Brochure for INFORCE 3 - Dairy Wellness
Brochure for INFORCE 3 - Dairy Wellness
Brochure for INFORCE 3 - Dairy Wellness
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SUPERIOR PROTECTION<br />
RIGHT FROM THE START.
The costs of respiratory disease are astounding.<br />
$1B<br />
ANNUAL COST<br />
#1<br />
BEEF<br />
It has been estimated that BRD costs the cattle industry $1 billion<br />
annually from death, reduced feed efficiency and treatment costs. 1<br />
Respiratory disease remains the most economically devastating<br />
condition in the beef industry 2<br />
• Approximately 75% of feedlot illnesses 3,4,5<br />
• 50% of feedlot deaths 3,4,5<br />
#2<br />
DAIRY<br />
The second-most significant disease in dairy operations. 6<br />
• 22% of unweaned heifer deaths 6<br />
• 46% of weaned heifer deaths 6<br />
BRSV IBR PI 3<br />
• Prevalence of 41% to 70% in U.S. 7<br />
• BRSV infection is<br />
associated with high<br />
morbidity (60% to 80%) 8<br />
• Fatality rates may<br />
be as high as 20% 8<br />
• Easily spread<br />
• Causes severe upper<br />
respiratory infections<br />
• Possible latent<br />
infection<br />
• Immunosuppressive<br />
• May predispose cattle<br />
to bacterial pneumonia 9
Safe <strong>for</strong> use in all types, ages and classes of cattle.<br />
The safety of <strong>INFORCE</strong> 3 was demonstrated in three separate studies.<br />
1. Field safety study 15 :<br />
The safety of <strong>INFORCE</strong> 3 was evaluated in a cattle safety study, which was one of the largest<br />
ever conducted by Zoetis. <strong>INFORCE</strong> 3 was administered intranasally to:<br />
• 0- to 8-day-old calves<br />
• Weaned calves<br />
• High-stress stocker cattle<br />
• Pregnant cows in all three trimesters<br />
• Total of 1,873 animals<br />
• Three geographic locations<br />
RESULTS — <strong>INFORCE</strong> 3: SAFE IN ALL TYPES, AGES AND CLASSES OF CATTLE<br />
2. Intensive safety study in young calves 16 :<br />
<strong>INFORCE</strong> 3 and a commercial 5-way intranasal vaccine were both administered intranasally:<br />
• A 10X concentrated dose to 3- to 10-day-old colostrum-deprived calves<br />
• A dose of a commercial vaccine was administered parenterally to all animals 14 days<br />
post-intranasal dose<br />
RESULTS — <strong>INFORCE</strong> 3: SAFE IN YOUNG CALVES<br />
3. High-risk stocker study 17 :<br />
<strong>INFORCE</strong> 3 and a commercial 5-way intranasal vaccine were both administered intranasally to:<br />
• High-risk stocker calves on arrival at a feedlot<br />
• A dose of a commercial vaccine was administered parenterally to all calves 14 days<br />
post-intranasal dose<br />
RESULTS — <strong>INFORCE</strong> 3: SAFE IN HIGH-RISK STOCKER CATTLE
BRSV can be prevented.<br />
<strong>INFORCE</strong> 3 is the first and only respiratory vaccine to be<br />
granted the “prevention of disease” indication, the highest<br />
label claim available <strong>for</strong> BRSV protection.<br />
100%<br />
90%<br />
100%<br />
80%<br />
% Mortality<br />
60%<br />
40%<br />
20%<br />
0%<br />
0% 0%<br />
3- to 9-dayold<br />
calves *<br />
6- to 8-weekold<br />
calves *<br />
<strong>INFORCE</strong> 3 = NO DEATHS<br />
All <strong>INFORCE</strong> 3 vaccinates survived<br />
severe BRSV challenges, while almost<br />
all unvaccinated controls died. 10,11<br />
(P–< 0.0001) (P – 0.0001)<br />
<strong>INFORCE</strong> 3 Control<br />
60%<br />
57.6%<br />
% Lung Damage<br />
40%<br />
20%<br />
0%<br />
13.5%<br />
43.8%<br />
3- to 9-dayold<br />
calves *<br />
5.8%<br />
6- to 8-weekold<br />
calves *<br />
<strong>INFORCE</strong> 3 = LESS LUNG DAMAGE<br />
Fewer lung lesions due to BRSV<br />
infections mean <strong>INFORCE</strong> 3 vaccinates<br />
should be expected to require reduced<br />
labor and treatment costs, and<br />
improved productivity. 9,10<br />
(P=0.0006)<br />
(P
A strong defense against IBR and PI 3<br />
viruses.<br />
100%<br />
100%<br />
100%<br />
80%<br />
% Morbidity<br />
60%<br />
40%<br />
