MSDS - Diazyme Laboratories

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MATERIAL SAFETY DATA SHEET Conforms to 93/112/EC, ISO 11014-1 and EC 1907/2006 SECTION 5: FIRE FIGHTING MEASURES Responsible Name: Diazyme Administration Effective: 02/04/11 DMSO: Flammable Properties: PPE for Firefighters: Extinguishing Media: Flash Point: 87 °C (189 °F) – closed cup. Ignition Temperature: 301 °C (574 °F) As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear if necessary. Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. SECTION 6: ACCIDENTAL RELEASE MEASURES DMSO: Personal Precautions: Avoid breathing vapors, mist or gas. Environmental Precautions: Do not let product enter drains. Spills/Leaks: Keep in suitable, closed disposal containers for disposal. SECTION 7: HANDLING AND STORAGE DMSO: Handling: Storage: Keep away from sources of ignition – No smoking. Take measures to prevent the buildup of electrostatic charge. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store under inert gas. Hygroscopic. SECTION 8: EXPOSURE CONTROLS / PERSONAL PROTECTION DMSO: Exposure Limits Contains no substances with occupational exposure limit values. Personal Protective Equipment Respirators: Respiratory protection is not required. Where protection is desired, use multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Eyes: Wear chemical safety goggles/glasses. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Hygiene measures: General industrial hygiene practice. SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES DMSO: Physical State: Liquid Color: Colorless pH: Not available Vapor Pressure: 0.55 hPa (0.41 mm Hg) @ 20 deg C (68 °F) Boiling Point: 189 deg C (372 °F) at 1,013 hPa (760 mmHg) Freezing/Melting Point: 18.4 deg C (65.1 C Autoignition Temperature: 301 deg C (574 °F) Flash Point: 87 deg C (198 °F) – closed cup Explosion Limits: Lower: 3.5 vol % Explosion Limits: Upper: 42 vol % Solubility in water: Completely miscible Specific Gravity/Density: 1.1 g/cm 3 Molecular Formula: C 2H 6 OS Molecular Weight: 78.13 g/mol Partition coefficient: log Pow: -2.03 Relative Vapor Density: 2.70 – (Air = 1.0) MSDS 1046 Rev B Page 2 of 5
MATERIAL SAFETY DATA SHEET Conforms to 93/112/EC, ISO 11014-1 and EC 1907/2006 SECTION 10: STABILITY AND REACTIVITY Responsible Name: Diazyme Administration Effective: 02/04/11 DMSO: Chemical Stability: Incompatibilities with Other Materials: Hazardous Decomposition Products: Hazardous Polymerization: Stable under recommended storage conditions. Hygroscopic: absorbs moisture or water from the air. Acid chlorides, Phosphorus halides, Strong acids, Strong oxidizing agents, Strong reducing agents. Hazardous decomposition products formed under fire conditions. – Carbon oxides, Sulfur oxides. Will not occur. SECTION 11: TOXICOLOGICAL INFORMATION DMSO: Acute toxicity: LD50 Oral – rat – 14,500 mg/kg LD50 Inhalation – rat – 4 hr. - 40250 ppm LD50 Dermal – rabbit – > 5,000 mg/kg Irritation and Corrosion: Skin – rabbit – mild skin irritation – 24 hr. Eyes – rabbit – mild eye irritation Sensitization: No data available. Chronic Exposure: Carcinogenicity – rat – Oral Tumorigenic : Equivocal tumorigenic agent by RTECS criteria. Skin and Appendages: Other: Tumors. Carcinogenicity – mouse – Oral Tumorigenic : Equivocal tumorigenic agent by RTECS criteria. Leukaemia Skin and Appendages: Other: Tumors. IARC: ACGIH: NTP: OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH. No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by ACGIH. No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA. Genotoxicity in vitro – mouse – lymphocyte Cytogenetic analysis Genotoxicity in vitro – mouse – lymphocyte Mutation in mammalian somatic cells Genotoxicity in vivo – rat – Intraperitoneal Cytogenetic analysis Genotoxicity in vivo – mouse – Intraperitoneal DNA damage Developmental toxicity – mouse – Intraperitoneal Effects on Embryo or Fetus: Fetotxicity (except death, e.g., stunted fetus). Specific Developmental Abnomalities: Musculoskeletal system. Reproductive toxicity – rat – Intraperitoneal Effects on Fertility: Abortion. Reproductive toxicity – rat – Intraperitoneal Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants). Reproductive toxicity – rat – Subcutaneous Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants). Effects on Fertility: Litter Size (e.g., number of fetuses per litter; measured before birth). Reproductive toxicity – mouse – Oral Effects on Fertility: Post-implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea). Effects on Embryo or Fetus: Fetotxicity (except death, e.g., stunted fetus). Specific Developmental Abnormalities: Musculoskeletal system. Potential Health Effects Eye: May cause eye irritation. Skin: May be harmful if absorbed through skin. May cause skin irritation. Ingestion: May be harmful if swallowed. Inhalation: May be harmful if inhaled. May cause respiratory tract irritation. Target Organs: Eyes, Skin. Additional Information: RTECS: PV6210000 MSDS 1046 Rev B Page 3 of 5
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MSDS - Diazyme Laboratories

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