBACCO 

SMOKE INHALATION EXPOSURE ON INFLAMMATORY PARAMETERS OF 

BRONCHOALVEOLAR LAVAGE 

M. Hurbánková 1 , M. Beňo 1 , S. Černá 1 , Z. Kováčiková 1 , P. Bobek 1 , S. A. 

Kyrtopoulos 2 1 Respiratory Toxicology, Institute of Preventive and Clinical Medicine, 

Bratislava, Slovak Republic 2 Institute of Biological Research and Biotechnology, 

National Hellenic Research Foundation, Athens, Greece 

289 RESPIRATORY SYMPTOMS AND VENTILATORY DISORDERS AMONG A 

GROUP OF RUBBER WORKERS 

A. Rajaeefard, M. Neghab Faculty of Health, PO Box 111, Postcode 71645, 

Shiraz, Iran 

290 ULTRAFINE PARTICLES CAUSE CYTOSKELETAL DYSFUNCTIONS IN 

MACROPHAGES: ROLE OF INTRACELLULAR CALCIUM 

Vicki Stone1 , David Brown1 , Winfried Möller2 , and Joachim Heyder2 1Napier University, School of Life Sciences, Edinburgh EH10 5DT, Scotland, UK. 

2GSF - National Research Centre for Environment and Health, Institute for 

Inhalation Biology, D-82131 Munich-Gauting, Germany 

66 

380 

381 

382 

383 

384 

385

291 STUDIES OF WORK -RELATED RESPIRATORY MORBIDITY AMONG 

EMPLOYEES OF A CEMENT INDUSTRY IN SHIRAZ, IRAN 

M. Neghab 1 , M. Kamalee Neya 1 , 1 School of Health, P. O. Box 111, post code 

71645, Shiraz, Iran 

292 TIME COURSE OF PULMONARY RESPONSES OF RATS AFTER INSTILLA- 

TION OF QUARTZ- IMPORTANCE OF SURFACE CHARACTERISTICS - 

C. Albrecht 1 , W. Drommer 3 , R. Schins 1 , A. Becker 1 , D. Höhr 1 , K. Unfried 2 , A. 

Knaapen 1 , P. Borm 1 1 Particle Research Core, 2 Experimental Toxicology, Institut für 

Umweltmedizinische Forschung (IUF), Düsseldorf, Germany; 3 Dept. of Pathology, 

School of Veterinary Medicine, Hannover, Germany 

293 LUNG TUMOR FORMATION IN RATS AFTER INTRATRACHEAL INSTILLATION 

OF FINE AND ULTRAFINE PARTICLES 

Paul J.A. Borm 1 , Catrin Albrecht 1 Wolfgang Drommer 2 , 1 Particle Research Group, 

Institut für Umweltmedizinische Forschung (IUF), Düsseldorf, and 2 Institute for 

Pathology, School of Veterinary Medicine, Hannover, Germany 

294 PM10 EFFECT ON EMAP-II EXPRESSION IN LUNG EPITHELIAL CELLS 

Ernesto Alfaro-Moreno 1 , Yee M Heng 2 , Jodie Edgson 2 , Peter Symonds 2 , Alvaro 

Osornio-Vargas 1 , Irma Rosas 3 , J. Clifford Murray 2 , 1 Subdirección de Investigación 

