High Fluoride Toothpaste Full - Alliance for a Cavity-Free Future

fluoride dentifrice. [11] The 5,000 ppm gel used in this study has been reformulated andis used as a fluoride dentifrice containing 5000 ppm fluoride.In other clinical studies the effectiveness of 5,000 ppm fluoride toothpaste and 1,100ppm fluoride gel in arresting root caries was compared. [12, 13] A total of 201 subjectswith at least one root carious lesion were recruited and randomly assigned to 5,000 ppmfluoride toothpaste or 1,100 ppm fluoride gel. Caries lesions were measured at baselineand after 3 months by a single examiner. At the end of 3 months, arrested caries lesionswere observed among 38% of those who used the 5,000 ppm toothpaste compared to11% of those who used the 1,100 ppm gel. The short duration of this study is a limitation.Overall, few studies have been conducted on assessing effectiveness of 5,000 ppmfluoride toothpaste. The studies that have been conducted have limitations. Therefore,the evidence for the highest concentration of fluoride toothpaste, while promising it is stillinsufficient. More studies are being conducted and future evidence may shed more lighton the effectiveness of high-fluoride toothpaste of 5,000 ppm.Summary and Recommendations:Based on the findings from the literature, the use of high fluoride dentifrice is effective inoverall caries reduction for concentrations above 1,500 ppm and up to 2,800 ppm. Theevidence for the highest concentration of 5,000 ppm is insufficient. The benefits ofconventional fluoride dentifrices may not suffice for those at high risk for caries. [3] Highconcentrations of fluoride may also be effective in arresting root caries lesions. [13] Mostof the studies on 1,500-2,800 ppm fluoride toothpastes have reported the effectivenessin caries prevention. In contrast, most of the studies on 5,000 ppm fluoride toothpastereport effectiveness in arresting existing caries. There is a need for future studies toinclude assessment of 5,000 ppm fluoride toothpaste on caries prevention. Whencompared to treatment procedures for caries in the dental office the use of high fluoridetoothpastes are more beneficial, easy to use and cost-effective. However, excellentpatient compliance is necessary. Safety in the use of these high concentration fluoridewww.allianceforacavityfreefuture.org | PAGE 4/6