contentsintroduction1Jonathan Braun, MD, PhDclinical services3567Growth In Outreach Enhances Teaching <strong>and</strong> ResearchWhile Streng<strong>the</strong>ning <strong>Department</strong>’s Bottom LineBringing <strong>UCLA</strong> Pathology/Laboratory Services to The Community<strong>Department</strong> Will Play Key Role In <strong>UCLA</strong> Health’s Partnership With China<strong>UCLA</strong>’s Exp<strong>and</strong>ing Global Presenceresearch enterprise9111213Deciphering The Genetic Basis <strong>of</strong> Disease Across Populations: Path <strong>and</strong> Lab’s Pioneering RoleClinical Genomics Center Uses Powerful Sequencing Test to Improve Diagnosis <strong>and</strong>Treatment <strong>of</strong> Genetic DisordersNext-Generation Sequencing <strong>of</strong> Human Genome Paving <strong>the</strong> Way Toward Personalized MedicineFund Managers: Invaluable Members <strong>of</strong> <strong>the</strong> Research Teameducation15171819“Flipping” <strong>the</strong> Traditional Classroom: Students Do <strong>the</strong> Teaching in DGSOM Histo<strong>pathology</strong> LabInteractive Labs Introduce Medical Students to Dermato<strong>pathology</strong>Med School puts Molecular Genetics FirstUnderst<strong>and</strong>ing <strong>the</strong> Complexities <strong>of</strong> Inflammationresearch services21232425Translational Pathology Core Laboratory Seeks to Fulfill <strong>the</strong> Promise <strong>of</strong> BiobankingPathology Portal Improves Access to <strong>Department</strong>’s ServicesEngageUC will Inform Federal <strong>and</strong> State Debate on Biobanking PracticesFreeze-Dried Storage <strong>of</strong> Tissues May Offer “Best Of Both Worlds”department in depth26293032Who’s Who in Pathology & MetricsAwards & RecognitionAlumniOpportunities for Givingeditors: karyn greenstone & sharon webb • writer: dan gordon • design: susan l<strong>and</strong>esmann designphotography: margaret sison • additional photography: todd cheney, reed hutchinson, jian yu rao & kosal taing© 2013 Regents <strong>of</strong> <strong>the</strong> University <strong>of</strong> California
jonathan braun, md, phd<strong>the</strong> quiet heroA friend <strong>of</strong> mine, whose work is philosophy, is always reading. Do you know his favoriteperiodical? It is People Magazine. He explained that it explored each week how fame <strong>and</strong> wealthdo not guarantee a happy or meaningful life! In this annual report, we reflect on my quiet heroes –those who not only bring about real <strong>and</strong> important change, but also provide <strong>the</strong> inspiration to bringout what is best in o<strong>the</strong>rs <strong>and</strong> make <strong>the</strong> world that much more <strong>of</strong> a better place.Thanks to Dr. Binder <strong>and</strong> <strong>the</strong> amazing people who fashion Pathology into a new mode <strong>of</strong> caredelivery, <strong>and</strong> educate our physician trainees not only in <strong>pathology</strong> expertise but also in <strong>the</strong> role <strong>of</strong>service. With <strong>the</strong> opening <strong>of</strong> BURL Laboratories, we are now poised to extend this special amalgam<strong>of</strong> quality <strong>and</strong> service to communities throughout <strong>the</strong> north, west, <strong>and</strong> south <strong>of</strong> Los Angeles County.Extending our boundaries even fur<strong>the</strong>r, our <strong>Department</strong>, along with <strong>UCLA</strong> Health <strong>and</strong> <strong>the</strong> Jonsson ComprehensiveCancer Center, has entered into l<strong>and</strong>mark arrangements with <strong>the</strong> Cancer Institute <strong>and</strong> Hospital, ChineseAcademy <strong>of</strong> Medical Sciences (CAMS). This builds on our successful partnerships over <strong>the</strong> past several years incare <strong>and</strong> teaching with academic health centers <strong>and</strong> municipal Hangzhou. The new relationship with CAMS willbroaden <strong>the</strong> scope <strong>of</strong> <strong>the</strong>se