Básica, Instituto Nacional de Cancerología, México, 2 Department of Clinical 

Oncology, University of Nottingham, Nottingham UK, 3 Centro de Ciencias de la 

Atmósfera, UNAM, México 

295 TRANSCRIPTIONAL REGULATION OF Nrf2-RELATED GENES BY 4-(N- 

METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE (NNK) IN HUMAN 

BRONCHIAL EPITHELIAL CELLS 

H. W. Kim 1 , D.H.Cho 2 , M. H. Cho 1 , 1 Laboratory of Toxicology, College of Veterinary 

Medicine, Seoul National University, Seoul, Korea 2 National Center for 

Toxicological Research, KFDA, Seoul, Korea 

296 DIFFERENTIAL EFFECTS OF TRIVALENT ANTIMONY, PENTAVALENT ANTI- 

MONY AND ANTIMONY TRIOXIDE ON RAT ALVEOLAR MACROPHAGES IN 

VITRO 

R. Poon, I. Chu. Environmental Health Science Bureau, Health Canada, Ottawa, 

Canada, K1A 0L2 

297 CO-ADMINISTRATION OF CAPTOPRIL OR NIACIN WITH PARAQUAT IN ISO- 

LATED RAT LUNG PERFUSION 

G. Nasiri, M Honarjoo, M. Ghazi-Khansari, Dept of Pharmacology, School of 

Medicine, Tehran University of Medical Sciences, Tehran, Iran 

67 

386 

387 

388 

389 

390 

391 

392 

MONDAY


GROUP A 




REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY 


298 HDAC-INHIBITORS ARE TERATOGENIC IN THE MOUSE 

Francesca Di Renzo, Maria Luisa Broccia, Valentina Massa, Elena Menegola, 

Erminio Giavini, University of Milan- Department of Biology, 20133 Milan, Italy 

299 MECHANISMS INVOLVED IN TRIAZOLE-INDUCED TERATOGENESIS: IN 

VITRO STUDY 

Valentina Massa, Maria Luisa Broccia, Francesca Di Renzo, Elena Menegola, 

Erminio Giavini, University of Milan- Department of Biology, 20133 Milan, Italy 

300 EMBRYOTOXIC EFFECTS OF RANITIDINE 

B. Nassrollazadeh, M. Lalancy, D. Onsory, Department of Anatomy, School of 

Medicine, Tehran University of Medical Sciences, Tehran, Iran 

301 THE EFFECTS OF A SINGLE TERATOGENIC DOSE OF VALPROIC ACID ON 

PLASMA ZINC CONCENTRATION IN THE FEMALE RAT 

P. Pasbakhsh 1 , M. Barbarestani 1 , F. Abolhassani 1 , M.Abozaripour 1 , 1 Department of 

Anatomy,Tehran university of medical science,Tehran, Iran 

302 MENSTRUAL FUNCTION IN FEMALE WORKERS PROFESSIONALLY EXPO- 

SED TO CYTOSTATIC DRUGS: MODEL OF TOXICOLOGICAL EVALUATION 

GF. Desogus, Study Reports of Toxicology, Azienda USL 7 di Carbonia, Italy 

303 STUDY OF THE EFFECTS OF MATERNAL ADMINISTRATION OF MORPHINE 

ON THE EMBRYONIC LIVER SINUSOID AND KUPFFER CELLS 

Gh. Kaka1 , H. Sahraei2 , SH. Sadraei1 , H.Bahadoran1 , H. Dashtnavard1 1 Departement of Anatomy, Baghyatallah University of Medical Sciences, Tehran, 

Iran 2 Departement of Physiology, Baghyatallah University of Medical Sciences, 

Tehran, Iran 

304 IN VIVO MICROINJECTION OF ANTISENSE MORPHOLINO OLIGOS TO PRE- 

DICT THE TERATOGENIC POTENTIAL OF NEW DRUGS: AN INITIAL VALIDA- 

TION WORK ON VEGF 

D. Manera, M. Longo, S. Zanoncelli, P.Meroni, K.Gunnarsson. Department of 

Discovery and Development Toxicology, Pharmacia S.p.a, Milan, Italy 

305 MODIFIED ONE-GENERATION REPRODUCTION STUDY OF URSODEOXYCHO- 

LIC ACID IN RATS AND ITS SUBCHRONIC TOXICITY IN THE F1 OFFSPRING 

V. Sˇ teˇtinová, V. Herout, J. Květina, Institute of Experimental Biopharmaceutics, 

Joint Research Center of PRO.MED.CS Praha a.s. and the Academy of Sciences 

of the Czech Republic, Hradec Králové, Czech Republic 

68 

393 

394 

395 

396 

397 

398 

399 

400

306 DEVELOPMENTAL TOXICITY OF 1,2-DIBROMOETHANE AND 1,3-BUTADIENE 

AFTER INHALATION EXPOSURE OF PREGNANT RATS 

Ludmila Vodicková1 , Emil Frantík1 , Miroslava Hornychová1 , Pavel Vodicka2 1National Institute of Public Health, Prague, Czech Republic 

