fMRI signal + - Neurometrika

Inference: Use Uncertainty of Parameter Estimatesa)b)noise noisenoisenoiseMean 2Mean 1RestStimRestStim• Same mean values in Rest and Stim condition in cases a) and b)Simple subtraction (difference = Mean 2 – Mean 1) yields same result !Simple subtraction does NOT consider variance of means (noise)• Statistical analysis (e.g., t test) relates estimate (mean difference) touncertainty of estimate = pooled variance of values within conditions, i.e.