Brochure for INFORCE 3 - Dairy Wellness

SUPERIOR PROTECTION
RIGHT FROM THE START.

The costs of respiratory disease are astounding.
$1B
ANNUAL COST
#1
BEEF
It has been estimated that BRD costs the cattle industry $1 billion
annually from death, reduced feed efficiency and treatment costs. 1
Respiratory disease remains the most economically devastating
condition in the beef industry 2
• Approximately 75% of feedlot illnesses 3,4,5
• 50% of feedlot deaths 3,4,5
#2
DAIRY
The second-most significant disease in dairy operations. 6
• 22% of unweaned heifer deaths 6
• 46% of weaned heifer deaths 6
BRSV IBR PI 3
• Prevalence of 41% to 70% in U.S. 7
• BRSV infection is
associated with high
morbidity (60% to 80%) 8
• Fatality rates may
be as high as 20% 8
• Easily spread
• Causes severe upper
respiratory infections
• Possible latent
infection
• Immunosuppressive
• May predispose cattle
to bacterial pneumonia 9

Safe for use in all types, ages and classes of cattle.
The safety of INFORCE 3 was demonstrated in three separate studies.
1. Field safety study 15 :
The safety of INFORCE 3 was evaluated in a cattle safety study, which was one of the largest
ever conducted by Zoetis. INFORCE 3 was administered intranasally to:
• 0- to 8-day-old calves
• Weaned calves
• High-stress stocker cattle
• Pregnant cows in all three trimesters
• Total of 1,873 animals
• Three geographic locations
RESULTS — INFORCE 3: SAFE IN ALL TYPES, AGES AND CLASSES OF CATTLE
2. Intensive safety study in young calves 16 :
INFORCE 3 and a commercial 5-way intranasal vaccine were both administered intranasally:
• A 10X concentrated dose to 3- to 10-day-old colostrum-deprived calves
• A dose of a commercial vaccine was administered parenterally to all animals 14 days
post-intranasal dose
RESULTS — INFORCE 3: SAFE IN YOUNG CALVES
3. High-risk stocker study 17 :
INFORCE 3 and a commercial 5-way intranasal vaccine were both administered intranasally to:
• High-risk stocker calves on arrival at a feedlot
• A dose of a commercial vaccine was administered parenterally to all calves 14 days
post-intranasal dose
RESULTS — INFORCE 3: SAFE IN HIGH-RISK STOCKER CATTLE

BRSV can be prevented.
INFORCE 3 is the first and only respiratory vaccine to be
granted the “prevention of disease” indication, the highest
label claim available for BRSV protection.
100%
90%
100%
80%
% Mortality
60%
40%
20%
0%
0% 0%
3- to 9-dayold
calves *
6- to 8-weekold
calves *
INFORCE 3 = NO DEATHS
All INFORCE 3 vaccinates survived
severe BRSV challenges, while almost
all unvaccinated controls died. 10,11
(P–< 0.0001) (P – 0.0001)
INFORCE 3 Control
60%
57.6%
% Lung Damage
40%
20%
0%
13.5%
43.8%
3- to 9-dayold
calves *
5.8%
6- to 8-weekold
calves *
INFORCE 3 = LESS LUNG DAMAGE
Fewer lung lesions due to BRSV
infections mean INFORCE 3 vaccinates
should be expected to require reduced
labor and treatment costs, and
improved productivity. 9,10
(P=0.0006)
(P

A strong defense against IBR and PI 3
viruses.
100%
100%
100%
80%
% Morbidity
60%
40%
20%
0%
5.6% 5%
3- to 9-dayold
calves
6- to 8-weekold
calves
INFORCE 3 = LESS IBR DISEASE
Fewer sick calves mean less treatment
cost, reduced labor requirements
and decreased chance of secondary
bacterial infection. 12,13
(P < 0.0001) (P < 0.0001)
INFORCE 3
Control
99.9%
PI
LESS VIRUS SHED
INFORCE 3 = LESS PI 3
VIRUS SHEDDING
Compared with unvaccinated controls,
INFORCE 3 vaccinates shed 99.9% less
3
virus after challenge. 14
Developed specifically for intranasal use.
• Helps stimulate local immunity
• Triggers a rapid innate immune response
• Helps provide protection where viruses attack first
• Helps prime the immune system for a memory
response to subsequent disease challenges

A strong foundation for a complete vaccination protocol.
Team up with your veterinarian to develop a complete
vaccination protocol, starting with INFORCE 3.
• INFORCE 3 helps give cattle a stronger start for greater productivity
• Early protection can help reduce susceptibility to secondary bacterial infections
• For dairy herds, use INFORCE 3 in baby calves, on arrival, at weaning,
before moving to group pens, or with cows and heifers prefreshening
• INFORCE 3 is perfect for use in calves in beef herds at branding, preconditioning,
weaning, pre-shipment or on arrival in stocker or feedlots
Get your cattle off to a stronger, healthier
start with INFORCE 3. To learn more, contact
your Zoetis representative, call 888-ZOETIS1
(888-963-8471) or visit zoetisUS.com.
INFORCE 3
is available in
four convenient
dose sizes.
1
Brodersen BA, Bovine respiratory syncytial virus. Vet Clin Food Anim 2010;26:323-333.
2
NAHMS Beef Cow/Calf Health & Productivity Audit; Part III: Beef Cow/Calf Health Management, January 2008. Available at: http://www.aphis.usda. Accessed July 2010.
3
Edwards AJ. Respiratory diseases of feedlot cattle in the USA. Bovine Practitioner 1996;30:5-7.
4
Galyean ML, Perino LJ, Duff CG. Interaction of cattle health/immunity and nutrition. J Anim Sci 1999;77:1120-1134.
5
Loneragan DH, Dargatz DA, Morley PS, et al. Trends in mortality rates among cattle in U.S. feedlots. J Amer Vet Med Assoc 2001;219:1122-1127.
6
NAHMS Dairy 2007 Part I: Reference of Dairy Cattle Health and Management Practices in the United States, October 2007. Available at: http://www.aphis.usda. Accessed July 2010.
7
Steven T, Grubbs ST, Kania SA, Potgieter LND. Prevalence of ovine and bovine respiratory syncytial virus infections in cattle determined with a synthetic peptide-based immunoassay. J Vet Diagn Invest 2001;13:128–132.
8
Valarcher JF, Geraldine Taylor G. Bovine respiratory syncytial virus infection Vet Res 2007;38:153-180.
9
Ellis JA. Bovine parainfluenza-3 virus, Vet Clin Food Anim, 2010 (In press).
10
Data on file, Study Report No. 3131R-60-08-557, Zoetis Inc.
11
Data on file, Study Report No. 3131R-60-09-669, Zoetis Inc.
12
Data on file, Study Report No. 3131R-60-08-548, Zoetis Inc.
13
Data on file, Study Report No. 3131R-60-09-720, Zoetis Inc.
14
Data on file, Study Report No. 3131R-60-08-568, Zoetis Inc.
15
Data on file, Study Report No. 3437R-60-09-716, Zoetis Inc.
16
Data on file, Study Report No. 3131R-60-09-671, Zoetis Inc.
17
Data on file, Study Report No. 3131W-60-09-672, Zoetis Inc.
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