MSDS - Diazyme Laboratories

MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC, ISO 11014-1 and EC 1907/2006
Responsible Name: Diazyme Administration
Effective: 02/04/11
SECTION 1: IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THECOMPANY/UNDERTAKING
Supplier: Diazyme Laboratories
12889 Gregg Ct.
Poway, CA 92064, USA
858-455-47568
Manufacturer:
PRODUCT NAME:
Liquid Stable Potassium
Enzymatic Assay
In case of Emergency: Call Diazyme Laboratories (858-455-4768)
Intended Use: Refer to the instruction booklet for proper and intended use.
Diazyme Laboratories
12889 Gregg Ct.
Poway, CA 92064, USA
858-455-4768
SECTION 2: COMPOSITION/INFORMATION ON INGREDIENTS
CATALOG #
DZ113C
Authorized Representative:
MDSS GmbH
Schiffgraben 41
30175 Hannover
Germany
(+49)-511-6262 8630
Product Ingredient Amount CAS # EINECS # Symbols R-Phrase S-Phrase
R1 DMSO 1% 67-68-5 200-664-3 None Listed None Listed S-24/25
NOTE: Physical and health hazard information on reagent mixtures has not been determined. Any physical and health information noted is based on 1) evaluation of
data for the pure ingredients, and 2) concentration of ingredients as packaged.
SECTION 3: HAZARD INDENTIFICATION
DMSO:
EMERGENCY OVERVIEW
OSHA Hazards
Combustible Liquid, Target Organ Effect
Target Organs
Eyes, Skin
Potential Health Effects
Eyes: May cause eye irritation.
Skin: May be harmful if absorbed through skin. May cause skin irritation.
Ingestion: May be harmful if swallowed.
Inhalation: May be harmful if inhaled. May cause respiratory tract irritation.
Chronic: No information found.
DMSO
HEALTH: 1
HMIS RATING FLAMMABILITY: 2
REACTIVITY: 0
HEALTH: 0
NFPA RATING FLAMMABILITY: 2
REACTIVITY: 0
HAZARD SYMBOLS: N/A
R-Phrase: None Listed
S-Phrase: None Listed
SECTION 4: FIRST AID MEASURES
DMSO:
General Advice: Move out of dangerous area.
Skin Contact: Wash off skin with soap and plenty of water.
Ingestion: Never give anything by mouth to an unconscious person. Rinse mouth with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration.
Eyes:
Flush eyes with plenty of water as a precaution.
Notes to Physician: None.
MSDS 1046 Rev B Page 1 of 5

MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC, ISO 11014-1 and EC 1907/2006
SECTION 5: FIRE FIGHTING MEASURES
Responsible Name: Diazyme Administration
Effective: 02/04/11
DMSO:
Flammable Properties:
PPE for Firefighters:
Extinguishing Media:
Flash Point: 87 °C (189 °F) – closed cup.
Ignition Temperature: 301 °C (574 °F)
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective
gear if necessary.
Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
SECTION 6: ACCIDENTAL RELEASE MEASURES
DMSO:
Personal Precautions: Avoid breathing vapors, mist or gas.
Environmental Precautions: Do not let product enter drains.
Spills/Leaks:
Keep in suitable, closed disposal containers for disposal.
SECTION 7: HANDLING AND STORAGE
DMSO:
Handling:
Storage:
Keep away from sources of ignition – No smoking. Take measures to prevent the buildup of electrostatic charge.
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store under inert gas. Hygroscopic.
SECTION 8: EXPOSURE CONTROLS / PERSONAL PROTECTION
DMSO:
Exposure Limits
Contains no substances with occupational exposure limit values.
Personal Protective Equipment
Respirators: Respiratory protection is not required. Where protection is desired, use multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Eyes: Wear chemical safety goggles/glasses.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to minimize contact with skin.
Hygiene measures: General industrial hygiene practice.
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
DMSO:
Physical State:
Liquid
Color:
Colorless
pH:
Not available
Vapor Pressure:
0.55 hPa (0.41 mm Hg) @ 20 deg C (68 °F)
Boiling Point:
189 deg C (372 °F) at 1,013 hPa (760 mmHg)
Freezing/Melting Point: 18.4 deg C (65.1 C
Autoignition Temperature: 301 deg C (574 °F)
Flash Point:
87 deg C (198 °F) – closed cup
Explosion Limits: Lower: 3.5 vol %
Explosion Limits: Upper: 42 vol %
Solubility in water:
Completely miscible
Specific Gravity/Density: 1.1 g/cm 3
Molecular Formula: C 2H 6 OS
Molecular Weight:
78.13 g/mol
Partition coefficient: log Pow: -2.03
Relative Vapor Density: 2.70 – (Air = 1.0)
MSDS 1046 Rev B Page 2 of 5

MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC, ISO 11014-1 and EC 1907/2006
SECTION 10: STABILITY AND REACTIVITY
Responsible Name: Diazyme Administration
Effective: 02/04/11
DMSO:
Chemical Stability:
Incompatibilities with Other Materials:
Hazardous Decomposition Products:
Hazardous Polymerization:
Stable under recommended storage conditions. Hygroscopic: absorbs moisture or water from the air.
Acid chlorides, Phosphorus halides, Strong acids, Strong oxidizing agents, Strong reducing agents.
Hazardous decomposition products formed under fire conditions. – Carbon oxides, Sulfur oxides.
Will not occur.
SECTION 11: TOXICOLOGICAL INFORMATION
DMSO:
Acute toxicity:
LD50 Oral – rat – 14,500 mg/kg
LD50 Inhalation – rat – 4 hr. - 40250 ppm
LD50 Dermal – rabbit – > 5,000 mg/kg
Irritation and Corrosion: Skin – rabbit – mild skin irritation – 24 hr.
Eyes – rabbit – mild eye irritation
Sensitization: No data available.
Chronic Exposure:
Carcinogenicity – rat – Oral
Tumorigenic : Equivocal tumorigenic agent by RTECS criteria. Skin and Appendages: Other: Tumors.
Carcinogenicity – mouse – Oral
Tumorigenic : Equivocal tumorigenic agent by RTECS criteria. Leukaemia Skin and Appendages: Other: Tumors.
IARC:
ACGIH:
NTP:
OSHA:
No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by
IARC.
No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH.
No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by ACGIH.
No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA.
Genotoxicity in vitro – mouse – lymphocyte
Cytogenetic analysis
Genotoxicity in vitro – mouse – lymphocyte
Mutation in mammalian somatic cells
Genotoxicity in vivo – rat – Intraperitoneal
Cytogenetic analysis
Genotoxicity in vivo – mouse – Intraperitoneal
DNA damage
Developmental toxicity – mouse – Intraperitoneal
Effects on Embryo or Fetus: Fetotxicity (except death, e.g., stunted fetus). Specific Developmental Abnomalities: Musculoskeletal system.
Reproductive toxicity – rat – Intraperitoneal
Effects on Fertility: Abortion.
Reproductive toxicity – rat – Intraperitoneal
Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants).
Reproductive toxicity – rat – Subcutaneous
Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter Size (e.g., number of fetuses per litter; measured before birth).
Reproductive toxicity – mouse – Oral
Effects on Fertility: Post-implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea).
Effects on Embryo or Fetus: Fetotxicity (except death, e.g., stunted fetus). Specific Developmental Abnormalities: Musculoskeletal system.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May be harmful if absorbed through skin. May cause skin irritation.
Ingestion: May be harmful if swallowed.
Inhalation: May be harmful if inhaled. May cause respiratory tract irritation.
Target Organs: Eyes, Skin.
Additional Information:
RTECS: PV6210000
MSDS 1046 Rev B Page 3 of 5

MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC, ISO 11014-1 and EC 1907/2006
SECTION 12: ECOLOGICAL INFORMATION
Responsible Name: Diazyme Administration
Effective: 02/04/11
DMSO:
Elimination Information (persistence and degradability:
No data available
Ecotoxicity Effects: Fish: Pimephales promelas (fathead minnow): LC50 = 34,000 mg/L; 96 Hr
Fish: Oncorhynchus mykiss (rainbow trout): LC50 = 35,000 mg/L; 96 Hr
Water flea Daphnia: Daphnia pulex (Water flea) EC50 = 27,500 mg/L
Algae: Lepomis macrochirus (Bluegill) EC50 > 400,000 mg/L; 96 Hr
Further information on ecology:
No data available
SECTION 13: DISPOSAL CONSIDERATIONS
DMSO:
Product: Contact a licensed professional waste disposal service to dispose this material. This combustible material may be burned in a chemical incinerator equipped
with an afterburner and scrubber. Observe all federal state and local environmental regulations.
Contaminated Packaging: Dispose of as unused product.
SECTION 14: TRANSPORTATION INFORMATION
DMSO:
IATA IMDG RID/ADR DOT (US)
Shipping Name: Not regulated. Not regulated. Not regulated. Combustible liquid, n.o.s. (Dimethyl Sulfoxide)
Hazard Class:
UN Number:
Packing Group:
SECTION 15: REGULATORY INFORMATION
DMSO:
OSHA Hazards
Combustible Liquid, Target Organ Effect
III
UN-Number: 1993, Class: CBL
Marine Pollutant: No, Poison Inhalation Hazard: No.
SARA 302 Components
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302
SARA 313 Components
SARA 302: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established
by SARA Title III, Section 313
SARA 1/312 Hazards
Fire hazard, Chronic Health Hazard
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Combustible
Risk Phrases:
Safety Phrases:
S-24/25: Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 67-68-5: 0
Canada
CAS# 67-68-5 is listed on Canada's DSL List
US Federal
TSCA
CAS# 67-68-5 is listed on the TSCA Inventory.
MSDS 1046 Rev B Page 4 of 5

MATERIAL SAFETY DATA SHEET
Conforms to 93/112/EC, ISO 11014-1 and EC 1907/2006
SECTION 16: OTHER INFORMATION
Responsible Name: Diazyme Administration
Effective: 02/04/11
PREPARED BY: Diazyme Administration
PHONE NO: 858-455-4768
DATE PREPARED: 2011-01-28
The information provided on this Material Safety Data Sheet is provided in the interest of promoting safe handling of the material. While this information is believed to
be correct Diazyme makes no warranty in respect to any of the information disclosed. Observe all federal, provincial, state and local laws concerning health and pollution.
MSDS 1046 Rev B Page 5 of 5