2Institute of Experimental Medicine, Academy of Sciences of the Czech Republic 

Prague, Czech Republic 

307 NEUROTOXICOLOGICAL EFFECTS OF METHYL MERCURY ON DEVELOPING 

BRAIN OF ALBINO RATS: HISTOLOGICAL STUDY 

Eman A. Seif 1 , Amany S. Ismaeel 2 , 1 Forensic Medicine and Toxicology, 2 Histology 

department, Faculty of Medicine, Alexandria University, Alexandria, Egypt 

308 ANALYSIS OF THE MORPHOLOGICAL CHANGES INDUCED BY INGESTION 

OF LEAD IN THE REPRODUCTIVE TRACT OF THE RAT 

Ruiz T. M 1 .; J. L. Morán 2 , C. Morán 2 , E. González 2 , A. Handal 2 . 1 Centro de Química 

Benemérita Universidad Autónoma de Puebla., Puebla, México. Laboratorio de 

Investigaciones Biológicas 2 del Instituto de Ciencias de la Benemérita Universidad 

Autónoma de Puebla, Puebla, México 

309 EFFECTS OF THE LEAD (PB) TREATMENT ON THE ONSET OF PUBERTY 

AND FOLLICULAR DEVELOPMENT IN FEMALE RATS 

E. H. Scott 1 , A. Handall 2 , J. L. Morán 2 , C. Morán 2 , 1 Escuela de Biología, Benemérita 

Universidad Autónoma de Puebla, Puebla, México, 2 Laboratorio de 

Investigaciones Biológicas, Instituto de Ciencias, Benemérita Universidad 

Autónoma de Puebla, Puebla, México 

310 THE EFFECT OF ORAL HIGH ALUMINIUM INTAKE ON RAT SPERMATOGENE- 

SIS 

I. Rashidi, Head of Department & Member of Expert Committee, Dept. of 

Pathology Medical School, Ahwaz Medical University, Ahwaz, Iran 

311 TOXIC EFFECTS OF HYDRO ALCOHOLIC EXTRACT OF KIWI ON THE HISTO- 

LOGICAL STRUCTURE OF THE MALE REPRODUCTIVE TISSUE 

T. Talaei, M.R. Panjehshahin, F. Dehghani, Z. Panahi, Department of Anatomy, 

Medical School, Shiraz University of Medical Sciences, Shiraz, Iran 

312 EFFECT OF CITRULUS COLOCYNTHIS ON FERTILITY RATE AND THE NUM- 

BER OF EMBRYO IN MOUSE 

F. Dehghani , M.R. Panjehshahin, M. Azizi, F. Mesbah, S. Karbalaedoost, T. Talaei, 

Department of Anatomy, Shiraz University of Medical Sciences, Shiraz, Iran 

313 MORPHOMETRIC STUDY OF ENDOMETRIAL LUMINAL EPITHELIUM IN 

ELECTROMAGNETIC FIELD EXPOSED RATS 

Rowshangar leila, Soleimani Rad J Department of Histology and Embryology, 

Faculty of Medicine, Tabriz Medical Sciences,Tabriz-Iran 

314 INTRAUTERINE EXPOSURE TO RADIOFREQUENCY FIELDS CAN INCREASE 

APOPTOSIS IN BONE FORMATION OF RAT EMBRYOS (ULTRASTRUCTURE 

STUDY) 

SH. Sadraie 1 , K. Parivar 2 , GH. Kaka 1 , H. Bahadoran 1 , H. Dastnavard 1 , MH. Asadi 1 . 

1 Laboratory of Cell Research, Department of Anatomy, Baghyiatallah University of 

Medical Sciences, Tehran, I.R. Iran , 2 Department of Cell Biology, Tarbiat Moallem 

University, Tehran, I.R. Iran 

315 EFFECT OF 2-ETHOXYETHANOL ON SPERMATOGENESIS IN THE EXPOSED 

WORKERS 

RS. Wang 1 , M. Suda 1 , X. Gao 2 , B.L. Wang 2 , T. Honma 1 , 1 Department of Health 

Effects Research, National Institute of Industrial Health, Japan, 2 Beijing Institute of 