partnerships for clinical trials <strong>and</strong> translational research with leading investigatorsthroughout China.While we extend our global presence in China <strong>and</strong> elsewhere, we are also mindful <strong>of</strong> <strong>the</strong> needs closer to home,as we begin consultative tele<strong>pathology</strong> services to underserved <strong>pathology</strong> practices located throughout Sou<strong>the</strong>rnCalifornia. Partnerships with six communities will initiate this program, <strong>and</strong> will build from <strong>the</strong>re to a network tosupport community-based practices throughout California.Even closer to home, our Clinical Genomics Center has implemented <strong>the</strong> remarkable breakthroughs in highthroughputsequencing <strong>and</strong> disease-diagnostic genetic bioinformatics as a practical health care service. Thisis finally bringing closure to families <strong>and</strong> individuals who have been waiting years for what <strong>the</strong>y once thought werequestions without answers. The rapid diagnosis <strong>of</strong> complex genetic diseases allows patients, families, <strong>and</strong> <strong>the</strong>irhealth care team to move onto planning for medical care, <strong>and</strong> strategies to identify <strong>and</strong> eventually avert diseasein unaffected family members.Our department is intensely devoted to research, nearly $50M presently in force. What drives this creativeenterprise is David Islas <strong>and</strong> our Fund Managers. They pilot projects through <strong>the</strong> complex path from inceptionto funding, <strong>and</strong> steward <strong>the</strong>se precious funds to assure <strong>the</strong> greatest value to our investigators <strong>and</strong> traineescientists in <strong>the</strong>ir challenging experimental work.It is in <strong>the</strong> classroom where researchers <strong>of</strong> tomorrow are inspired by some <strong>of</strong> <strong>the</strong> most creative <strong>and</strong> innovativefaculty in <strong>the</strong> nation. Through <strong>the</strong> innovation <strong>of</strong> <strong>the</strong> “flipped” classroom, Elena Stark inspires future medicalleaders to think independently, <strong>and</strong> Wayne Grody, Steve Bensinger <strong>and</strong> Ch<strong>and</strong>ra Smart encourage fundamentalunderst<strong>and</strong>ing <strong>of</strong> human processes, <strong>and</strong> not simple rote learning.As <strong>the</strong> path from research to clinical innovation shortens, <strong>the</strong> distinctions between health care <strong>and</strong> researchdiminish as patient biospecimens serve care <strong>and</strong> research today, <strong>and</strong> data to guide care <strong>of</strong> <strong>the</strong> same patientswith improved care tomorrow. This creates conceptual, ethical, <strong>and</strong> operational challenges for dynamic healthsystems like <strong>UCLA</strong> centers. Sarah Dry, William Yong , Justin Perry <strong>and</strong> <strong>the</strong>ir teams in <strong>the</strong> TranslationalPathology Core Laboratory, EngageUC, <strong>and</strong> <strong>the</strong> Pathology Portal, have created a new framework to solve<strong>the</strong>se challenges for <strong>the</strong> <strong>UCLA</strong> clinical <strong>and</strong> research communities.In this annual report, read <strong>the</strong> stories <strong>of</strong> <strong>the</strong>se quiet heroes: exceptional people, <strong>and</strong> <strong>the</strong> exceptional ways that<strong>the</strong>y enable <strong>UCLA</strong> to serve <strong>the</strong> needs <strong>and</strong> dreams <strong>of</strong> our community.Dr. Jonathan Braun, Pr<strong>of</strong>essor <strong>and</strong> Chair, <strong>Department</strong> <strong>of</strong> Pathology <strong>and</strong> Laboratory Medicine<strong>pathology</strong> & <strong>laboratory</strong> <strong>medicine</strong> at <strong>ucla</strong> 1
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