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Section 22. Melanocytic Tumors 122 Benign Neoplasias and Hyperplasias of Melanocytes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1377 James M. Grichnik, MD, PhD, Arthur R. Rhodes, MD, MPH, & Arthur J. Sober, MD 133 Amyloidosis of the Skin . . . . . . . . . . . . . . . . . . . 1574 Helen J. Lachmann, MD, FRCP & Philip N. Hawkins, PhD, FRCP, FRCPath, FMedSci 134 Systemic Autoinflammatory Diseases . . . . . . . 1584 Chyi-Chia Richard Lee, MD, PhD & Raphaela Goldbach-Mansky, MD, MHS Contents 123 Atypical (Dysplastic) Melanocytic Nevi . . . . . 1410 James M. Grichnik, MD, PhD & Margaret A. Tucker, MD 124 Cutaneous Melanoma . . . . . . . . . . . . . . . . . . . . . 1416 Evans C. Bailey, MD, PhD, Arthur J. Sober, MD, Hensin Tsao, MD, PhD, Martin C. Mihm Jr, MD, FACP, & Timothy M. Johnson, MD Section 23. Tumors and Hyperplasias of the Dermis and Subcutaneous Fat 125 Malignant Fibrous, Fibrohistiocytic, and Histiocytic Tumors of the Dermis . . . . . . . . . . . 1445 Jürgen C. Becker, MD, PhD, Bernadette Liegl, & Selma Ugurel, MD 126 Vascular Tumors . . . . . . . . . . . . . . . . . . . . . . . . . 1456 Erin F. Mathes, MD & Ilona J. Frieden, MD 127 Neoplasias and Hyperplasias of Muscular and Neural Origin . . . . . . . . . . . . . . . 1470 Lucile E. White, MD, Ross M. Levy, MD, & Murad Alam, MD, MSci 128 Kaposi’s Sarcoma and Angiosarcoma . . . . . . . 1481 Erwin Tschachler, MD 135 Xanthomatoses and Lipoprotein Disorders . . . 1600 Ernst J. Schaefer, MD & Raul D. Santos, MD, PhD 136 Fabry Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1613 Atul B. Mehta, MD, FRCP, FRCPath & Catherine H. Orteu, MBBS, BSc, MD, FRCP 137 Lipoid Proteinosis and Heritable Disorders of Connective Tissue . . . . . . . . . . . . . 1624 Jonathan A. Dyer, MD 138 Cutaneous Mineralization and Ossification . . . 1649 Janet A. Fairley, MD 139 Hereditary Disorders of Genome Instability and DNA Repair . . . . . . . . . . . . . . . . 1654 Thomas M. Rünger, MD, PhD, John J. DiGiovanna, MD, & Kenneth H. Kraemer, MD 140 Tuberous Sclerosis Complex . . . . . . . . . . . . . . . 1671 Thomas N. Darling, MD, PhD 141 The Neurofibromatoses. . . . . . . . . . . . . . . . . . . . 1680 Robert Listernick, MD & Joel Charrow, MD 142 Ectodermal Dysplasias . . . . . . . . . . . . . . . . . . . . 1691 Alanna F. Bree, MD, Nnenna Agim, MD, & Virginia P. Sybert, MD x 129 Neoplasms of Subcutaneous Fat . . . . . . . . . . . . 1489 Thomas Brenn, MD, PhD, FRCPath Volume Two PART 8 THE SKIN IN SYSTEMIC DISEASE Section 24. Skin in Nutritional, Metabolic, and Heritable Disease 130 Cutaneous Changes in Nutritional Disease . . . 1499 Melinda Jen, MD & Albert C. Yan, MD 131 Cutaneous Changes in Errors of Amino Acid Metabolism . . . . . . . . . . . . . . . . . . . 1525 Peter H. Itin, MD 132 The Porphyrias . . . . . . . . . . . . . . . . . . . . . . . . . . . 1538 David R. Bickers, MD & Jorge Frank, MD, PhD 143 Genetic Immunodeficiency Diseases . . . . . . . . 1703 Ramsay L. Fuleihan, MD & Amy S. Paller, MD Section 25. Skin Manifestations of Bone Marrow or Blood Chemistry Disorders 144 Hematologic Diseases . . . . . . . . . . . . . . . . . . . . . 1726 Warren W. Piette, MD 145 Cutaneous Lymphoma . . . . . . . . . . . . . . . . . . . . 1745 Marc Beyer, MD & Wolfram Sterry, Prof. Dr. 146 Inflammatory Diseases That Simulate Lymphomas: Cutaneous Pseudolymphomas . . . . . . . . . . . . . . 1767 Gary S. Wood, MD 147 Cutaneous Langerhans Cell Histiocytosis . . . . 1782 Carlo Gelmetti, MD 148 Non-Langerhans Cell Histiocytosis . . . . . . . . . 1795 Carlo Gelmetti, MD