20%<br />
0%<br />
5.6% 5%<br />
3- to 9-dayold<br />
calves<br />
6- to 8-weekold<br />
calves<br />
<strong>INFORCE</strong> 3 = LESS IBR DISEASE<br />
Fewer sick calves mean less treatment<br />
cost, reduced labor requirements<br />
and decreased chance of secondary<br />
bacterial infection. 12,13<br />
(P < 0.0001) (P < 0.0001)<br />
<strong>INFORCE</strong> 3<br />
Control<br />
99.9%<br />
PI<br />
LESS VIRUS SHED<br />
<strong>INFORCE</strong> 3 = LESS PI 3<br />
VIRUS SHEDDING<br />
Compared with unvaccinated controls,<br />
<strong>INFORCE</strong> 3 vaccinates shed 99.9% less<br />
3<br />
virus after challenge. 14<br />
Developed specifically <strong>for</strong> intranasal use.<br />
• Helps stimulate local immunity<br />
• Triggers a rapid innate immune response<br />
• Helps provide protection where viruses attack first<br />
• Helps prime the immune system <strong>for</strong> a memory<br />
response to subsequent disease challenges
A strong foundation <strong>for</strong> a complete vaccination protocol.<br />
Team up with your veterinarian to develop a complete<br />
vaccination protocol, starting with <strong>INFORCE</strong> 3.<br />
• <strong>INFORCE</strong> 3 helps give cattle a stronger start <strong>for</strong> greater productivity<br />
• Early protection can help reduce susceptibility to secondary bacterial infections<br />
• For dairy herds, use <strong>INFORCE</strong> 3 in baby calves, on arrival, at weaning,<br />
be<strong>for</strong>e moving to group pens, or with cows and heifers prefreshening<br />
• <strong>INFORCE</strong> 3 is perfect <strong>for</strong> use in calves in beef herds at branding, preconditioning,<br />
weaning, pre-shipment or on arrival in stocker or feedlots<br />
Get your cattle off to a stronger, healthier<br />
start with <strong>INFORCE</strong> 3. To learn more, contact<br />
your Zoetis representative, call 888-ZOETIS1<br />
(888-963-8471) or visit zoetisUS.com.<br />
<strong>INFORCE</strong> 3<br />
is available in<br />
four convenient<br />
dose sizes.<br />
1<br />
Brodersen BA, Bovine respiratory syncytial virus. Vet Clin Food Anim 2010;26:323-333.<br />
2<br />
NAHMS Beef Cow/Calf Health & Productivity Audit; Part III: Beef Cow/Calf Health Management, January 2008. Available at: http://www.aphis.usda. Accessed July 2010.<br />
3<br />
Edwards AJ. Respiratory diseases of feedlot cattle in the USA. Bovine Practitioner 1996;30:5-7.<br />
4<br />
Galyean ML, Perino LJ, Duff CG. Interaction of cattle health/immunity and nutrition. J Anim Sci 1999;77:1120-1134.<br />
5<br />
Loneragan DH, Dargatz DA, Morley PS, et al. Trends in mortality rates among cattle in U.S. feedlots. J Amer Vet Med Assoc 2001;219:1122-1127.<br />
6<br />
NAHMS <strong>Dairy</strong> 2007 Part I: Reference of <strong>Dairy</strong> Cattle Health and Management Practices in the United States, October 2007. Available at: http://www.aphis.usda. Accessed July 2010.<br />
7<br />
Steven T, Grubbs ST, Kania SA, Potgieter LND. Prevalence of ovine and bovine respiratory syncytial virus infections in cattle determined with a synthetic peptide-based immunoassay. J Vet Diagn Invest 2001;13:128–132.<br />
8<br />
Valarcher JF, Geraldine Taylor G. Bovine respiratory syncytial virus infection Vet Res 2007;38:153-180.<br />
9<br />
Ellis JA. Bovine parainfluenza-3 virus, Vet Clin Food Anim, 2010 (In press).<br />
10<br />
Data on file, Study Report No. 3131R-60-08-557, Zoetis Inc.<br />
11<br />
Data on file, Study Report No. 3131R-60-09-669, Zoetis Inc.<br />
12<br />
Data on file, Study Report No. 3131R-60-08-548, Zoetis Inc.<br />
13<br />
Data on file, Study Report No. 3131R-60-09-720, Zoetis Inc.<br />
14<br />
Data on file, Study Report No. 3131R-60-08-568, Zoetis Inc.<br />
15<br />
Data on file, Study Report No. 3437R-60-09-716, Zoetis Inc.<br />
16<br />
Data on file, Study Report No. 3131R-60-09-671, Zoetis Inc.<br />
17<br />
Data on file, Study Report No. 3131W-60-09-672, Zoetis Inc.<br />
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