Industrial Hygiene and Occupational Diseases, Beijing, China 

69 

401 

402 

403 

404 

405 

406 

407 

408 

409 

410 

MONDAY

316 CYTOTOXICITY OF HERBICIDE ATRAZINE ON CHINESE HAMSTER OVARY 

CELL LINE IN MONOLAYER 

J. Kniewals, I. Kmetič, V. Gaurina Srček, B. Sˇ imić, Z. Kniewald, Faculty of Food 

Technology and Biotechnology, University of Zagreb, Zagreb, Croatia 

317 IDENTIFICATION OF PESTICIDES SEX-SPECIFIC GONADAL TOXICITY 

N.R. Shepelskaya, M.G.Prodanchuk , Medved Institute of Ecohygiene and 

Toxicology, Kiev,Ukraine 

318 OCP INTAKE DURING PREGNANCY AND ITS SIDE EFFECTS LEADING TO 

ANOMALIES 

N. Takzaree, A-R. Takzaree, K. Yarmohammady, S. Takzaree B. Rashidi, B. 

Montazeri, Tehran university of medical sciences, Faculty of medicine, Dept of 

Anatomy, Iran 

319 COMPARATIVE STUDY OF ABORTION BETWEEN THE WORKERS OF SUR- 

GERY AND NON- SURGERY WARDS OF HOSPITALS IN AHVAZ, IRAN 

P. Afshari, S. Sadeghi Midwifery and Nursing Dept., Dezful Azad University of 

Medical Sciences. Iran 

320 A STUDY OF SHORT/LONG-TERM RESPIRATORY COMPLICATIONS IN 

MUSTARD GAS VICTIMS 

P. Afshari, Dezful Azad University, Ahvaz, Tehran 

321 ENDOCRINE DISRUPTING CHEMICALS, EXPOSURES AND CLINICAL OUT- 

COMES IN 324 PREGNANCIES IN CALGARY, CANADA 

J. Jarrell 1 and S. Chan 2 , Department of Obstetrics and Gynecology 1 and 

Toxicology 2 , University of Calgary, 1403 29th St. Calgary Alberta Canada 

322 CIGARETTE SMOKING AND p53 EXPRESSION IN THE PLACENTAL TISSUE 

P. Myllynen 1 , P. Pienimäki 1 , and K. Vähäkangas 1,2 , 1 Department of Pharmacology 

and Toxicology, University of Oulu, Oulu, Finland, 2 Department of Pharmacology 

and Toxicology, University of Kuopio, Kuopio, Finland 

323 STRUCTURAL CHANGES IN SELECTED MORPHOMETRIC PARAMETERS 

AND LEVELS OF NICOTINE AND COTININE IN PLACENTAE OF SMOKING 

MOTHERS 

Ewa Wielgus 1 , Rafał Celiński 2 , Krzysztof Pawlicki 1 , Halina Sybirska 2 , Marcin 

Kamiński 1 , 1 II Department of Histology and Embriology, Silesian Medical University, 

Katowice, Poland, 2 Forensic Medicine Department, Silesian Medical University, 

Katowice, Poland 

324 THE EFFECT OF ENVIRONMENTAL FACTORS ON SPONTANEOUS ABOR- 

TION:A CASE CONTROL STUDY IN IRAN 

Nouhjah-S. Sorri- H. School of Health, Ahwaz University of Medical Sciences, 

Ahwaz, Iran 

325 TERATOGENIC EFFECT OF LORAZEPAM ON THE MORPHOGENESIS AND 

ORGANOGENESIS OF THE EYE AND PALATE 

K. Mehrannia, P. Pasbakhsh, T. Mehrannia University of Tehran, Medicine Faculty, 

Tehran, Iran 

326 OCULAR ABNORMALITIES DUE TO TOXIC EFFECTS OF THE CARTHAMUS 

TINCTORIUS IN THE MOUSE EMBRYO 

S. Bahmanpour PhD 1 , K. Javidnia PhD 2 , 1 Department of Anatomy, School of 

Medicine, and 2 Department of Medicinal Chemistry, School of Pharmacy, Shiraz 

University of Medical Sciences, Shiraz, Iran 

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POSTERS Poster Session 1 ALLERGY SENSITISATION

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