149 Mastocytosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1809 Michael D. Tharp, MD Section 26. Skin Manifestations of Internal Organ Disorders 150 The Skin and Disorders of the Alimentary Tract, the Hepatobiliary System, the Kidney, and the Cardiopulmonary System . . . . . . . . . . 1819 Graham A. Johnston, MBChB, FRCP & Robin A.C. Graham-Brown, BSc, MB, FRCP, FRCPCH 151 Diabetes Mellitus and Other Endocrine Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1840 Andrea A. Kalus, MD, Andy J. Chien, MD, PhD, & John E. Olerud, MD 152 Sarcoidosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1869 Richard M. Marchell, MD, Bruce Thiers, MD, & Marc A. Judson, MD 153 Cutaneous Manifestations of Internal Malignant Disease: Cutaneous Paraneoplastic Syndromes . . . . . . . . . . . . . . . . . 1880 Christine A. DeWitt, MD, Lucinda S. Buescher, MD, & Stephen P. Stone, MD 161 Sjögren’s Syndrome . . . . . . . . . . . . . . . . . . . . . . . 1976 Gabor Illei, MD, PhD, MHS & Stamatina Danielides, MD Section 28. The Skin in Inflammatory and Other Vascular Disorders 162 Endothelium in Inflammation and Angiogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1986 Peter Petzelbauer, MD, Robert Loewe, MD, & Jordan S. Pober, MD, PhD 163 Cutaneous Necrotizing Venulitis . . . . . . . . . . . 2003 Nicholas A. Soter, MD 164 Systemic Necrotizing Arteritis . . . . . . . . . . . . . . 2013 Peter A. Merkel, MD, MPH & Paul A. Monach, MD, PhD 165 Erythema Elevatum Diutinum . . . . . . . . . . . . . 2029 Nneka I. Comfere, MD & Lawrence E. Gibson, MD 166 Adamantiades–Behçet Disease . . . . . . . . . . . . . 2033 Christos C. Zouboulis, MD, PhD Contents Section 27. The Skin in Vascular and Connective Tissue and Other Autoimmune Disorders 154 Mechanisms of Autoimmune Disease . . . . . . . 1901 Insoo Kang, MD & Joseph Craft, MD 155 Lupus Erythematosus . . . . . . . . . . . . . . . . . . . . . 1909 Melissa I. Costner, MD & Richard D. Sontheimer, MD 156 Dermatomyositis . . . . . . . . . . . . . . . . . . . . . . . . . 1926 Richard D. Sontheimer, MD, Christopher B. Hansen, MD, & Melissa I. Costner, MD 157 Scleroderma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1942 P. Moinzadeh, MD, Christopher P. Denton, PhD, FRCP, T. Krieg, MD, & Carol M. Black, MD, FRCP, FMedSci 158 Scleredema and Scleromyxedema . . . . . . . . . . . 1957 Roger H. Weenig, MD, MPH & Mark R. Pittelkow, MD 159 Relapsing Polychondritis . . . . . . . . . . . . . . . . . . 1962 Camille Francès, MD 160 Rheumatoid Arthritis, Rheumatic Fever, and Gout . . . . . . . . . . . . . . . . . . . . . . . . . . 1965 Warren W. Piette, MD 167 Kawasaki Disease . . . . . . . . . . . . . . . . . . . . . . . . . 2042 Anne H. Rowley, MD 168 Pigmented Purpuric Dermatoses . . . . . . . . . . . 2049 Theresa Schroeder Devere, MD & Anisha B. Patel, MD 169 Cryoglobulinemia and Cryofibrinogenemia . . . . . . . . . . . . . . . . . . . . . . . 2055 Holger Schmid, MD, MSc PD & Gerald S. Braun, MD 170 Raynaud Phenomenon . . . . . . . . . . . . . . . . . . . . 2065 John H. Klippel, MD 171 Malignant Atrophic Papulosis (Degos Disease) . . . . . . . . . . . . . . . . . . . . . . . . . . .2072 Dan Lipsker, MD, PhD 172 Vascular Malformations . . . . . . . . . . . . . . . . . . . .2076 Laurence M. Boon, MD, PhD & Miikka Vikkula, MD, PhD 173 Cutaneous Changes in Peripheral Arterial Vascular Disease . . . . . . . . . . . . . . . . . . 2094 Veerendra Chadachan, MD Steven M. Dean, DO, FACP, RPVI, & Robert T. Eberhardt, MD, FACC, FSVM, RPVI 174 Cutaneous Changes in Peripheral Venous and Lymphatic Insufficiency . . . . . . . . 2110 Craig N. Burkhart, MD, Chris Adigun, MD, & Claude S. Burton, MD xi
Page 1 and 2: Contents Contributors .. . . . . .
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