6 Elgefors, B., Julin, A., Johansson, S.G.O.: Immunoglobulin E in bronchialasthma. Acta Allergol 1974;29:327.7 Norman, P.S., The clinical significance of IgE. Hosp. Pract. 1975;10:41-49.8 Bryant, D.A., Burns, M.W., Lazarus, L.: The correlation between skin tests,bronchial provocation tests and the serum level of IgE specific for commonallergens in patients with asthma. Clin .<strong>Allergy</strong> 1975;5:145.9 Loeffler, J.A., Cawley, L.P., Moeder, M.: Serum IgE levels - correlation withskin test sensitivity. Ann. <strong>Allergy</strong> 1973;31:331.10 Pepys, J.: Skin tests in diagnosis. In Gell, P.G.H., Coombs, R.R.A.,Lachman, P.J., editors: Clinical aspects of Immunology. Blackwell ScientificPublications, Ltd., Oxford, 1975.11 Burrows, B., et al.: Respiratory disorders and allergy skin test reactions.Ann. Intern. Med. 84:134, 1976.12 Implementation of Efficacy Review, Allergenic Extracts. Federal Register1985;50:3082-3288.13 Levy, D.A., Lichenstein, L.M., Goldstein, E.O., Ishizaka, K.: Immunologicand cellular changes accompanying the therapy of pollen allergy. J. Clin.Invest.1973;50:360.14 Gurka, G., Rocklin, R.: Immunologic responses during allergen-specificimmunotherapy for respiratory allergy. Annals of <strong>Allergy</strong> 1988;61:239-43.15 Zeiss, C.R., Jr.: Patient evaluation. In <strong>Allergy</strong> and Clinical Immunology,p.616, edited by R.F. Lockey, Medical Examination Publishing Co., GardenCity, New York, 1976.16 Frankland, A.W., Augustin, R.: Prophylaxis of summer hay-fever and asthma:a controlled trial comparing crude grass-pollen extracts with the isolated mainprotein component. Lancet 1954;1:1055.17 Frankland, A.W., Augustin, R.: Grass pollen antigens effective in treatment.Clin. Sci. 1962;23:95.18 Rohr, A.S., Marshall, N.A., Saxon, A.: Successful immunotherapy for Triatomaprotracta-induced anaphylaxis. J. <strong>Allergy</strong> Clin. Immunol. 1984;73:369-75.19 Greenberg, M.A., Kaufman, C.R., Gonzalez, G.E., Rosenblatt, C.D., Smith,L.J., Summers, R.J.: Late and immediate systemic-allergic reactions to inhalantallergen immunotherapy. J. <strong>Allergy</strong> Clin. Immunol. 1986;77:865-70.20 Ouellette, J.J.: Emergency management of the allergic reactions. ModernMedicine 1975;99.21 Anderson, J.A., et al.: Personnel and equipment to treat systemic reactionscaused by immunotherapy with allergenic extracts. J. <strong>Allergy</strong> Clin. Immunol.1986;77:271-3.22 Executive Committee, American Academy of <strong>Allergy</strong> and Immunology.The waiting period after allergen skin testing and immunotherapy (Positionstatement). J. <strong>Allergy</strong> Clin. Immunol. 1990;85:526-7.23 Sadan,N., Rhyne, M.B., Mellits, E.D., et al.: Immunotherapy of pollenosisin children: investigation of the immunologic basis of clinical improvement.N. Eng. J. Med. 1969;280:623.24 Johnstone, D.E.: Value of hyposensitization therapy for perennial bronchialasthma in children. Pediatrics 1961;27:39.15
25 VanAsperin, P.P., Kemp, A.S., Mellis, C.M.: Skin test reactivity and clinicalallergen sensitivity in infancy. J. <strong>Allergy</strong> Clin. Immunol. 73:381-6.26 Committee on Safety of Medicine: Desensitizing vaccines. Br. Med. J1986;293:948.27 Lockey, R.F., Benedict, L.M., Turkeltaub, P.C., Bukantz, S.C.: Fatalities fromimmunotherapy (IT) and skin testing (ST). J. <strong>Allergy</strong> Clin .Immunol .1987;79:660-7.28 Norman, P.S., Van Metre, T.E., Jr: The safety of allergenic immunotherapy.J. <strong>Allergy</strong> Clin. Immunol. 1990;85:522-5.29 Ownby, D.R., Adinoff, A.D.: The appropriate use of skin testing and allergenimmunotherapy in young children. J. <strong>Allergy</strong> Clin. Immunol. 1994;94:662-5.30 Data on File - Center for Biologics Evaluation and Research, Food and DrugAdministration, Rockville, MD.31 Board of Directors, American Academy of <strong>Allergy</strong> and Immunology Guidelinesto minimize the risk from systemic reactions caused by immunotherapy withallergenic extracts. (Position statement). J. <strong>Allergy</strong> Clin. Immunol. 1994;93:811-12.32 Reid, M.J., Lockey, R.F., Turkeltaub, P.C., and Platts-Mills, T.A.E.: Survey offatalities from skin testing and immunotherapy 1985-1989. J. <strong>Allergy</strong> Clin.Immunol. 1993;92:6-15.33 Bousquet, J.: In Vivo Methods For Study of <strong>Allergy</strong>: Skin tests, techniques,and interpretation. In <strong>Allergy</strong> Principles and Practice, 4th Edition, Middleton,et al eds., C.V. Mosby, St. Louis, MO, 1993.16