Report of the UK Cystic Fibrosis Trust Antibiotic Working Group

Liposomal Amphotericin (“Ambisome”) - for systemic candidiasis or infection of indwellingintravenous access deviceAge Dose FrequencyAll ages 100 microgram/kg (max 1 mg) Test dose1 mg/kg 24 hourly day 12 mg/kg 24 hourly day 23 mg/kg 24 hourly to continuePreparationsAdministrationSide-effectsNotes50 mg vials.Reconstitute each vial with 12 ml water for injection and shake vigorously this gives 4 mg/ml. Dilute therequired dose in glucose 5% via the filter provided to a final concentration of 0.2–2 mg/ml. Infuse over 30–60minutes.Sensitivity reactions. Electrolyte disturbances.Can increase to a maximum dose of 5 mg/kg. If attempting to treat infection in an intravenous access device, thenamphotericin should be administered IV, through the device.CaspofunginAge Dose Frequency2–18 years 70 mg/m2 (max 70 mg) loading dose then 50 mg/m2 (max 70 mg) 24 hourlyAdult 12 years 50 mg 12 hourlyPreparationsAdministrationSide-effectsNotes50 mg vials.Dilute to 100 ml and give over 30–60 minutes.Nausea and vomiting, dizziness, headache, sensitivity reactions.Nausea may be severe, pre-medicate with an anti-emetic.Cystic Fibrosis Trust 8.15March 2009